RU2015141314A - Адгезивные клетки жировой ткани или плаценты и их использование в лечебных целях - Google Patents
Адгезивные клетки жировой ткани или плаценты и их использование в лечебных целях Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/50—Placenta; Placental stem cells; Amniotic fluid; Amnion; Amniotic stem cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/35—Fat tissue; Adipocytes; Stromal cells; Connective tissues
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Developmental Biology & Embryology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Virology (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Pregnancy & Childbirth (AREA)
- Reproductive Health (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Transplantation (AREA)
- Diabetes (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Materials For Medical Uses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Claims (12)
1. Фармацевтическая композиция, включающая адгезивные клетки плаценты для использования при лечении ишемии, отличающаяся тем, что упомянутые клетки размножают, используя двухмерное (2D) культивирование, затем культивирование на трехмерной (3D) подложке, затем удаление упомянутых адгезивных клеток плаценты из упомянутой 3D-подложки и введение упомянутых адгезивных клеток плаценты в упомянутую фармацевтическую композицию.
2. Фармацевтическая композиция для использования по п. 1, отличающаяся тем, что упомянутые клетки способны подавлять иммунный ответ пациента.
3. Фармацевтическая композиция для использования по п. 1, отличающаяся тем, что по меньшей мере 10% из упомянутых адгезивных клеток находятся на стадии пролиферации.
4. Фармацевтическая композиция для использования по п. 1, отличающаяся тем, что культивирование упомянутых клеток в упомянутой культуре на 3D-подложке осуществляют с перфузией.
5. Фармацевтическая композиция для использования по п. 1, отличающаяся тем, что упомянутое культивирование на трехмерной (3D) подложке включает 3D-биореактор.
6. Фармацевтическая композиция для использования по п. 5, отличающаяся тем, что культивирование упомянутых клеток в упомянутой культуре на 3D-подложке осуществляют с перфузией.
7. Фармацевтическая композиция для использования по любому одному из пп. 1 и 4-6, отличающаяся тем, что упомянутая трехмерная подложка включает адгезивный материал, выбираемый из группы, состоящей из полиэфира и полипропилена.
8. Фармацевтическая композиция для использования по п. 1, отличающаяся тем, что упомянутые клетки экспрессируют маркер, выбираемый из группы, состоящей из CD73, CD90, CD29 и CD105.
9. Фармацевтическая композиция для использования по п. 1, отличающаяся тем, что упомянутые клетки не экспрессируют маркер, выбираемый из группы, состоящей из CD3, CD4, CD45, CD80, HLA-DR, CD11b, CD14, CD19, CD34 и CD79.
10. Фармацевтическая композиция для использования по п. 1, отличающаяся тем, что упомянутые адгезивные клетки включают фенотип стромальных стволовых клеток.
11. Фармацевтическая композиция для использования по п. 1, отличающаяся тем, что упомянутая ишемия является заболеванием периферических артерий (ЗПА).
12. Фармацевтическая композиция для использования по п. 1, отличающаяся тем, что упомянутая ишемия является ишемией центральной нервной системы (ЦНС).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US96018407P | 2007-09-19 | 2007-09-19 | |
US60/960,184 | 2007-09-19 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2010109698/15A Division RU2010109698A (ru) | 2007-09-19 | 2008-09-02 | Адгезивные клетки жировой ткани или плаценты и их использование в лечебных целях |
Publications (3)
Publication Number | Publication Date |
---|---|
RU2015141314A true RU2015141314A (ru) | 2018-12-26 |
RU2015141314A3 RU2015141314A3 (ru) | 2019-03-14 |
RU2709780C2 RU2709780C2 (ru) | 2019-12-20 |
Family
ID=40118825
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2010109698/15A RU2010109698A (ru) | 2007-09-19 | 2008-09-02 | Адгезивные клетки жировой ткани или плаценты и их использование в лечебных целях |
RU2015141314A RU2709780C2 (ru) | 2007-09-19 | 2008-09-02 | Адгезивные клетки жировой ткани или плаценты и их использование в лечебных целях |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
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RU2010109698/15A RU2010109698A (ru) | 2007-09-19 | 2008-09-02 | Адгезивные клетки жировой ткани или плаценты и их использование в лечебных целях |
Country Status (19)
Country | Link |
---|---|
US (4) | US8529888B2 (ru) |
EP (3) | EP3103463B1 (ru) |
JP (5) | JP2010539228A (ru) |
KR (4) | KR20140107677A (ru) |
CN (2) | CN107050057B (ru) |
AU (1) | AU2008300185B2 (ru) |
BR (1) | BRPI0815946B8 (ru) |
CA (1) | CA2699664C (ru) |
ES (1) | ES2392729T5 (ru) |
HK (2) | HK1145800A1 (ru) |
HR (1) | HRP20120887T4 (ru) |
IL (4) | IL204566A (ru) |
MX (1) | MX2010003019A (ru) |
PL (1) | PL2200622T5 (ru) |
PT (1) | PT2200622E (ru) |
RU (2) | RU2010109698A (ru) |
SI (1) | SI2200622T2 (ru) |
WO (1) | WO2009037690A1 (ru) |
ZA (1) | ZA201001929B (ru) |
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