ES2358381T3 - Nuevo procedimiento de una etapa para la preparación de polímeros de poli(alilamina) reticulados. - Google Patents
Nuevo procedimiento de una etapa para la preparación de polímeros de poli(alilamina) reticulados. Download PDFInfo
- Publication number
- ES2358381T3 ES2358381T3 ES08775124T ES08775124T ES2358381T3 ES 2358381 T3 ES2358381 T3 ES 2358381T3 ES 08775124 T ES08775124 T ES 08775124T ES 08775124 T ES08775124 T ES 08775124T ES 2358381 T3 ES2358381 T3 ES 2358381T3
- Authority
- ES
- Spain
- Prior art keywords
- salt
- formula
- allylamine
- polymers
- crosslinked polymer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 title claims abstract description 98
- 229920000642 polymer Polymers 0.000 title claims abstract description 53
- 238000002360 preparation method Methods 0.000 title claims description 16
- 150000003839 salts Chemical class 0.000 claims abstract description 67
- 230000008569 process Effects 0.000 claims abstract description 59
- 150000001875 compounds Chemical class 0.000 claims abstract description 41
- 229920000083 poly(allylamine) Polymers 0.000 claims abstract description 36
- 239000003431 cross linking reagent Substances 0.000 claims abstract description 17
- 238000004519 manufacturing process Methods 0.000 claims abstract description 15
- -1 poly(allylamine) Polymers 0.000 claims abstract description 15
- 239000003814 drug Substances 0.000 claims abstract description 13
- VVJKKWFAADXIJK-UHFFFAOYSA-N Allylamine Chemical compound NCC=C VVJKKWFAADXIJK-UHFFFAOYSA-N 0.000 claims description 54
- 229920006037 cross link polymer Polymers 0.000 claims description 42
- 239000002245 particle Substances 0.000 claims description 38
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 38
- 239000002904 solvent Substances 0.000 claims description 32
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims description 27
- 229910019142 PO4 Inorganic materials 0.000 claims description 27
- 239000000203 mixture Substances 0.000 claims description 27
- 239000010452 phosphate Substances 0.000 claims description 27
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 26
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 24
- 239000004094 surface-active agent Substances 0.000 claims description 23
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 20
- 239000002253 acid Substances 0.000 claims description 16
- 239000003999 initiator Substances 0.000 claims description 15
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- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 12
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims description 12
- 102000006335 Phosphate-Binding Proteins Human genes 0.000 claims description 10
- 108010058514 Phosphate-Binding Proteins Proteins 0.000 claims description 10
- 150000005323 carbonate salts Chemical class 0.000 claims description 10
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 10
- 235000017550 sodium carbonate Nutrition 0.000 claims description 10
- 208000010444 Acidosis Diseases 0.000 claims description 9
- 206010027417 Metabolic acidosis Diseases 0.000 claims description 9
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 9
- VTAKZNRDSPNOAU-UHFFFAOYSA-M 2-(chloromethyl)oxirane;hydron;prop-2-en-1-amine;n-prop-2-enyldecan-1-amine;trimethyl-[6-(prop-2-enylamino)hexyl]azanium;dichloride Chemical compound Cl.[Cl-].NCC=C.ClCC1CO1.CCCCCCCCCCNCC=C.C[N+](C)(C)CCCCCCNCC=C VTAKZNRDSPNOAU-UHFFFAOYSA-M 0.000 claims description 8
- 229920002905 Colesevelam Polymers 0.000 claims description 8
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- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 7
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 7
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- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims description 5
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims description 5
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims description 5
- 108010007979 Glycocholic Acid Proteins 0.000 claims description 5
- 229910002651 NO3 Inorganic materials 0.000 claims description 5
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 claims description 5
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 5
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- RFDAIACWWDREDC-FRVQLJSFSA-N glycocholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(=O)NCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 RFDAIACWWDREDC-FRVQLJSFSA-N 0.000 claims description 5
- QAOWNCQODCNURD-UHFFFAOYSA-M hydrogensulfate Chemical compound OS([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-M 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 claims description 5
- JRKICGRDRMAZLK-UHFFFAOYSA-L peroxydisulfate Chemical compound [O-]S(=O)(=O)OOS([O-])(=O)=O JRKICGRDRMAZLK-UHFFFAOYSA-L 0.000 claims description 5
- OJMIONKXNSYLSR-UHFFFAOYSA-N phosphorous acid Chemical compound OP(O)O OJMIONKXNSYLSR-UHFFFAOYSA-N 0.000 claims description 5
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 claims description 5
- LSNNMFCWUKXFEE-UHFFFAOYSA-L sulfite Chemical compound [O-]S([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-L 0.000 claims description 5
- 229940095064 tartrate Drugs 0.000 claims description 5
- 229960001152 colesevelam Drugs 0.000 claims description 4
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 4
- 239000011541 reaction mixture Substances 0.000 claims description 4
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims description 3
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 3
- 150000001449 anionic compounds Chemical class 0.000 claims description 3
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 3
- 229910052794 bromium Inorganic materials 0.000 claims description 3
- 229910052801 chlorine Inorganic materials 0.000 claims description 3
- 125000001309 chloro group Chemical group Cl* 0.000 claims description 3
- 239000011630 iodine Chemical group 0.000 claims description 3
- 229910052740 iodine Inorganic materials 0.000 claims description 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 3
- 125000001624 naphthyl group Chemical group 0.000 claims description 3
- 150000002891 organic anions Chemical class 0.000 claims description 3
- 150000001451 organic peroxides Chemical class 0.000 claims description 3
- 125000001037 p-tolyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 claims description 3
- 239000011736 potassium bicarbonate Substances 0.000 claims description 3
- 235000015497 potassium bicarbonate Nutrition 0.000 claims description 3
- 229910000028 potassium bicarbonate Inorganic materials 0.000 claims description 3
- 235000015320 potassium carbonate Nutrition 0.000 claims description 3
- 229910000027 potassium carbonate Inorganic materials 0.000 claims description 3
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 claims description 3
- 235000011118 potassium hydroxide Nutrition 0.000 claims description 3
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 3
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 3
- 238000003786 synthesis reaction Methods 0.000 claims description 3
- ZNSIZMQNQCNRBW-UHFFFAOYSA-N sevelamer Chemical group NCC=C.ClCC1CO1 ZNSIZMQNQCNRBW-UHFFFAOYSA-N 0.000 claims description 2
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- WBWWGRHZICKQGZ-HZAMXZRMSA-M taurocholate Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(=O)NCCS([O-])(=O)=O)C)[C@@]2(C)[C@@H](O)C1 WBWWGRHZICKQGZ-HZAMXZRMSA-M 0.000 claims 2
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- 239000000758 substrate Substances 0.000 abstract description 4
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- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 13
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- PADGNZFOVSZIKZ-UHFFFAOYSA-N 2-(chloromethyl)oxirane;hydrogen carbonate;prop-2-enylazanium Chemical compound NCC=C.OC(O)=O.ClCC1CO1 PADGNZFOVSZIKZ-UHFFFAOYSA-N 0.000 description 8
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- LBSPZZSGTIBOFG-UHFFFAOYSA-N bis[2-(4,5-dihydro-1h-imidazol-2-yl)propan-2-yl]diazene;dihydrochloride Chemical compound Cl.Cl.N=1CCNC=1C(C)(C)N=NC(C)(C)C1=NCCN1 LBSPZZSGTIBOFG-UHFFFAOYSA-N 0.000 description 7
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- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F226/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen
- C08F226/02—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen by a single or double bond to nitrogen
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F226/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen
- C08F226/02—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen by a single or double bond to nitrogen
- C08F226/04—Diallylamine
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Obesity (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Polymers & Plastics (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polymerisation Methods In General (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07112604A EP2016947A1 (en) | 2007-07-17 | 2007-07-17 | Novel one step process for preparing cross-linked poly(allylamine) polymers |
| EP07112604 | 2007-07-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2358381T3 true ES2358381T3 (es) | 2011-05-10 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES08775124T Active ES2358381T3 (es) | 2007-07-17 | 2008-07-16 | Nuevo procedimiento de una etapa para la preparación de polímeros de poli(alilamina) reticulados. |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8394416B2 (enExample) |
| EP (2) | EP2016947A1 (enExample) |
| JP (1) | JP2010533758A (enExample) |
| KR (1) | KR20100051616A (enExample) |
| CN (1) | CN101743012B (enExample) |
| AT (1) | ATE493136T1 (enExample) |
| BR (1) | BRPI0813829A2 (enExample) |
| CA (1) | CA2697130A1 (enExample) |
| DE (1) | DE602008004259D1 (enExample) |
| DK (1) | DK2175866T3 (enExample) |
| ES (1) | ES2358381T3 (enExample) |
| HR (1) | HRP20110181T1 (enExample) |
| PL (1) | PL2175866T3 (enExample) |
| PT (1) | PT2175866E (enExample) |
| SI (1) | SI2175866T1 (enExample) |
| WO (1) | WO2009010531A1 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8404784B2 (en) * | 2008-12-03 | 2013-03-26 | Navinta Llc | Manufacturing process of making polymeric amine salts |
| EP2443157A1 (en) * | 2009-06-16 | 2012-04-25 | Watson Pharma Private Limited | Processes for the preparation of sevelamer carbonate |
| IT1404163B1 (it) * | 2011-02-01 | 2013-11-15 | Chemi Spa | Processo per la preparazione di poliallilamine reticolate o loro sali farmaceuticamente accettabili |
| CN102796262B (zh) * | 2011-05-24 | 2014-11-12 | 北大方正集团有限公司 | 一种碳酸司维拉姆的制备方法 |
| CN102796259B (zh) * | 2011-05-24 | 2014-11-12 | 北大方正集团有限公司 | 碳酸司维拉姆的制备方法 |
| CN103012789B (zh) * | 2011-09-23 | 2015-02-25 | 北大方正集团有限公司 | 烟酸司维拉姆的制备方法 |
| CN102675510B (zh) * | 2012-05-28 | 2014-04-02 | 诚达药业股份有限公司 | 司维拉姆的合成工艺 |
| CN102942646B (zh) * | 2012-10-26 | 2016-06-29 | 青岛正大海尔制药有限公司 | 一种高分子聚合物的合成与分离纯化方法 |
| ES2733493T3 (es) | 2013-06-05 | 2019-11-29 | Tricida Inc | Polímeros de unión a protones para la administración oral |
| CN104448139B (zh) * | 2014-11-21 | 2016-08-17 | 新发药业有限公司 | 一种盐酸考来维仑的制备方法 |
| IL322207A (en) | 2014-12-10 | 2025-09-01 | Tricida Inc | Proton-binding polymers for oral administration |
| MA41202A (fr) * | 2014-12-18 | 2017-10-24 | Genzyme Corp | Copolymères polydiallymine réticulé pour le traitement du diabète de type 2 |
| MA44875A (fr) | 2016-05-06 | 2019-03-13 | Tricida Inc | Compositions pour le traitement de troubles acido-basiques |
| CN106008813B (zh) * | 2016-06-15 | 2017-11-14 | 新发药业有限公司 | 溶液聚合制备盐酸考来维仑的方法 |
| KR101853260B1 (ko) * | 2016-11-29 | 2018-06-14 | 주식회사 퍼슨 | 세벨라머 카보네이트의 제조방법 |
| WO2018124264A1 (ja) | 2016-12-28 | 2018-07-05 | 富士フイルム株式会社 | 窒素原子含有ポリマー又はその塩の乳化液、その製造方法、及び粒子の製造方法 |
| CN110831984B (zh) * | 2017-07-05 | 2023-06-06 | 日东纺绩株式会社 | 高纯度烯丙胺（共）聚合物及其制造方法 |
| US10934380B1 (en) | 2017-09-25 | 2021-03-02 | Tricida, Inc. | Crosslinked poly(allylamine) polymer pharmaceutical compositions |
| JP6992084B2 (ja) | 2017-10-16 | 2022-01-13 | 富士フイルム株式会社 | 高リン血症治療剤 |
| WO2019090176A1 (en) * | 2017-11-03 | 2019-05-09 | Tricida, Inc. | Compositions for and method of treating acid-base disorders |
| CN108751208B (zh) * | 2018-06-05 | 2020-06-30 | 山东师范大学 | 一种无表面活性剂微乳液制备的单分散二氧化硅纳米球及其制备方法 |
| ES2980624T3 (es) * | 2021-08-24 | 2024-10-02 | Waterstone Pharmaceuticals Wuhan Co Ltd | Polímeros, composiciones y métodos para tratar hiperuricemia |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE757856A (fr) * | 1969-10-27 | 1971-04-22 | Michelin & Cie | Perfectionnements aux polyurethanes vulcanisables au soufre |
| JPS6090243A (ja) | 1983-10-25 | 1985-05-21 | Nitto Boseki Co Ltd | 小球状モノアリルアミン橋かけ重合体の製造方法 |
| JP2862933B2 (ja) * | 1990-02-06 | 1999-03-03 | 東芝シリコーン株式会社 | Ｎ―アルケニル―ｎ―グリシジル（メタ）アクリルアミド化合物の製造方法 |
| JP2967952B2 (ja) * | 1991-07-23 | 1999-10-25 | 日本化薬株式会社 | 多孔性ポリマーの製造方法 |
| US5496545A (en) * | 1993-08-11 | 1996-03-05 | Geltex Pharmaceuticals, Inc. | Phosphate-binding polymers for oral administration |
| US5667775A (en) | 1993-08-11 | 1997-09-16 | Geltex Pharmaceuticals, Inc. | Phosphate-binding polymers for oral administration |
| US5414068A (en) * | 1994-01-24 | 1995-05-09 | Rohm And Haas Company | Crosslinked anion exchange particles and method for producing the particles |
| TW474813B (en) | 1994-06-10 | 2002-02-01 | Geltex Pharma Inc | Alkylated composition for removing bile salts from a patient |
| JP3952223B2 (ja) * | 1997-05-28 | 2007-08-01 | 日東紡績株式会社 | アリルアミン重合体 |
| JP3363143B2 (ja) * | 1998-10-12 | 2003-01-08 | 中外製薬株式会社 | リン酸結合性ポリマー粒子 |
| TW568788B (en) * | 1998-10-12 | 2004-01-01 | Chugai Pharmaceutical Co Ltd | Polymer combining with phosphoric acid and preparation containing the same |
| US6362266B1 (en) | 1999-09-03 | 2002-03-26 | The Dow Chemical Company | Process for reducing cohesiveness of polyallylamine polymer gels during drying |
| US6733780B1 (en) | 1999-10-19 | 2004-05-11 | Genzyme Corporation | Direct compression polymer tablet core |
| MY133977A (en) * | 2000-06-16 | 2007-11-30 | Nippon Catalytic Chem Ind | Crosslinked polymers containing tertiary amine and/or quaternary ammonium salt structures, processes for making and uses thereof |
| BR0209020A (pt) | 2001-04-18 | 2004-08-10 | Genzyme Corp | Composição farmacêutica de polialilamina |
| US7459502B2 (en) * | 2003-11-03 | 2008-12-02 | Ilypsa, Inc. | Pharmaceutical compositions comprising crosslinked polyamine polymers |
| US7985418B2 (en) | 2004-11-01 | 2011-07-26 | Genzyme Corporation | Aliphatic amine polymer salts for tableting |
| KR101547925B1 (ko) | 2005-09-15 | 2015-08-27 | 젠자임 코포레이션 | 아민 중합체에 대한 샤셋 제형 |
-
2007
- 2007-07-17 EP EP07112604A patent/EP2016947A1/en not_active Withdrawn
-
2008
- 2008-07-16 PT PT08775124T patent/PT2175866E/pt unknown
- 2008-07-16 US US12/668,758 patent/US8394416B2/en not_active Expired - Fee Related
- 2008-07-16 EP EP08775124A patent/EP2175866B1/en not_active Not-in-force
- 2008-07-16 ES ES08775124T patent/ES2358381T3/es active Active
- 2008-07-16 CN CN2008800248423A patent/CN101743012B/zh not_active Expired - Fee Related
- 2008-07-16 HR HR20110181T patent/HRP20110181T1/hr unknown
- 2008-07-16 JP JP2010516501A patent/JP2010533758A/ja active Pending
- 2008-07-16 SI SI200830184T patent/SI2175866T1/sl unknown
- 2008-07-16 KR KR1020107001256A patent/KR20100051616A/ko not_active Ceased
- 2008-07-16 AT AT08775124T patent/ATE493136T1/de active
- 2008-07-16 BR BRPI0813829-0A2A patent/BRPI0813829A2/pt not_active IP Right Cessation
- 2008-07-16 CA CA2697130A patent/CA2697130A1/en not_active Abandoned
- 2008-07-16 DK DK08775124.4T patent/DK2175866T3/da active
- 2008-07-16 DE DE602008004259T patent/DE602008004259D1/de active Active
- 2008-07-16 WO PCT/EP2008/059303 patent/WO2009010531A1/en not_active Ceased
- 2008-07-16 PL PL08775124T patent/PL2175866T3/pl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN101743012B (zh) | 2012-07-04 |
| DK2175866T3 (da) | 2011-04-04 |
| JP2010533758A (ja) | 2010-10-28 |
| EP2175866A1 (en) | 2010-04-21 |
| HK1140945A1 (en) | 2010-10-29 |
| DE602008004259D1 (de) | 2011-02-10 |
| CA2697130A1 (en) | 2009-01-22 |
| WO2009010531A1 (en) | 2009-01-22 |
| HRP20110181T1 (hr) | 2011-04-30 |
| SI2175866T1 (sl) | 2011-04-29 |
| BRPI0813829A2 (pt) | 2015-01-06 |
| CN101743012A (zh) | 2010-06-16 |
| PT2175866E (pt) | 2011-04-01 |
| KR20100051616A (ko) | 2010-05-17 |
| US8394416B2 (en) | 2013-03-12 |
| EP2016947A1 (en) | 2009-01-21 |
| US20100183732A1 (en) | 2010-07-22 |
| PL2175866T3 (pl) | 2011-05-31 |
| ATE493136T1 (de) | 2011-01-15 |
| EP2175866B1 (en) | 2010-12-29 |
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