JP2010533758A5 - - Google Patents
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- Publication number
- JP2010533758A5 JP2010533758A5 JP2010516501A JP2010516501A JP2010533758A5 JP 2010533758 A5 JP2010533758 A5 JP 2010533758A5 JP 2010516501 A JP2010516501 A JP 2010516501A JP 2010516501 A JP2010516501 A JP 2010516501A JP 2010533758 A5 JP2010533758 A5 JP 2010533758A5
- Authority
- JP
- Japan
- Prior art keywords
- acid
- salt
- formula
- crosslinked polymer
- preferably less
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 20
- 150000003839 salts Chemical class 0.000 claims 12
- 229920006037 cross link polymer Polymers 0.000 claims 10
- VVJKKWFAADXIJK-UHFFFAOYSA-N Allylamine Chemical compound NCC=C VVJKKWFAADXIJK-UHFFFAOYSA-N 0.000 claims 8
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 6
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 239000002904 solvent Substances 0.000 claims 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-L 2-(carboxymethyl)-2-hydroxysuccinate Chemical compound [O-]C(=O)CC(O)(C(=O)O)CC([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-L 0.000 claims 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-M 3-carboxy-2-(carboxymethyl)-2-hydroxypropanoate Chemical compound OC(=O)CC(O)(C(O)=O)CC([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-M 0.000 claims 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims 2
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 2
- 108010007979 Glycocholic Acid Proteins 0.000 claims 2
- 229910019142 PO4 Inorganic materials 0.000 claims 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims 2
- LSNNMFCWUKXFEE-UHFFFAOYSA-N Sulfurous acid Chemical compound OS(O)=O LSNNMFCWUKXFEE-UHFFFAOYSA-N 0.000 claims 2
- UCKMPCXJQFINFW-UHFFFAOYSA-N Sulphide Chemical compound [S-2] UCKMPCXJQFINFW-UHFFFAOYSA-N 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims 2
- 235000010323 ascorbic acid Nutrition 0.000 claims 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims 2
- BHQCQFFYRZLCQQ-OELDTZBJSA-M cholate Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC([O-])=O)C)[C@@]2(C)[C@@H](O)C1 BHQCQFFYRZLCQQ-OELDTZBJSA-M 0.000 claims 2
- 239000003431 cross linking reagent Substances 0.000 claims 2
- RFDAIACWWDREDC-FRVQLJSFSA-N glycocholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(=O)NCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 RFDAIACWWDREDC-FRVQLJSFSA-N 0.000 claims 2
- 150000004820 halides Chemical class 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 claims 2
- 239000003999 initiator Substances 0.000 claims 2
- 239000002245 particle Substances 0.000 claims 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 2
- 239000010452 phosphate Substances 0.000 claims 2
- WBWWGRHZICKQGZ-HZAMXZRMSA-N taurocholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(=O)NCCS(O)(=O)=O)C)[C@@]2(C)[C@@H](O)C1 WBWWGRHZICKQGZ-HZAMXZRMSA-N 0.000 claims 2
- VTAKZNRDSPNOAU-UHFFFAOYSA-M 2-(chloromethyl)oxirane;hydron;prop-2-en-1-amine;n-prop-2-enyldecan-1-amine;trimethyl-[6-(prop-2-enylamino)hexyl]azanium;dichloride Chemical compound Cl.[Cl-].NCC=C.ClCC1CO1.CCCCCCCCCCNCC=C.C[N+](C)(C)CCCCCCNCC=C VTAKZNRDSPNOAU-UHFFFAOYSA-M 0.000 claims 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims 1
- 208000010444 Acidosis Diseases 0.000 claims 1
- 239000005711 Benzoic acid Substances 0.000 claims 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims 1
- 229920002905 Colesevelam Polymers 0.000 claims 1
- 150000000994 L-ascorbates Chemical class 0.000 claims 1
- 206010027417 Metabolic acidosis Diseases 0.000 claims 1
- 229910002651 NO3 Inorganic materials 0.000 claims 1
- RFDAIACWWDREDC-UHFFFAOYSA-N Na salt-Glycocholic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(=O)NCC(O)=O)C)C1(C)C(O)C2 RFDAIACWWDREDC-UHFFFAOYSA-N 0.000 claims 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 claims 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 claims 1
- 102000006335 Phosphate-Binding Proteins Human genes 0.000 claims 1
- 108010058514 Phosphate-Binding Proteins Proteins 0.000 claims 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims 1
- WBWWGRHZICKQGZ-UHFFFAOYSA-N Taurocholic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(=O)NCCS(O)(=O)=O)C)C1(C)C(O)C2 WBWWGRHZICKQGZ-UHFFFAOYSA-N 0.000 claims 1
- 235000011054 acetic acid Nutrition 0.000 claims 1
- 150000001242 acetic acid derivatives Chemical class 0.000 claims 1
- 150000001450 anions Chemical class 0.000 claims 1
- 239000011668 ascorbic acid Substances 0.000 claims 1
- 229960005070 ascorbic acid Drugs 0.000 claims 1
- -1 azo compound Chemical class 0.000 claims 1
- 235000010233 benzoic acid Nutrition 0.000 claims 1
- 150000001558 benzoic acid derivatives Chemical class 0.000 claims 1
- 239000003833 bile salt Substances 0.000 claims 1
- 229940093761 bile salts Drugs 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 1
- 229910052794 bromium Inorganic materials 0.000 claims 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 claims 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 239000000460 chlorine Substances 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 229940099352 cholate Drugs 0.000 claims 1
- 235000015165 citric acid Nutrition 0.000 claims 1
- 150000001860 citric acid derivatives Chemical class 0.000 claims 1
- 229960001152 colesevelam Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940099347 glycocholic acid Drugs 0.000 claims 1
- QAOWNCQODCNURD-UHFFFAOYSA-M hydrogensulfate Chemical compound OS([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-M 0.000 claims 1
- 239000011630 iodine Chemical group 0.000 claims 1
- 229910052740 iodine Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 125000001624 naphthyl group Chemical group 0.000 claims 1
- 229910017604 nitric acid Inorganic materials 0.000 claims 1
- 150000001451 organic peroxides Chemical class 0.000 claims 1
- 235000006408 oxalic acid Nutrition 0.000 claims 1
- 125000001037 p-tolyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 claims 1
- JRKICGRDRMAZLK-UHFFFAOYSA-L peroxydisulfate Chemical compound [O-]S(=O)(=O)OOS([O-])(=O)=O JRKICGRDRMAZLK-UHFFFAOYSA-L 0.000 claims 1
- 150000004968 peroxymonosulfuric acids Chemical class 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- OJMIONKXNSYLSR-UHFFFAOYSA-N phosphorous acid Chemical compound OP(O)O OJMIONKXNSYLSR-UHFFFAOYSA-N 0.000 claims 1
- 229920000083 poly(allylamine) Polymers 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 239000011541 reaction mixture Substances 0.000 claims 1
- ZNSIZMQNQCNRBW-UHFFFAOYSA-N sevelamer Chemical group NCC=C.ClCC1CO1 ZNSIZMQNQCNRBW-UHFFFAOYSA-N 0.000 claims 1
- 229960003693 sevelamer Drugs 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 claims 1
- 239000011975 tartaric acid Substances 0.000 claims 1
- 235000002906 tartaric acid Nutrition 0.000 claims 1
- 229940095064 tartrate Drugs 0.000 claims 1
- ISIJQEHRDSCQIU-UHFFFAOYSA-N tert-butyl 2,7-diazaspiro[4.5]decane-7-carboxylate Chemical compound C1N(C(=O)OC(C)(C)C)CCCC11CNCC1 ISIJQEHRDSCQIU-UHFFFAOYSA-N 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07112604A EP2016947A1 (en) | 2007-07-17 | 2007-07-17 | Novel one step process for preparing cross-linked poly(allylamine) polymers |
| PCT/EP2008/059303 WO2009010531A1 (en) | 2007-07-17 | 2008-07-16 | Novel one step process for preparing cross-linked poly(allylamine) polymers |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010533758A JP2010533758A (ja) | 2010-10-28 |
| JP2010533758A5 true JP2010533758A5 (enExample) | 2011-07-14 |
Family
ID=38921775
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010516501A Pending JP2010533758A (ja) | 2007-07-17 | 2008-07-16 | 架橋ポリ（アリルアミン）ポリマーを調製するための新規な一工程方法 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8394416B2 (enExample) |
| EP (2) | EP2016947A1 (enExample) |
| JP (1) | JP2010533758A (enExample) |
| KR (1) | KR20100051616A (enExample) |
| CN (1) | CN101743012B (enExample) |
| AT (1) | ATE493136T1 (enExample) |
| BR (1) | BRPI0813829A2 (enExample) |
| CA (1) | CA2697130A1 (enExample) |
| DE (1) | DE602008004259D1 (enExample) |
| DK (1) | DK2175866T3 (enExample) |
| ES (1) | ES2358381T3 (enExample) |
| HR (1) | HRP20110181T1 (enExample) |
| PL (1) | PL2175866T3 (enExample) |
| PT (1) | PT2175866E (enExample) |
| SI (1) | SI2175866T1 (enExample) |
| WO (1) | WO2009010531A1 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8404784B2 (en) * | 2008-12-03 | 2013-03-26 | Navinta Llc | Manufacturing process of making polymeric amine salts |
| EP2443157A1 (en) * | 2009-06-16 | 2012-04-25 | Watson Pharma Private Limited | Processes for the preparation of sevelamer carbonate |
| IT1404163B1 (it) * | 2011-02-01 | 2013-11-15 | Chemi Spa | Processo per la preparazione di poliallilamine reticolate o loro sali farmaceuticamente accettabili |
| CN102796262B (zh) * | 2011-05-24 | 2014-11-12 | 北大方正集团有限公司 | 一种碳酸司维拉姆的制备方法 |
| CN102796259B (zh) * | 2011-05-24 | 2014-11-12 | 北大方正集团有限公司 | 碳酸司维拉姆的制备方法 |
| CN103012789B (zh) * | 2011-09-23 | 2015-02-25 | 北大方正集团有限公司 | 烟酸司维拉姆的制备方法 |
| CN102675510B (zh) * | 2012-05-28 | 2014-04-02 | 诚达药业股份有限公司 | 司维拉姆的合成工艺 |
| CN102942646B (zh) * | 2012-10-26 | 2016-06-29 | 青岛正大海尔制药有限公司 | 一种高分子聚合物的合成与分离纯化方法 |
| ES2733493T3 (es) | 2013-06-05 | 2019-11-29 | Tricida Inc | Polímeros de unión a protones para la administración oral |
| CN104448139B (zh) * | 2014-11-21 | 2016-08-17 | 新发药业有限公司 | 一种盐酸考来维仑的制备方法 |
| IL322207A (en) | 2014-12-10 | 2025-09-01 | Tricida Inc | Proton-binding polymers for oral administration |
| MA41202A (fr) * | 2014-12-18 | 2017-10-24 | Genzyme Corp | Copolymères polydiallymine réticulé pour le traitement du diabète de type 2 |
| MA44875A (fr) | 2016-05-06 | 2019-03-13 | Tricida Inc | Compositions pour le traitement de troubles acido-basiques |
| CN106008813B (zh) * | 2016-06-15 | 2017-11-14 | 新发药业有限公司 | 溶液聚合制备盐酸考来维仑的方法 |
| KR101853260B1 (ko) * | 2016-11-29 | 2018-06-14 | 주식회사 퍼슨 | 세벨라머 카보네이트의 제조방법 |
| WO2018124264A1 (ja) | 2016-12-28 | 2018-07-05 | 富士フイルム株式会社 | 窒素原子含有ポリマー又はその塩の乳化液、その製造方法、及び粒子の製造方法 |
| CN110831984B (zh) * | 2017-07-05 | 2023-06-06 | 日东纺绩株式会社 | 高纯度烯丙胺（共）聚合物及其制造方法 |
| US10934380B1 (en) | 2017-09-25 | 2021-03-02 | Tricida, Inc. | Crosslinked poly(allylamine) polymer pharmaceutical compositions |
| JP6992084B2 (ja) | 2017-10-16 | 2022-01-13 | 富士フイルム株式会社 | 高リン血症治療剤 |
| WO2019090176A1 (en) * | 2017-11-03 | 2019-05-09 | Tricida, Inc. | Compositions for and method of treating acid-base disorders |
| CN108751208B (zh) * | 2018-06-05 | 2020-06-30 | 山东师范大学 | 一种无表面活性剂微乳液制备的单分散二氧化硅纳米球及其制备方法 |
| ES2980624T3 (es) * | 2021-08-24 | 2024-10-02 | Waterstone Pharmaceuticals Wuhan Co Ltd | Polímeros, composiciones y métodos para tratar hiperuricemia |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE757856A (fr) * | 1969-10-27 | 1971-04-22 | Michelin & Cie | Perfectionnements aux polyurethanes vulcanisables au soufre |
| JPS6090243A (ja) | 1983-10-25 | 1985-05-21 | Nitto Boseki Co Ltd | 小球状モノアリルアミン橋かけ重合体の製造方法 |
| JP2862933B2 (ja) * | 1990-02-06 | 1999-03-03 | 東芝シリコーン株式会社 | Ｎ―アルケニル―ｎ―グリシジル（メタ）アクリルアミド化合物の製造方法 |
| JP2967952B2 (ja) * | 1991-07-23 | 1999-10-25 | 日本化薬株式会社 | 多孔性ポリマーの製造方法 |
| US5496545A (en) * | 1993-08-11 | 1996-03-05 | Geltex Pharmaceuticals, Inc. | Phosphate-binding polymers for oral administration |
| US5667775A (en) | 1993-08-11 | 1997-09-16 | Geltex Pharmaceuticals, Inc. | Phosphate-binding polymers for oral administration |
| US5414068A (en) * | 1994-01-24 | 1995-05-09 | Rohm And Haas Company | Crosslinked anion exchange particles and method for producing the particles |
| TW474813B (en) | 1994-06-10 | 2002-02-01 | Geltex Pharma Inc | Alkylated composition for removing bile salts from a patient |
| JP3952223B2 (ja) * | 1997-05-28 | 2007-08-01 | 日東紡績株式会社 | アリルアミン重合体 |
| JP3363143B2 (ja) * | 1998-10-12 | 2003-01-08 | 中外製薬株式会社 | リン酸結合性ポリマー粒子 |
| TW568788B (en) * | 1998-10-12 | 2004-01-01 | Chugai Pharmaceutical Co Ltd | Polymer combining with phosphoric acid and preparation containing the same |
| US6362266B1 (en) | 1999-09-03 | 2002-03-26 | The Dow Chemical Company | Process for reducing cohesiveness of polyallylamine polymer gels during drying |
| US6733780B1 (en) | 1999-10-19 | 2004-05-11 | Genzyme Corporation | Direct compression polymer tablet core |
| MY133977A (en) * | 2000-06-16 | 2007-11-30 | Nippon Catalytic Chem Ind | Crosslinked polymers containing tertiary amine and/or quaternary ammonium salt structures, processes for making and uses thereof |
| BR0209020A (pt) | 2001-04-18 | 2004-08-10 | Genzyme Corp | Composição farmacêutica de polialilamina |
| US7459502B2 (en) * | 2003-11-03 | 2008-12-02 | Ilypsa, Inc. | Pharmaceutical compositions comprising crosslinked polyamine polymers |
| US7985418B2 (en) | 2004-11-01 | 2011-07-26 | Genzyme Corporation | Aliphatic amine polymer salts for tableting |
| KR101547925B1 (ko) | 2005-09-15 | 2015-08-27 | 젠자임 코포레이션 | 아민 중합체에 대한 샤셋 제형 |
-
2007
- 2007-07-17 EP EP07112604A patent/EP2016947A1/en not_active Withdrawn
-
2008
- 2008-07-16 PT PT08775124T patent/PT2175866E/pt unknown
- 2008-07-16 US US12/668,758 patent/US8394416B2/en not_active Expired - Fee Related
- 2008-07-16 EP EP08775124A patent/EP2175866B1/en not_active Not-in-force
- 2008-07-16 ES ES08775124T patent/ES2358381T3/es active Active
- 2008-07-16 CN CN2008800248423A patent/CN101743012B/zh not_active Expired - Fee Related
- 2008-07-16 HR HR20110181T patent/HRP20110181T1/hr unknown
- 2008-07-16 JP JP2010516501A patent/JP2010533758A/ja active Pending
- 2008-07-16 SI SI200830184T patent/SI2175866T1/sl unknown
- 2008-07-16 KR KR1020107001256A patent/KR20100051616A/ko not_active Ceased
- 2008-07-16 AT AT08775124T patent/ATE493136T1/de active
- 2008-07-16 BR BRPI0813829-0A2A patent/BRPI0813829A2/pt not_active IP Right Cessation
- 2008-07-16 CA CA2697130A patent/CA2697130A1/en not_active Abandoned
- 2008-07-16 DK DK08775124.4T patent/DK2175866T3/da active
- 2008-07-16 DE DE602008004259T patent/DE602008004259D1/de active Active
- 2008-07-16 WO PCT/EP2008/059303 patent/WO2009010531A1/en not_active Ceased
- 2008-07-16 PL PL08775124T patent/PL2175866T3/pl unknown
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