IT1150812B - Procedimento per l'ottenimento di mucopolisaccaridi biologicamente attivi, aventi purezza elevata, mediante depolimerizzazione controllata della eparina - Google Patents

Procedimento per l'ottenimento di mucopolisaccaridi biologicamente attivi, aventi purezza elevata, mediante depolimerizzazione controllata della eparina

Info

Publication number
IT1150812B
IT1150812B IT20662/82A IT2066282A IT1150812B IT 1150812 B IT1150812 B IT 1150812B IT 20662/82 A IT20662/82 A IT 20662/82A IT 2066282 A IT2066282 A IT 2066282A IT 1150812 B IT1150812 B IT 1150812B
Authority
IT
Italy
Prior art keywords
mucopolisaccharides
heparin
procedure
biologically active
high purity
Prior art date
Application number
IT20662/82A
Other languages
English (en)
Other versions
IT8220662A0 (it
Inventor
Jean-Claude Lormeau
Maurice Petitou
Jean Choay
Original Assignee
Choay Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Choay Sa filed Critical Choay Sa
Publication of IT8220662A0 publication Critical patent/IT8220662A0/it
Application granted granted Critical
Publication of IT1150812B publication Critical patent/IT1150812B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078—Degradation products

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
IT20662/82A 1981-04-10 1982-04-09 Procedimento per l'ottenimento di mucopolisaccaridi biologicamente attivi, aventi purezza elevata, mediante depolimerizzazione controllata della eparina IT1150812B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8107283A FR2503714B1 (fr) 1981-04-10 1981-04-10 Procede d'obtention de mucopolysaccharides biologiquement actifs, de purete elevee, par depolymerisation de l'heparine

Publications (2)

Publication Number Publication Date
IT8220662A0 IT8220662A0 (it) 1982-04-09
IT1150812B true IT1150812B (it) 1986-12-17

Family

ID=9257273

Family Applications (1)

Application Number Title Priority Date Filing Date
IT20662/82A IT1150812B (it) 1981-04-10 1982-04-09 Procedimento per l'ottenimento di mucopolisaccaridi biologicamente attivi, aventi purezza elevata, mediante depolimerizzazione controllata della eparina

Country Status (11)

Country Link
US (1) US5019649A (it)
EP (1) EP0076279B1 (it)
JP (1) JPS58500485A (it)
AU (1) AU561167B2 (it)
CA (1) CA1213276A (it)
DE (1) DE3273278D1 (it)
FR (1) FR2503714B1 (it)
IE (1) IE52878B1 (it)
IT (1) IT1150812B (it)
SU (1) SU1531859A3 (it)
WO (1) WO1982003627A1 (it)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2572080B1 (fr) * 1984-10-18 1987-06-26 Dropic Procede de preparation de compositions de mucopolysaccharides dotees d'une activite antithrombotique elevee, les compositions obtenues et leur application en tant que medicaments
CA1260461A (fr) * 1984-10-18 1989-09-26 Jean-Claude Lormeau Procede de preparation de compositions de mucopolysaccharides dotes d'une activite antithrombotique elevee
FR2584606A1 (fr) * 1985-07-12 1987-01-16 Dropic Utilisation de poly- et oligosaccharides pour l'obtention de medicaments actifs dans les pathologies du tissu conjonctif
FR2663639B1 (fr) * 1990-06-26 1994-03-18 Rhone Poulenc Sante Melanges de polysaccharides de bas poids moleculaires procede de preparation et utilisation.
USRE38743E1 (en) 1990-06-26 2005-06-14 Aventis Pharma S.A. Mixtures of particular LMW heparinic polysaccharides for the prophylaxis/treatment of acute thrombotic events
ES2049561B1 (es) * 1991-04-27 1994-12-16 Andromaco Lab Procedimiento para la obtencion de polimeros con actividad sobre el sistema hematopoyetico.
FR2704861B1 (fr) * 1993-05-07 1995-07-28 Sanofi Elf Fractions d'héparine purifiées, procédé d'obtention et compositions pharmaceutiques les contenant.
US5763427A (en) * 1995-03-31 1998-06-09 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US6001820A (en) * 1995-03-31 1999-12-14 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US5744457A (en) * 1995-03-31 1998-04-28 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US5646130A (en) * 1995-06-30 1997-07-08 Ocean University Of Oingdao Low molecular weight sulfated polysaccharides and uses thereof
IT1282994B1 (it) * 1996-05-10 1998-04-03 Inalco Spa Derivati del polisaccaride k5 aventi elevata attivita' anticoagulante
US5767269A (en) * 1996-10-01 1998-06-16 Hamilton Civic Hospitals Research Development Inc. Processes for the preparation of low-affinity, low molecular weight heparins useful as antithrombotics
AP1390A (en) * 1996-11-27 2005-04-15 Aventis Pharmaceuticals Products Inc Pharmaceutical composition comprising a compound having anti-Xa activity and a platelet aggregation antagonist compound.
US5945457A (en) * 1997-10-01 1999-08-31 A.V. Topchiev Institute Of Petrochemical Synthesis, Russian Academy Of Science Process for preparing biologically compatible polymers and their use in medical devices
EP1188773A1 (en) * 2000-08-30 2002-03-20 Nicox S.A. Nitroderivatives of polysaccharides
EP2284535A1 (en) 2002-03-11 2011-02-16 Momenta Pharmaceuticals, Inc. Low molecular weight heparins
CN1671744A (zh) * 2002-06-18 2005-09-21 格利考斯2000有限公司 低分子量过硫酸化多糖
US20120253029A1 (en) 2002-06-18 2012-10-04 Pasqua Anna Oreste Process for the preparation of highly o-sulfated epimerized derivatives of k5 polysaccharide and intermediates therein
GB2396080B (en) * 2002-11-26 2006-03-01 Nec Technologies Improvements in standby time for dual mode mobile communication devices
EP1582531A1 (en) 2004-03-24 2005-10-05 Aventis Pharma S.A. Process for oxidizing unfractionated heparins and detecting presence or absence of glycoserine in heparin and heparin products
ITMO20040199A1 (it) * 2004-07-29 2004-10-29 Biofer Spa Procedimento per la purificazione da gruppi e n no rsidui di eparine a basso peso molecolare ottentite tramite nitrosazione.
ATE552004T1 (de) 2005-11-30 2012-04-15 Istituto G Ronzoni Oral verabreichbare heparinderivate
US9139876B1 (en) 2007-05-03 2015-09-22 Momenta Pharmacueticals, Inc. Method of analyzing a preparation of a low molecular weight heparin
EP2283045A1 (en) * 2008-05-20 2011-02-16 Crystal Clear Partnership Separation of polysaccharides by charge density gradient
CN102791742B (zh) * 2010-01-19 2014-12-24 动量制药公司 评价肝素制剂
US9068957B2 (en) 2011-02-21 2015-06-30 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations
CN111727204B (zh) 2018-02-14 2023-01-31 生物E有限公司 用于制备达肝素钠的改进方法
BR112022000255A8 (pt) 2019-07-09 2022-03-22 Optimvia Llc Métodos para sintetizar polissacarídeos anticoagulantes
EP4182452A1 (en) 2020-07-14 2023-05-24 Optimvia, LLC Methods for synthesizing non-anticoagulant heparan sulfate

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1083903B (it) * 1977-08-09 1985-05-25 Lobo Srl Oligo-eteropolisaccaridi con attivita' eparinosimili,procedimento per il loro ottenimento e relative composizioni terapeutiche
FR2478646A2 (fr) * 1980-03-20 1981-09-25 Choay Sa Composition mucopolysaccharidique ayant une activite regulatrice de la coagulation, medicament la contenant et procede pour l'obtenir
SE449753B (sv) * 1978-11-06 1987-05-18 Choay Sa Mukopolysackaridkomposition med reglerande verkan pa koagulation, lekemedel innehallande densamma samt forfarande for framstellning derav
FR2461719A2 (fr) * 1979-07-20 1981-02-06 Choay Sa Composition mucopolysaccharidique ayant une activite regulatrice de la coagulation, medicament la contenant et procede pour l'obtenir
CA1136620A (en) * 1979-01-08 1982-11-30 Ulf P.F. Lindahl Heparin fragments having selective anticoagulation activity
IL61201A (en) * 1979-10-05 1984-09-30 Choay Sa Oligosaccharides having no more than 8 saccharide moieties,their obtention from heparin and pharmaceutical compositions containing them
US4351938A (en) * 1980-05-19 1982-09-28 Riker Laboratories, Inc. Anticoagulant substance

Also Published As

Publication number Publication date
FR2503714A1 (fr) 1982-10-15
AU8279482A (en) 1982-11-04
DE3273278D1 (en) 1986-10-23
SU1531859A3 (ru) 1989-12-23
JPS58500485A (ja) 1983-03-31
EP0076279A1 (fr) 1983-04-13
IT8220662A0 (it) 1982-04-09
IE52878B1 (en) 1988-03-30
CA1213276A (fr) 1986-10-28
EP0076279B1 (fr) 1986-09-17
FR2503714B1 (fr) 1986-11-21
AU561167B2 (en) 1987-04-30
WO1982003627A1 (en) 1982-10-28
IE820878L (en) 1982-10-10
US5019649A (en) 1991-05-28

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