JP2011190259A5 - - Google Patents
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- Publication number
- JP2011190259A5 JP2011190259A5 JP2011052316A JP2011052316A JP2011190259A5 JP 2011190259 A5 JP2011190259 A5 JP 2011190259A5 JP 2011052316 A JP2011052316 A JP 2011052316A JP 2011052316 A JP2011052316 A JP 2011052316A JP 2011190259 A5 JP2011190259 A5 JP 2011190259A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- pharmaceutically acceptable
- acceptable excipient
- disintegrant
- methylnaltrexone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31301810P | 2010-03-11 | 2010-03-11 | |
| US61/313,018 | 2010-03-11 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015178184A Division JP2016029054A (ja) | 2010-03-11 | 2015-09-10 | メチルナルトレキソンの経口製剤および親油性塩 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011190259A JP2011190259A (ja) | 2011-09-29 |
| JP2011190259A5 true JP2011190259A5 (https=) | 2013-12-12 |
| JP6143409B2 JP6143409B2 (ja) | 2017-06-07 |
Family
ID=44148539
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011052316A Active JP6143409B2 (ja) | 2010-03-11 | 2011-03-10 | メチルナルトレキソンの経口製剤および親油性塩 |
| JP2015178184A Pending JP2016029054A (ja) | 2010-03-11 | 2015-09-10 | メチルナルトレキソンの経口製剤および親油性塩 |
| JP2017152275A Active JP6429955B2 (ja) | 2010-03-11 | 2017-08-07 | メチルナルトレキソンの経口製剤および親油性塩 |
| JP2018203748A Active JP6647368B2 (ja) | 2010-03-11 | 2018-10-30 | メチルナルトレキソンの経口製剤および親油性塩 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015178184A Pending JP2016029054A (ja) | 2010-03-11 | 2015-09-10 | メチルナルトレキソンの経口製剤および親油性塩 |
| JP2017152275A Active JP6429955B2 (ja) | 2010-03-11 | 2017-08-07 | メチルナルトレキソンの経口製剤および親油性塩 |
| JP2018203748A Active JP6647368B2 (ja) | 2010-03-11 | 2018-10-30 | メチルナルトレキソンの経口製剤および親油性塩 |
Country Status (32)
| Country | Link |
|---|---|
| US (8) | US8524276B2 (https=) |
| EP (2) | EP3178472B1 (https=) |
| JP (4) | JP6143409B2 (https=) |
| KR (2) | KR101913102B1 (https=) |
| CN (2) | CN102918039B (https=) |
| AR (1) | AR080491A1 (https=) |
| AU (1) | AU2011224275B2 (https=) |
| BR (1) | BR112012022873B1 (https=) |
| CA (1) | CA2789798C (https=) |
| CL (1) | CL2012002192A1 (https=) |
| CO (1) | CO6630134A2 (https=) |
| CR (1) | CR20120476A (https=) |
| EA (1) | EA029096B1 (https=) |
| EC (1) | ECSP12012208A (https=) |
| ES (1) | ES2623926T3 (https=) |
| GE (1) | GEP201606550B (https=) |
| GT (1) | GT201200247A (https=) |
| HU (1) | HUE033133T2 (https=) |
| IL (1) | IL221452A (https=) |
| MA (1) | MA34146B1 (https=) |
| MX (2) | MX349145B (https=) |
| MY (1) | MY160727A (https=) |
| NZ (3) | NZ702826A (https=) |
| PE (1) | PE20130063A1 (https=) |
| PH (1) | PH12012501622A1 (https=) |
| PL (2) | PL2371357T3 (https=) |
| SG (3) | SG183133A1 (https=) |
| TN (1) | TN2012000392A1 (https=) |
| TW (2) | TWI589293B (https=) |
| UA (2) | UA123856C2 (https=) |
| WO (1) | WO2011112816A1 (https=) |
| ZA (1) | ZA201808498B (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20150037T4 (hr) | 2003-04-08 | 2022-09-02 | Progenics Pharmaceuticals, Inc. | Farmaceutske formulacije koje sadrže metilnaltrekson |
| TWI489984B (zh) | 2006-08-04 | 2015-07-01 | Wyeth Corp | 用於非經腸道傳輸化合物之配方及其用途 |
| MX2009010550A (es) | 2007-03-29 | 2009-12-14 | Progenics Pharm Inc | Formas de cristal de bromuro de (r)-n-metilnaltrexona y uso de las mismas. |
| WO2008153725A2 (en) | 2007-05-25 | 2008-12-18 | North Carolina State University | Viral nanoparticle cell-targeted delivery platform |
| UA123856C2 (uk) | 2010-03-11 | 2021-06-16 | Уайт Елелсі | Фармацевтичні композиції метилналтрексону та натрію додецилсульфату для перорального введення |
| US8627816B2 (en) | 2011-02-28 | 2014-01-14 | Intelliject, Inc. | Medicament delivery device for administration of opioid antagonists including formulations for naloxone |
| US8939943B2 (en) | 2011-01-26 | 2015-01-27 | Kaleo, Inc. | Medicament delivery device for administration of opioid antagonists including formulations for naloxone |
| KR20140107540A (ko) * | 2011-12-19 | 2014-09-04 | 샐릭스 파마슈티컬스 리미티드 | 메틸날트렉손의 경구 조성물을 사용하는 오피오이드 유발성 변비의 치료 및 예방 방법 |
| WO2015191686A1 (en) * | 2014-06-10 | 2015-12-17 | Salix Pharmaceuticals, Inc. | Methods of administering methylnaltrexone |
| US10722510B2 (en) * | 2014-07-08 | 2020-07-28 | Hikma Pharmaceuticals Usa Inc. | Liquid naloxone spray |
| US11135155B2 (en) | 2014-07-08 | 2021-10-05 | Hikma Pharmaceuticals Usa Inc. | Liquid naloxone spray |
| CA2954370A1 (en) * | 2014-07-08 | 2016-01-14 | Insys Pharma, Inc. | Sublingual naloxone spray |
| US10617686B2 (en) * | 2014-07-08 | 2020-04-14 | Hikma Pharmaceuticals Usa Inc. | Liquid naloxone spray |
| US10441538B2 (en) * | 2014-07-08 | 2019-10-15 | Hikma Pharmaceuticals Usa Inc. | Liquid naloxone spray |
| WO2016061531A1 (en) | 2014-10-17 | 2016-04-21 | Salix Pharmaceuticals, Inc. | Use of methylnaltrexone to attenuate tumor progression |
| WO2020128583A1 (en) * | 2018-12-19 | 2020-06-25 | Friulchem S.P.A. | Process for the manufacture of a tablet of rifaximin and tablet of rifaximin |
| BR112021022194A2 (pt) * | 2019-05-07 | 2021-12-28 | Bausch Health Ireland Ltd | Formulações líquidas para dosagem oral de metilnaltrexona |
| WO2020245214A1 (en) | 2019-06-03 | 2020-12-10 | Bausch Health Ireland Limited | Use of methylnaltrexone and rifaximin for treatment of increased gut permeability or associated disorders |
| CA3177250A1 (en) | 2020-05-02 | 2021-11-11 | Bausch Health Ireland Limited | Methods of reducing mortality risk in subjects suffering from an underlying disease or condition by administration of methylnaltrexone |
| WO2023031955A1 (en) * | 2021-08-28 | 2023-03-09 | Redasani Vijayendrakumar Virendrakumar Ji | Oral pharmaceutical compositions of methylnaltrexone and salt thereof |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4176186A (en) | 1978-07-28 | 1979-11-27 | Boehringer Ingelheim Gmbh | Quaternary derivatives of noroxymorphone which relieve intestinal immobility |
| US4719215A (en) | 1986-03-07 | 1988-01-12 | University Of Chicago | Quaternary derivatives of noroxymorphone which relieve nausea and emesis |
| US4861781A (en) | 1986-03-07 | 1989-08-29 | The University Of Chicago | Quaternary derivatives of noroxymorphone which relieve nausea and emesis |
| CA1297218C (en) | 1986-03-14 | 1992-03-10 | Edward David Weil | Thermally stable diphosphonate-type flame retardant additive for plastics |
| US5102887A (en) | 1989-02-17 | 1992-04-07 | Arch Development Corporation | Method for reducing emesis and nausea induced by the administration of an emesis causing agent |
| US5780012A (en) | 1990-06-21 | 1998-07-14 | Huland; Edith | Method for reducing lung afflictions by inhalation of cytokine solutions |
| AU5171293A (en) | 1992-10-14 | 1994-05-09 | Regents Of The University Of Colorado, The | Ion-pairing of drugs for improved efficacy and delivery |
| US5866154A (en) | 1994-10-07 | 1999-02-02 | The Dupont Merck Pharmaceutical Company | Stabilized naloxone formulations |
| DE19651551C2 (de) | 1996-12-11 | 2000-02-03 | Klinge Co Chem Pharm Fab | Opioidantagonisthaltige galenische Formulierung |
| WO1998035679A1 (de) | 1997-02-14 | 1998-08-20 | Gödecke Aktiengesellschaft | Stabilisierung von naloxonhydrochlorid |
| US6274591B1 (en) | 1997-11-03 | 2001-08-14 | Joseph F. Foss | Use of methylnaltrexone and related compounds |
| ATE210983T1 (de) | 1997-11-03 | 2002-01-15 | Stada Arzneimittel Ag | Stabilisiertes kombinationsarzneimittel enthaltend naloxone und ein opiatanalgetikum |
| US20030158220A1 (en) | 1997-11-03 | 2003-08-21 | Foss Joseph F. | Use of methylnaltrexone and related compounds to treat chronic opioid use side effects |
| US5972954A (en) | 1997-11-03 | 1999-10-26 | Arch Development Corporation | Use of methylnaltrexone and related compounds |
| US6559158B1 (en) | 1997-11-03 | 2003-05-06 | Ur Labs, Inc. | Use of methylnaltrexone and related compounds to treat chronic opioid use side affects |
| GB0100115D0 (en) | 2001-01-04 | 2001-02-14 | Alchemia Pty Ltd | Delivery systems |
| EP1387673B1 (en) * | 2001-05-11 | 2010-12-29 | Endo Pharmaceuticals Inc. | Abuse-resistant controlled-release opioid dosage form |
| US20030022909A1 (en) | 2001-06-05 | 2003-01-30 | University Of Chicago | Use of methylnaltrexone to treat immune suppression |
| ES2654819T3 (es) | 2001-10-18 | 2018-02-15 | Nektar Therapeutics | Conjugados poliméricos de antagonistas de opioides |
| EP1451174B1 (en) * | 2001-11-29 | 2010-08-18 | Schering Corporation | Process for the preparation of compositions having an increased amount of pharmaceutically active salts of rotamers |
| ATE510534T1 (de) | 2002-03-14 | 2011-06-15 | Euro Celtique Sa | Naltrexonhydrochlorid-zusammensetzungen |
| US20030191147A1 (en) | 2002-04-09 | 2003-10-09 | Barry Sherman | Opioid antagonist compositions and dosage forms |
| MXPA05010819A (es) | 2003-04-08 | 2006-03-30 | Progenics Pharm Inc | Uso de antagonistas de opioide perifericos, especialmente metilnaltrexona para tratar sindrome de intestino irritable. |
| HRP20150037T4 (hr) | 2003-04-08 | 2022-09-02 | Progenics Pharmaceuticals, Inc. | Farmaceutske formulacije koje sadrže metilnaltrekson |
| RU2005134364A (ru) | 2003-04-08 | 2006-06-10 | Проджиникс Фармасьютикалз, Инк. (Us) | Комбинированное лечение запора |
| JP5165239B2 (ja) * | 2003-07-15 | 2013-03-21 | ピーアール ファーマシューティカルズ， インコーポレイテッド | 制御放出処方物の調製のための方法 |
| US8946262B2 (en) | 2003-12-04 | 2015-02-03 | Adolor Corporation | Methods of preventing and treating gastrointestinal dysfunction |
| WO2005060981A2 (en) | 2003-12-19 | 2005-07-07 | Schering Corporation | Pharmaceutical compositions |
| CA2551254A1 (en) * | 2003-12-31 | 2005-07-21 | Pfizer Products Inc. | Stabilized pharmaceutical solid compositions of low-solubility drugs, poloxamers, and stabilizing polymers |
| CN1294728C (zh) | 2004-08-05 | 2007-01-10 | 华为技术有限公司 | 边缘路由器提供服务质量保证的方法及系统 |
| CN101061073A (zh) | 2004-09-30 | 2007-10-24 | 贝克顿·迪金森公司 | 减少或消除玻璃容器中残余物的方法以及根据该方法制成的玻璃容器 |
| US20060177380A1 (en) * | 2004-11-24 | 2006-08-10 | Acura Pharmaceuticals, Inc. | Methods and compositions for deterring abuse of orally administered pharmaceutical products |
| AR057035A1 (es) * | 2005-05-25 | 2007-11-14 | Progenics Pharm Inc | SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS |
| TWI489984B (zh) * | 2006-08-04 | 2015-07-01 | Wyeth Corp | 用於非經腸道傳輸化合物之配方及其用途 |
| WO2008021394A2 (en) * | 2006-08-15 | 2008-02-21 | Theraquest Biosciences, Llc | Pharmaceutical formulations of cannabinoids and method of use |
| JP4970542B2 (ja) * | 2006-08-16 | 2012-07-11 | ノバルティス アーゲー | 有色レンズケア溶液の時間的光漂白及びその使用 |
| US20080233156A1 (en) * | 2006-10-11 | 2008-09-25 | Alpharma, Inc. | Pharmaceutical compositions |
| TW200843802A (en) | 2007-02-09 | 2008-11-16 | Drugtech Corp | Compositions for improving gastrointestinal nutrient and drug absorption |
| SI2565195T1 (sl) * | 2007-03-29 | 2015-09-30 | Wyeth Llc | Periferalni opioidni receptorji in antagonisti in njih uporaba |
| MX2009010550A (es) * | 2007-03-29 | 2009-12-14 | Progenics Pharm Inc | Formas de cristal de bromuro de (r)-n-metilnaltrexona y uso de las mismas. |
| JP5178064B2 (ja) * | 2007-06-27 | 2013-04-10 | 富士フイルム株式会社 | 金属表面粗化層を有する金属層積層体及びその製造方法 |
| MX2010011727A (es) * | 2008-05-07 | 2010-11-30 | Nektar Therapeutics | Administracion oral de antagonistas opioides que actuan perifericamente. |
| CA2676881C (en) | 2008-09-30 | 2017-04-25 | Wyeth | Peripheral opioid receptor antagonists and uses thereof |
| JP5525247B2 (ja) * | 2009-08-04 | 2014-06-18 | 株式会社神戸製鋼所 | 高強度で曲げ加工性に優れた銅合金 |
| UA123856C2 (uk) | 2010-03-11 | 2021-06-16 | Уайт Елелсі | Фармацевтичні композиції метилналтрексону та натрію додецилсульфату для перорального введення |
| TW201235609A (en) * | 2010-07-13 | 2012-09-01 | Koninkl Philips Electronics Nv | Low cost mounting of LEDs in TL-retrofit tubes |
-
2011
- 2011-03-10 UA UAA201602306A patent/UA123856C2/uk unknown
- 2011-03-10 TW TW100108143A patent/TWI589293B/zh active
- 2011-03-10 US US13/045,108 patent/US8524276B2/en active Active
- 2011-03-10 NZ NZ702826A patent/NZ702826A/en unknown
- 2011-03-10 MA MA35290A patent/MA34146B1/fr unknown
- 2011-03-10 PE PE2012001538A patent/PE20130063A1/es active IP Right Grant
- 2011-03-10 GE GEAP201112868A patent/GEP201606550B/en unknown
- 2011-03-10 WO PCT/US2011/027913 patent/WO2011112816A1/en not_active Ceased
- 2011-03-10 KR KR1020127026488A patent/KR101913102B1/ko active Active
- 2011-03-10 AU AU2011224275A patent/AU2011224275B2/en active Active
- 2011-03-10 SG SG2012057261A patent/SG183133A1/en unknown
- 2011-03-10 NZ NZ601595A patent/NZ601595A/en unknown
- 2011-03-10 JP JP2011052316A patent/JP6143409B2/ja active Active
- 2011-03-10 TW TW105105359A patent/TWI605814B/zh active
- 2011-03-10 AR ARP110100757A patent/AR080491A1/es unknown
- 2011-03-10 EA EA201270741A patent/EA029096B1/ru unknown
- 2011-03-10 BR BR112012022873-0A patent/BR112012022873B1/pt active IP Right Grant
- 2011-03-10 CA CA2789798A patent/CA2789798C/en active Active
- 2011-03-10 PH PH1/2012/501622A patent/PH12012501622A1/en unknown
- 2011-03-10 CN CN201180013511.1A patent/CN102918039B/zh active Active
- 2011-03-10 SG SG10201501821RA patent/SG10201501821RA/en unknown
- 2011-03-10 NZ NZ703564A patent/NZ703564A/en unknown
- 2011-03-10 KR KR1020187030676A patent/KR101982482B1/ko active Active
- 2011-03-10 MY MYPI2012003442A patent/MY160727A/en unknown
- 2011-03-10 MX MX2012009125A patent/MX349145B/es active IP Right Grant
- 2011-03-10 SG SG10201606618PA patent/SG10201606618PA/en unknown
- 2011-03-10 MX MX2015010803A patent/MX368805B/es unknown
- 2011-03-10 CN CN201710321015.1A patent/CN107308125B/zh active Active
- 2011-03-11 EP EP17153285.6A patent/EP3178472B1/en active Active
- 2011-03-11 PL PL11157837T patent/PL2371357T3/pl unknown
- 2011-03-11 HU HUE11157837A patent/HUE033133T2/en unknown
- 2011-03-11 ES ES11157837.3T patent/ES2623926T3/es active Active
- 2011-03-11 PL PL17153285T patent/PL3178472T3/pl unknown
- 2011-03-11 EP EP11157837.3A patent/EP2371357B1/en active Active
- 2011-10-03 UA UAA201211733A patent/UA111717C2/uk unknown
-
2012
- 2012-08-02 TN TNP2012000392A patent/TN2012000392A1/en unknown
- 2012-08-07 CL CL2012002192A patent/CL2012002192A1/es unknown
- 2012-08-14 IL IL221452A patent/IL221452A/en active IP Right Grant
- 2012-08-23 GT GT201200247A patent/GT201200247A/es unknown
- 2012-09-19 CR CR20120476A patent/CR20120476A/es unknown
- 2012-10-02 EC ECSP12012208 patent/ECSP12012208A/es unknown
- 2012-10-10 CO CO12178897A patent/CO6630134A2/es unknown
-
2013
- 2013-07-31 US US13/956,050 patent/US9314461B2/en active Active
- 2013-08-14 US US13/966,779 patent/US8956651B2/en active Active
-
2015
- 2015-09-10 JP JP2015178184A patent/JP2016029054A/ja active Pending
-
2016
- 2016-03-15 US US15/070,555 patent/US20160206612A1/en not_active Abandoned
-
2017
- 2017-08-07 JP JP2017152275A patent/JP6429955B2/ja active Active
-
2018
- 2018-10-30 JP JP2018203748A patent/JP6647368B2/ja active Active
- 2018-12-13 US US16/219,681 patent/US10307417B2/en active Active
- 2018-12-13 US US16/219,159 patent/US10376505B2/en active Active
- 2018-12-18 ZA ZA2018/08498A patent/ZA201808498B/en unknown
-
2019
- 2019-06-24 US US16/450,157 patent/US10507206B2/en active Active
- 2019-10-25 US US16/664,239 patent/US20200121673A1/en not_active Abandoned
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