JP2010539228A - 脂肪組織または胎盤組織に由来する接着性細胞および治療におけるその使用 - Google Patents

脂肪組織または胎盤組織に由来する接着性細胞および治療におけるその使用 Download PDF

Info

Publication number
JP2010539228A
JP2010539228A JP2010525491A JP2010525491A JP2010539228A JP 2010539228 A JP2010539228 A JP 2010539228A JP 2010525491 A JP2010525491 A JP 2010525491A JP 2010525491 A JP2010525491 A JP 2010525491A JP 2010539228 A JP2010539228 A JP 2010539228A
Authority
JP
Japan
Prior art keywords
cells
tissue
adherent cells
product
culture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2010525491A
Other languages
English (en)
Japanese (ja)
Other versions
JP2010539228A5 (enExample
Inventor
モラン メイロン,
アミル トレン,
レイチェル オフィル,
ザミ アバーマン,
ニリット ドロリ−カーミ,
Original Assignee
プルリステム リミテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40118825&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP2010539228(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by プルリステム リミテッド filed Critical プルリステム リミテッド
Publication of JP2010539228A publication Critical patent/JP2010539228A/ja
Publication of JP2010539228A5 publication Critical patent/JP2010539228A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48Reproductive organs
    • A61K35/50Placenta; Placental stem cells; Amniotic fluid; Amnion; Amniotic stem cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/35Fat tissue; Adipocytes; Stromal cells; Connective tissues
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/36Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/04Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pregnancy & Childbirth (AREA)
  • Reproductive Health (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Transplantation (AREA)
  • Diabetes (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2010525491A 2007-09-19 2008-09-02 脂肪組織または胎盤組織に由来する接着性細胞および治療におけるその使用 Pending JP2010539228A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US96018407P 2007-09-19 2007-09-19
PCT/IL2008/001185 WO2009037690A1 (en) 2007-09-19 2008-09-02 Adherent cells from adipose or placenta tissues and use thereof in therapy

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014132003A Division JP5931132B2 (ja) 2007-09-19 2014-06-27 脂肪組織または胎盤組織に由来する接着性細胞および治療におけるその使用

Publications (2)

Publication Number Publication Date
JP2010539228A true JP2010539228A (ja) 2010-12-16
JP2010539228A5 JP2010539228A5 (enExample) 2011-08-25

Family

ID=40118825

Family Applications (5)

Application Number Title Priority Date Filing Date
JP2010525491A Pending JP2010539228A (ja) 2007-09-19 2008-09-02 脂肪組織または胎盤組織に由来する接着性細胞および治療におけるその使用
JP2014132003A Active JP5931132B2 (ja) 2007-09-19 2014-06-27 脂肪組織または胎盤組織に由来する接着性細胞および治療におけるその使用
JP2016012622A Pending JP2016094464A (ja) 2007-09-19 2016-01-26 脂肪組織または胎盤組織に由来する接着性細胞および治療におけるその使用
JP2017021090A Active JP6294517B2 (ja) 2007-09-19 2017-02-08 脂肪組織または胎盤組織に由来する接着性細胞および治療におけるその使用
JP2018025190A Active JP6560381B2 (ja) 2007-09-19 2018-02-15 脂肪組織または胎盤組織に由来する接着性細胞および治療におけるその使用

Family Applications After (4)

Application Number Title Priority Date Filing Date
JP2014132003A Active JP5931132B2 (ja) 2007-09-19 2014-06-27 脂肪組織または胎盤組織に由来する接着性細胞および治療におけるその使用
JP2016012622A Pending JP2016094464A (ja) 2007-09-19 2016-01-26 脂肪組織または胎盤組織に由来する接着性細胞および治療におけるその使用
JP2017021090A Active JP6294517B2 (ja) 2007-09-19 2017-02-08 脂肪組織または胎盤組織に由来する接着性細胞および治療におけるその使用
JP2018025190A Active JP6560381B2 (ja) 2007-09-19 2018-02-15 脂肪組織または胎盤組織に由来する接着性細胞および治療におけるその使用

Country Status (18)

Country Link
US (4) US8529888B2 (enExample)
EP (3) EP2591789B2 (enExample)
JP (5) JP2010539228A (enExample)
KR (4) KR101738285B1 (enExample)
CN (2) CN107028981B (enExample)
AU (1) AU2008300185B2 (enExample)
BR (1) BRPI0815946B8 (enExample)
CA (1) CA2699664C (enExample)
ES (1) ES2392729T5 (enExample)
HR (1) HRP20120887T4 (enExample)
IL (4) IL204566A (enExample)
MX (1) MX2010003019A (enExample)
PL (1) PL2200622T5 (enExample)
PT (1) PT2200622E (enExample)
RU (2) RU2709780C2 (enExample)
SI (1) SI2200622T2 (enExample)
WO (1) WO2009037690A1 (enExample)
ZA (1) ZA201001929B (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014508799A (ja) * 2011-03-22 2014-04-10 プルリステム リミテッド 放射線照射または化学物質による傷害を治療するための方法
JP2015532656A (ja) * 2012-09-04 2015-11-12 プルリステム リミテッド 子癇前症の予防及び治療方法
JP2019509999A (ja) * 2016-02-18 2019-04-11 プルリステム リミテッド がん及び新生物の治療方法及び治療用組成物

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060045872A1 (en) 2004-08-25 2006-03-02 Universidad Autonoma De Madrid Ciudad Universitaria de Cantoblanco Use of adipose tissue-derived stromal stem cells in treating fistula
JP5925408B2 (ja) 2005-09-23 2016-05-25 タイジェニックス、ソシエダッド、アノニマ、ウニペルソナルTigenix S.A.U. 免疫調節活性を有する細胞集団、単離方法および使用
EP1933852B1 (en) 2005-09-27 2018-12-19 TissueTech, Inc. Amniotic membrane preparations and purified compositions and methods of use
KR20220146689A (ko) 2007-07-23 2022-11-01 더 차이니즈 유니버시티 오브 홍콩 핵산 서열 불균형의 결정
US12180549B2 (en) 2007-07-23 2024-12-31 The Chinese University Of Hong Kong Diagnosing fetal chromosomal aneuploidy using genomic sequencing
RU2709780C2 (ru) 2007-09-19 2019-12-20 Плуристем Лтд. Адгезивные клетки жировой ткани или плаценты и их использование в лечебных целях
KR20200136051A (ko) * 2007-09-26 2020-12-04 안트로제네시스 코포레이션 인간 태반 관류액으로부터의 혈관형성 세포
BRPI0909541A2 (pt) * 2008-05-27 2016-10-11 Pluristem Ltd ''método para tratamento de doenças inflamatórias do cólon''
MX339624B (es) 2008-08-20 2016-06-02 Anthrogenesis Corp Composiciones mejoradas de celulas y metodos para preparar las mismas.
WO2010026575A2 (en) 2008-09-02 2010-03-11 Pluristem Ltd. Adherent cells from placenta tissue and use thereof in therapy
ES2749500T3 (es) 2008-11-19 2020-03-20 Celularity Inc Células adherentes derivadas del amnios
ES2553712T3 (es) 2009-11-30 2015-12-11 Pluristem Ltd. Células adherentes de la placenta y uso de las mismas en el tratamiento de enfermedad
AU2013203479B2 (en) * 2010-04-07 2016-05-19 Celularity Inc. Angiogenesis using placental stem cells
SI2556145T1 (sl) 2010-04-07 2017-01-31 Anthrogenesis Corporation Angiogeneza z uporabo placentnih matičnih celic
US20130039892A1 (en) 2010-04-23 2013-02-14 Pluristem Ltd. Adherent stromal cells derived from plancentas of multiple donors and uses thereof
ES2572211T3 (es) 2010-05-27 2016-05-30 Pluristem Ltd Regeneración de músculo esquelético utilizando células madre mesenquimales
WO2012048275A2 (en) 2010-10-08 2012-04-12 Caridianbct, Inc. Configurable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system
AR093183A1 (es) 2010-12-31 2015-05-27 Anthrogenesis Corp Aumento de la potencia de celulas madre de placenta usando moleculas de arn moduladoras
MX349171B (es) * 2011-04-15 2017-07-17 Pluristem Ltd Metodos y sistemas para cosechar celulas.
US9526770B2 (en) 2011-04-28 2016-12-27 Tissuetech, Inc. Methods of modulating bone remodeling
ES2707579T3 (es) 2011-06-01 2019-04-04 Celularity Inc Tratamiento del dolor usando citoblastos placentarios
KR101955053B1 (ko) 2011-06-06 2019-03-06 리제네시스 비브이비에이 중공 섬유 생물 반응기에서의 줄기 세포의 확장
EP2731440A4 (en) * 2011-07-15 2015-04-29 Anthrogenesis Corp RADIATION LESSON TREATMENT USING ADHESENT CELLS DERIVED FROM AMNIOS
US20130142762A1 (en) 2011-11-07 2013-06-06 Hina W. Chaudhry Methods of cardiac repair
US9892230B2 (en) 2012-03-08 2018-02-13 The Chinese University Of Hong Kong Size-based analysis of fetal or tumor DNA fraction in plasma
AU2013311288B2 (en) 2012-09-06 2015-04-16 Pluristem Ltd. Devices and methods for culture of cells
US9662355B2 (en) 2013-01-18 2017-05-30 Mimedx Group, Inc. Methods for treating cardiac conditions
DK2956543T3 (da) * 2013-02-12 2019-01-02 Replicel Life Sciences Inc Sammensætninger og fremgangsmåder til behandling og reparation af sener
WO2014128634A1 (en) 2013-02-20 2014-08-28 Pluristem Ltd. Gene and protein expression properties of adherent stromal cells cultured in 3d
WO2014141111A1 (en) 2013-03-14 2014-09-18 Pluristem Ltd. Methods for prevention and treatment of graft-versus-host disease
KR20160006694A (ko) * 2013-04-05 2016-01-19 클라우디아 질버버그 매트릭스 메탈로프로테나아제 및 그의 용도
WO2015004609A2 (en) 2013-07-09 2015-01-15 Pluristem Ltd. Adherent cells from placenta and use thereof in treatment of injured tendons
EP3068866B1 (en) 2013-11-16 2018-04-25 Terumo BCT, Inc. Expanding cells in a bioreactor
WO2015109329A1 (en) 2014-01-17 2015-07-23 Mimedx Group, Inc. Method for inducing angiogenesis
WO2015132729A1 (en) 2014-03-04 2015-09-11 Pluristem Ltd. Systems and methods for growing and harvesting cells
US11008547B2 (en) 2014-03-25 2021-05-18 Terumo Bct, Inc. Passive replacement of media
US20160090569A1 (en) 2014-09-26 2016-03-31 Terumo Bct, Inc. Scheduled Feed
WO2016068616A1 (ko) * 2014-10-29 2016-05-06 차의과학대학교 산학협력단 C3 또는 c1r 보체를 분비하는 태반 유래 세포 및 이를 포함하는 조성물
US10364467B2 (en) 2015-01-13 2019-07-30 The Chinese University Of Hong Kong Using size and number aberrations in plasma DNA for detecting cancer
WO2016151476A1 (en) 2015-03-23 2016-09-29 Pluristem Ltd. Use of adherent stromal cells for enhancing hematopoiesis in a subject in need thereof
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
WO2017039251A1 (ko) * 2015-08-28 2017-03-09 주식회사 차바이오텍 향상된 산후 부착형 세포 및 그의 용도
GB201604304D0 (en) 2016-03-14 2016-04-27 Tigenix S A U Adipose tissue-derived stromal stem cells for use in treating refractory complex perianal fistulas in crohn's disease
EP3464565A4 (en) 2016-05-25 2020-01-01 Terumo BCT, Inc. CELL EXPANSION
EP3464563B1 (en) * 2016-06-06 2021-07-28 Pluristem Ltd. Altered adherent stromal cells and methods of producing and using same
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
CN109641078A (zh) 2016-08-24 2019-04-16 阿瑟雷克斯股份有限公司 用于修复损伤的组织
CN110612344B (zh) 2017-03-31 2023-09-12 泰尔茂比司特公司 细胞扩增
US12234441B2 (en) 2017-03-31 2025-02-25 Terumo Bct, Inc. Cell expansion
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
CN106932571A (zh) * 2017-04-12 2017-07-07 广东国盛医学科技有限公司 基于rcn2标志物检测的心血管病检测方法及试剂盒
WO2018198012A1 (en) 2017-04-24 2018-11-01 Pluristem Ltd. Methods and compositions for treating neurological disorders
CA3061508A1 (en) * 2017-04-25 2018-11-01 Abraham J And Phyllis Katz Cord Blood Foundation Enriched cellular compositions and therapeutic use
CN111566205B (zh) * 2017-12-28 2024-10-29 株式会社钟化 包含贴壁性干细胞的细胞群、其制备方法、以及医药组合物
CN109810992A (zh) * 2019-02-01 2019-05-28 天津师范大学 一种编码牙鲆胞外ATP水解酶CD39的cDNA全长序列及其应用
KR102143840B1 (ko) * 2019-02-22 2020-08-12 송미연 손상된 성상교세포 치료방법
US11511017B2 (en) 2019-03-12 2022-11-29 Arthrex, Inc. Ligament reconstruction
US20220160787A1 (en) * 2019-03-15 2022-05-26 Celularity Inc. Placenta derived adherent cells for improved xenoplantation
AU2020247621A1 (en) * 2019-03-27 2021-07-22 Pluri Biotech Ltd Methods and compositions for aesthetic and cosmetic treatment and stimulating hair growth
US20200392448A1 (en) * 2019-06-14 2020-12-17 Ge Healthcare Uk Limited Monitoring of Cell Expansion
KR20200000415A (ko) * 2019-12-24 2020-01-02 (주)안트로젠 면역 질환 또는 염증성 질환의 예방 또는 치료용 중간엽줄기세포 배양액 및 이의 제조방법
GB2619893A (en) 2021-03-23 2023-12-20 Terumo Bct Inc Cell capture and expansion
WO2023037358A1 (en) * 2021-09-09 2023-03-16 Pluri Biotech Ltd. Placental cell treatment for critical limb ischemia patient subpopulations
US12209689B2 (en) 2022-02-28 2025-01-28 Terumo Kabushiki Kaisha Multiple-tube pinch valve assembly
USD1099116S1 (en) 2022-09-01 2025-10-21 Terumo Bct, Inc. Display screen or portion thereof with a graphical user interface for displaying cell culture process steps and measurements of an associated bioreactor device

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006501169A (ja) * 2002-03-15 2006-01-12 デパートメント・オヴ・ヴェテランズ・アフェアズ,リハビリテイション・アール・アンド・ディー・サーヴィス 細胞性アシアロ決定基および複合糖質を使用して細胞に組織および器官を標的とさせるための方法および組成物
JP2007505904A (ja) * 2003-09-17 2007-03-15 サイトリ セラピューティクス インコーポレイテッド 抹消血管疾患およびそれに関連する障害の治療において新生細胞を利用する方法
WO2007083093A1 (en) * 2006-01-18 2007-07-26 University Of Leeds Enrichment of cells
WO2007091255A2 (en) * 2006-02-06 2007-08-16 Pluristem Ltd. Method and apparatus for maintenance and expansion of hematopoietic stem cells from mononuclear cells

Family Cites Families (108)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL154600B (nl) 1971-02-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen.
NL154598B (nl) 1970-11-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking.
NL154599B (nl) 1970-12-28 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen, alsmede testverpakking.
US3901654A (en) 1971-06-21 1975-08-26 Biological Developments Receptor assays of biologically active compounds employing biologically specific receptors
US3853987A (en) 1971-09-01 1974-12-10 W Dreyer Immunological reagent and radioimmuno assay
US3867517A (en) 1971-12-21 1975-02-18 Abbott Lab Direct radioimmunoassay for antigens and their antibodies
NL171930C (nl) 1972-05-11 1983-06-01 Akzo Nv Werkwijze voor het aantonen en bepalen van haptenen, alsmede testverpakkingen.
US3850578A (en) 1973-03-12 1974-11-26 H Mcconnell Process for assaying for biologically active molecules
US3935074A (en) 1973-12-17 1976-01-27 Syva Company Antibody steric hindrance immunoassay with two antibodies
US3996345A (en) 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4034074A (en) 1974-09-19 1977-07-05 The Board Of Trustees Of Leland Stanford Junior University Universal reagent 2-site immunoradiometric assay using labelled anti (IgG)
US3984533A (en) 1975-11-13 1976-10-05 General Electric Company Electrophoretic method of detecting antigen-antibody reaction
US4098876A (en) 1976-10-26 1978-07-04 Corning Glass Works Reverse sandwich immunoassay
US4879219A (en) 1980-09-19 1989-11-07 General Hospital Corporation Immunoassay utilizing monoclonal high affinity IgM antibodies
US5011771A (en) 1984-04-12 1991-04-30 The General Hospital Corporation Multiepitopic immunometric assay
US4666828A (en) 1984-08-15 1987-05-19 The General Hospital Corporation Test for Huntington's disease
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4801531A (en) 1985-04-17 1989-01-31 Biotechnology Research Partners, Ltd. Apo AI/CIII genomic polymorphisms predictive of atherosclerosis
US5902741A (en) 1986-04-18 1999-05-11 Advanced Tissue Sciences, Inc. Three-dimensional cartilage cultures
US4846835A (en) * 1987-06-15 1989-07-11 Grande Daniel A Technique for healing lesions in cartilage
US5272057A (en) 1988-10-14 1993-12-21 Georgetown University Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase
US5192659A (en) 1989-08-25 1993-03-09 Genetype Ag Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes
US5108989A (en) * 1990-04-04 1992-04-28 Genentech, Inc. Method of predisposing mammals to accelerated tissue repair
US5486359A (en) 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
US5281521A (en) 1992-07-20 1994-01-25 The Trustees Of The University Of Pennsylvania Modified avidin-biotin technique
US5877295A (en) * 1992-09-30 1999-03-02 The Center For Blood Research Antibodies which bind a subpopulation of Mac-1 (CD11b/CD18) molecules which mediate neutrophil adhesion to ICAM-1 and fibrinogen
US5629186A (en) 1994-04-28 1997-05-13 Lockheed Martin Corporation Porous matrix and method of its production
US5474687A (en) * 1994-08-31 1995-12-12 Activated Cell Therapy, Inc. Methods for enriching CD34+ human hematopoietic progenitor cells
US5736396A (en) 1995-01-24 1998-04-07 Case Western Reserve University Lineage-directed induction of human mesenchymal stem cell differentiation
US6132463A (en) 1995-05-19 2000-10-17 Etex Corporation Cell seeding of ceramic compositions
DE69634303T2 (de) 1995-11-16 2006-01-05 Case Western Reserve University, Cleveland Chondrogene in vitro induktion von menschlichen mensenchymalen stammzellen
ATE227338T1 (de) 1998-03-18 2002-11-15 Massachusetts Inst Technology Vaskularisierte perfundierte anordnungen für mikrogewebe und mikroorgane
FR2784284B1 (fr) * 1998-10-13 2000-12-15 Natural Implant Sa Procede de preparation d'un implant dentaire par immersion dans une culture de cellules mesenchymateuses, dispositif de culture de cellules pour la preparation dudit implant et implant obtenu
US6153432A (en) 1999-01-29 2000-11-28 Zen-Bio, Inc Methods for the differentiation of human preadipocytes into adipocytes
ATE452181T1 (de) 1999-02-04 2010-01-15 Pluristem Ltd Verfahren und vorrichtung zur haltung und expansion von hematopoietischen stammzellen und/oder vorläuferzellen
KR100979664B1 (ko) 1999-03-10 2010-09-02 유니버시티 오브 피츠버그 오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 지방 유래 간세포 및 격자
US7582292B2 (en) 2000-02-26 2009-09-01 Artecel, Inc. Adipose tissue derived stromal cells for the treatment of neurological disorders
ES2300320T3 (es) 2000-02-26 2008-06-16 Artecel, Inc. Celulas madre pluripotentes generadas a partir de celulas del estroma derivadas de tejido adiposo y sus usos.
DE60107560T2 (de) 2000-05-03 2006-01-05 FIDIA ADVANCED BIOPOLYMERS, S.R.L., Abano Terme Preadipozyten enthaltende biomaterialien zur regeneration von weichgewebe
US7311905B2 (en) 2002-02-13 2007-12-25 Anthrogenesis Corporation Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells
JP4294316B2 (ja) 2000-12-06 2009-07-08 ハリリ,ロバート,ジェイ. 胎盤幹細胞の回収方法
KR100973615B1 (ko) 2001-02-14 2010-08-02 안트로제네시스 코포레이션 산후 포유류의 태반, 이의 용도 및 태반 줄기세포
AU2002251935B2 (en) 2001-02-14 2007-11-29 Celularity Inc. Post-partum mammalian placenta, its use and placental stem cells therefrom
US20030180947A1 (en) * 2001-09-21 2003-09-25 J.H. David Wu Circadian control of stem/progenitor cell self-renewal and differentiation and of clock controlled gene expression
US9597395B2 (en) * 2001-12-07 2017-03-21 Cytori Therapeutics, Inc. Methods of using adipose tissue-derived cells in the treatment of cardiovascular conditions
US7504099B2 (en) 2001-12-27 2009-03-17 Yissum Research Development Company Of The Hebrew University Of Jerusalem Methods of inducing or enhancing connective tissue repair
EP1482787A4 (en) 2002-02-13 2006-02-15 Anthrogenesis Corp EMBRYONIC TYPE DERIVED STEM CELLS DERIVED FROM MAMMALIAN POST-PARTUM PLACENTA, USES THEREOF, AND METHODS OF TREATMENT BASED ON CELLS OF THIS TYPE
CN1281739C (zh) * 2002-02-19 2006-10-25 美迪宝斯特有限公司 从脐带血中分离并扩大培养间充质干细胞/祖细胞及将脐带血来源的间充质干细胞/祖细胞分化成各种间充质组织的方法
WO2003082305A1 (en) * 2002-04-03 2003-10-09 Naohide Yamashita Drug containing human placenta-origin mesenchymal cells and process for producing vegf using the cells
US7498171B2 (en) 2002-04-12 2009-03-03 Anthrogenesis Corporation Modulation of stem and progenitor cell differentiation, assays, and uses thereof
US20040161419A1 (en) 2002-04-19 2004-08-19 Strom Stephen C. Placental stem cells and uses thereof
WO2003089619A2 (en) 2002-04-19 2003-10-30 University Of Pittsburgh Of The Commonwealth System Of Higher Education Placental derived stem cells and uses thereof
CN1234429C (zh) * 2002-05-09 2006-01-04 中国人民解放军军事医学科学院野战输血研究所 一种人工皮肤及其制备方法与应用
EP1525308A4 (en) * 2002-05-30 2006-11-02 Celgene Corp METHODS OF USING JNK OR MKK INHIBITORS TO MODULATE CELL DIFFERENTIATION AND TREAT MYELOPROLIFERATIVE DISORDERS AND MYELODYSPLASIC SYNDROMES
ATE519115T1 (de) * 2002-06-13 2011-08-15 Merck Patent Gmbh Verfahren für die identifizierung von allo- antigenen und ihre verwendung für krebstherapie und transplantation
US8455458B2 (en) * 2002-10-16 2013-06-04 Arthrodynamic Technologies, Animal Health Division, Inc. Composition and method for treating connective tissue damage
PL376714A1 (pl) * 2002-11-01 2006-01-09 Boys Town National Research Hospital Indukowalny ligand Ó1ß1 integryny i zastosowania
RU2372924C2 (ru) * 2003-02-20 2009-11-20 Ситори Терапьютикс,Инк Применение композиции, состоящей из концентрированной клеточной популяции, представляющей собой стволовые клетки и недифференцированные клетки-предшественники
CN1901802B (zh) 2003-02-20 2010-12-29 马克罗珀尔生物外科公司 用脂肪组织来源的细胞治疗心血管疾病的方法
JP2004254674A (ja) * 2003-02-25 2004-09-16 Mutsumi Takagi 動物細胞の分化誘導培養方法
US20060172304A1 (en) 2003-02-27 2006-08-03 Elaine Fuchs Method for modulating epithelial stem cell lineage
CN1548529A (zh) * 2003-05-09 2004-11-24 中国人民解放军军事医学科学院基础医 一种人胎盘间充质干细胞的分离方法
CA2530421C (en) 2003-06-27 2015-04-21 Ethicon, Incorporated Repair and regeneration of ocular tissue using postpartum-derived cells
US20060205071A1 (en) * 2003-07-17 2006-09-14 Gamida-Cell Ltd. Methods for ex-vivo expanding stem/progenitor cells
DK1651756T3 (da) 2003-08-01 2011-01-31 Two Cells Co Ltd Scaffold-fri selv-organiseret 3D syntetisk væv
FR2859381B1 (fr) 2003-09-05 2008-07-25 Centre Nat Rech Scient Utilisaton de cellules issues du tissu adipeux pour induire la formation d'un reseau vasculaire fonctionnel
TWI338714B (en) 2003-12-02 2011-03-11 Cathay General Hospital Method of isolation and enrichment of mesenchymal stem cells from amniotic fluid
US7534606B2 (en) 2004-01-12 2009-05-19 National Health Research Institutes Placental stem cell and methods thereof
CN1910159A (zh) * 2004-01-16 2007-02-07 诺瓦提斯公司 2,4-二氨基嘧啶和它们用于诱导心肌发生的用途
JP4445765B2 (ja) * 2004-02-05 2010-04-07 グンゼ株式会社 細胞培養装置
EP2298863B1 (en) 2004-03-22 2015-07-22 Mesoblast International Sàrl Mesenchymal stem cells and uses therefor
EP1756267A2 (en) * 2004-05-14 2007-02-28 Becton, Dickinson and Company Stem cell populations and methods of use
CN1746296A (zh) * 2004-09-09 2006-03-15 中国人民解放军军事医学科学院基础医学研究所 一种基于胎盘来源间充质干细胞的组织工程化骨及其制造方法
CN1746295A (zh) * 2004-09-09 2006-03-15 中国人民解放军军事医学科学院基础医学研究所 一种基于胎盘来源间充质干细胞的组织工程化软骨及其制造方法
CN100336567C (zh) * 2004-10-19 2007-09-12 北京科宇联合干细胞生物技术有限公司 医用角膜贴片
CA2589063C (en) 2004-12-23 2016-08-09 Ethicon Incorporated Treatment of parkinson's disease and related disorders using postpartum derived cells
WO2006074075A2 (en) 2004-12-30 2006-07-13 Primegen Biotech, Llc Adipose-derived stem cells for tissue regeneration and wound healing
CN101589137B (zh) 2005-03-31 2013-06-05 斯丹姆涅恩有限公司 羊膜来源的细胞组合物及其制备方法和用途
WO2006121532A2 (en) * 2005-03-31 2006-11-16 Mytogen, Inc. Treatment for heart disease
US20080317720A1 (en) 2005-04-14 2008-12-25 Noritoshi Nagaya Fat-Derived Progenitor Cell and Use Thereof
US8202551B2 (en) * 2005-06-15 2012-06-19 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Tissue engineered cartilage, method of making same, therapeutic and cosmetic surgical applications using same
EP2530145A1 (en) * 2005-10-13 2012-12-05 Anthrogenesis Corporation Immunomodulation using placental stem cells
NZ567334A (en) 2005-10-13 2012-08-31 Anthrogenesis Corp Production of oligodendrocytes from placenta-derived stem cells
CN103555655B (zh) 2005-10-21 2018-02-27 细胞研究私人有限公司 自脐带羊膜分离和培养干/祖细胞及其分化的细胞的应用
US20070160588A1 (en) * 2005-12-28 2007-07-12 Ethicon, Incorporated Treatment Of Peripheral Vascular Disease Using Postpartum-Derived Cells
CN103060263B (zh) 2005-12-29 2016-03-16 人类起源公司 胎盘干细胞群
AU2007228341B2 (en) 2006-03-23 2013-10-17 Pluri Biotech Ltd Methods for cell expansion and uses of cells and conditioned media produced thereby for therapy
US20110171182A1 (en) 2006-03-23 2011-07-14 Pluristem Ltd. Methods for cell expansion and uses of cells and conditioned media produced thereby for therapy
US20110293583A1 (en) 2006-03-23 2011-12-01 Pluristem Ltd. Methods for cell expansion and uses of cells and conditioned media produced thereby for therapy
EP1845154A1 (en) 2006-04-12 2007-10-17 RNL Bio Co., Ltd. Multipotent stem cells derived from placenta tissue and cellular therapeutic agents comprising the same
DE102006043625B4 (de) * 2006-09-12 2012-02-23 Eberhard-Karls-Universität Tübingen Universitätsklinikum Verfahren zur Isolierung und/oder Identifizierung von mesenchymalen Stammzellen (MSC)
US20080138415A1 (en) * 2006-09-26 2008-06-12 Mehboob Hussain Composition and method for producing composition for constructing tissue, and tissue construct
NZ595854A (en) * 2006-10-23 2013-04-26 Anthrogenesis Corp Methods and compositions for treatment of bone defects with placental cell populations (ELOVL2, ST3GAL6, STGALNAC5, SLC12A8)
KR20150039214A (ko) 2007-02-12 2015-04-09 안트로제네시스 코포레이션 태반 줄기세포를 이용한 염증 질환의 치료
EP2578677A1 (en) * 2007-08-09 2013-04-10 Genzyme Corporation Method of treating autoimmune disease with mesenchymal stem cells
RU2709780C2 (ru) 2007-09-19 2019-12-20 Плуристем Лтд. Адгезивные клетки жировой ткани или плаценты и их использование в лечебных целях
BRPI0909541A2 (pt) 2008-05-27 2016-10-11 Pluristem Ltd ''método para tratamento de doenças inflamatórias do cólon''
WO2010026575A2 (en) 2008-09-02 2010-03-11 Pluristem Ltd. Adherent cells from placenta tissue and use thereof in therapy
WO2010026573A1 (en) 2008-09-02 2010-03-11 Pluristem Ltd. Methods of selection of cells for transplantation
EP2334310B1 (en) 2008-09-02 2016-06-29 Pluristem Ltd. Adherent cells from placenta tissue and use thereof in therapy
ES2553712T3 (es) 2009-11-30 2015-12-11 Pluristem Ltd. Células adherentes de la placenta y uso de las mismas en el tratamiento de enfermedad
US20130039892A1 (en) 2010-04-23 2013-02-14 Pluristem Ltd. Adherent stromal cells derived from plancentas of multiple donors and uses thereof
ES2572211T3 (es) 2010-05-27 2016-05-30 Pluristem Ltd Regeneración de músculo esquelético utilizando células madre mesenquimales
US20140017209A1 (en) 2011-03-22 2014-01-16 Pluristem Ltd. Methods for treating radiation or chemical injury
MX349171B (es) 2011-04-15 2017-07-17 Pluristem Ltd Metodos y sistemas para cosechar celulas.
US9950014B2 (en) 2012-09-04 2018-04-24 Pluristem Ltd. Methods for prevention and treatment of preeclampsia
AU2013311288B2 (en) 2012-09-06 2015-04-16 Pluristem Ltd. Devices and methods for culture of cells
WO2014068508A2 (en) 2012-10-31 2014-05-08 Pluristem Ltd. Method and device for thawing biological material

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006501169A (ja) * 2002-03-15 2006-01-12 デパートメント・オヴ・ヴェテランズ・アフェアズ,リハビリテイション・アール・アンド・ディー・サーヴィス 細胞性アシアロ決定基および複合糖質を使用して細胞に組織および器官を標的とさせるための方法および組成物
JP2007505904A (ja) * 2003-09-17 2007-03-15 サイトリ セラピューティクス インコーポレイテッド 抹消血管疾患およびそれに関連する障害の治療において新生細胞を利用する方法
WO2007083093A1 (en) * 2006-01-18 2007-07-26 University Of Leeds Enrichment of cells
WO2007091255A2 (en) * 2006-02-06 2007-08-16 Pluristem Ltd. Method and apparatus for maintenance and expansion of hematopoietic stem cells from mononuclear cells

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JPN5010013031; ZHAO FENG: BIOTECHNOLOGY AND BIOENGINEERING V91 N4, 20050820, P482-493, WILEY & SONS *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014508799A (ja) * 2011-03-22 2014-04-10 プルリステム リミテッド 放射線照射または化学物質による傷害を治療するための方法
JP2017061472A (ja) * 2011-03-22 2017-03-30 プルリステム リミテッド 放射線照射または化学物質による傷害を治療するための方法
JP2018070646A (ja) * 2011-03-22 2018-05-10 プルリステム リミテッド 放射線照射または化学物質による傷害を治療するための方法
JP2015532656A (ja) * 2012-09-04 2015-11-12 プルリステム リミテッド 子癇前症の予防及び治療方法
JP2019509999A (ja) * 2016-02-18 2019-04-11 プルリステム リミテッド がん及び新生物の治療方法及び治療用組成物

Also Published As

Publication number Publication date
ZA201001929B (en) 2011-02-23
US20220378847A1 (en) 2022-12-01
EP2591789A3 (en) 2014-01-01
CN107050057A (zh) 2017-08-18
IL204566A0 (en) 2010-11-30
SI2200622T2 (sl) 2015-09-30
EP2200622A1 (en) 2010-06-30
KR20140107677A (ko) 2014-09-04
MX2010003019A (es) 2010-04-30
EP2591789B1 (en) 2016-06-22
EP3103463B1 (en) 2020-01-01
PL2200622T5 (pl) 2016-08-31
KR101738285B1 (ko) 2017-05-29
EP2591789B2 (en) 2022-07-20
JP2014208682A (ja) 2014-11-06
EP2200622B1 (en) 2012-08-08
CN107028981B (zh) 2021-04-20
PT2200622E (pt) 2012-11-06
IL272587A (en) 2020-03-31
EP2200622B2 (en) 2015-07-29
RU2015141314A (ru) 2018-12-26
IL272587B2 (en) 2023-02-01
PL2200622T3 (pl) 2013-01-31
KR20160081994A (ko) 2016-07-08
US9517248B2 (en) 2016-12-13
JP6560381B2 (ja) 2019-08-14
BRPI0815946B8 (pt) 2021-05-25
HK1180241A1 (en) 2013-10-18
JP5931132B2 (ja) 2016-06-08
RU2709780C2 (ru) 2019-12-20
KR20150100959A (ko) 2015-09-02
IL272587B (en) 2022-10-01
AU2008300185A1 (en) 2009-03-26
US20180256648A9 (en) 2018-09-13
AU2008300185B2 (en) 2013-09-05
CA2699664C (en) 2016-10-18
IL204566A (en) 2016-11-30
BRPI0815946A2 (pt) 2018-06-26
CN101861156A (zh) 2010-10-13
RU2010109698A (ru) 2011-09-27
HRP20120887T4 (hr) 2015-12-04
IL248956A0 (en) 2017-01-31
HK1145800A1 (en) 2011-05-06
CN107028981A (zh) 2017-08-11
EP3103463A1 (en) 2016-12-14
US20100209403A1 (en) 2010-08-19
IL248955B (en) 2020-03-31
ES2392729T5 (es) 2015-08-28
IL248955A0 (en) 2017-01-31
KR101738323B1 (ko) 2017-05-19
JP6294517B2 (ja) 2018-03-14
KR20100075924A (ko) 2010-07-05
JP2017095516A (ja) 2017-06-01
WO2009037690A1 (en) 2009-03-26
US20140242039A1 (en) 2014-08-28
BRPI0815946B1 (pt) 2020-12-01
RU2015141314A3 (enExample) 2019-03-14
SI2200622T1 (sl) 2013-01-31
EP2591789A2 (en) 2013-05-15
US20130323213A1 (en) 2013-12-05
CA2699664A1 (en) 2009-03-26
JP2016094464A (ja) 2016-05-26
HRP20120887T1 (en) 2012-12-31
JP2018109031A (ja) 2018-07-12
ES2392729T3 (es) 2012-12-13
US8529888B2 (en) 2013-09-10
IL248956B (en) 2019-07-31
CN107050057B (zh) 2021-04-20

Similar Documents

Publication Publication Date Title
JP6560381B2 (ja) 脂肪組織または胎盤組織に由来する接着性細胞および治療におけるその使用
US20210113627A1 (en) Adherent stromal cells derived from placentas of multiple donors and uses thereof
CN101861156B (zh) 来自脂肪或胎盘组织的粘附细胞及其在治疗中的用途
AU2013267050B2 (en) Adherent cells from adipose or placenta tissues and use thereof in therapy
HK1145800B (en) Adherent cells from adipose or placenta tissues and use thereof in therapy

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20110705

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20110705

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20110705

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20130319

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130618

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20140228