BR112013008601A2 - formulações de emulsão de clevidipina contendo agentes antimicrobianos - Google Patents

formulações de emulsão de clevidipina contendo agentes antimicrobianos

Info

Publication number
BR112013008601A2
BR112013008601A2 BR112013008601A BR112013008601A BR112013008601A2 BR 112013008601 A2 BR112013008601 A2 BR 112013008601A2 BR 112013008601 A BR112013008601 A BR 112013008601A BR 112013008601 A BR112013008601 A BR 112013008601A BR 112013008601 A2 BR112013008601 A2 BR 112013008601A2
Authority
BR
Brazil
Prior art keywords
antimicrobial agents
formulations containing
emulsion formulations
containing antimicrobial
clevidipine emulsion
Prior art date
Application number
BR112013008601A
Other languages
English (en)
Other versions
BR112013008601A8 (pt
BR112013008601B1 (pt
Inventor
Charles Williams Gregory
Motheram Rajeshwar
Original Assignee
The Medicines Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45925617&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112013008601(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by The Medicines Co filed Critical The Medicines Co
Publication of BR112013008601A2 publication Critical patent/BR112013008601A2/pt
Publication of BR112013008601A8 publication Critical patent/BR112013008601A8/pt
Publication of BR112013008601B1 publication Critical patent/BR112013008601B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
BR112013008601-7A 2010-10-12 2011-10-10 Formulações de emulsão de clevidipina contendo agentes antimicrobianos BR112013008601B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US39229410P 2010-10-12 2010-10-12
US61/392,294 2010-10-12
PCT/US2011/055617 WO2012051116A1 (en) 2010-10-12 2011-10-10 Clevidipine emulsion formulations containing antimicrobial agents

Publications (3)

Publication Number Publication Date
BR112013008601A2 true BR112013008601A2 (pt) 2017-07-25
BR112013008601A8 BR112013008601A8 (pt) 2017-12-12
BR112013008601B1 BR112013008601B1 (pt) 2020-03-31

Family

ID=45925617

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013008601-7A BR112013008601B1 (pt) 2010-10-12 2011-10-10 Formulações de emulsão de clevidipina contendo agentes antimicrobianos

Country Status (18)

Country Link
US (1) US10010537B2 (pt)
EP (1) EP2627173B2 (pt)
JP (3) JP6040437B2 (pt)
KR (2) KR20130101080A (pt)
CN (1) CN103237446B (pt)
AU (1) AU2011313852B2 (pt)
BR (1) BR112013008601B1 (pt)
CA (1) CA2814495C (pt)
DK (1) DK2627173T4 (pt)
EA (1) EA022849B1 (pt)
ES (1) ES2539861T5 (pt)
HK (1) HK1187495A1 (pt)
HU (1) HUE026295T2 (pt)
MX (2) MX2013004151A (pt)
NZ (1) NZ610465A (pt)
PL (1) PL2627173T5 (pt)
PT (1) PT2627173E (pt)
WO (1) WO2012051116A1 (pt)

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PL2320740T3 (pl) 2008-08-01 2014-09-30 The Medicines Co Kompozycje farmaceutyczne klewidypiny oraz sposoby ich wytwarzania z niskim stężeniem zanieczyszczeń
US8658676B2 (en) 2010-10-12 2014-02-25 The Medicines Company Clevidipine emulsion formulations containing antimicrobial agents
PT2627173E (pt) 2010-10-12 2015-07-24 Medicines Co Formulações de clevidipina em emulsão contendo agentes antimicrobianos
CN103781479A (zh) * 2011-04-01 2014-05-07 医药公司 用于减轻中风损害的短效二氢吡啶（氯维地平）
CA2889584C (en) * 2012-10-26 2018-08-14 The Medicines Company Methods for controlling blood pressure and reducing dyspnea in heart failure
CN103169672A (zh) * 2012-12-26 2013-06-26 辰欣药业股份有限公司 一种丁酸氯维地平冻干乳剂
CN103110580B (zh) * 2013-02-20 2014-09-17 北京德立福瑞医药科技有限公司 丁酸氯维地平注射剂
CN103126986A (zh) * 2013-03-19 2013-06-05 董慧芳 一种丁酸氯维地平静脉注射用乳剂及其制备方法
TW201538181A (zh) * 2014-03-19 2015-10-16 Pures Biotech Co Ltd 用於潤滑保濕消毒滅菌之半流體組成物及其使用方法
CA2947486C (en) * 2014-05-19 2023-09-26 The Medicines Company Clevidipine nanoparticles and pharmaceutical compositions thereof
CN105456189A (zh) * 2014-09-12 2016-04-06 武汉大安制药有限公司 一种丁酸氯维地平乳剂注射剂及其制备方法
CN104523590B (zh) * 2014-12-09 2017-09-15 山东威高药业股份有限公司 一种丁酸氯维地平脂肪乳注射液
CN107661294B (zh) * 2016-07-27 2020-04-14 武汉科福新药有限责任公司 抗高血压药物脂肪乳注射剂及其制备方法
WO2019123221A1 (en) * 2017-12-20 2019-06-27 Aurobindo Pharma Limited Pharmaceutical composition comprising clevidipine and process for preparation thereof
CN108324703B (zh) * 2018-01-26 2020-07-28 中国医学科学院阜外医院 用于保护缺血心肌的注射剂及其制备方法
CN109602704A (zh) * 2019-01-23 2019-04-12 广东嘉博制药有限公司 丁酸氯维地平脂肪乳注射液及其制备工艺
CN109776405A (zh) * 2019-03-07 2019-05-21 重庆安格龙翔医药科技有限公司 一种丁酸氯维地平杂质的制备方法
US11135208B2 (en) 2019-08-12 2021-10-05 American Regent, Inc. 1,4-dihydropyridine compositions, methods of making and use

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PT2627173E (pt) 2010-10-12 2015-07-24 Medicines Co Formulações de clevidipina em emulsão contendo agentes antimicrobianos

Also Published As

Publication number Publication date
BR112013008601A8 (pt) 2017-12-12
CN103237446B (zh) 2014-11-05
US10010537B2 (en) 2018-07-03
EA201390541A1 (ru) 2013-11-29
WO2012051116A8 (en) 2013-05-02
EA022849B1 (ru) 2016-03-31
PL2627173T3 (pl) 2015-08-31
JP6040437B2 (ja) 2016-12-07
KR20160032266A (ko) 2016-03-23
NZ610465A (en) 2015-05-29
AU2011313852A1 (en) 2013-05-09
KR20130101080A (ko) 2013-09-12
DK2627173T4 (en) 2018-10-22
HK1187495A1 (en) 2014-04-11
AU2011313852A8 (en) 2013-07-25
DK2627173T3 (en) 2015-07-06
KR101786857B1 (ko) 2017-10-18
EP2627173A4 (en) 2014-05-07
CN103237446A (zh) 2013-08-07
CA2814495C (en) 2018-07-31
AU2011313852B2 (en) 2015-07-02
EP2627173B2 (en) 2018-07-04
CA2814495A1 (en) 2012-04-19
JP2014196322A (ja) 2014-10-16
ES2539861T5 (es) 2018-11-16
JP2016183183A (ja) 2016-10-20
BR112013008601B1 (pt) 2020-03-31
JP6437743B2 (ja) 2018-12-12
PL2627173T5 (pl) 2019-11-29
MX2013004151A (es) 2013-05-20
EP2627173B1 (en) 2015-03-25
EP2627173A1 (en) 2013-08-21
HUE026295T2 (en) 2016-06-28
JP6326094B2 (ja) 2018-05-16
MX356537B (es) 2018-06-01
JP2014504259A (ja) 2014-02-20
PT2627173E (pt) 2015-07-24
ES2539861T3 (es) 2015-07-06
US20120088804A1 (en) 2012-04-12
WO2012051116A1 (en) 2012-04-19

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