KR20100051616A - 교차결합형 폴리（알릴아민）폴리머의 제조를 위한 새로운 원스텝 방법 - Google Patents
교차결합형 폴리（알릴아민）폴리머의 제조를 위한 새로운 원스텝 방법 Download PDFInfo
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- KR20100051616A KR20100051616A KR1020107001256A KR20107001256A KR20100051616A KR 20100051616 A KR20100051616 A KR 20100051616A KR 1020107001256 A KR1020107001256 A KR 1020107001256A KR 20107001256 A KR20107001256 A KR 20107001256A KR 20100051616 A KR20100051616 A KR 20100051616A
- Authority
- KR
- South Korea
- Prior art keywords
- acid
- salt
- allylamine
- crosslinked polymer
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229920000083 poly(allylamine) Polymers 0.000 title claims abstract description 38
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 28
- -1 poly(allylamine) Polymers 0.000 title claims abstract description 26
- 238000000034 method Methods 0.000 claims abstract description 122
- 150000003839 salts Chemical class 0.000 claims abstract description 80
- 150000001875 compounds Chemical class 0.000 claims abstract description 44
- 230000008569 process Effects 0.000 claims abstract description 24
- 239000003814 drug Substances 0.000 claims abstract description 15
- VVJKKWFAADXIJK-UHFFFAOYSA-N Allylamine Chemical compound NCC=C VVJKKWFAADXIJK-UHFFFAOYSA-N 0.000 claims description 63
- 229920006037 cross link polymer Polymers 0.000 claims description 57
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 41
- 239000002904 solvent Substances 0.000 claims description 40
- 239000002245 particle Substances 0.000 claims description 36
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 35
- 239000000203 mixture Substances 0.000 claims description 31
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims description 30
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- 229910019142 PO4 Inorganic materials 0.000 claims description 27
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- 239000004094 surface-active agent Substances 0.000 claims description 26
- 239000007787 solid Substances 0.000 claims description 25
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- 239000003999 initiator Substances 0.000 claims description 16
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims description 15
- 239000004971 Cross linker Substances 0.000 claims description 15
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical group C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims description 13
- 238000003756 stirring Methods 0.000 claims description 13
- OZAIFHULBGXAKX-UHFFFAOYSA-N 2-(2-cyanopropan-2-yldiazenyl)-2-methylpropanenitrile Chemical group N#CC(C)(C)N=NC(C)(C)C#N OZAIFHULBGXAKX-UHFFFAOYSA-N 0.000 claims description 12
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 12
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- LXEKPEMOWBOYRF-UHFFFAOYSA-N [2-[(1-azaniumyl-1-imino-2-methylpropan-2-yl)diazenyl]-2-methylpropanimidoyl]azanium;dichloride Chemical compound Cl.Cl.NC(=N)C(C)(C)N=NC(C)(C)C(N)=N LXEKPEMOWBOYRF-UHFFFAOYSA-N 0.000 claims description 8
- MVPPADPHJFYWMZ-UHFFFAOYSA-N chlorobenzene Chemical compound ClC1=CC=CC=C1 MVPPADPHJFYWMZ-UHFFFAOYSA-N 0.000 claims description 8
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- LBSPZZSGTIBOFG-UHFFFAOYSA-N bis[2-(4,5-dihydro-1h-imidazol-2-yl)propan-2-yl]diazene;dihydrochloride Chemical compound Cl.Cl.N=1CCNC=1C(C)(C)N=NC(C)(C)C1=NCCN1 LBSPZZSGTIBOFG-UHFFFAOYSA-N 0.000 claims description 7
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- NLMKTBGFQGKQEV-UHFFFAOYSA-N 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-hexadecoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol Chemical compound CCCCCCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO NLMKTBGFQGKQEV-UHFFFAOYSA-N 0.000 claims description 6
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 6
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- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 6
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 claims description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 6
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- KRKNYBCHXYNGOX-UHFFFAOYSA-L 2-(carboxymethyl)-2-hydroxysuccinate Chemical compound [O-]C(=O)CC(O)(C(=O)O)CC([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-L 0.000 claims description 5
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- ZFSPZXXKYPTSTJ-UHFFFAOYSA-N 5-methyl-2-propan-2-yl-4,5-dihydro-1h-imidazole Chemical compound CC(C)C1=NCC(C)N1 ZFSPZXXKYPTSTJ-UHFFFAOYSA-N 0.000 claims description 4
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- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
- C07C215/06—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
- C07C215/18—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic with hydroxy groups and at least two amino groups bound to the carbon skeleton
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F226/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen
- C08F226/02—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen by a single or double bond to nitrogen
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F226/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen
- C08F226/02—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen by a single or double bond to nitrogen
- C08F226/04—Diallylamine
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Obesity (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Polymers & Plastics (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
- Polymerisation Methods In General (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07112604.9 | 2007-07-17 | ||
| EP07112604A EP2016947A1 (en) | 2007-07-17 | 2007-07-17 | Novel one step process for preparing cross-linked poly(allylamine) polymers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20100051616A true KR20100051616A (ko) | 2010-05-17 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020107001256A Ceased KR20100051616A (ko) | 2007-07-17 | 2008-07-16 | 교차결합형 폴리（알릴아민）폴리머의 제조를 위한 새로운 원스텝 방법 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8394416B2 (enExample) |
| EP (2) | EP2016947A1 (enExample) |
| JP (1) | JP2010533758A (enExample) |
| KR (1) | KR20100051616A (enExample) |
| CN (1) | CN101743012B (enExample) |
| AT (1) | ATE493136T1 (enExample) |
| BR (1) | BRPI0813829A2 (enExample) |
| CA (1) | CA2697130A1 (enExample) |
| DE (1) | DE602008004259D1 (enExample) |
| DK (1) | DK2175866T3 (enExample) |
| ES (1) | ES2358381T3 (enExample) |
| HR (1) | HRP20110181T1 (enExample) |
| PL (1) | PL2175866T3 (enExample) |
| PT (1) | PT2175866E (enExample) |
| SI (1) | SI2175866T1 (enExample) |
| WO (1) | WO2009010531A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101853260B1 (ko) * | 2016-11-29 | 2018-06-14 | 주식회사 퍼슨 | 세벨라머 카보네이트의 제조방법 |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8404784B2 (en) * | 2008-12-03 | 2013-03-26 | Navinta Llc | Manufacturing process of making polymeric amine salts |
| EP2443157A1 (en) * | 2009-06-16 | 2012-04-25 | Watson Pharma Private Limited | Processes for the preparation of sevelamer carbonate |
| IT1404163B1 (it) | 2011-02-01 | 2013-11-15 | Chemi Spa | Processo per la preparazione di poliallilamine reticolate o loro sali farmaceuticamente accettabili |
| CN102796259B (zh) * | 2011-05-24 | 2014-11-12 | 北大方正集团有限公司 | 碳酸司维拉姆的制备方法 |
| CN102796262B (zh) * | 2011-05-24 | 2014-11-12 | 北大方正集团有限公司 | 一种碳酸司维拉姆的制备方法 |
| CN103012789B (zh) * | 2011-09-23 | 2015-02-25 | 北大方正集团有限公司 | 烟酸司维拉姆的制备方法 |
| CN102675510B (zh) * | 2012-05-28 | 2014-04-02 | 诚达药业股份有限公司 | 司维拉姆的合成工艺 |
| CN102942646B (zh) * | 2012-10-26 | 2016-06-29 | 青岛正大海尔制药有限公司 | 一种高分子聚合物的合成与分离纯化方法 |
| HRP20171590T1 (hr) | 2013-06-05 | 2017-12-29 | Tricida Inc. | Polimeri koji vežu protone za oralnu primjenu |
| CN104448139B (zh) * | 2014-11-21 | 2016-08-17 | 新发药业有限公司 | 一种盐酸考来维仑的制备方法 |
| PL3229816T3 (pl) | 2014-12-10 | 2020-09-21 | Tricida Inc. | Polimery wiążące protony do podawania doustnego |
| MA41202A (fr) * | 2014-12-18 | 2017-10-24 | Genzyme Corp | Copolymères polydiallymine réticulé pour le traitement du diabète de type 2 |
| EP3452028A4 (en) * | 2016-05-06 | 2020-04-15 | Tricida Inc. | COMPOSITIONS AND METHOD FOR TREATING ACID-BASED DISORDERS |
| CN106008813B (zh) * | 2016-06-15 | 2017-11-14 | 新发药业有限公司 | 溶液聚合制备盐酸考来维仑的方法 |
| KR20190084125A (ko) | 2016-12-28 | 2019-07-15 | 후지필름 가부시키가이샤 | 질소 원자 함유 폴리머 또는 그 염의 유화액, 그 제조 방법, 및 입자의 제조 방법 |
| CN116217763B (zh) * | 2017-07-05 | 2025-02-11 | 日东纺绩株式会社 | 高纯度烯丙胺（共）聚合物及其制造方法 |
| US10934380B1 (en) | 2017-09-25 | 2021-03-02 | Tricida, Inc. | Crosslinked poly(allylamine) polymer pharmaceutical compositions |
| WO2019078197A1 (ja) | 2017-10-16 | 2019-04-25 | 富士フイルム株式会社 | 高リン血症治療剤 |
| AU2018360867B2 (en) * | 2017-11-03 | 2024-12-12 | Tricida, Inc. | Compositions for and method of treating acid-base disorders |
| CN108751208B (zh) * | 2018-06-05 | 2020-06-30 | 山东师范大学 | 一种无表面活性剂微乳液制备的单分散二氧化硅纳米球及其制备方法 |
| EP4164659B1 (en) * | 2021-08-24 | 2024-03-27 | Waterstone Pharmaceuticals (Wuhan) Co., Ltd. | Polymers, compositions and methods for treating hyperuricemia |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE757856A (fr) * | 1969-10-27 | 1971-04-22 | Michelin & Cie | Perfectionnements aux polyurethanes vulcanisables au soufre |
| JPS6090243A (ja) | 1983-10-25 | 1985-05-21 | Nitto Boseki Co Ltd | 小球状モノアリルアミン橋かけ重合体の製造方法 |
| JP2862933B2 (ja) * | 1990-02-06 | 1999-03-03 | 東芝シリコーン株式会社 | Ｎ―アルケニル―ｎ―グリシジル（メタ）アクリルアミド化合物の製造方法 |
| JP2967952B2 (ja) * | 1991-07-23 | 1999-10-25 | 日本化薬株式会社 | 多孔性ポリマーの製造方法 |
| US5667775A (en) | 1993-08-11 | 1997-09-16 | Geltex Pharmaceuticals, Inc. | Phosphate-binding polymers for oral administration |
| US5496545A (en) | 1993-08-11 | 1996-03-05 | Geltex Pharmaceuticals, Inc. | Phosphate-binding polymers for oral administration |
| US5414068A (en) * | 1994-01-24 | 1995-05-09 | Rohm And Haas Company | Crosslinked anion exchange particles and method for producing the particles |
| TW474813B (en) | 1994-06-10 | 2002-02-01 | Geltex Pharma Inc | Alkylated composition for removing bile salts from a patient |
| JP3952223B2 (ja) * | 1997-05-28 | 2007-08-01 | 日東紡績株式会社 | アリルアミン重合体 |
| TW568788B (en) * | 1998-10-12 | 2004-01-01 | Chugai Pharmaceutical Co Ltd | Polymer combining with phosphoric acid and preparation containing the same |
| JP3363143B2 (ja) * | 1998-10-12 | 2003-01-08 | 中外製薬株式会社 | リン酸結合性ポリマー粒子 |
| US6362266B1 (en) | 1999-09-03 | 2002-03-26 | The Dow Chemical Company | Process for reducing cohesiveness of polyallylamine polymer gels during drying |
| US6733780B1 (en) | 1999-10-19 | 2004-05-11 | Genzyme Corporation | Direct compression polymer tablet core |
| GB2374072B (en) * | 2000-06-16 | 2004-09-22 | Nippon Catalytic Chem Ind | Crosslinked polymer method for manufacturing it and use thereof |
| BR0209020A (pt) | 2001-04-18 | 2004-08-10 | Genzyme Corp | Composição farmacêutica de polialilamina |
| US7459502B2 (en) * | 2003-11-03 | 2008-12-02 | Ilypsa, Inc. | Pharmaceutical compositions comprising crosslinked polyamine polymers |
| US7985418B2 (en) | 2004-11-01 | 2011-07-26 | Genzyme Corporation | Aliphatic amine polymer salts for tableting |
| JP5595660B2 (ja) | 2005-09-15 | 2014-09-24 | ジェンザイム コーポレーション | アミンポリマー用サシェ製剤 |
-
2007
- 2007-07-17 EP EP07112604A patent/EP2016947A1/en not_active Withdrawn
-
2008
- 2008-07-16 WO PCT/EP2008/059303 patent/WO2009010531A1/en not_active Ceased
- 2008-07-16 DK DK08775124.4T patent/DK2175866T3/da active
- 2008-07-16 KR KR1020107001256A patent/KR20100051616A/ko not_active Ceased
- 2008-07-16 CN CN2008800248423A patent/CN101743012B/zh not_active Expired - Fee Related
- 2008-07-16 US US12/668,758 patent/US8394416B2/en not_active Expired - Fee Related
- 2008-07-16 HR HR20110181T patent/HRP20110181T1/hr unknown
- 2008-07-16 SI SI200830184T patent/SI2175866T1/sl unknown
- 2008-07-16 EP EP08775124A patent/EP2175866B1/en not_active Not-in-force
- 2008-07-16 BR BRPI0813829-0A2A patent/BRPI0813829A2/pt not_active IP Right Cessation
- 2008-07-16 DE DE602008004259T patent/DE602008004259D1/de active Active
- 2008-07-16 JP JP2010516501A patent/JP2010533758A/ja active Pending
- 2008-07-16 ES ES08775124T patent/ES2358381T3/es active Active
- 2008-07-16 PL PL08775124T patent/PL2175866T3/pl unknown
- 2008-07-16 PT PT08775124T patent/PT2175866E/pt unknown
- 2008-07-16 AT AT08775124T patent/ATE493136T1/de active
- 2008-07-16 CA CA2697130A patent/CA2697130A1/en not_active Abandoned
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101853260B1 (ko) * | 2016-11-29 | 2018-06-14 | 주식회사 퍼슨 | 세벨라머 카보네이트의 제조방법 |
Also Published As
| Publication number | Publication date |
|---|---|
| US8394416B2 (en) | 2013-03-12 |
| SI2175866T1 (sl) | 2011-04-29 |
| ES2358381T3 (es) | 2011-05-10 |
| CN101743012A (zh) | 2010-06-16 |
| PT2175866E (pt) | 2011-04-01 |
| CN101743012B (zh) | 2012-07-04 |
| HRP20110181T1 (hr) | 2011-04-30 |
| EP2175866B1 (en) | 2010-12-29 |
| PL2175866T3 (pl) | 2011-05-31 |
| DK2175866T3 (da) | 2011-04-04 |
| EP2016947A1 (en) | 2009-01-21 |
| BRPI0813829A2 (pt) | 2015-01-06 |
| US20100183732A1 (en) | 2010-07-22 |
| WO2009010531A1 (en) | 2009-01-22 |
| EP2175866A1 (en) | 2010-04-21 |
| CA2697130A1 (en) | 2009-01-22 |
| HK1140945A1 (en) | 2010-10-29 |
| DE602008004259D1 (de) | 2011-02-10 |
| JP2010533758A (ja) | 2010-10-28 |
| ATE493136T1 (de) | 2011-01-15 |
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