ES2103740T3 - Factor de crecimiento celular endotelialico, su aislamiento y su expresion. - Google Patents
Factor de crecimiento celular endotelialico, su aislamiento y su expresion.Info
- Publication number
- ES2103740T3 ES2103740T3 ES90907823T ES90907823T ES2103740T3 ES 2103740 T3 ES2103740 T3 ES 2103740T3 ES 90907823 T ES90907823 T ES 90907823T ES 90907823 T ES90907823 T ES 90907823T ES 2103740 T3 ES2103740 T3 ES 2103740T3
- Authority
- ES
- Spain
- Prior art keywords
- growth factor
- factor
- insulation
- expression
- fsdgf
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Materials For Medical Uses (AREA)
Abstract
UN FACTOR DE CRECIMIENTO NUEVO, ESPECIFICO PARA LAS CELULAS ENDOTELIAS VASCULARES HA SIDO IDENTIFICADO EN UN MEDIO ACONDICIONADO CON CELULAS ESTRELLADAS FOLICULARES DERIVADAS DE BOVINOS. ESTE FACTOR, LLAMADO FACTOR DE CRECIMIENTO DERIVADO ESTRELLADO FOLICULAR (FSDGF) O FACTOR DE CRECIMIENTO ENDOTELIAL VASCULAR (VEGF), FUE PURIFICADO HASTA LA HOMOGENEIDAD MEDIANTE UNA COMBINACION DE COMATOGRAFIA DE EXCLUSION, LA CROMATOGRAFIA DE INTERCAMBIO DE IONES MONO S Y CROMATOGRAFIA HIDROFOBICA EN UNA COLUMNA HPLC DE FASE REVERSA C4. EL FACTOR TAMBIEN SE ENCUENTRA EN LA LINEA DE CELULA DE MURINA ATT-20. EL FSDGF, CON UN PESO MOLECULAR DE UNOS 43.000 DALTON, FUE CARACTERIZADO COMO UNA GLICOPROTEINA COMPUESTA DE DOS SUBNIDADES HOMOLOGAS CON UN PESO MOLECULAR DE UNOS 23.000 DALTONS.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US32818189A | 1989-03-24 | 1989-03-24 | |
US34616589A | 1989-05-02 | 1989-05-02 | |
US36023589A | 1989-06-01 | 1989-06-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2103740T3 true ES2103740T3 (es) | 1997-10-01 |
Family
ID=27406587
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES90907823T Expired - Lifetime ES2103740T3 (es) | 1989-03-24 | 1990-03-22 | Factor de crecimiento celular endotelialico, su aislamiento y su expresion. |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0464155B1 (es) |
JP (1) | JP3549202B2 (es) |
AT (1) | ATE152626T1 (es) |
AU (1) | AU647737B2 (es) |
CA (1) | CA2050318C (es) |
DE (1) | DE69030660T2 (es) |
DK (1) | DK0464155T3 (es) |
ES (1) | ES2103740T3 (es) |
IL (1) | IL93846A0 (es) |
NZ (1) | NZ233067A (es) |
PT (1) | PT93560B (es) |
WO (1) | WO1990011084A1 (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7300791B2 (en) | 1989-05-12 | 2007-11-27 | Genentech, Inc. | Production of vascular endothelial cell growth factor and DNA encoding same |
US5332671A (en) * | 1989-05-12 | 1994-07-26 | Genetech, Inc. | Production of vascular endothelial cell growth factor and DNA encoding same |
US5194596A (en) * | 1989-07-27 | 1993-03-16 | California Biotechnology Inc. | Production of vascular endothelial cell growth factor |
DE69233803D1 (de) * | 1992-10-28 | 2011-03-31 | Genentech Inc | Verwendung von vaskulären Endothelwachstumsfaktor-Antagonisten |
CN1173991C (zh) * | 1992-11-13 | 2004-11-03 | 马克斯普朗克科学促进协会 | 作为血管内皮生长因子受体的f1k-1 |
US7030083B2 (en) | 1998-09-09 | 2006-04-18 | University Of Washington | Treatment of eclampsia and preeclampsia |
AU5910599A (en) | 1998-09-09 | 2000-03-27 | Scios Inc. | Treatment of microvascular angiopathies |
US6783953B1 (en) | 1998-12-22 | 2004-08-31 | Janssen Pharmaceutica N.V. | Vascular endothelial growth factor-X |
US7067317B2 (en) | 2000-12-07 | 2006-06-27 | Sangamo Biosciences, Inc. | Regulation of angiogenesis with zinc finger proteins |
AU2884102A (en) | 2000-12-07 | 2002-06-18 | Sangamo Biosciences Inc | Regulation of angiogenesis with zinc finger proteins |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4456550A (en) * | 1982-11-22 | 1984-06-26 | President And Fellows Of Harvard College | Vascular permeability factor |
US5008196A (en) * | 1987-08-21 | 1991-04-16 | Monsanto Company | Stimulation of endothelial cell growth |
US5240848A (en) * | 1988-11-21 | 1993-08-31 | Monsanto Company | Dna sequences encoding human vascular permeability factor having 189 amino acids |
US5332671A (en) * | 1989-05-12 | 1994-07-26 | Genetech, Inc. | Production of vascular endothelial cell growth factor and DNA encoding same |
EP0399816B1 (en) * | 1989-05-24 | 1995-12-20 | Merck & Co. Inc. | Purification and characterization of a glioma-derived growth factor |
US5194596A (en) * | 1989-07-27 | 1993-03-16 | California Biotechnology Inc. | Production of vascular endothelial cell growth factor |
-
1990
- 1990-03-22 AT AT90907823T patent/ATE152626T1/de not_active IP Right Cessation
- 1990-03-22 CA CA2050318A patent/CA2050318C/en not_active Expired - Lifetime
- 1990-03-22 JP JP50705690A patent/JP3549202B2/ja not_active Expired - Lifetime
- 1990-03-22 ES ES90907823T patent/ES2103740T3/es not_active Expired - Lifetime
- 1990-03-22 AU AU55659/90A patent/AU647737B2/en not_active Expired
- 1990-03-22 DK DK90907823.0T patent/DK0464155T3/da active
- 1990-03-22 EP EP90907823A patent/EP0464155B1/en not_active Expired - Lifetime
- 1990-03-22 WO PCT/US1990/001568 patent/WO1990011084A1/en active IP Right Grant
- 1990-03-22 IL IL93846A patent/IL93846A0/xx not_active IP Right Cessation
- 1990-03-22 DE DE69030660T patent/DE69030660T2/de not_active Expired - Lifetime
- 1990-03-23 NZ NZ233067A patent/NZ233067A/xx unknown
- 1990-03-23 PT PT93560A patent/PT93560B/pt not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
IL93846A0 (en) | 1990-12-23 |
AU647737B2 (en) | 1994-03-31 |
EP0464155A4 (en) | 1992-05-06 |
JPH04504262A (ja) | 1992-07-30 |
DE69030660D1 (de) | 1997-06-12 |
CA2050318C (en) | 2011-04-12 |
PT93560A (pt) | 1990-11-07 |
EP0464155A1 (en) | 1992-01-08 |
JP3549202B2 (ja) | 2004-08-04 |
DK0464155T3 (da) | 1997-11-17 |
ATE152626T1 (de) | 1997-05-15 |
PT93560B (pt) | 1996-08-30 |
NZ233067A (en) | 1993-05-26 |
DE69030660T2 (de) | 1997-09-25 |
WO1990011084A1 (en) | 1990-10-04 |
CA2050318A1 (en) | 1990-09-25 |
EP0464155B1 (en) | 1997-05-07 |
AU5565990A (en) | 1990-10-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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