JP2004537260A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2004537260A5 JP2004537260A5 JP2002548129A JP2002548129A JP2004537260A5 JP 2004537260 A5 JP2004537260 A5 JP 2004537260A5 JP 2002548129 A JP2002548129 A JP 2002548129A JP 2002548129 A JP2002548129 A JP 2002548129A JP 2004537260 A5 JP2004537260 A5 JP 2004537260A5
- Authority
- JP
- Japan
- Prior art keywords
- zinc finger
- use according
- amino acids
- finger protein
- consecutive amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000000034 method Methods 0.000 claims 33
- 101710185494 Zinc finger protein Proteins 0.000 claims 19
- 102100023597 Zinc finger protein 816 Human genes 0.000 claims 19
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims 13
- 239000011701 zinc Substances 0.000 claims 13
- 229910052725 zinc Inorganic materials 0.000 claims 13
- 150000001413 amino acids Chemical class 0.000 claims 11
- 230000001105 regulatory effect Effects 0.000 claims 8
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 7
- 230000033115 angiogenesis Effects 0.000 claims 7
- 239000013604 expression vector Substances 0.000 claims 7
- 108020004707 nucleic acids Proteins 0.000 claims 6
- 102000039446 nucleic acids Human genes 0.000 claims 6
- 150000007523 nucleic acids Chemical class 0.000 claims 6
- 241001465754 Metazoa Species 0.000 claims 3
- 230000004913 activation Effects 0.000 claims 3
- 108020001507 fusion proteins Proteins 0.000 claims 3
- 102000037865 fusion proteins Human genes 0.000 claims 3
- 208000028867 ischemia Diseases 0.000 claims 3
- 206010052428 Wound Diseases 0.000 claims 2
- 208000027418 Wounds and injury Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 230000007998 vessel formation Effects 0.000 claims 2
- 108010068250 Herpes Simplex Virus Protein Vmw65 Proteins 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000018262 Peripheral vascular disease Diseases 0.000 claims 1
- 101800001065 Protein 2B Proteins 0.000 claims 1
- 210000004204 blood vessel Anatomy 0.000 claims 1
- 208000029078 coronary artery disease Diseases 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 230000006884 regulation of angiogenesis Effects 0.000 claims 1
- 230000001177 retroviral effect Effects 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 claims 1
- 230000035897 transcription Effects 0.000 claims 1
- 238000013518 transcription Methods 0.000 claims 1
- 239000013598 vector Substances 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
- 230000029663 wound healing Effects 0.000 claims 1
Images
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73360400A | 2000-12-07 | 2000-12-07 | |
| US73608300A | 2000-12-12 | 2000-12-12 | |
| US09/846,033 US7067317B2 (en) | 2000-12-07 | 2001-04-30 | Regulation of angiogenesis with zinc finger proteins |
| PCT/US2001/046861 WO2002046412A2 (en) | 2000-12-07 | 2001-12-06 | Regulation of angiogenesis with zinc finger proteins |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007321556A Division JP4931246B2 (ja) | 2000-12-07 | 2007-12-13 | ジンクフィンガータンパク質による血管新生の調節 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004537260A JP2004537260A (ja) | 2004-12-16 |
| JP2004537260A5 true JP2004537260A5 (enExample) | 2006-01-19 |
Family
ID=27419178
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002548129A Withdrawn JP2004537260A (ja) | 2000-12-07 | 2001-12-06 | ジンクフィンガータンパク質による血管新生の調節 |
Country Status (6)
| Country | Link |
|---|---|
| US (4) | US7026462B2 (enExample) |
| EP (1) | EP1341914A2 (enExample) |
| JP (1) | JP2004537260A (enExample) |
| AU (2) | AU2884102A (enExample) |
| CA (1) | CA2431308C (enExample) |
| WO (1) | WO2002046412A2 (enExample) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030104526A1 (en) | 1999-03-24 | 2003-06-05 | Qiang Liu | Position dependent recognition of GNN nucleotide triplets by zinc fingers |
| AUPQ439299A0 (en) * | 1999-12-01 | 1999-12-23 | Silverbrook Research Pty Ltd | Interface system |
| US20020061512A1 (en) * | 2000-02-18 | 2002-05-23 | Kim Jin-Soo | Zinc finger domains and methods of identifying same |
| WO2002046412A2 (en) | 2000-12-07 | 2002-06-13 | Sangamo Biosciences, Inc. | Regulation of angiogenesis with zinc finger proteins |
| CA2469477A1 (en) * | 2001-12-07 | 2003-06-12 | Toolgen, Inc. | Phenotypic screen of chimeric proteins |
| KR100766952B1 (ko) * | 2002-12-09 | 2007-10-17 | 주식회사 툴젠 | 조절성 징크 핑거 단백질 |
| ATE352346T1 (de) * | 2003-07-28 | 2007-02-15 | Medtronic Inc | Myokard-stimulation |
| US20050220821A1 (en) * | 2004-03-31 | 2005-10-06 | Allergan, Inc. | Pressure sore treatment |
| ATE418346T1 (de) * | 2004-04-08 | 2009-01-15 | Sangamo Biosciences Inc | Zusammensetzungen zur behandlung von neuropathischen und neurodegenerativen erkrankungen |
| AU2005233583B2 (en) * | 2004-04-08 | 2011-02-03 | Sangamo Therapeutics, Inc. | Methods and compositions for modulating cardiac contractility |
| US20060184198A1 (en) * | 2005-01-31 | 2006-08-17 | Kms Biopsy, Llc | End effector for surgical instrument, surgical instrument, and method for forming the end effector |
| CA2599004C (en) | 2005-02-28 | 2015-05-26 | Sangamo Biosciences, Inc. | Anti-angiogenic methods and compositions |
| WO2007106603A2 (en) * | 2006-01-06 | 2007-09-20 | The Scripps Research Institute | Specific labeling of proteins with zinc finger tags and use of zinc-finger-tagged proteins for analysis |
| KR100756055B1 (ko) * | 2006-01-27 | 2007-09-07 | 연세대학교 산학협력단 | 신생혈관 생성을 조절하는 재조합 아데노바이러스 |
| AU2007212260A1 (en) * | 2006-02-09 | 2007-08-16 | Sangamo Therapeutics, Inc. | Method for treating peripheral arterial disease with zinc finger proteins |
| GB0607063D0 (en) * | 2006-04-07 | 2006-05-17 | Cellcentric Ltd | Compositions and methods for epigenetic modification of nucleic acid sequences in vivo |
| TWI496579B (zh) * | 2011-07-12 | 2015-08-21 | Univ Nat Cheng Kung | 類鋅手指胜肽、其表現質體、及包含其之醫藥組成物之用途 |
| JP6023218B2 (ja) | 2012-01-27 | 2016-11-09 | サンバイオ，インコーポレイティド | 血管新生及び血管発生を調節するための方法及び組成物 |
| EP4148134A1 (en) | 2012-09-04 | 2023-03-15 | The Scripps Research Institute | Chimeric polypeptides having targeted binding specificity |
| MX2015010841A (es) | 2013-02-20 | 2016-05-09 | Regeneron Pharma | Modificacion genetica de ratas. |
| DK3456831T3 (da) | 2013-04-16 | 2021-09-06 | Regeneron Pharma | Målrettet modifikation af rottegenom |
| EP3460063B1 (en) | 2013-12-11 | 2024-03-13 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for the targeted modification of a genome |
| MX388127B (es) | 2013-12-11 | 2025-03-19 | Regeneron Pharma | Metodos y composiciones para la modificacion dirigida de un genoma. |
| DK3152312T3 (da) | 2014-06-06 | 2020-04-06 | Regeneron Pharma | Fremgangsmåder og sammensætninger til modifikation af et mållocus |
| US9738897B2 (en) | 2014-06-23 | 2017-08-22 | Regeneron Pharmaceuticals, Inc. | Nuclease-mediated DNA assembly |
| DK3161128T3 (en) | 2014-06-26 | 2018-11-05 | Regeneron Pharma | METHODS AND COMPOSITIONS FOR TARGETED GENTICAL MODIFICATIONS AND PROCEDURES FOR USE THEREOF |
| BR112017007770A2 (pt) | 2014-10-15 | 2018-01-16 | Regeneron Pharma | cultura in vitro, população de hipscs, método para modificar um locus-alvo genômico, e, hipsc. |
| MX388784B (es) | 2014-12-19 | 2025-03-20 | Regeneron Pharma | Métodos y composiciones para la modificación genética dirigida a través de direccionamiento múltiple de una sola etapa. |
| WO2017024343A1 (en) | 2015-08-07 | 2017-02-16 | Commonwealth Scientific And Industrial Research Organisation | Method for producing an animal comprising a germline genetic modification |
| CN108603188A (zh) | 2015-11-24 | 2018-09-28 | 联邦科学技术研究组织 | 在细胞培养物中产生病毒 |
| CA3005980A1 (en) | 2015-11-24 | 2017-06-01 | Commonwealth Scientific And Industrial Research Organisation | Production of viruses in avian eggs |
| CN109803530A (zh) | 2016-07-29 | 2019-05-24 | 瑞泽恩制药公司 | 包含引起c-截短的原纤维蛋白-1表达的突变的小鼠 |
| CN110214184B (zh) | 2016-12-01 | 2024-07-02 | 桑格摩生物治疗股份有限公司 | τ蛋白调节剂以及用于其递送的方法和组合物 |
| CA3049980A1 (en) | 2017-01-23 | 2018-07-26 | Regeneron Pharmaceuticals, Inc. | Hydroxysteroid 17-beta dehydrogenase 13 (hsd17b13) variants and uses thereof |
| US11913015B2 (en) | 2017-04-17 | 2024-02-27 | University Of Maryland, College Park | Embryonic cell cultures and methods of using the same |
| ES2875579T3 (es) | 2017-06-06 | 2021-11-10 | Zymergen Inc | Plataforma de ingeniería genómica de HTP para mejorar Escherichia coli |
| HUE073358T2 (hu) | 2017-08-29 | 2026-01-28 | Kws Saat Se & Co Kgaa | Továbbfejlesztett kék aleuron és egyéb szegregációs rendszerek |
| WO2019067875A1 (en) | 2017-09-29 | 2019-04-04 | Regeneron Pharmaceuticals, Inc. | NON-HUMAN ANIMALS COMPRISING A HUMANIZED TTR LOCUS AND METHODS OF USE |
| US12635675B2 (en) | 2018-03-20 | 2026-05-26 | Tsinghua University | Alzheimers disease animal model and use thereof |
| IL326834A (en) | 2018-10-02 | 2026-04-01 | Sangamo Therapeutics Inc | Artificial zinc finger protein transcription factors repressing mapt expression for the prevention and/or treatment of tauopathies |
| WO2020131632A1 (en) | 2018-12-20 | 2020-06-25 | Regeneron Pharmaceuticals, Inc. | Nuclease-mediated repeat expansion |
| EP3945800A1 (en) | 2019-04-03 | 2022-02-09 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for insertion of antibody coding sequences into a safe harbor locus |
| AU2020253531C1 (en) | 2019-04-04 | 2022-06-16 | Regeneron Pharmaceuticals, Inc. | Methods for scarless introduction of targeted modifications into targeting vectors |
| JP7506686B2 (ja) | 2019-04-04 | 2024-06-26 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ヒト化凝固因子１２遺伝子座を含む非ヒト動物 |
| WO2020247452A1 (en) | 2019-06-04 | 2020-12-10 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a humanized ttr locus with a beta-slip mutation and methods of use |
| CN113939595A (zh) | 2019-06-07 | 2022-01-14 | 瑞泽恩制药公司 | 包括人源化白蛋白基因座的非人动物 |
| KR20220024053A (ko) | 2019-06-14 | 2022-03-03 | 리제너론 파마슈티칼스 인코포레이티드 | 타우병증의 모델 |
| US12521451B2 (en) | 2019-11-08 | 2026-01-13 | Regeneron Pharmaceuticals, Inc. | CRISPR and AAV strategies for x-linked juvenile retinoschisis therapy |
| WO2021108363A1 (en) | 2019-11-25 | 2021-06-03 | Regeneron Pharmaceuticals, Inc. | Crispr/cas-mediated upregulation of humanized ttr allele |
| JP7837276B2 (ja) | 2020-03-04 | 2026-03-30 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 免疫療法に対する腫瘍細胞の感作のための方法及び組成物 |
| CA3214352A1 (en) | 2021-05-27 | 2022-12-01 | Bijan Nejadnik | Cell therapies and methods of treatment for small-volume stroke |
| WO2023055893A1 (en) * | 2021-09-30 | 2023-04-06 | Peter Biotherapeutics, Inc. | Gene regulation |
| KR20240128067A (ko) | 2021-12-29 | 2024-08-23 | 브리스톨-마이어스 스큅 컴퍼니 | 랜딩 패드 세포주의 생성 |
| AU2023269134A1 (en) | 2022-05-09 | 2024-12-12 | Regeneron Pharmaceuticals, Inc. | Vectors and methods for in vivo antibody production |
| CN120659627A (zh) | 2022-07-29 | 2025-09-16 | 瑞泽恩制药公司 | 用于转铁蛋白受体（tfr）介导的脑和肌肉递送的组合物和方法 |
| EP4565603A1 (en) | 2022-08-05 | 2025-06-11 | Regeneron Pharmaceuticals, Inc. | Aggregation-resistant variants of tdp-43 |
| AU2023379457A1 (en) | 2022-11-14 | 2025-05-15 | Regeneron Pharmaceuticals, Inc. | Compositions and methods for fibroblast growth factor receptor 3-mediated delivery to astrocytes |
| WO2024163615A1 (en) | 2023-02-02 | 2024-08-08 | University Of Florida Research Foundation, Incorporated | Brain-derived neurotrophic factor-nano luciferase transgenic rodents and methods of use thereof |
| WO2025235388A1 (en) | 2024-05-06 | 2025-11-13 | Regeneron Pharmaceuticals, Inc. | Transgene genomic identification by nuclease-mediated long read sequencing |
| WO2025258415A1 (en) | 2024-06-14 | 2025-12-18 | SanBio Co. Ltd. | Methods and compositions for treatment of neurodegenerative disorders and reducing tau protein aggregates |
| WO2026072529A1 (en) | 2024-09-24 | 2026-04-02 | University Of Florida Research Foundation, Incorporated | Mettl7a for improved embryo competence |
Family Cites Families (105)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4456550A (en) | 1982-11-22 | 1984-06-26 | President And Fellows Of Harvard College | Vascular permeability factor |
| DE3410650A1 (de) | 1984-03-23 | 1985-10-03 | Kernforschungsanlage Jülich GmbH, 5170 Jülich | Mit mikroorganismen bewachsene poroese anorganische traeger, verfahren zur immobilisierung von mikroorganismen und dafuer geeignete traegerkoerper |
| US5455170A (en) | 1986-08-22 | 1995-10-03 | Hoffmann-La Roche Inc. | Mutated thermostable nucleic acid polymerase enzyme from Thermus species Z05 |
| US5073492A (en) | 1987-01-09 | 1991-12-17 | The Johns Hopkins University | Synergistic composition for endothelial cell growth |
| US5317090A (en) | 1987-12-16 | 1994-05-31 | Institut Pasteur | Steroid/thyroid hormone receptor-related gene, which is inappropriately expressed in human hepatocellular carcinoma, and which is a retinoic acid receptor |
| US5324819A (en) | 1988-04-08 | 1994-06-28 | Stryker Corporation | Osteogenic proteins |
| US5340739A (en) | 1988-07-13 | 1994-08-23 | Brigham & Women's Hospital | Hematopoietic cell specific transcriptional regulatory elements of serglycin and uses thereof |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US5240848A (en) | 1988-11-21 | 1993-08-31 | Monsanto Company | Dna sequences encoding human vascular permeability factor having 189 amino acids |
| EP0451206A4 (en) | 1988-12-23 | 1992-07-22 | The Salk Institute For Biological Studies | Receptor transcription-repression activity compositions and methods |
| US5198346A (en) | 1989-01-06 | 1993-03-30 | Protein Engineering Corp. | Generation and selection of novel DNA-binding proteins and polypeptides |
| US5096815A (en) | 1989-01-06 | 1992-03-17 | Protein Engineering Corporation | Generation and selection of novel dna-binding proteins and polypeptides |
| US4990607A (en) | 1989-03-14 | 1991-02-05 | The Rockefeller University | Alteration of gene expression in plants |
| EP0463081B1 (en) | 1989-03-17 | 1998-05-20 | The Salk Institute For Biological Studies | Hormone response element compositions and assay |
| ES2103740T3 (es) | 1989-03-24 | 1997-10-01 | Univ California | Factor de crecimiento celular endotelialico, su aislamiento y su expresion. |
| US5332671A (en) | 1989-05-12 | 1994-07-26 | Genetech, Inc. | Production of vascular endothelial cell growth factor and DNA encoding same |
| US5194596A (en) | 1989-07-27 | 1993-03-16 | California Biotechnology Inc. | Production of vascular endothelial cell growth factor |
| US5219739A (en) | 1989-07-27 | 1993-06-15 | Scios Nova Inc. | DNA sequences encoding bVEGF120 and hVEGF121 and methods for the production of bovine and human vascular endothelial cell growth factors, bVEGF120 and hVEGF121 |
| JP3393867B2 (ja) | 1989-11-13 | 2003-04-07 | マサチユーセツツ・インステイテユート・オブ・テクノロジー | ウィルムス腫瘍遺伝子の位置決定と特徴付け |
| US5578482A (en) | 1990-05-25 | 1996-11-26 | Georgetown University | Ligand growth factors that bind to the erbB-2 receptor protein and induce cellular responses |
| US5219596A (en) | 1990-08-24 | 1993-06-15 | Cargill, Incorporated | Composition and method thereof for increasing milk production in dairy cattle |
| DE69132040T2 (de) | 1990-09-21 | 2000-11-02 | Merck & Co., Inc. | Wachstumsfaktor II für vaskuläre Endothelzellen |
| JPH06503642A (ja) | 1990-09-21 | 1994-04-21 | ザ ソーク インスティテュート フォア バイオロジカル スタディーズ | プロトオンコタンパク質ｃ−ＪＵＮとホルモン受容体との間の機能的拮抗作用 |
| US5348864A (en) | 1991-01-25 | 1994-09-20 | E. R. Squibb & Sons, Inc. | Mouse vav proto-oncogene DNA and protein sequences |
| DE69229454T2 (de) | 1991-03-28 | 2000-01-05 | Merck & Co., Inc. | Untereinheit-C des vaskulären endothelialen Zellwachstumsfaktors |
| US5871907A (en) | 1991-05-15 | 1999-02-16 | Medical Research Council | Methods for producing members of specific binding pairs |
| US5324818A (en) | 1991-08-21 | 1994-06-28 | The Regents Of The University Of Michigan | Proteins useful in the regulation of κB-containing genes |
| US5243041A (en) | 1991-08-22 | 1993-09-07 | Fernandez Pol Jose A | DNA vector with isolated CDNA gene encoding metallopanstimulin |
| US5302519A (en) | 1991-09-09 | 1994-04-12 | Fred Hutchinson Cancer Research Center | Method of producing a Mad polypeptide |
| US5270170A (en) | 1991-10-16 | 1993-12-14 | Affymax Technologies N.V. | Peptide library and screening method |
| US5792640A (en) | 1992-04-03 | 1998-08-11 | The Johns Hopkins University | General method to clone hybrid restriction endonucleases using lig gene |
| US5487994A (en) | 1992-04-03 | 1996-01-30 | The Johns Hopkins University | Insertion and deletion mutants of FokI restriction endonuclease |
| US5436150A (en) | 1992-04-03 | 1995-07-25 | The Johns Hopkins University | Functional domains in flavobacterium okeanokoities (foki) restriction endonuclease |
| US5356802A (en) | 1992-04-03 | 1994-10-18 | The Johns Hopkins University | Functional domains in flavobacterium okeanokoites (FokI) restriction endonuclease |
| US5916794A (en) | 1992-04-03 | 1999-06-29 | Johns Hopkins University | Methods for inactivating target DNA and for detecting conformational change in a nucleic acid |
| US5324638A (en) | 1992-05-13 | 1994-06-28 | Sloan-Kettering Institute For Cancer Research | Brain transcription factor, nucleic acids encoding same and uses thereof |
| US5776755A (en) | 1992-10-09 | 1998-07-07 | Helsinki University Licensing, Ltd. | FLT4, a receptor tyrosine kinase |
| WO1995003402A1 (en) * | 1993-07-22 | 1995-02-02 | Merck & Co., Inc. | EXPRESSION OF HUMAN INTERLEUKIN-1β IN A TRANSGENIC ANIMAL |
| JP4012243B2 (ja) | 1994-01-18 | 2007-11-21 | ザ スクリップス リサーチ インスティチュート | 亜鉛フィンガータンパク質誘導体およびそのための方法 |
| US6140466A (en) | 1994-01-18 | 2000-10-31 | The Scripps Research Institute | Zinc finger protein derivatives and methods therefor |
| US5932540A (en) | 1994-03-08 | 1999-08-03 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 |
| DK0751992T3 (da) | 1994-03-08 | 2006-03-06 | Human Genome Sciences Inc | Karendotelvækstfaktor 2 |
| US6608182B1 (en) | 1994-03-08 | 2003-08-19 | Human Genome Sciences, Inc. | Human vascular endothelial growth factor 2 |
| US6040157A (en) | 1994-03-08 | 2000-03-21 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 |
| WO1996006110A1 (en) | 1994-08-18 | 1996-02-29 | Gilman, Michael, Z. | Composite dna-binding proteins and materials and methods relating thereto |
| CA2196419C (en) | 1994-08-20 | 2007-08-21 | Yen Choo | Improvements in or relating to binding proteins for recognition of dna |
| GB9824544D0 (en) | 1998-11-09 | 1999-01-06 | Medical Res Council | Screening system |
| DE4435919C1 (de) | 1994-10-07 | 1995-12-07 | Deutsches Krebsforsch | Zinkfinger-DNA, -Protein und ihre Verwendung |
| US5814464A (en) | 1994-10-07 | 1998-09-29 | Regeneron Pharma | Nucleic acids encoding TIE-2 ligand-2 |
| US6130071A (en) | 1997-02-05 | 2000-10-10 | Helsinki University Licensing, Ltd. | Vascular endothelial growth factor C (VEGF-C) ΔCys156 protein and gene, and uses thereof |
| WO1998033917A1 (en) | 1994-11-14 | 1998-08-06 | The Ludwig Institute For Cancer Research | Vascular endothelial growth factor c (vegf-c) protein and gene, mutants thereof, and uses thereof |
| US6645933B1 (en) | 1995-08-01 | 2003-11-11 | Helsinki University Licensing Ltd. Oy | Receptor ligand VEGF-C |
| US5871902A (en) | 1994-12-09 | 1999-02-16 | The Gene Pool, Inc. | Sequence-specific detection of nucleic acid hybrids using a DNA-binding molecule or assembly capable of discriminating perfect hybrids from non-perfect hybrids |
| US5702914A (en) | 1994-12-21 | 1997-12-30 | The Salk Institute For Biological Studies | Use of reporter genes for retinoid receptor screening assays having novel retinoid-associated response elements |
| ATE544776T1 (de) | 1994-12-29 | 2012-02-15 | Massachusetts Inst Technology | Chimäre dna-bindeproteine |
| US5789538A (en) | 1995-02-03 | 1998-08-04 | Massachusetts Institute Of Technology | Zinc finger proteins with high affinity new DNA binding specificities |
| US5928939A (en) | 1995-03-01 | 1999-07-27 | Ludwig Institute For Cancer Research | Vascular endothelial growth factor-b and dna coding therefor |
| US5607918A (en) | 1995-03-01 | 1997-03-04 | Ludwig Institute For Cancer Research | Vascular endothelial growth factor-B and DNA coding therefor |
| WO1996027007A1 (en) | 1995-03-02 | 1996-09-06 | Amrad Operations Pty. Ltd. | A novel growth factor and a genetic sequence encoding same |
| AU5445296A (en) | 1995-04-12 | 1996-10-30 | Cheng Cheng | Methods for preparing dna-binding proteins |
| US20020026037A1 (en) | 1995-06-06 | 2002-02-28 | Jing-Shan Hu | Vascular endothelial growth factor 3 antibodies |
| PT848755E (pt) | 1995-09-08 | 2003-12-31 | Genentech Inc | Proteina relacionada com o vegf |
| WO1997017442A1 (en) | 1995-11-08 | 1997-05-15 | Immunex Corporation | Flk-1 binding protein |
| EP0877752B1 (en) | 1996-01-23 | 2003-05-21 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for screening for transdominant effector peptides and rna molecules |
| DE69733204T3 (de) | 1996-07-15 | 2012-03-08 | Chugai Seiyaku K.K. | Neuartige vegf-ähnliche faktoren |
| EP0956339B1 (en) | 1996-08-23 | 2005-10-12 | Ludwig Institute For Cancer Research | Recombinant vascular endothelial cell growth factor d (vegf-d) |
| FR2752734B1 (fr) | 1996-09-02 | 1998-11-06 | Cird Galderma | Utilisation de retinoides pour la preparation d'un medicament destine a traiter les affections liees a une surexpression de vegf |
| AU4107397A (en) | 1996-09-05 | 1998-03-26 | David Goltzman | Cloning of full-length human pex cdna |
| US6013780A (en) | 1996-09-06 | 2000-01-11 | Technion Research & Development Co. Ltd. | VEGF145 expression vectors |
| US5939538A (en) | 1996-10-25 | 1999-08-17 | Immusol Incorporated | Methods and compositions for inhibiting HIV infection of cells by cleaving HIV co-receptor RNA |
| AU5439998A (en) | 1996-12-06 | 1998-06-29 | Zymogenetics Inc. | Vascular endothelial growth factor |
| NZ500530A (en) | 1997-04-25 | 2001-12-21 | Collateral Therapeutics | Truncated VEGF-B, VEGF-C, VEGF-3, PlGF, VRF-2, poxvirus ORF-1 and ORF-2 proteins |
| DE19718249A1 (de) | 1997-04-30 | 1998-11-05 | Basf Ag | Myc-bindende Zinkfinger-Proteine, ihre Herstellung und ihre Verwendung |
| GB9710807D0 (en) | 1997-05-23 | 1997-07-23 | Medical Res Council | Nucleic acid binding proteins |
| GB9710809D0 (en) | 1997-05-23 | 1997-07-23 | Medical Res Council | Nucleic acid binding proteins |
| US6007408A (en) | 1997-08-21 | 1999-12-28 | Micron Technology, Inc. | Method and apparatus for endpointing mechanical and chemical-mechanical polishing of substrates |
| CA2315977A1 (en) | 1997-12-24 | 1999-07-08 | Ludwig Institute For Cancer Research | Expression vectors and cell lines expressing vascular endothelial growth factor d, and method of treating melanomas |
| WO1999036553A2 (en) | 1998-01-15 | 1999-07-22 | Ariad Gene Therapeutics, Inc. | Regulation of biological events using multimeric chimeric proteins |
| US5972615A (en) | 1998-01-21 | 1999-10-26 | Urocor, Inc. | Biomarkers and targets for diagnosis, prognosis and management of prostate disease |
| WO1999037671A1 (en) | 1998-01-27 | 1999-07-29 | Eli Lilly And Company | Vegf related gene and protein |
| US6410248B1 (en) | 1998-01-30 | 2002-06-25 | Massachusetts Institute Of Technology | General strategy for selecting high-affinity zinc finger proteins for diverse DNA target sites |
| CN1295617A (zh) * | 1998-02-06 | 2001-05-16 | 科莱特诺医疗公司 | 血管生成因子－血管内皮细胞生长因子vegf的突变体 |
| CA2319112C (en) | 1998-02-13 | 2003-10-28 | Genetrace Systems, Inc. | Use of ribozymes for functionating genes |
| AU758728B2 (en) | 1998-02-20 | 2003-03-27 | Genome Dynamics, Inc. | Method for designing DNA-binding proteins of the zinc-finger class |
| DE69942334D1 (de) * | 1998-03-02 | 2010-06-17 | Massachusetts Inst Technology | Poly-zinkfinger-proteine mit verbesserten linkern |
| DE19811081C1 (de) | 1998-03-13 | 1999-10-28 | Siemens Ag | Haltevorrichtung für Photoblanks |
| JP2002505873A (ja) | 1998-03-13 | 2002-02-26 | ヒューマン ジノーム サイエンシーズ， インコーポレイテッド | 血管内皮増殖因子２ |
| EP1064382B1 (en) | 1998-03-17 | 2008-08-20 | Genentech, Inc. | Polypeptides homologous to vegf and bmp1 |
| DE69932813D1 (de) | 1998-03-17 | 2006-09-28 | Gendaq Ltd | Nukleinsäurebindungsproteine |
| DE19813774A1 (de) | 1998-03-27 | 1999-09-30 | Max Planck Gesellschaft | Parapockenvirus-kodierter vaskulärer Endothelzell Wachstumsfaktor (PPV-VEGF) |
| US6140081A (en) | 1998-10-16 | 2000-10-31 | The Scripps Research Institute | Zinc finger binding domains for GNN |
| WO2000025805A1 (en) | 1998-11-02 | 2000-05-11 | Ludwig Institute For Cancer Research | Vascular endothelial growth factor-like protein from orf virus nz2 binds and activates mammalian vegf receptor-2 |
| IL143832A0 (en) | 1998-12-22 | 2002-04-21 | Janssen Pharmaceutica Nv | Vascular endothelial growth factor-x |
| US6534261B1 (en) * | 1999-01-12 | 2003-03-18 | Sangamo Biosciences, Inc. | Regulation of endogenous gene expression in cells using zinc finger proteins |
| US6599692B1 (en) * | 1999-09-14 | 2003-07-29 | Sangamo Bioscience, Inc. | Functional genomics using zinc finger proteins |
| US6453242B1 (en) * | 1999-01-12 | 2002-09-17 | Sangamo Biosciences, Inc. | Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites |
| EP1147193A4 (en) | 1999-01-29 | 2003-01-22 | Ludwig Inst Cancer Res | GROWTH FACTOR / VASCULAR ENDOTHEL GROWTH FACTOR-LIKE GROWTH FACTOR, DOGS DERIVED FROM BLOOD PLATES |
| CA2361615A1 (en) | 1999-02-08 | 2000-08-10 | Human Genome Sciences, Inc. | The use of vascular endothelial growth factor 2 antagonist in the treatment of an injury to or disorder of an eye |
| US6410519B1 (en) * | 1999-03-04 | 2002-06-25 | United States Surgical Corporation | Scar reduction |
| US7217509B2 (en) * | 2000-04-28 | 2007-05-15 | Sangamo Biosciences, Inc. | Databases of regulatory sequences; methods of making and using same |
| EP1276859B1 (en) * | 2000-04-28 | 2007-02-07 | Sangamo Biosciences Inc. | Targeted modification of chromatin structure |
| AU2001257331A1 (en) * | 2000-04-28 | 2001-11-12 | Sangamo Biosciences, Inc. | Methods for designing exogenous regulatory molecules |
| AU2001257421A1 (en) * | 2000-04-28 | 2001-11-12 | Sangamo Biosciences, Inc. | Pharmacogenomics and identification of drug targets by reconstruction of signal transduction pathways based on sequences of accessible regions |
| US7067317B2 (en) * | 2000-12-07 | 2006-06-27 | Sangamo Biosciences, Inc. | Regulation of angiogenesis with zinc finger proteins |
| WO2002046412A2 (en) | 2000-12-07 | 2002-06-13 | Sangamo Biosciences, Inc. | Regulation of angiogenesis with zinc finger proteins |
-
2001
- 2001-12-06 WO PCT/US2001/046861 patent/WO2002046412A2/en not_active Ceased
- 2001-12-06 AU AU2884102A patent/AU2884102A/xx active Pending
- 2001-12-06 CA CA2431308A patent/CA2431308C/en not_active Expired - Fee Related
- 2001-12-06 JP JP2002548129A patent/JP2004537260A/ja not_active Withdrawn
- 2001-12-06 EP EP01989961A patent/EP1341914A2/en not_active Withdrawn
- 2001-12-06 AU AU2002228841A patent/AU2002228841C1/en not_active Ceased
- 2001-12-06 US US10/006,069 patent/US7026462B2/en not_active Expired - Fee Related
-
2005
- 2005-04-26 US US11/115,922 patent/US7605140B2/en not_active Expired - Fee Related
-
2006
- 2006-07-14 US US11/486,994 patent/US7560440B2/en not_active Expired - Fee Related
-
2009
- 2009-09-03 US US12/553,826 patent/US8071564B2/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP7248760B2 (ja) | 肝特異的核酸調節要素ならびにその方法および用途 | |
| CA2431308A1 (en) | Regulation of angiogenesis with zinc finger proteins | |
| US12558416B2 (en) | Endothelium-specific nucleic acid regulatory elements and methods and use thereof | |
| Marcu et al. | Myc function and regulation | |
| Shiama | The p300/CBP family: integrating signals with transcription factors and chromatin | |
| Harju et al. | Chromatin structure and control of β-like globin gene switching | |
| JP2021534798A5 (enExample) | ||
| RU2197993C2 (ru) | Самоусиливающиеся фармакологически контролируемые экспрессионные системы | |
| JP2017537611A5 (enExample) | ||
| RU2017126975A (ru) | Модифицированные посттранскрипционные регуляторные элементы вирусов гепатита | |
| EP0935001A4 (en) | NEW VEGF-LIKE FACTORS | |
| Schneider et al. | Muscle LIM protein: expressed in slow muscle and induced in fast muscle by enhanced contractile activity | |
| JP2000514421A (ja) | 脂肪細胞におけるアデノウイルスを介した遺伝子導入および関連のインプラント | |
| Yoshida et al. | Development of an integrated CRISPRi targeting ΔNp63 for treatment of squamous cell carcinoma | |
| JP2018538003A5 (enExample) | ||
| Kitajima et al. | Human T-cell leukemia virus type I tax transformation is associated with increased uptake of oligodeoxynucleotides in vitro and in vivo. | |
| Lu-Nguyen et al. | Transgenic expression of human glial cell line-derived neurotrophic factor from integration-deficient lentiviral vectors is neuroprotective in a rodent model of Parkinson's disease | |
| JP2003503355A5 (enExample) | ||
| JP2024535145A5 (enExample) | ||
| JP2005536231A (ja) | アデノウイルスに細胞選択的複製をもたらすための、スプライセオソーム媒介型ｒｎａトランススプライシングの使用 | |
| CN109929865A (zh) | 基于gal4-uas系统的crispr辅助反式增强子激活基因表达的方法及其应用 | |
| JP2007536891A5 (enExample) | ||
| JP2024533314A5 (enExample) | ||
| Takahashi et al. | The 5′-flanking region of the human smooth muscle cell calponin gene contains a cis-acting domain for interaction with a methylated DNA-binding transcription repressor | |
| CN107073078B (zh) | 利用肝细胞生长因子和基质细胞衍生因子1α的用于预防或治疗外周动脉疾病的组合物 |