JP2011505340A5 - - Google Patents

Download PDF

Info

Publication number
JP2011505340A5
JP2011505340A5 JP2010534533A JP2010534533A JP2011505340A5 JP 2011505340 A5 JP2011505340 A5 JP 2011505340A5 JP 2010534533 A JP2010534533 A JP 2010534533A JP 2010534533 A JP2010534533 A JP 2010534533A JP 2011505340 A5 JP2011505340 A5 JP 2011505340A5
Authority
JP
Japan
Prior art keywords
mer
oligomer
subject
alginate
alginate oligomer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2010534533A
Other languages
English (en)
Japanese (ja)
Other versions
JP2011505340A (ja
JP5639475B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/GB2008/003607 external-priority patent/WO2009068841A2/en
Publication of JP2011505340A publication Critical patent/JP2011505340A/ja
Publication of JP2011505340A5 publication Critical patent/JP2011505340A5/ja
Application granted granted Critical
Publication of JP5639475B2 publication Critical patent/JP5639475B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2010534533A 2007-11-27 2008-10-24 バイオフィルムと闘う際のアルギネートオリゴマーの使用 Active JP5639475B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US99661107P 2007-11-27 2007-11-27
US60/996,611 2007-11-27
PCT/GB2008/003607 WO2009068841A2 (en) 2007-11-27 2008-10-24 Use of alginate oligomers in combating biofilms

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014216271A Division JP6014101B2 (ja) 2007-11-27 2014-10-23 バイオフィルムと闘う際のアルギネートオリゴマーの使用

Publications (3)

Publication Number Publication Date
JP2011505340A JP2011505340A (ja) 2011-02-24
JP2011505340A5 true JP2011505340A5 (https=) 2011-12-08
JP5639475B2 JP5639475B2 (ja) 2014-12-10

Family

ID=40527942

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2010534533A Active JP5639475B2 (ja) 2007-11-27 2008-10-24 バイオフィルムと闘う際のアルギネートオリゴマーの使用
JP2014216271A Active JP6014101B2 (ja) 2007-11-27 2014-10-23 バイオフィルムと闘う際のアルギネートオリゴマーの使用

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2014216271A Active JP6014101B2 (ja) 2007-11-27 2014-10-23 バイオフィルムと闘う際のアルギネートオリゴマーの使用

Country Status (17)

Country Link
US (3) US8680072B2 (https=)
EP (1) EP2268142B1 (https=)
JP (2) JP5639475B2 (https=)
KR (1) KR101690631B1 (https=)
CN (3) CN101939030B (https=)
AU (1) AU2008328567B2 (https=)
BR (1) BRPI0819613B1 (https=)
CA (1) CA2706637C (https=)
DK (1) DK2268142T3 (https=)
ES (1) ES2625866T3 (https=)
HU (1) HUE034051T2 (https=)
PL (1) PL2268142T3 (https=)
PT (1) PT2268142T (https=)
RS (1) RS55933B1 (https=)
RU (1) RU2527894C2 (https=)
SI (1) SI2268142T1 (https=)
WO (1) WO2009068841A2 (https=)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101801521B (zh) 2007-05-14 2015-06-17 纽约州立大学研究基金会 生物膜中细菌细胞内的生理学分散响应诱导
HUE034051T2 (en) 2007-11-27 2018-01-29 Algipharma As Use of alginate-containing oligomers to combat biofilms
GB0909557D0 (en) * 2009-06-03 2009-07-15 Algipharma Ipr As Anti-microbial alginate oligomers
ES2444541T3 (es) * 2009-06-03 2014-02-25 Algipharma As Oligómeros de alginato para usar para superar la multirresistencia a fármacos en bacterias
GB0909529D0 (en) * 2009-06-03 2009-07-15 Algipharma Ipr As Alginate oligomers for the inhibition of microbial adherence to surfaces
GB2477914B (en) 2010-02-12 2012-01-04 Univ Newcastle Compounds and methods for biofilm disruption and prevention
US9572774B2 (en) 2011-05-19 2017-02-21 Savara Inc. Dry powder vancomycin compositions and associated methods
GB201116010D0 (en) 2011-09-15 2011-10-26 Algipharma As Use of alginate oligomers to enhance the effects of antifungal agents
US10039777B2 (en) 2012-03-20 2018-08-07 Neuro-Lm Sas Methods and pharmaceutical compositions of the treatment of autistic syndrome disorders
WO2013170128A1 (en) 2012-05-11 2013-11-14 Smith & Nephew, Inc. Use of seaprose to remove bacterial biofilm
GB201208879D0 (en) * 2012-05-21 2012-07-04 London School Hygiene & Tropical Medicine Therapeutic for treating Clostridium difficile infection
US9546361B2 (en) * 2012-10-12 2017-01-17 Lehigh University Thermally stable enzymes, compositions thereof and methods of using same
BR112015015348A2 (pt) 2012-12-25 2017-07-11 Univ Melbourne materiais e métodos
KR101438969B1 (ko) * 2012-12-27 2014-09-11 현대자동차주식회사 무취 에바코어 코팅용 미생물 슈도모나스 나이트로리듀센스 및 이의 용도
US10203329B2 (en) 2013-09-12 2019-02-12 The Johns Hopkins University Biofilm formation to define risk for colon cancer
GB201322777D0 (en) * 2013-12-20 2014-02-05 Algipharma As Use of alginate oligomers as blood anticoagulants
JP2017501221A (ja) * 2013-12-23 2017-01-12 ノルウェージャン ユニバーシティ オブ サイエンス アンド テクノロジー（エヌティーエヌユー） がん治療におけるオリゴウロン酸塩の使用
RU2016136449A (ru) * 2014-02-28 2018-04-02 АльгиФарма АС Применение олигометов альгината в лечении муковисцидоза и других состояний, ассоциированных с нарушенной функцией ионных каналов cftr
BR112016023188A2 (pt) * 2014-04-11 2018-01-16 Novozymes As uso de um polipeptídeo, composição detergente, métodos de lavagem para a lavagem de um item e de produção do polipeptídeo, polipeptídeo isolado, construção de ácido nucleico ou vetor de expressão, célula hospedeira recombinante, e, formulação de caldo inteiro ou composição de cultura de células
FR3024358B1 (fr) * 2014-08-01 2017-11-10 Soc De Courtage Et De Diffusion Codif Int Compositions cosmetiques et complements alimentaires neuro-protecteurs comprenant de l'oligoalginate ayant un degre de polymerisation de 10 pour lutter contre le vieillissement de la peau.
GB201415381D0 (en) * 2014-08-29 2014-10-15 Algipharma As Inhalable powder formulations of alginate oligomers
GB201504878D0 (en) * 2015-03-23 2015-05-06 Algipharma As Use of alginate oligomers and CFTR modulators in the treatment of conditions associated with CFTR dysfuntion
GB201517639D0 (en) 2015-10-06 2015-11-18 Algipharma As Use of alginate oligomers to treat or prevent microbial overgrowth in the intestinal tract
ES3013598T3 (en) * 2015-10-12 2025-04-14 Amsilk Gmbh Use of a biopolymer for reducing the formation of a biofilm
RU2646488C2 (ru) * 2016-04-25 2018-03-05 Государственное бюджетное образовательное учреждение высшего профессионального образования "Оренбургский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ГБОУ ВПО ОрГМУ Минздрава России) Средство для селективного влияния на биопленкообразование микроорганизмами
AU2017304271B2 (en) 2016-07-27 2024-07-18 Smith & Nephew, Inc. Use of thermolysin to reduce or eliminate bacterial biofilms from surfaces
WO2018064284A1 (en) 2016-09-30 2018-04-05 Novaflux, Inc. Compositions for cleaning and decontamination
AU2017345295A1 (en) * 2016-10-21 2019-05-02 Algipharma As Polymyxin-alginate oligomer conjugates
GB2555391B (en) * 2016-10-21 2019-06-26 Algipharma As Bacitracin-alginate oligomer conjugates
JP6927512B2 (ja) * 2016-10-26 2021-09-01 地方独立行政法人神奈川県立産業技術総合研究所 物体表面の抗菌性試験用菌液媒体
WO2018127819A1 (en) 2017-01-03 2018-07-12 The University Of North Carolina At Chapel Hill Nitric oxide-releasing alginates as biodegradable antibacterial scaffolds and methods pertaining thereto
EP3573622B1 (en) 2017-01-30 2023-10-18 Smith & Nephew, Inc. Synergistic combination of thermolysin and an antibacterial agent to reduce or eliminate bacterial biofilms from surfaces
JP7403152B2 (ja) 2017-03-28 2023-12-22 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル 生分解可能な抗菌性スキャフォールドとしての一酸化窒素放出性ポリアミノグリコシドおよびそれに関する方法背景
EP3710514B1 (en) 2017-11-15 2023-06-07 The University of North Carolina at Chapel Hill Nitric oxide-releasing hyperbranched compounds as antibacterial scaffolds and methods pertaining thereto
CA3091458A1 (en) 2018-03-06 2019-09-12 The University Of North Carolina At Chapel Hill Nitric oxide-releasing cyclodextrins as biodegradable antibacterial scaffolds and methods pertaining thereto
EP3775133B1 (en) 2018-04-03 2024-10-09 Novaflux, Inc. Cleaning composition with superabsorbent polymer
US11541105B2 (en) 2018-06-01 2023-01-03 The Research Foundation For The State University Of New York Compositions and methods for disrupting biofilm formation and maintenance
GB201812473D0 (en) 2018-07-31 2018-09-12 Algipharma As Method for the qualitative and quantitative detection of alginate oligomers in body fluids
EP3898934A4 (en) * 2018-12-17 2023-01-18 Dennis C. Mynarcik COMPOSITIONS AND METHODS FOR REMOVING TARTAR
US12478571B2 (en) 2018-12-17 2025-11-25 Pontis Biologics, Inc. Enzyme based compositions and methods for removing dental calculi
CN109431962B (zh) * 2018-12-19 2021-10-29 仙婷(广州)科技研发有限公司 一种浮游生物代谢物和浮游生物发酵液及其应用
CN113383019B (zh) 2018-12-28 2023-11-17 北卡罗来纳大学教堂山分校 一氧化氮释放型抗菌聚合物和由其制成的支架和其相关方法
WO2020247582A1 (en) 2019-06-06 2020-12-10 Danisco Us Inc Methods and compositions for cleaning
GB201908639D0 (en) 2019-06-17 2019-07-31 Algipharma Ipr As Use of alginate oligomers in the anticoagulation therapy of subjects at risk of blood clots which have an abnormally dense microstructure
JP7273983B2 (ja) * 2019-09-27 2023-05-15 森永乳業株式会社 酪酸菌用プレバイオティクス組成物
US12064495B2 (en) 2019-10-03 2024-08-20 Protegera, Inc. Oral cavity cleaning composition, method, and apparatus
WO2021067872A1 (en) 2019-10-03 2021-04-08 Novaflux, Inc. Oral cavity cleaning composition, method, and apparatus
US20210330715A1 (en) * 2020-04-23 2021-10-28 Amebagone, Llc Anti-biofilm agents and uses thereof
KR102450964B1 (ko) * 2020-04-27 2022-10-05 경희대학교 산학협력단 아세타니솔을 포함하는 바이오필름 형성 억제용 조성물
RU2759744C1 (ru) * 2020-09-07 2021-11-17 Олег Владимирович Емшанов Способ борьбы с биологическими плёнками
WO2022094589A1 (en) * 2020-10-29 2022-05-05 The Procter & Gamble Company Cleaning compositions containing alginase enzymes
KR102566917B1 (ko) * 2021-03-16 2023-08-14 영남대학교 산학협력단 쏘팔메토 오일 및 이의 불포화 지방산을 유효성분으로 함유하는 다중 병원성 미생물 바이오필름 형성 억제용 조성물
EP4396320A2 (en) 2021-09-03 2024-07-10 Danisco US Inc. Laundry compositions for cleaning
KR102731274B1 (ko) * 2021-12-09 2024-11-19 한양대학교 에리카산학협력단 1d-1h nmr 분석을 통한 마이크로캡슐의 생분해 메커니즘의 예측방법
JP2026502943A (ja) 2022-12-30 2026-01-27 アルギファルマ エーエス 経口投与されるポリペプチド治療剤の全身バイオアベイラビリティを高める組成物および方法
CN116019828B (zh) * 2023-02-17 2025-09-30 山东大学 一种聚甘露糖醛酸在制备胃和/或肠内菌落调节剂的应用
WO2025110156A1 (ja) * 2023-11-20 2025-05-30 国立大学法人神戸大学 腸内細菌叢において被験物質を評価する方法
WO2026008878A1 (en) 2024-07-04 2026-01-08 Algipharma As Antimycotic polyene-alginate oligomer conjugates

Family Cites Families (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE268865C (https=)
US1234567A (en) * 1915-09-14 1917-07-24 Edward J Quigley Soft collar.
NL297511A (https=) 1956-12-20
FR7576M (https=) 1968-03-27 1970-01-05
HU172831B (hu) 1976-03-31 1978-12-28 Egyt Gyogyszervegyeszeti Gyar Sposob poluchenija kompleksov oligo- i poligalakturonnyk kislot s ionami zhiznenno vazhnykh metallov
JPH0714842B2 (ja) * 1985-12-11 1995-02-22 ダイセル化学工業株式会社 防かび殺菌方法
DD268865A1 (de) 1987-01-16 1989-06-14 Adw Ddr Verfahren zur herstellung eines pharmazeutischen praeparates
US4898852A (en) 1987-06-02 1990-02-06 Walsh William E Cyclopolgalcturonic acid composition and treatment
US4855128A (en) 1988-01-14 1989-08-08 Warner-Lambert Company Saccharide inhibition of dental plaque
GB8803157D0 (en) 1988-02-11 1988-03-09 Nat Res Dev Denture protection
US5139945A (en) * 1988-09-16 1992-08-18 Novo Industri A/S Thermostable alginate lyase from bacillus steraothermophilus
WO1991011205A1 (en) 1990-01-23 1991-08-08 Trancel Corporation Mannuronic acid containing alginate wound healing composition and method
JPH0436228A (ja) * 1990-05-30 1992-02-06 Lion Corp 口腔用組成物
CN1021798C (zh) 1990-12-19 1993-08-18 大连市医药科学研究所 净癣涂膜剂制备工艺
US5169840A (en) * 1991-03-27 1992-12-08 Nobipols Forskningsstiftelse Diequatorially bound β-1, 4 polyuronates and use of same for cytokine stimulation
US5166137A (en) 1991-03-27 1992-11-24 Nobipols Forskningsstiftelse Guluronic acid polymers and use of same for inhibition of cytokine production
JPH05252970A (ja) 1991-10-04 1993-10-05 Maruha Corp 静菌作用を有するアルギン酸オリゴ糖の製造法及 びそれを有効成分として含む静菌剤
CA2106609A1 (en) 1992-09-28 1994-03-29 Irene Yeatman Aldridge Proteases to inhibit and remove biofilm
GB9221163D0 (en) 1992-10-08 1992-11-25 Nobipol And Protan Biopolymer Dna compounds
DE4330773A1 (de) 1993-09-10 1995-03-16 Laevosan Gmbh & Co Kg Blockierung der Anlagerung von Keimen an menschliche Zellen
AUPM322393A0 (en) 1993-12-24 1994-01-27 Austin Research Institute, The Mucin carbohydrate compounds and their use in immunotherapy
JPH093031A (ja) 1995-04-17 1997-01-07 Mitsubishi Chem Corp ヒドロキサム酸誘導体並びにそれを含有する農園芸用殺菌剤
AU723170B2 (en) 1995-10-19 2000-08-17 Bio-Origyn Llc Methods and compositions to improve germ cell and embryo survival and function
JP3512553B2 (ja) 1996-01-30 2004-03-29 ポーラ化成工業株式会社 便秘抑制剤及びそれを含有する組成物
GB9605247D0 (en) * 1996-03-13 1996-05-15 Giltech Ltd Composition
EP0807631B1 (en) 1996-05-15 2003-03-12 Sankyo Company Limited Tricyclic compounds having fungicidal activity, their preparation and their use
NO305441B1 (no) * 1996-07-12 1999-05-31 Norsk Hydro As Anvendelse av G-blokk polysakkarider
JPH10127281A (ja) * 1996-10-31 1998-05-19 Tanabe Seiyaku Co Ltd Ｐｅｇ修飾アルギン酸リアーゼおよびその用途
US6395307B1 (en) * 1997-04-30 2002-05-28 Reckitt Benckiser (Uk) Limited Pourable alginate compositions
NO305033B1 (no) 1997-05-09 1999-03-22 Algipharma As Fremgangsmate for fremstilling av uronsyreblokker fra alginat
GB2325233B (en) 1997-05-16 2001-07-18 Norsk Hydro As Substrates having bound polysaccharides and bacterial nucleic acids
US6339075B1 (en) 1997-06-30 2002-01-15 The University Of British Columbia Use of dextran and other polysaccharides to improve mucus clearance
AU9374298A (en) 1997-09-12 1999-04-05 Oceanix Biosciences Corporation Preparation and use of biofilm-degrading, multiple-specificit y, hydrolytic enzyme mixtures
US20020022005A1 (en) * 1997-10-16 2002-02-21 Budny John A. Compositions for treating cystic fibrosis
US6830745B1 (en) * 1997-10-16 2004-12-14 Pharmacal Biotechnologies, Llc Compositions for treating biofilm
JP2000063208A (ja) * 1998-08-20 2000-02-29 Daicel Chem Ind Ltd 抗菌性組成物
KR100322511B1 (ko) 1998-11-13 2002-10-25 한국해양연구원 알긴산 올리고당 유도체를 이용한 적조소멸제 및 어병치료제
AU6679300A (en) 1999-08-26 2001-03-26 Governors Of The University Of Alberta, The Use of charged dextran as a mucoactive agent and methods and pharmaceutical compositions relating thereto
US20040224922A1 (en) 1999-08-26 2004-11-11 Malcolm King Use of charged dextran as a mucoactive agent and methods and pharmaceutical compositions relating thereto
WO2001021536A1 (en) * 1999-09-23 2001-03-29 Reckitt Benckiser (Uk) Limited Method for combating hard water and scale by using algins
DE10006989A1 (de) 2000-02-16 2001-08-23 Nutricia Nv Antiadhäsive Kohlenhydratmischung
WO2001066084A2 (en) 2000-03-07 2001-09-13 Rush-Presbyterian-St. Luke's Medical Center Compositions and methods for trapping and inactivating pathogenic microbes and spermatozoa
GB0005743D0 (en) * 2000-03-10 2000-05-03 Reckitt & Colmann Prod Ltd Pharmaceutical compositions including alginates
DE10019076A1 (de) 2000-04-06 2001-10-18 Lang Christine Verwendung von Polygalakturoniden als Lebensmittelzusatzstoffe
PT2301524E (pt) 2000-12-27 2013-07-10 Gilead Sciences Inc Aztreonam inalável sem arginina para tratamento e prevenção de infecções bacterianas pulmonares
ITMI20010347A1 (it) 2001-02-21 2002-08-21 Grisotech S A Complessi di immunoglobuline e polisaccaridi per assorbimento orale etrans-mucosale
US7494669B2 (en) 2001-02-28 2009-02-24 Carrington Laboratories, Inc. Delivery of physiological agents with in-situ gels comprising anionic polysaccharides
JP2002315551A (ja) * 2001-04-19 2002-10-29 Yoshinaga Nakai 食品用防腐剤およびその製造方法
NO324131B1 (no) 2001-11-30 2007-09-03 Fmc Biopolymer As Fremgangsmate for fremstilling av alginat som har et hoyt mannuronsyre-innhold
NO326145B1 (no) 2001-11-30 2008-10-06 Fmc Biopolymer As Fremgangsmate for a stimulere vektokning hos pattedyr, fugler og krypdyr.
IL162823A0 (en) * 2002-01-03 2005-11-20 Yissum Res Dev Co Edible compositions capable of removing oral biofilm
DE10221748B4 (de) 2002-05-16 2006-08-10 Kaczmarek, André, Dr.med.dent. Antimykotisches Haftpulver gegen Prothesenstomatitis, die Herstellung und Verabreichungsform
US6610331B1 (en) 2002-05-30 2003-08-26 Scott M. Sweazy Fertility kit
NO20023581D0 (no) 2002-07-26 2002-07-26 Fmc Biopolymer As Nye mutantstammer av Pseudomonas fluorescens og varianter derav, metoder for produksjon og bruk derav til produksjon avalginat
US20070237812A1 (en) 2006-04-11 2007-10-11 Tyco Healthcare Group Multi-layer wound dressings
GB0300597D0 (en) * 2003-01-10 2003-02-12 Microbiological Res Authority Phage biofilms
DK1663326T3 (da) * 2003-09-08 2010-06-21 Fmc Biopolymer As Gel-skum baseret på biopolymer
AU2004275594A1 (en) 2003-09-30 2005-04-07 Solubest Ltd. Water soluble nanoparticles inclusion complexes
JP2005145885A (ja) 2003-11-14 2005-06-09 Japan Science & Technology Agency アルギン酸オリゴマーからなる免疫機構賦活剤
CN101001635A (zh) 2003-12-04 2007-07-18 生物膜策略公司 预防生物膜形成、减少现有生物膜和减少细菌群的方法和组合物
KR20070001970A (ko) * 2004-02-26 2007-01-04 보오슈 앤드 롬 인코포레이팃드 알기네이트 점탄성 조성물, 사용 방법 및 팩키지
US7790699B2 (en) * 2004-10-12 2010-09-07 Fmc Biopolymer As Self-gelling alginate systems and uses thereof
EP1714660A1 (en) 2005-04-21 2006-10-25 N.V. Nutricia Uronic acid and probiotics
JP2008540515A (ja) 2005-05-13 2008-11-20 ヴィーナス・レメディーズ・リミテッド 嚢胞性線維症を含む重症感染症の処置および管理
EP1745705A1 (en) 2005-07-20 2007-01-24 N.V. Nutricia Process for preparing uronic acid oligosaccharides by extrusion
GB2430881B (en) 2005-10-06 2010-10-13 Ntnu Technology Transfer As Oligoelectrolyte polyols for the treatment of mucosal hyperviscosity
JP5110860B2 (ja) * 2006-11-30 2012-12-26 花王株式会社 バイオフィルム制御剤組成物
EP1872791A1 (en) 2006-06-30 2008-01-02 Institut Pasteur Use of bacterial polysaccharides for biofilm inhibition
EP2046288B1 (en) 2006-07-14 2013-07-03 FMC Biopolymer AS Hydrogels containing low molecular weight alginates and biostructures made therefrom
DE102006059510A1 (de) 2006-12-14 2008-06-19 Grünenthal GmbH Beschichtete Pellets
WO2008082948A2 (en) 2006-12-29 2008-07-10 Bausch & Lomb Incorporated Ophthalmic alginate composition related methods of manufacture and methods of use
EP2526928B1 (en) 2007-02-05 2018-12-26 Biophile Corporation, Ltd Increased effectiveness of allylamine drug compounds
GB0707096D0 (en) * 2007-04-12 2007-05-23 Ntnu Technology Transfer As Method
JP2008285431A (ja) 2007-05-16 2008-11-27 Japan Science & Technology Agency 養殖魚のウイルス感染症の予防・治療組成物
US20090036554A1 (en) 2007-08-01 2009-02-05 Burke Susan E Ophthalmic compositions comprising a terpene compound
US20090036404A1 (en) 2007-08-02 2009-02-05 Macleod Steven K Ophthalmic compositions comprising a carboxyl-modified fructan or a salt thereof
HUE034051T2 (en) * 2007-11-27 2018-01-29 Algipharma As Use of alginate-containing oligomers to combat biofilms
WO2009129525A2 (en) 2008-04-18 2009-10-22 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Antifungal and anti-cariogenic cellobio-oligosaccharides produced by dextransucrase
WO2010069519A1 (en) 2008-12-18 2010-06-24 Merz Pharma Gmbh & Co. Kgaa Topical compositions comprising at least one active ingredient poorly soluble in water and biopolymers such as hyaluronic acid with a pka-value between 5-7
GB0909529D0 (en) 2009-06-03 2009-07-15 Algipharma Ipr As Alginate oligomers for the inhibition of microbial adherence to surfaces
ES2444541T3 (es) * 2009-06-03 2014-02-25 Algipharma As Oligómeros de alginato para usar para superar la multirresistencia a fármacos en bacterias

Similar Documents

Publication Publication Date Title
JP2011505340A5 (https=)
CA2706637A1 (en) Use of alginate oligomers in combating biofilms
KR101569134B1 (ko) 일산화 이염소 함유 항균 용액, 그의 제조 방법 및 사용 방법
CA2821032C (en) A composition comprising an antibiotic and a dispersant or an anti -adhesive agent
RU2682642C1 (ru) Материалы и способы борьбы c инфекциями
US11096992B2 (en) Use of seaprose to remove bacterial biofilm
RU2011143399A (ru) Ингибирование организмов биопленки
US20200281970A1 (en) Method of treating gingivitis using low concentration hypochlorous acid solutions
WO2020089693A1 (en) Compositions for treating biofilms without inducing antimicrobial resistance
US20210154158A1 (en) Devices, methods, and compositions for controlling infections
JP2012529506A (ja) 粘膜炎治療用組成物の使用
CN100450546C (zh) 一种溶葡萄球菌酶复配制剂及其制备方法
US20210177892A1 (en) Prevention and treatment of infectious disease using low concentration hypochlorous acid solutions
JP5796728B1 (ja) 創傷治癒を促進し生体諸臓器の被覆（コーチング）及び庇護を目的とした生体皮膜剤。
CA2778081A1 (en) Devices, methods, and composition for controlling infections
JP5572110B2 (ja) 粘膜の疾患および障害の予防および処置のための液体製剤
EP4598608B1 (en) Wound irrigation devices and methods for delivering synergistic active agents
US20230390325A1 (en) Oral and Nasal Wash
Leach The impact of antibiotics on current surgical practice