ECSP12012208A - Formulaciones orales y sales lipofílicas de metilnaltrexona - Google Patents

Formulaciones orales y sales lipofílicas de metilnaltrexona

Info

Publication number
ECSP12012208A
ECSP12012208A ECSP12012208A ECSP12012208A EC SP12012208 A ECSP12012208 A EC SP12012208A EC SP12012208 A ECSP12012208 A EC SP12012208A EC SP12012208 A ECSP12012208 A EC SP12012208A
Authority
EC
Ecuador
Prior art keywords
methylntrexone
lipophylic
salts
oral formulations
formulations
Prior art date
Application number
Other languages
English (en)
Spanish (es)
Inventor
Syed M Shah
Christopher Richard Diorio
Eric C Ehrnsperger
Xu Meng
Shareffi Kadum A Al
Jonathan Mare Cohen
Original Assignee
Wyeth Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44148539&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP12012208(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Llc filed Critical Wyeth Llc
Publication of ECSP12012208A publication Critical patent/ECSP12012208A/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806Coating materials
    • A61K9/2833Organic macromolecular compounds
    • A61K9/284Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/485Morphinan derivatives, e.g. morphine, codeine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12Carboxylic acids; Salts or anhydrides thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2009Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2013Organic compounds, e.g. phospholipids, fats
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2072Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10Laxatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D489/00Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08Oxygen atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Emergency Medicine (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Inorganic Chemistry (AREA)
  • Otolaryngology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ECSP12012208 2010-03-11 2012-10-02 Formulaciones orales y sales lipofílicas de metilnaltrexona ECSP12012208A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US31301810P 2010-03-11 2010-03-11

Publications (1)

Publication Number Publication Date
ECSP12012208A true ECSP12012208A (es) 2015-03-31

Family

ID=44148539

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSP12012208 ECSP12012208A (es) 2010-03-11 2012-10-02 Formulaciones orales y sales lipofílicas de metilnaltrexona

Country Status (32)

Country Link
US (8) US8524276B2 (https=)
EP (2) EP3178472B1 (https=)
JP (4) JP6143409B2 (https=)
KR (2) KR101913102B1 (https=)
CN (2) CN102918039B (https=)
AR (1) AR080491A1 (https=)
AU (1) AU2011224275B2 (https=)
BR (1) BR112012022873B1 (https=)
CA (1) CA2789798C (https=)
CL (1) CL2012002192A1 (https=)
CO (1) CO6630134A2 (https=)
CR (1) CR20120476A (https=)
EA (1) EA029096B1 (https=)
EC (1) ECSP12012208A (https=)
ES (1) ES2623926T3 (https=)
GE (1) GEP201606550B (https=)
GT (1) GT201200247A (https=)
HU (1) HUE033133T2 (https=)
IL (1) IL221452A (https=)
MA (1) MA34146B1 (https=)
MX (2) MX349145B (https=)
MY (1) MY160727A (https=)
NZ (3) NZ702826A (https=)
PE (1) PE20130063A1 (https=)
PH (1) PH12012501622A1 (https=)
PL (2) PL2371357T3 (https=)
SG (3) SG183133A1 (https=)
TN (1) TN2012000392A1 (https=)
TW (2) TWI589293B (https=)
UA (2) UA123856C2 (https=)
WO (1) WO2011112816A1 (https=)
ZA (1) ZA201808498B (https=)

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Also Published As

Publication number Publication date
CN102918039A (zh) 2013-02-06
TW201622724A (zh) 2016-07-01
TN2012000392A1 (en) 2014-01-30
US20190314365A1 (en) 2019-10-17
CA2789798C (en) 2020-09-22
US8524276B2 (en) 2013-09-03
SG10201501821RA (en) 2015-05-28
JP6647368B2 (ja) 2020-02-14
NZ702826A (en) 2016-08-26
US20200121673A1 (en) 2020-04-23
GT201200247A (es) 2013-09-11
JP2019034958A (ja) 2019-03-07
MY160727A (en) 2017-03-15
KR20130010900A (ko) 2013-01-29
EP3178472A1 (en) 2017-06-14
JP6429955B2 (ja) 2018-11-28
CO6630134A2 (es) 2013-03-01
US10507206B2 (en) 2019-12-17
US9314461B2 (en) 2016-04-19
US20190117645A1 (en) 2019-04-25
MX2012009125A (es) 2012-09-07
PH12012501622A1 (en) 2012-11-05
JP2017206553A (ja) 2017-11-24
TW201141479A (en) 2011-12-01
HK1245673A1 (zh) 2018-08-31
EP3178472B1 (en) 2021-10-27
NZ601595A (en) 2015-01-30
US10307417B2 (en) 2019-06-04
CN107308125B (zh) 2021-07-16
SG10201606618PA (en) 2016-09-29
CR20120476A (es) 2012-11-30
AR080491A1 (es) 2012-04-11
PL2371357T3 (pl) 2017-09-29
MA34146B1 (fr) 2013-04-03
UA111717C2 (uk) 2016-06-10
EA029096B1 (ru) 2018-02-28
AU2011224275B2 (en) 2015-10-01
CA2789798A1 (en) 2011-09-15
US20140249171A1 (en) 2014-09-04
CN107308125A (zh) 2017-11-03
IL221452A (en) 2017-07-31
UA123856C2 (uk) 2021-06-16
BR112012022873A2 (pt) 2016-08-30
SG183133A1 (en) 2012-09-27
KR101913102B1 (ko) 2018-10-31
JP2016029054A (ja) 2016-03-03
TWI605814B (zh) 2017-11-21
US10376505B2 (en) 2019-08-13
ES2623926T3 (es) 2017-07-12
KR20180118260A (ko) 2018-10-30
PL3178472T3 (pl) 2022-02-14
KR101982482B1 (ko) 2019-05-27
US8956651B2 (en) 2015-02-17
HUE033133T2 (en) 2017-11-28
NZ703564A (en) 2016-08-26
CL2012002192A1 (es) 2012-09-28
MX368805B (es) 2019-10-17
IL221452A0 (en) 2012-10-31
PE20130063A1 (es) 2013-02-11
EP2371357A1 (en) 2011-10-05
GEP201606550B (en) 2016-10-10
EP2371357B1 (en) 2017-02-01
WO2011112816A1 (en) 2011-09-15
JP6143409B2 (ja) 2017-06-07
JP2011190259A (ja) 2011-09-29
AU2011224275A1 (en) 2012-08-23
US20120070495A1 (en) 2012-03-22
US20130330407A1 (en) 2013-12-12
TWI589293B (zh) 2017-07-01
ZA201808498B (en) 2019-08-28
EA201270741A1 (ru) 2013-02-28
CN102918039B (zh) 2017-06-09
MX349145B (es) 2017-07-14
US20190117646A1 (en) 2019-04-25
US20160206612A1 (en) 2016-07-21
BR112012022873B1 (pt) 2021-09-14

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