JP2017537611A5 - - Google Patents
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- JP2017537611A5 JP2017537611A5 JP2017522083A JP2017522083A JP2017537611A5 JP 2017537611 A5 JP2017537611 A5 JP 2017537611A5 JP 2017522083 A JP2017522083 A JP 2017522083A JP 2017522083 A JP2017522083 A JP 2017522083A JP 2017537611 A5 JP2017537611 A5 JP 2017537611A5
- Authority
- JP
- Japan
- Prior art keywords
- domain
- dna binding
- atr
- operably linked
- binding domain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 230000004568 DNA-binding Effects 0.000 claims description 131
- 108091033319 polynucleotide Proteins 0.000 claims description 61
- 102000040430 polynucleotide Human genes 0.000 claims description 61
- 239000002157 polynucleotide Substances 0.000 claims description 61
- 238000013518 transcription Methods 0.000 claims description 46
- 230000035897 transcription Effects 0.000 claims description 46
- 102100024811 DNA (cytosine-5)-methyltransferase 3-like Human genes 0.000 claims description 36
- 102100024812 DNA (cytosine-5)-methyltransferase 3A Human genes 0.000 claims description 36
- 108010024491 DNA Methyltransferase 3A Proteins 0.000 claims description 36
- 101000909250 Homo sapiens DNA (cytosine-5)-methyltransferase 3-like Proteins 0.000 claims description 36
- 108010009540 DNA (Cytosine-5-)-Methyltransferase 1 Proteins 0.000 claims description 33
- 102100036279 DNA (cytosine-5)-methyltransferase 1 Human genes 0.000 claims description 33
- 102100024810 DNA (cytosine-5)-methyltransferase 3B Human genes 0.000 claims description 33
- 101710123222 DNA (cytosine-5)-methyltransferase 3B Proteins 0.000 claims description 33
- 108090000623 proteins and genes Proteins 0.000 claims description 29
- 102100023696 Histone-lysine N-methyltransferase SETDB1 Human genes 0.000 claims description 28
- 101000684609 Homo sapiens Histone-lysine N-methyltransferase SETDB1 Proteins 0.000 claims description 28
- 238000002560 therapeutic procedure Methods 0.000 claims description 19
- 102000004169 proteins and genes Human genes 0.000 claims description 12
- 239000012636 effector Substances 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 11
- 108091006107 transcriptional repressors Proteins 0.000 claims description 11
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 10
- 108091033409 CRISPR Proteins 0.000 claims description 9
- 238000010354 CRISPR gene editing Methods 0.000 claims description 9
- 230000027455 binding Effects 0.000 claims description 8
- 102100025169 Max-binding protein MNT Human genes 0.000 claims description 6
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 6
- 101150061166 tetR gene Proteins 0.000 claims description 6
- 239000011701 zinc Substances 0.000 claims description 6
- 229910052725 zinc Inorganic materials 0.000 claims description 6
- 238000001415 gene therapy Methods 0.000 claims description 5
- 239000013598 vector Substances 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 4
- 230000030279 gene silencing Effects 0.000 claims description 3
- 230000010474 transient expression Effects 0.000 claims description 3
- 239000003085 diluting agent Substances 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 238000000338 in vitro Methods 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 238000001890 transfection Methods 0.000 claims description 2
- 210000004027 cell Anatomy 0.000 description 19
- 108020004414 DNA Proteins 0.000 description 5
- 210000000130 stem cell Anatomy 0.000 description 3
- 230000014509 gene expression Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000010361 transduction Methods 0.000 description 2
- 230000026683 transduction Effects 0.000 description 2
- 230000004069 differentiation Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021213691A JP7623272B2 (ja) | 2014-10-24 | 2021-12-28 | 持続的エピジェネティック遺伝子サイレンシング |
| JP2025005873A JP2025063201A (ja) | 2014-10-24 | 2025-01-16 | 持続的エピジェネティック遺伝子サイレンシング |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1418965.8A GB201418965D0 (enExample) | 2014-10-24 | 2014-10-24 | |
| GB1418965.8 | 2014-10-24 | ||
| PCT/IB2015/058202 WO2016063264A1 (en) | 2014-10-24 | 2015-10-23 | Permanent epigenetic gene silencing |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021213691A Division JP7623272B2 (ja) | 2014-10-24 | 2021-12-28 | 持続的エピジェネティック遺伝子サイレンシング |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017537611A JP2017537611A (ja) | 2017-12-21 |
| JP2017537611A5 true JP2017537611A5 (enExample) | 2018-12-06 |
| JP7002936B2 JP7002936B2 (ja) | 2022-02-04 |
Family
ID=52103358
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017522083A Active JP7002936B2 (ja) | 2014-10-24 | 2015-10-23 | 持続的エピジェネティック遺伝子サイレンシング |
| JP2021213691A Active JP7623272B2 (ja) | 2014-10-24 | 2021-12-28 | 持続的エピジェネティック遺伝子サイレンシング |
| JP2025005873A Pending JP2025063201A (ja) | 2014-10-24 | 2025-01-16 | 持続的エピジェネティック遺伝子サイレンシング |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021213691A Active JP7623272B2 (ja) | 2014-10-24 | 2021-12-28 | 持続的エピジェネティック遺伝子サイレンシング |
| JP2025005873A Pending JP2025063201A (ja) | 2014-10-24 | 2025-01-16 | 持続的エピジェネティック遺伝子サイレンシング |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US12152240B2 (enExample) |
| EP (2) | EP3209783B1 (enExample) |
| JP (3) | JP7002936B2 (enExample) |
| CN (2) | CN116789846A (enExample) |
| AU (3) | AU2015334469B2 (enExample) |
| CA (1) | CA2965591A1 (enExample) |
| DK (1) | DK3209783T3 (enExample) |
| ES (1) | ES2906263T3 (enExample) |
| GB (1) | GB201418965D0 (enExample) |
| HU (1) | HUE057846T2 (enExample) |
| PL (1) | PL3209783T3 (enExample) |
| PT (1) | PT3209783T (enExample) |
| WO (1) | WO2016063264A1 (enExample) |
Families Citing this family (57)
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| CN107847524A (zh) * | 2015-03-27 | 2018-03-27 | 哈佛学院校长同事会 | 经过修饰的t细胞及其制备和使用方法 |
| US11674144B2 (en) * | 2015-04-16 | 2023-06-13 | California Institute Of Technology | Fractional regulation of transcription |
| JP2018515139A (ja) | 2015-05-08 | 2018-06-14 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 万能ドナー幹細胞および関連する方法 |
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| EA201891317A3 (ru) | 2015-11-30 | 2019-04-30 | Дьюк Юниверсити | Терапевтические мишени для коррекции гена дистрофина человека с помощью редактирования генов и способы их применения |
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| SG10201913151TA (en) | 2015-09-09 | 2020-03-30 | Seattle Childrens Hospital Dba Seattle Childrens Res Inst | Genetic engineering of macrophages for immunotherapy |
| EP3147363B1 (en) | 2015-09-26 | 2019-10-16 | B.R.A.I.N. Ag | Activation of taste receptor genes in mammalian cells using crispr-cas-9 |
| JP6500293B2 (ja) | 2015-11-25 | 2019-04-17 | 国立大学法人群馬大学 | Ｄｎａメチル化編集用キットおよびｄｎａメチル化編集方法 |
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2014
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2015
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