JP2010535252A - 代謝障害を治療または予防するためのα７ｎＡＣｈＲアゴニスト - Google Patents

代謝障害を治療または予防するためのα７ｎＡＣｈＲアゴニスト Download PDF

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JP2010535252A
JP2010535252A JP2010520219A JP2010520219A JP2010535252A JP 2010535252 A JP2010535252 A JP 2010535252A JP 2010520219 A JP2010520219 A JP 2010520219A JP 2010520219 A JP2010520219 A JP 2010520219A JP 2010535252 A JP2010535252 A JP 2010535252A
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azabicyclo
pyridinyl
methyl
oct
compound
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JP2010535252A5 (pt-PT
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ベンチェリフ，メローン
ビー． マレロ，マリオ
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ターガセプト，インコーポレイテッド
メディカル カレッジ オブ ジョージア リサーチ インスティテュート，インコーポレーテッド
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39945177&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP2010535252(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by ターガセプト，インコーポレイテッド, メディカル カレッジ オブ ジョージア リサーチ インスティテュート，インコーポレーテッド filed Critical ターガセプト，インコーポレイテッド
Publication of JP2010535252A publication Critical patent/JP2010535252A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2010520219A 2007-08-02 2008-08-01 代謝障害を治療または予防するためのα７ｎＡＣｈＲアゴニスト Pending JP2010535252A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US95361307P 2007-08-02 2007-08-02
US95361007P 2007-08-02 2007-08-02
US95361407P 2007-08-02 2007-08-02
US97165407P 2007-09-12 2007-09-12
PCT/US2008/071893 WO2009018511A2 (en) 2007-08-02 2008-08-01 Alpha7 nachr agonists for treating or preventing metabolic disorders

Publications (2)

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JP2010535252A true JP2010535252A (ja) 2010-11-18
JP2010535252A5 JP2010535252A5 (pt-PT) 2011-01-06

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JP2010520213A Active JP5358573B2 (ja) 2007-08-02 2008-08-01 （２ｓ，３ｒ）−ｎ−（２−（（３−ピリジニル）メチル）−１−アザビシクロ［２．２．２］オクタ−３−イル）ベンゾフラン−２−カルボキサミド、その新規塩形態およびその使用方法
JP2010520219A Pending JP2010535252A (ja) 2007-08-02 2008-08-01 代謝障害を治療または予防するためのα７ｎＡＣｈＲアゴニスト
JP2013148091A Active JP6106549B2 (ja) 2007-08-02 2013-07-17 （２ｓ，３ｒ）−ｎ−（２−（（３−ピリジニル）メチル）−１−アザビシクロ［２．２．２］オクタ−３−イル）ベンゾフラン−２−カルボキサミド、その新規塩形態およびその使用方法
JP2013148087A Active JP5852611B2 (ja) 2007-08-02 2013-07-17 （２ｓ，３ｒ）−ｎ−（２−（（３−ピリジニル）メチル）−１−アザビシクロ［２．２．２］オクタ−３−イル）ベンゾフラン−２−カルボキサミド、その新規塩形態およびその使用方法

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JP2010520213A Active JP5358573B2 (ja) 2007-08-02 2008-08-01 （２ｓ，３ｒ）−ｎ−（２−（（３−ピリジニル）メチル）−１−アザビシクロ［２．２．２］オクタ−３−イル）ベンゾフラン−２−カルボキサミド、その新規塩形態およびその使用方法

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JP2013148091A Active JP6106549B2 (ja) 2007-08-02 2013-07-17 （２ｓ，３ｒ）−ｎ−（２−（（３−ピリジニル）メチル）−１−アザビシクロ［２．２．２］オクタ−３−イル）ベンゾフラン−２−カルボキサミド、その新規塩形態およびその使用方法
JP2013148087A Active JP5852611B2 (ja) 2007-08-02 2013-07-17 （２ｓ，３ｒ）−ｎ−（２−（（３−ピリジニル）メチル）−１−アザビシクロ［２．２．２］オクタ−３−イル）ベンゾフラン−２−カルボキサミド、その新規塩形態およびその使用方法

Country Status (35)

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US (6) US20110124678A1 (pt-PT)
EP (6) EP2185152A2 (pt-PT)
JP (4) JP5358573B2 (pt-PT)
KR (2) KR20100051684A (pt-PT)
CN (4) CN103172628A (pt-PT)
AR (1) AR067775A1 (pt-PT)
AU (3) AU2008283807B2 (pt-PT)
BR (2) BRPI0814889A2 (pt-PT)
CA (2) CA2694504C (pt-PT)
CL (3) CL2008002271A1 (pt-PT)
CO (2) CO6260081A2 (pt-PT)
CY (1) CY1113561T1 (pt-PT)
DK (2) DK2431037T3 (pt-PT)
EC (2) ECSP10010008A (pt-PT)
ES (3) ES2606752T3 (pt-PT)
HK (1) HK1140968A1 (pt-PT)
HR (1) HRP20130286T1 (pt-PT)
HU (1) HUE030387T2 (pt-PT)
IL (1) IL218976A0 (pt-PT)
ME (1) ME01508B (pt-PT)
MX (3) MX346451B (pt-PT)
MY (1) MY148002A (pt-PT)
NO (2) NO20100078L (pt-PT)
NZ (2) NZ582986A (pt-PT)
PE (3) PE20090566A1 (pt-PT)
PL (1) PL2182949T3 (pt-PT)
PT (1) PT2182949E (pt-PT)
RS (1) RS52743B (pt-PT)
RU (2) RU2012140148A (pt-PT)
SA (2) SA08290475B1 (pt-PT)
SI (1) SI2182949T1 (pt-PT)
TW (3) TW201402116A (pt-PT)
UY (1) UY31265A (pt-PT)
WO (2) WO2009018505A1 (pt-PT)
ZA (1) ZA201000719B (pt-PT)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010535251A (ja) * 2007-08-02 2010-11-18 ターガセプト，インコーポレイテッド （２ｓ，３ｒ）−ｎ−（２−（（３−ピリジニル）メチル）−１−アザビシクロ［２．２．２］オクタ−３−イル）ベンゾフラン−２−カルボキサミド、その新規塩形態およびその使用方法

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