PT2200622E - Células aderentes provenientes de tecido adiposo ou placentário e respetiva utilização terapêutica - Google Patents

Células aderentes provenientes de tecido adiposo ou placentário e respetiva utilização terapêutica Download PDF

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Publication number
PT2200622E
PT2200622E PT08789856T PT08789856T PT2200622E PT 2200622 E PT2200622 E PT 2200622E PT 08789856 T PT08789856 T PT 08789856T PT 08789856 T PT08789856 T PT 08789856T PT 2200622 E PT2200622 E PT 2200622E
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cells
adherent
culture
cell
protein
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PT08789856T
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English (en)
Portuguese (pt)
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Moran Meiron
Amir Toren
Rachel Ofir
Zami Aberman
Nirit Drori-Carmi
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Pluristem Ltd
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40118825&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT2200622(E) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
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Publication of PT2200622E publication Critical patent/PT2200622E/pt

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48Reproductive organs
    • A61K35/50Placenta; Placental stem cells; Amniotic fluid; Amnion; Amniotic stem cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/35Fat tissue; Adipocytes; Stromal cells; Connective tissues
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/36Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/04Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pregnancy & Childbirth (AREA)
  • Reproductive Health (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Transplantation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PT08789856T 2007-09-19 2008-09-02 Células aderentes provenientes de tecido adiposo ou placentário e respetiva utilização terapêutica PT2200622E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US96018407P 2007-09-19 2007-09-19

Publications (1)

Publication Number Publication Date
PT2200622E true PT2200622E (pt) 2012-11-06

Family

ID=40118825

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PT08789856T PT2200622E (pt) 2007-09-19 2008-09-02 Células aderentes provenientes de tecido adiposo ou placentário e respetiva utilização terapêutica

Country Status (18)

Country Link
US (4) US8529888B2 (enExample)
EP (3) EP3103463B1 (enExample)
JP (5) JP2010539228A (enExample)
KR (4) KR101738323B1 (enExample)
CN (2) CN107028981B (enExample)
AU (1) AU2008300185B2 (enExample)
BR (1) BRPI0815946B8 (enExample)
CA (1) CA2699664C (enExample)
ES (1) ES2392729T5 (enExample)
HR (1) HRP20120887T4 (enExample)
IL (4) IL204566A (enExample)
MX (1) MX2010003019A (enExample)
PL (1) PL2200622T5 (enExample)
PT (1) PT2200622E (enExample)
RU (2) RU2709780C2 (enExample)
SI (1) SI2200622T2 (enExample)
WO (1) WO2009037690A1 (enExample)
ZA (1) ZA201001929B (enExample)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060045872A1 (en) 2004-08-25 2006-03-02 Universidad Autonoma De Madrid Ciudad Universitaria de Cantoblanco Use of adipose tissue-derived stromal stem cells in treating fistula
SG165418A1 (en) 2005-09-23 2010-10-28 Cellerix Sl Cell populations having immunoregulatory activity, method for isolation and uses
CN104873956B (zh) 2005-09-27 2019-04-23 组织技术公司 羊膜制品和纯化的组合物及其使用方法
WO2011132087A1 (en) 2010-04-23 2011-10-27 Pluristem Ltd. Adherent stromal cells derived from plancentas of multiple donors and uses thereof
US12180549B2 (en) 2007-07-23 2024-12-31 The Chinese University Of Hong Kong Diagnosing fetal chromosomal aneuploidy using genomic sequencing
KR102458210B1 (ko) 2007-07-23 2022-10-24 더 차이니즈 유니버시티 오브 홍콩 핵산 서열 불균형의 결정
SI2200622T2 (sl) 2007-09-19 2015-09-30 Pluristem Ltd. Adherentne celice iz adipoznih ali placentnih tkiv in njihova uporaba pri terapiji
US20090104164A1 (en) * 2007-09-26 2009-04-23 Celgene Cellular Therapeutics Angiogenic cells from human placental perfusate
EP2303293A1 (en) * 2008-05-27 2011-04-06 Pluristem Ltd. Methods of treating inflammatory colon diseases
KR20110050521A (ko) 2008-08-20 2011-05-13 안트로제네시스 코포레이션 개선된 세포 조성물 및 그의 제조 방법
CN102282249A (zh) * 2008-09-02 2011-12-14 普拉里斯坦有限公司 来自胎盘组织的粘附细胞及其在治疗中的用途
WO2010059828A1 (en) 2008-11-19 2010-05-27 Anthrogenesis Corporation Amnion derived adherent cells
IL288647B2 (en) 2009-11-30 2023-12-01 Pluri Biotech Ltd Adherent Cells From Placenta And Use Of Same In Treating Heart Failure
CN102933703A (zh) 2010-04-07 2013-02-13 人类起源公司 使用胎盘干细胞的血管生成
AU2013203479B2 (en) * 2010-04-07 2016-05-19 Celularity Inc. Angiogenesis using placental stem cells
WO2011147967A1 (en) 2010-05-27 2011-12-01 Georg Duda Skeletal muscle regeneration using mesenchymal stem cells
US9677042B2 (en) 2010-10-08 2017-06-13 Terumo Bct, Inc. Customizable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system
AR093183A1 (es) 2010-12-31 2015-05-27 Anthrogenesis Corp Aumento de la potencia de celulas madre de placenta usando moleculas de arn moduladoras
KR101835917B1 (ko) 2011-03-22 2018-03-07 플루리스템 리미티드 방사선 또는 화학적 손상을 치료하는 방법들
US9657266B2 (en) * 2011-04-15 2017-05-23 Pluristem Ltd. Methods and systems for harvesting cells
WO2012149486A1 (en) 2011-04-28 2012-11-01 Tissuetech, Inc. Methods of modulating bone remodeling
PT2714059T (pt) 2011-06-01 2019-02-04 Celularity Inc Tratamento da dor utilizando células estaminais da placenta
PL2718416T3 (pl) 2011-06-06 2020-05-18 ReGenesys BVBA Namnażanie komórek macierzystych w bioreaktorach włóknisto-kapilarnych
CA2841713A1 (en) * 2011-07-15 2013-01-24 Anthrogenesis Corporation Treatment of radiation injury using amnion derived adherent cells
WO2013070734A1 (en) 2011-11-07 2013-05-16 Chaudhry Hina W Methods of cardiac repair
US9892230B2 (en) 2012-03-08 2018-02-13 The Chinese University Of Hong Kong Size-based analysis of fetal or tumor DNA fraction in plasma
KR101921787B1 (ko) 2012-09-04 2018-11-23 플루리스템 리미티드 자간전증의 예방 및 치료 방법
ES2529501T3 (es) 2012-09-06 2015-02-20 Pluristem Ltd. Dispositivos y métodos para el cultivo de células
JP6545102B2 (ja) 2013-01-18 2019-07-17 ミメディクス グループ インコーポレイテッド 心病態を治療する方法
DK2956543T3 (da) * 2013-02-12 2019-01-02 Replicel Life Sciences Inc Sammensætninger og fremgangsmåder til behandling og reparation af sener
US10351910B2 (en) 2013-02-20 2019-07-16 Pluristem Ltd Gene and protein expression properties of adherent stromal cells cultured in 3D
WO2014141111A1 (en) 2013-03-14 2014-09-18 Pluristem Ltd. Methods for prevention and treatment of graft-versus-host disease
EP3290047A1 (en) * 2013-04-05 2018-03-07 Claudia Zylberberg Matrix metalloproteinases and uses thereof
WO2015004609A2 (en) 2013-07-09 2015-01-15 Pluristem Ltd. Adherent cells from placenta and use thereof in treatment of injured tendons
US9617506B2 (en) 2013-11-16 2017-04-11 Terumo Bct, Inc. Expanding cells in a bioreactor
WO2015109329A1 (en) 2014-01-17 2015-07-23 Mimedx Group, Inc. Method for inducing angiogenesis
WO2015132729A1 (en) 2014-03-04 2015-09-11 Pluristem Ltd. Systems and methods for growing and harvesting cells
WO2015148704A1 (en) 2014-03-25 2015-10-01 Terumo Bct, Inc. Passive replacement of media
JP6830059B2 (ja) 2014-09-26 2021-02-17 テルモ ビーシーティー、インコーポレーテッド スケジュール化された細胞フィーディング
KR101808762B1 (ko) * 2014-10-29 2017-12-14 차의과학대학교 산학협력단 C3 또는 C1r 보체를 분비하는 태반 유래 세포 및 이를 포함하는 조성물
US10364467B2 (en) 2015-01-13 2019-07-30 The Chinese University Of Hong Kong Using size and number aberrations in plasma DNA for detecting cancer
CN107864627A (zh) 2015-03-23 2018-03-30 普拉里斯坦有限公司 包含粘附基质细胞的方法和组合物
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
WO2017039251A1 (ko) * 2015-08-28 2017-03-09 주식회사 차바이오텍 향상된 산후 부착형 세포 및 그의 용도
US20210205370A1 (en) * 2016-02-18 2021-07-08 Pluristem Ltd. Methods and compositions for treating cancers and neoplasms
GB201604304D0 (en) 2016-03-14 2016-04-27 Tigenix S A U Adipose tissue-derived stromal stem cells for use in treating refractory complex perianal fistulas in crohn's disease
EP3464565A4 (en) 2016-05-25 2020-01-01 Terumo BCT, Inc. CELL EXPANSION
EP3464563B1 (en) * 2016-06-06 2021-07-28 Pluristem Ltd. Altered adherent stromal cells and methods of producing and using same
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
CN109641078A (zh) 2016-08-24 2019-04-16 阿瑟雷克斯股份有限公司 用于修复损伤的组织
JP7393945B2 (ja) 2017-03-31 2023-12-07 テルモ ビーシーティー、インコーポレーテッド 細胞増殖
US12234441B2 (en) 2017-03-31 2025-02-25 Terumo Bct, Inc. Cell expansion
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
CN106932571A (zh) * 2017-04-12 2017-07-07 广东国盛医学科技有限公司 基于rcn2标志物检测的心血管病检测方法及试剂盒
IL270114B2 (en) 2017-04-24 2024-01-01 Pluri Biotech Ltd Methods and compounds for the treatment of neurological diseases
EP3615064A4 (en) * 2017-04-25 2021-02-24 Abraham J and Phyllis Katz Cord Blood Foundation ENRICHED CELL COMPOSITIONS AND THERAPEUTIC USES
US20200360444A1 (en) * 2017-12-28 2020-11-19 Kaneka Corporation Cell population including adhesive stem cells, production method therefor and pharmaceutical composition
CN109810992A (zh) * 2019-02-01 2019-05-28 天津师范大学 一种编码牙鲆胞外ATP水解酶CD39的cDNA全长序列及其应用
KR102143840B1 (ko) * 2019-02-22 2020-08-12 송미연 손상된 성상교세포 치료방법
US11511017B2 (en) 2019-03-12 2022-11-29 Arthrex, Inc. Ligament reconstruction
US20220160787A1 (en) * 2019-03-15 2022-05-26 Celularity Inc. Placenta derived adherent cells for improved xenoplantation
CN113365644A (zh) * 2019-03-27 2021-09-07 普拉里斯坦有限公司 用于美容和整容治疗以及刺激毛发生长的方法和组合物
US20200392448A1 (en) * 2019-06-14 2020-12-17 Ge Healthcare Uk Limited Monitoring of Cell Expansion
KR20200000415A (ko) * 2019-12-24 2020-01-02 (주)안트로젠 면역 질환 또는 염증성 질환의 예방 또는 치료용 중간엽줄기세포 배양액 및 이의 제조방법
WO2022204315A1 (en) 2021-03-23 2022-09-29 Terumo Bct, Inc. Cell capture and expansion
US20240293471A1 (en) * 2021-09-09 2024-09-05 Pluri Biotech Ltd. Placental cell treatment for critical limb ischemia patient subpopulations
US12152699B2 (en) 2022-02-28 2024-11-26 Terumo Bct, Inc. Multiple-tube pinch valve assembly
USD1099116S1 (en) 2022-09-01 2025-10-21 Terumo Bct, Inc. Display screen or portion thereof with a graphical user interface for displaying cell culture process steps and measurements of an associated bioreactor device

Family Cites Families (112)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL154600B (nl) 1971-02-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen.
NL154598B (nl) 1970-11-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking.
NL154599B (nl) 1970-12-28 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen, alsmede testverpakking.
US3901654A (en) 1971-06-21 1975-08-26 Biological Developments Receptor assays of biologically active compounds employing biologically specific receptors
US3853987A (en) 1971-09-01 1974-12-10 W Dreyer Immunological reagent and radioimmuno assay
US3867517A (en) 1971-12-21 1975-02-18 Abbott Lab Direct radioimmunoassay for antigens and their antibodies
NL171930C (nl) 1972-05-11 1983-06-01 Akzo Nv Werkwijze voor het aantonen en bepalen van haptenen, alsmede testverpakkingen.
US3850578A (en) 1973-03-12 1974-11-26 H Mcconnell Process for assaying for biologically active molecules
US3935074A (en) 1973-12-17 1976-01-27 Syva Company Antibody steric hindrance immunoassay with two antibodies
US3996345A (en) 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4034074A (en) 1974-09-19 1977-07-05 The Board Of Trustees Of Leland Stanford Junior University Universal reagent 2-site immunoradiometric assay using labelled anti (IgG)
US3984533A (en) 1975-11-13 1976-10-05 General Electric Company Electrophoretic method of detecting antigen-antibody reaction
US4098876A (en) 1976-10-26 1978-07-04 Corning Glass Works Reverse sandwich immunoassay
US4879219A (en) 1980-09-19 1989-11-07 General Hospital Corporation Immunoassay utilizing monoclonal high affinity IgM antibodies
US5011771A (en) 1984-04-12 1991-04-30 The General Hospital Corporation Multiepitopic immunometric assay
US4666828A (en) 1984-08-15 1987-05-19 The General Hospital Corporation Test for Huntington's disease
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4801531A (en) 1985-04-17 1989-01-31 Biotechnology Research Partners, Ltd. Apo AI/CIII genomic polymorphisms predictive of atherosclerosis
US5902741A (en) * 1986-04-18 1999-05-11 Advanced Tissue Sciences, Inc. Three-dimensional cartilage cultures
US4846835A (en) * 1987-06-15 1989-07-11 Grande Daniel A Technique for healing lesions in cartilage
US5272057A (en) 1988-10-14 1993-12-21 Georgetown University Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase
US5192659A (en) 1989-08-25 1993-03-09 Genetype Ag Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes
US5108989A (en) * 1990-04-04 1992-04-28 Genentech, Inc. Method of predisposing mammals to accelerated tissue repair
US5486359A (en) 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
US5281521A (en) 1992-07-20 1994-01-25 The Trustees Of The University Of Pennsylvania Modified avidin-biotin technique
US5877295A (en) * 1992-09-30 1999-03-02 The Center For Blood Research Antibodies which bind a subpopulation of Mac-1 (CD11b/CD18) molecules which mediate neutrophil adhesion to ICAM-1 and fibrinogen
US5629186A (en) 1994-04-28 1997-05-13 Lockheed Martin Corporation Porous matrix and method of its production
US5474687A (en) * 1994-08-31 1995-12-12 Activated Cell Therapy, Inc. Methods for enriching CD34+ human hematopoietic progenitor cells
US5736396A (en) 1995-01-24 1998-04-07 Case Western Reserve University Lineage-directed induction of human mesenchymal stem cell differentiation
US6132463A (en) 1995-05-19 2000-10-17 Etex Corporation Cell seeding of ceramic compositions
CA2237890C (en) 1995-11-16 2011-03-29 Case Western Reserve University In vitro chondrogenic induction of human mesenchymal stem cells
CA2324208C (en) 1998-03-18 2009-06-30 Massachusetts Institute Of Technology Vascularized perfused microtissue/micro-organ arrays
FR2784284B1 (fr) * 1998-10-13 2000-12-15 Natural Implant Sa Procede de preparation d'un implant dentaire par immersion dans une culture de cellules mesenchymateuses, dispositif de culture de cellules pour la preparation dudit implant et implant obtenu
US6153432A (en) 1999-01-29 2000-11-28 Zen-Bio, Inc Methods for the differentiation of human preadipocytes into adipocytes
ATE452181T1 (de) * 1999-02-04 2010-01-15 Pluristem Ltd Verfahren und vorrichtung zur haltung und expansion von hematopoietischen stammzellen und/oder vorläuferzellen
CA2366078C (en) * 1999-03-10 2015-09-01 University Of Pittsburgh Of The Commonwealth System Of Higher Education Adipose-derived stem cells and lattices
US7582292B2 (en) 2000-02-26 2009-09-01 Artecel, Inc. Adipose tissue derived stromal cells for the treatment of neurological disorders
ATE384124T1 (de) 2000-02-26 2008-02-15 Artecel Inc Pluripotente stammzellen erzeugt aus stromalzellen aus dem fettgewebe und deren verwendungen
ES2233650T3 (es) 2000-05-03 2005-06-16 Fidia Advanced Biopolymers S.R.L. Biomateriales formados por celulas preadipocito para reparacion de tejidos blandos.
US7311905B2 (en) * 2002-02-13 2007-12-25 Anthrogenesis Corporation Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells
MXPA03005014A (es) * 2000-12-06 2004-09-10 Robert J Hariri Metodo para recolectar celulas madres de la placenta.
EP2316463B1 (en) * 2001-02-14 2017-04-12 Anthrogenesis Corporation Tissue matrices comprising placental stem cells, and methods of making them
EP2314673B1 (en) * 2001-02-14 2013-07-24 Anthrogenesis Corporation Post-partum mammalian placenta, its use and placental stem cells therefrom
US20030180947A1 (en) * 2001-09-21 2003-09-25 J.H. David Wu Circadian control of stem/progenitor cell self-renewal and differentiation and of clock controlled gene expression
US9597395B2 (en) * 2001-12-07 2017-03-21 Cytori Therapeutics, Inc. Methods of using adipose tissue-derived cells in the treatment of cardiovascular conditions
US7504099B2 (en) 2001-12-27 2009-03-17 Yissum Research Development Company Of The Hebrew University Of Jerusalem Methods of inducing or enhancing connective tissue repair
NZ534643A (en) * 2002-02-13 2010-06-25 Anthrogenesis Corp Embryonic-like stem cells derived from post-partum mammalian placenta and uses and methods of treatment using said cells
CN1281739C (zh) * 2002-02-19 2006-10-25 美迪宝斯特有限公司 从脐带血中分离并扩大培养间充质干细胞/祖细胞及将脐带血来源的间充质干细胞/祖细胞分化成各种间充质组织的方法
WO2003077864A2 (en) * 2002-03-15 2003-09-25 Department Of Veterans Affairs, Rehabilitation R & D Service Methods and compositions for directing cells to target organs
AU2003220966A1 (en) 2002-04-03 2003-10-13 Naohide Yamashita Drug containing human placenta-origin mesenchymal cells and process for producing vegf using the cells
US7498171B2 (en) * 2002-04-12 2009-03-03 Anthrogenesis Corporation Modulation of stem and progenitor cell differentiation, assays, and uses thereof
EP1497435A4 (en) * 2002-04-19 2005-07-27 Univ Pittsburgh STEM CELLS DERIVED FROM PLAZENTA AND THEIR USES
US20040161419A1 (en) 2002-04-19 2004-08-19 Strom Stephen C. Placental stem cells and uses thereof
CN1234429C (zh) * 2002-05-09 2006-01-04 中国人民解放军军事医学科学院野战输血研究所 一种人工皮肤及其制备方法与应用
JP2005528105A (ja) * 2002-05-30 2005-09-22 セルジーン・コーポレーション 細胞分化をモジュレートするため、並びに骨髄増殖性疾患及び骨髄異形成症候群を治療するためのjnk又はmkk阻害剤の使用方法
PT1512014E (pt) * 2002-06-13 2009-11-10 Merck Patent Gmbh Método de identificação de alo-antigénios e sua utilização para terapia de cancro e transplante
US8455458B2 (en) * 2002-10-16 2013-06-04 Arthrodynamic Technologies, Animal Health Division, Inc. Composition and method for treating connective tissue damage
EA200500576A1 (ru) * 2002-11-01 2006-02-24 Бойз Таун Нэшнл Рисерч Хоспитал ИНДУЦИБЕЛЬНЫЙ ЛИГАНД ИНТЕГРИНА α1β1 И ПРИМЕНЕНИЯ
CA2516510C (en) * 2003-02-20 2012-07-10 Macropore Biosurgery, Inc. Method of using adipose tissue-derived cells in the treatment of cardiovascular conditions
CN1901802B (zh) 2003-02-20 2010-12-29 马克罗珀尔生物外科公司 用脂肪组织来源的细胞治疗心血管疾病的方法
JP2004254674A (ja) * 2003-02-25 2004-09-16 Mutsumi Takagi 動物細胞の分化誘導培養方法
US20060172304A1 (en) 2003-02-27 2006-08-03 Elaine Fuchs Method for modulating epithelial stem cell lineage
CN1548529A (zh) * 2003-05-09 2004-11-24 中国人民解放军军事医学科学院基础医 一种人胎盘间充质干细胞的分离方法
US7510873B2 (en) 2003-06-27 2009-03-31 Ethicon, Incorporated Postpartum cells isolated from umbilical cord tissue, and methods of making and using the same
EP1649007A4 (en) * 2003-07-17 2008-05-14 Gamida Cell Ltd PROCESS FOR THE EX-VIVO EXPANSION OF STEM / PROVIDER CELLS
AU2004261899A1 (en) 2003-08-01 2005-02-10 Norimasa Nakamura Scaffold-free self-organized 3D synthetic tissue
FR2859381B1 (fr) 2003-09-05 2008-07-25 Centre Nat Rech Scient Utilisaton de cellules issues du tissu adipeux pour induire la formation d'un reseau vasculaire fonctionnel
SG146666A1 (en) 2003-09-17 2008-10-30 Macropore Biosurgery Inc Methods of using regenerative cells in the treatment of peripheral vascular disease and related disorders
TWI338714B (en) 2003-12-02 2011-03-11 Cathay General Hospital Method of isolation and enrichment of mesenchymal stem cells from amniotic fluid
US7534606B2 (en) 2004-01-12 2009-05-19 National Health Research Institutes Placental stem cell and methods thereof
KR20060133552A (ko) * 2004-01-16 2006-12-26 노파르티스 아게 2,4-디아미노피리미딘 및 심장근육발생 유도를 위한 그의용도
JP4445765B2 (ja) * 2004-02-05 2010-04-07 グンゼ株式会社 細胞培養装置
US20050239897A1 (en) 2004-03-22 2005-10-27 Pittenger Mark F Mesenchymal stem cells and uses therefor
EP1745125A1 (en) * 2004-05-14 2007-01-24 Becton, Dickinson and Company Cell culture environments for the serum-free expansion of mesenchymal stem cells
CN1746296A (zh) * 2004-09-09 2006-03-15 中国人民解放军军事医学科学院基础医学研究所 一种基于胎盘来源间充质干细胞的组织工程化骨及其制造方法
CN1746295A (zh) * 2004-09-09 2006-03-15 中国人民解放军军事医学科学院基础医学研究所 一种基于胎盘来源间充质干细胞的组织工程化软骨及其制造方法
CN100336567C (zh) * 2004-10-19 2007-09-12 北京科宇联合干细胞生物技术有限公司 医用角膜贴片
AU2005322133B2 (en) 2004-12-23 2011-06-30 Ethicon Incorporated Treatment of Parkinson's disease and related disorders using postpartum derived cells
WO2006074075A2 (en) 2004-12-30 2006-07-13 Primegen Biotech, Llc Adipose-derived stem cells for tissue regeneration and wound healing
EP2460875A1 (en) 2005-03-31 2012-06-06 Stemnion, Inc. Amnion-derived cell compositions, methods of making and uses thereof
WO2006121532A2 (en) * 2005-03-31 2006-11-16 Mytogen, Inc. Treatment for heart disease
EP1878789A4 (en) 2005-04-14 2008-08-27 Japan As Represented By Genera STEM CELL DERIVED FROM FAT AND USE THEREOF
US8202551B2 (en) * 2005-06-15 2012-06-19 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Tissue engineered cartilage, method of making same, therapeutic and cosmetic surgical applications using same
AU2006304274B2 (en) 2005-10-13 2012-08-16 Celularity Inc. Production of oligodendrocytes from placenta-derived stem cells
PL1957633T3 (pl) * 2005-10-13 2014-05-30 Anthrogenesis Corp Immunomodulacja z zastosowaniem komórek macierzystych łożyska
CN101330935B (zh) 2005-10-21 2013-11-13 细胞研究私人有限公司 自脐带羊膜分离和培养干/祖细胞及其分化的细胞的应用
ES2628129T3 (es) * 2005-12-28 2017-08-01 DePuy Synthes Products, Inc. Tratamiento de la enfermedad vascular periférica utilizando células derivadas del posparto
EP2471904B1 (en) 2005-12-29 2018-10-24 Celularity, Inc. Placental stem cell populations
GB0600972D0 (en) 2006-01-18 2006-03-01 Univ Leeds Enrichment of cells
EP1994143A4 (en) * 2006-02-06 2009-08-26 Pluristem Ltd METHOD AND DEVICE FOR MAINTAINING AND EXPANSION OF HEMOPOETIC STEM CELLS FROM MONONUCLEAR CELLS
KR101490449B1 (ko) 2006-03-23 2015-02-05 플루리스템 리미티드 세포 증식 방법 및 세포의 용도 및 치료를 위해 그 세포에 의해 제조되는 조절된 배지
WO2011132087A1 (en) 2010-04-23 2011-10-27 Pluristem Ltd. Adherent stromal cells derived from plancentas of multiple donors and uses thereof
US20110293583A1 (en) 2006-03-23 2011-12-01 Pluristem Ltd. Methods for cell expansion and uses of cells and conditioned media produced thereby for therapy
US20110171182A1 (en) 2006-03-23 2011-07-14 Pluristem Ltd. Methods for cell expansion and uses of cells and conditioned media produced thereby for therapy
EP1845154A1 (en) 2006-04-12 2007-10-17 RNL Bio Co., Ltd. Multipotent stem cells derived from placenta tissue and cellular therapeutic agents comprising the same
DE102006043625B4 (de) * 2006-09-12 2012-02-23 Eberhard-Karls-Universität Tübingen Universitätsklinikum Verfahren zur Isolierung und/oder Identifizierung von mesenchymalen Stammzellen (MSC)
US20080138415A1 (en) * 2006-09-26 2008-06-12 Mehboob Hussain Composition and method for producing composition for constructing tissue, and tissue construct
CA2667359C (en) * 2006-10-23 2014-07-22 Anthrogenesis Corporation Methods and compositions for treatment of bone defects with placental cell populations
EP2687220A3 (en) 2007-02-12 2014-05-14 Anthrogenesis Corporation Treatment of inflammatory diseases using placental stem cells
US20090324609A1 (en) * 2007-08-09 2009-12-31 Genzyme Corporation Method of treating autoimmune disease with mesenchymal stem cells
SI2200622T2 (sl) 2007-09-19 2015-09-30 Pluristem Ltd. Adherentne celice iz adipoznih ali placentnih tkiv in njihova uporaba pri terapiji
EP2303293A1 (en) 2008-05-27 2011-04-06 Pluristem Ltd. Methods of treating inflammatory colon diseases
CN102282249A (zh) 2008-09-02 2011-12-14 普拉里斯坦有限公司 来自胎盘组织的粘附细胞及其在治疗中的用途
WO2010026574A2 (en) 2008-09-02 2010-03-11 Pluristem Ltd. Adherent cells from placenta tissue and use thereof in therapy
WO2010026573A1 (en) 2008-09-02 2010-03-11 Pluristem Ltd. Methods of selection of cells for transplantation
IL288647B2 (en) 2009-11-30 2023-12-01 Pluri Biotech Ltd Adherent Cells From Placenta And Use Of Same In Treating Heart Failure
WO2011147967A1 (en) 2010-05-27 2011-12-01 Georg Duda Skeletal muscle regeneration using mesenchymal stem cells
US20140017209A1 (en) 2011-03-22 2014-01-16 Pluristem Ltd. Methods for treating radiation or chemical injury
US9657266B2 (en) 2011-04-15 2017-05-23 Pluristem Ltd. Methods and systems for harvesting cells
KR101921787B1 (ko) 2012-09-04 2018-11-23 플루리스템 리미티드 자간전증의 예방 및 치료 방법
ES2529501T3 (es) 2012-09-06 2015-02-20 Pluristem Ltd. Dispositivos y métodos para el cultivo de células
RU2640427C2 (ru) 2012-10-31 2018-01-09 Плуристем Лтд. Способ и устройство для размораживания биологического материала

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