JP2010526541A5 - - Google Patents
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- JP2010526541A5 JP2010526541A5 JP2010507728A JP2010507728A JP2010526541A5 JP 2010526541 A5 JP2010526541 A5 JP 2010526541A5 JP 2010507728 A JP2010507728 A JP 2010507728A JP 2010507728 A JP2010507728 A JP 2010507728A JP 2010526541 A5 JP2010526541 A5 JP 2010526541A5
- Authority
- JP
- Japan
- Prior art keywords
- oligonucleotide decoy
- transcription factor
- sequence
- composition
- factor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 108091034117 Oligonucleotide Proteins 0.000 claims description 54
- 102000040945 Transcription factor Human genes 0.000 claims description 40
- 108091023040 Transcription factor Proteins 0.000 claims description 40
- 210000004027 cell Anatomy 0.000 claims description 12
- 102100023226 Early growth response protein 1 Human genes 0.000 claims description 10
- 101001049697 Homo sapiens Early growth response protein 1 Proteins 0.000 claims description 10
- 208000002193 Pain Diseases 0.000 claims description 10
- 102100034808 CCAAT/enhancer-binding protein alpha Human genes 0.000 claims description 8
- 102100027313 Calsenilin Human genes 0.000 claims description 8
- 102000005636 Cyclic AMP Response Element-Binding Protein Human genes 0.000 claims description 8
- 108010045171 Cyclic AMP Response Element-Binding Protein Proteins 0.000 claims description 8
- 102100032057 ETS domain-containing protein Elk-1 Human genes 0.000 claims description 8
- 102100035075 ETS-related transcription factor Elf-1 Human genes 0.000 claims description 8
- 101000914063 Eucalyptus globulus Leafy/floricaula homolog FL1 Proteins 0.000 claims description 8
- 108091010837 Glial cell line-derived neurotrophic factor Proteins 0.000 claims description 8
- 102100022057 Hepatocyte nuclear factor 1-alpha Human genes 0.000 claims description 8
- 101000945515 Homo sapiens CCAAT/enhancer-binding protein alpha Proteins 0.000 claims description 8
- 101000726098 Homo sapiens Calsenilin Proteins 0.000 claims description 8
- 101000877395 Homo sapiens ETS-related transcription factor Elf-1 Proteins 0.000 claims description 8
- 101001045751 Homo sapiens Hepatocyte nuclear factor 1-alpha Proteins 0.000 claims description 8
- 101001139134 Homo sapiens Krueppel-like factor 4 Proteins 0.000 claims description 8
- 101001139117 Homo sapiens Krueppel-like factor 7 Proteins 0.000 claims description 8
- 101100456626 Homo sapiens MEF2A gene Proteins 0.000 claims description 8
- 101001094741 Homo sapiens POU domain, class 4, transcription factor 1 Proteins 0.000 claims description 8
- 101001094700 Homo sapiens POU domain, class 5, transcription factor 1 Proteins 0.000 claims description 8
- 101001096159 Homo sapiens Pituitary-specific positive transcription factor 1 Proteins 0.000 claims description 8
- 101000881764 Homo sapiens Transcription elongation factor 1 homolog Proteins 0.000 claims description 8
- 101000653735 Homo sapiens Transcriptional enhancer factor TEF-1 Proteins 0.000 claims description 8
- 101000744900 Homo sapiens Zinc finger homeobox protein 3 Proteins 0.000 claims description 8
- 102000043138 IRF family Human genes 0.000 claims description 8
- 108091054729 IRF family Proteins 0.000 claims description 8
- 102100020677 Krueppel-like factor 4 Human genes 0.000 claims description 8
- 102100020692 Krueppel-like factor 7 Human genes 0.000 claims description 8
- 101100079042 Mus musculus Myef2 gene Proteins 0.000 claims description 8
- 102100021148 Myocyte-specific enhancer factor 2A Human genes 0.000 claims description 8
- 102100035395 POU domain, class 4, transcription factor 1 Human genes 0.000 claims description 8
- 102100035423 POU domain, class 5, transcription factor 1 Human genes 0.000 claims description 8
- 102000003728 Peroxisome Proliferator-Activated Receptors Human genes 0.000 claims description 8
- 108090000029 Peroxisome Proliferator-Activated Receptors Proteins 0.000 claims description 8
- 102100037914 Pituitary-specific positive transcription factor 1 Human genes 0.000 claims description 8
- 101710163352 Potassium voltage-gated channel subfamily H member 4 Proteins 0.000 claims description 8
- 101710156592 Putative TATA-binding protein pB263R Proteins 0.000 claims description 8
- 108010042291 Serum Response Factor Proteins 0.000 claims description 8
- 102100022056 Serum response factor Human genes 0.000 claims description 8
- 101000805921 Strongylocentrotus purpuratus Upstream stimulatory factor Proteins 0.000 claims description 8
- 102100040296 TATA-box-binding protein Human genes 0.000 claims description 8
- 101710145783 TATA-box-binding protein Proteins 0.000 claims description 8
- 102100029898 Transcriptional enhancer factor TEF-1 Human genes 0.000 claims description 8
- 102100040105 Upstream stimulatory factor 1 Human genes 0.000 claims description 8
- 101000671634 Xenopus borealis Upstream stimulatory factor 1 Proteins 0.000 claims description 8
- 102100039966 Zinc finger homeobox protein 3 Human genes 0.000 claims description 8
- 210000002540 macrophage Anatomy 0.000 claims description 8
- 101150014102 mef-2 gene Proteins 0.000 claims description 8
- 102100031690 Erythroid transcription factor Human genes 0.000 claims description 6
- 101001066268 Homo sapiens Erythroid transcription factor Proteins 0.000 claims description 6
- 101000876829 Homo sapiens Protein C-ets-1 Proteins 0.000 claims description 6
- 101000617830 Homo sapiens Sterol O-acyltransferase 1 Proteins 0.000 claims description 6
- 102100035251 Protein C-ets-1 Human genes 0.000 claims description 6
- 102100021993 Sterol O-acyltransferase 1 Human genes 0.000 claims description 6
- 101000697584 Streptomyces lavendulae Streptothricin acetyltransferase Proteins 0.000 claims description 6
- 230000008055 nociceptive signaling Effects 0.000 claims description 5
- 108090000623 proteins and genes Proteins 0.000 claims description 5
- -1 IKZF Proteins 0.000 claims description 4
- 210000002569 neuron Anatomy 0.000 claims description 4
- 230000035897 transcription Effects 0.000 claims description 3
- 238000013518 transcription Methods 0.000 claims description 3
- 102000005869 Activating Transcription Factors Human genes 0.000 claims description 2
- 102000004219 Brain-derived neurotrophic factor Human genes 0.000 claims description 2
- 108090000715 Brain-derived neurotrophic factor Proteins 0.000 claims description 2
- 208000000094 Chronic Pain Diseases 0.000 claims description 2
- 102100026865 Cyclin-dependent kinase 5 activator 1 Human genes 0.000 claims description 2
- 102100027346 GTP cyclohydrolase 1 Human genes 0.000 claims description 2
- 102000017679 HTR3A Human genes 0.000 claims description 2
- 101000761343 Homo sapiens 5-hydroxytryptamine receptor 3A Proteins 0.000 claims description 2
- 101000862581 Homo sapiens GTP cyclohydrolase 1 Proteins 0.000 claims description 2
- 101001032845 Homo sapiens Metabotropic glutamate receptor 5 Proteins 0.000 claims description 2
- 101001123678 Homo sapiens Phenylethanolamine N-methyltransferase Proteins 0.000 claims description 2
- 101000654386 Homo sapiens Sodium channel protein type 9 subunit alpha Proteins 0.000 claims description 2
- 102100038357 Metabotropic glutamate receptor 5 Human genes 0.000 claims description 2
- 108010008858 Nitric Oxide Synthase Type I Proteins 0.000 claims description 2
- 102000006538 Nitric Oxide Synthase Type I Human genes 0.000 claims description 2
- 102100024611 Phosphatidylethanolamine N-methyltransferase Human genes 0.000 claims description 2
- 208000004550 Postoperative Pain Diseases 0.000 claims description 2
- 102100031367 Sodium channel protein type 9 subunit alpha Human genes 0.000 claims description 2
- 230000001154 acute effect Effects 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 230000014509 gene expression Effects 0.000 claims description 2
- 108010064131 neuronal Cdk5 activator (p25-p35) Proteins 0.000 claims description 2
- 239000002773 nucleotide Substances 0.000 claims description 2
- 125000003729 nucleotide group Chemical group 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 15
- 238000000034 method Methods 0.000 description 16
- 238000007913 intrathecal administration Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 230000017854 proteolysis Effects 0.000 description 1
- 230000022532 regulation of transcription, DNA-dependent Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91758307P | 2007-05-11 | 2007-05-11 | |
| US60/917,583 | 2007-05-11 | ||
| PCT/US2008/063471 WO2008141308A2 (en) | 2007-05-11 | 2008-05-12 | Gene expression and pain |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014149516A Division JP5890869B2 (ja) | 2007-05-11 | 2014-07-23 | 遺伝子発現と疼痛 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010526541A JP2010526541A (ja) | 2010-08-05 |
| JP2010526541A5 true JP2010526541A5 (enExample) | 2012-04-05 |
| JP5646320B2 JP5646320B2 (ja) | 2014-12-24 |
Family
ID=40002879
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010507728A Expired - Fee Related JP5646320B2 (ja) | 2007-05-11 | 2008-05-12 | 遺伝子発現と疼痛 |
| JP2014149516A Expired - Fee Related JP5890869B2 (ja) | 2007-05-11 | 2014-07-23 | 遺伝子発現と疼痛 |
| JP2015207655A Expired - Fee Related JP6082796B2 (ja) | 2007-05-11 | 2015-10-22 | 遺伝子発現と疼痛 |
| JP2016064037A Expired - Fee Related JP6306075B2 (ja) | 2007-05-11 | 2016-03-28 | 遺伝子発現と疼痛 |
| JP2017106521A Pending JP2017148074A (ja) | 2007-05-11 | 2017-05-30 | 遺伝子発現と疼痛 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014149516A Expired - Fee Related JP5890869B2 (ja) | 2007-05-11 | 2014-07-23 | 遺伝子発現と疼痛 |
| JP2015207655A Expired - Fee Related JP6082796B2 (ja) | 2007-05-11 | 2015-10-22 | 遺伝子発現と疼痛 |
| JP2016064037A Expired - Fee Related JP6306075B2 (ja) | 2007-05-11 | 2016-03-28 | 遺伝子発現と疼痛 |
| JP2017106521A Pending JP2017148074A (ja) | 2007-05-11 | 2017-05-30 | 遺伝子発現と疼痛 |
Country Status (13)
| Country | Link |
|---|---|
| US (5) | US7943591B2 (enExample) |
| EP (3) | EP3199635B1 (enExample) |
| JP (5) | JP5646320B2 (enExample) |
| AU (1) | AU2008251320B2 (enExample) |
| CA (1) | CA2723672C (enExample) |
| DK (1) | DK2158316T3 (enExample) |
| ES (2) | ES2542511T3 (enExample) |
| HR (1) | HRP20150759T1 (enExample) |
| HU (1) | HUE025701T2 (enExample) |
| PL (1) | PL2158316T3 (enExample) |
| PT (1) | PT2158316E (enExample) |
| SI (1) | SI2158316T1 (enExample) |
| WO (1) | WO2008141308A2 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3199635B1 (en) * | 2007-05-11 | 2019-02-06 | Adynxx, Inc. | Gene expression and pain |
| SG171914A1 (en) | 2008-12-02 | 2011-07-28 | Chiralgen Ltd | Method for the synthesis of phosphorus atom modified nucleic acids |
| EP2451461A4 (en) | 2009-07-06 | 2013-05-29 | Ontorii Inc | NOVEL NUCLEIC ACID PRODRUGS AND METHOD OF USE THEREOF |
| US8609617B2 (en) | 2009-09-04 | 2013-12-17 | University Of Miami | KLF family members regulate intrinsic axon regeneration ability |
| DK2620428T3 (da) | 2010-09-24 | 2019-07-01 | Wave Life Sciences Ltd | Asymmetrisk hjælpegruppe |
| US9605019B2 (en) | 2011-07-19 | 2017-03-28 | Wave Life Sciences Ltd. | Methods for the synthesis of functionalized nucleic acids |
| CA2848740A1 (en) | 2011-09-16 | 2013-03-21 | Mingxing Wang | Amphiphilic cationic polymers for the delivery of therapeutic agents |
| US9139829B2 (en) * | 2012-02-28 | 2015-09-22 | Medical Diagnostic Laboratories, Llc | SiRNA targeting ETS1 and ELK1 and method of using same in the inhibition of CIP2A gene in cancer treatment |
| CN104487096B (zh) * | 2012-05-10 | 2020-09-15 | 埃迪恩克斯股份有限公司 | 用于活性成分递送的配制物 |
| DK2872485T3 (da) | 2012-07-13 | 2021-03-08 | Wave Life Sciences Ltd | Asymmetrisk hjælpegruppe |
| CN112007045B (zh) | 2012-07-13 | 2026-01-06 | 波涛生命科学有限公司 | 手性控制 |
| JP6246121B2 (ja) | 2012-07-13 | 2017-12-13 | 株式会社新日本科学 | キラル核酸アジュバント |
| GB201310853D0 (en) * | 2013-06-18 | 2013-07-31 | Ucb Pharma Sa | Method |
| WO2015108048A1 (ja) | 2014-01-15 | 2015-07-23 | 株式会社新日本科学 | 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤 |
| EP3095461A4 (en) | 2014-01-15 | 2017-08-23 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator |
| US10322173B2 (en) | 2014-01-15 | 2019-06-18 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent |
| KR102423317B1 (ko) | 2014-01-16 | 2022-07-22 | 웨이브 라이프 사이언시스 리미티드 | 키랄 디자인 |
| AU2015301491A1 (en) * | 2014-08-15 | 2017-02-02 | Adynxx, Inc. | Oligonucleotide decoys for the treatment of pain |
| ES2912176T3 (es) * | 2015-09-09 | 2022-05-24 | Anges Inc | Señuelo quimérico |
| US20200017853A1 (en) * | 2016-02-29 | 2020-01-16 | Adynxx, Inc. | Compositions and methods for pain amelioration via modification of gene expression |
| US20260078376A1 (en) * | 2022-08-26 | 2026-03-19 | Core Biotherapeutics, Inc. | Oligonucleotides for the treatment of breast cancer |
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