ATE418346T1 - Zusammensetzungen zur behandlung von neuropathischen und neurodegenerativen erkrankungen - Google Patents
Zusammensetzungen zur behandlung von neuropathischen und neurodegenerativen erkrankungenInfo
- Publication number
- ATE418346T1 ATE418346T1 AT05732726T AT05732726T ATE418346T1 AT E418346 T1 ATE418346 T1 AT E418346T1 AT 05732726 T AT05732726 T AT 05732726T AT 05732726 T AT05732726 T AT 05732726T AT E418346 T1 ATE418346 T1 AT E418346T1
- Authority
- AT
- Austria
- Prior art keywords
- treatment
- neuropathic
- compositions
- neurodegenerative diseases
- disclosed
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title 1
- 208000015122 neurodegenerative disease Diseases 0.000 title 1
- 230000002981 neuropathic effect Effects 0.000 title 1
- 102000009524 Vascular Endothelial Growth Factor A Human genes 0.000 abstract 2
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 abstract 2
- 101710185494 Zinc finger protein Proteins 0.000 abstract 2
- 102100023597 Zinc finger protein 816 Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 208000032131 Diabetic Neuropathies Diseases 0.000 abstract 1
- 208000027418 Wounds and injury Diseases 0.000 abstract 1
- 230000006378 damage Effects 0.000 abstract 1
- 208000014674 injury Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000001537 neural effect Effects 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 201000001119 neuropathy Diseases 0.000 abstract 1
- 230000007823 neuropathy Effects 0.000 abstract 1
- 230000000508 neurotrophic effect Effects 0.000 abstract 1
- 208000033808 peripheral neuropathy Diseases 0.000 abstract 1
- 230000035897 transcription Effects 0.000 abstract 1
- 238000013518 transcription Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/71—Fusion polypeptide containing domain for protein-protein interaction containing domain for transcriptional activaation, e.g. VP16
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
- C07K2319/81—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor containing a Zn-finger domain for DNA binding
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
- C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
- C12N2830/003—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor tet inducible
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Plant Pathology (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US56056604P | 2004-04-08 | 2004-04-08 | |
US63145504P | 2004-11-29 | 2004-11-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE418346T1 true ATE418346T1 (de) | 2009-01-15 |
Family
ID=34981912
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT05732726T ATE418346T1 (de) | 2004-04-08 | 2005-04-07 | Zusammensetzungen zur behandlung von neuropathischen und neurodegenerativen erkrankungen |
Country Status (10)
Country | Link |
---|---|
US (3) | US20050267061A1 (de) |
EP (1) | EP1732614B1 (de) |
JP (1) | JP4903689B2 (de) |
AT (1) | ATE418346T1 (de) |
AU (2) | AU2005232665B2 (de) |
CA (1) | CA2561714A1 (de) |
DE (1) | DE602005011943D1 (de) |
ES (1) | ES2315859T3 (de) |
HK (1) | HK1095761A1 (de) |
WO (1) | WO2005099771A2 (de) |
Families Citing this family (117)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007073513A2 (en) * | 2005-11-10 | 2007-06-28 | Genvec, Inc. | Method for propagating adenoviral vectors encoding inhibitory gene products |
AU2007212260A1 (en) * | 2006-02-09 | 2007-08-16 | Sangamo Therapeutics, Inc. | Method for treating peripheral arterial disease with zinc finger proteins |
JP5632610B2 (ja) | 2006-12-14 | 2014-11-26 | ダウ アグロサイエンシィズ エルエルシー | 最適化された非正準ジンクフィンガータンパク質 |
AU2008305568B2 (en) | 2007-09-27 | 2013-11-21 | Corteva Agriscience Llc | Engineered zinc finger proteins targeting 5-enolpyruvyl shikimate-3-phosphate synthase genes |
US8563314B2 (en) | 2007-09-27 | 2013-10-22 | Sangamo Biosciences, Inc. | Methods and compositions for modulating PD1 |
US8551945B2 (en) * | 2009-02-04 | 2013-10-08 | Sangamo Biosciences, Inc. | Methods and compositions for treating neuropathies |
US9234016B2 (en) * | 2009-07-28 | 2016-01-12 | Sangamo Biosciences, Inc. | Engineered zinc finger proteins for treating trinucleotide repeat disorders |
US8383405B2 (en) | 2010-05-31 | 2013-02-26 | Imperium Biotechnologies, Inc. | Methods of using ideotypically modulated pharmacoeffectors for selective cell treatment |
US8518409B2 (en) * | 2010-05-31 | 2013-08-27 | Imperium Biotechnologies, Inc. | System for selective cell treatment using ideotypically modulated pharmacoeffectors |
CA2993567C (en) | 2010-07-21 | 2022-06-28 | Sangamo Biosciences, Inc. | Methods and compositions for modification of a t-cell receptor gene |
CA2811364C (en) | 2010-09-27 | 2022-01-04 | Sangamo Biosciences, Inc. | Methods and compositions for inhibiting viral entry into cells |
AU2011316575B2 (en) | 2010-10-12 | 2015-10-29 | Sangamo Therapeutics, Inc. | Methods and compositions for treating hemophilia B |
WO2012094132A1 (en) | 2011-01-05 | 2012-07-12 | Sangamo Biosciences, Inc. | Methods and compositions for gene correction |
RU2459630C1 (ru) * | 2011-04-27 | 2012-08-27 | Федеральное государственное автономное образовательное учреждение высшего профессионального образования "Казанский (Приволжский) Федеральный Университет" (ФГАОУ ВПО КФУ) | Способ стимулирования нейрогенерации с помощью генетических конструкций |
US9161995B2 (en) | 2011-07-25 | 2015-10-20 | Sangamo Biosciences, Inc. | Methods and compositions for alteration of a cystic fibrosis transmembrane conductance regulator (CFTR) gene |
EP3498833B1 (de) | 2011-09-21 | 2023-08-16 | Sangamo Therapeutics, Inc. | Verfahren und zusammensetzungen zur regulierung der transgenexpression |
EP2771457B1 (de) | 2011-10-27 | 2017-11-22 | Sangamo Therapeutics, Inc. | Verfahren und zusammensetzungen zur veränderung des hprt-locus |
US9458205B2 (en) | 2011-11-16 | 2016-10-04 | Sangamo Biosciences, Inc. | Modified DNA-binding proteins and uses thereof |
CN108285491B (zh) | 2012-02-29 | 2021-08-10 | 桑格摩生物科学股份有限公司 | 治疗亨廷顿氏病的方法和组合物 |
CN104471067B (zh) | 2012-05-07 | 2020-08-14 | 桑格摩生物治疗股份有限公司 | 用于核酸酶介导的转基因靶向整合的方法和组合物 |
US10648001B2 (en) | 2012-07-11 | 2020-05-12 | Sangamo Therapeutics, Inc. | Method of treating mucopolysaccharidosis type I or II |
HUE030799T2 (en) | 2012-07-11 | 2017-06-28 | Sangamo Biosciences Inc | Methods and preparations for the treatment of lysosomal storage diseases |
EP2872154B1 (de) | 2012-07-11 | 2017-05-31 | Sangamo BioSciences, Inc. | Verfahren und zusammensetzungen zur freisetzung von biologischen wirkstoffen |
AU2013308770B2 (en) | 2012-08-29 | 2019-01-17 | Sangamo Therapeutics, Inc. | Methods and compositions for treatment of a genetic condition |
CA2884162C (en) | 2012-09-07 | 2020-12-29 | Dow Agrosciences Llc | Fad3 performance loci and corresponding target site specific binding proteins capable of inducing targeted breaks |
UA118090C2 (uk) | 2012-09-07 | 2018-11-26 | ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі | Спосіб інтегрування послідовності нуклеїнової кислоти, що представляє інтерес, у ген fad2 у клітині сої та специфічний для локусу fad2 білок, що зв'язується, здатний індукувати спрямований розрив |
UA119135C2 (uk) | 2012-09-07 | 2019-05-10 | ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі | Спосіб отримання трансгенної рослини |
EP2906684B8 (de) | 2012-10-10 | 2020-09-02 | Sangamo Therapeutics, Inc. | T-zell-modifizierende verbindungen und verwendungen davon |
AU2013355327A1 (en) | 2012-12-05 | 2015-06-11 | Sangamo Therapeutics, Inc. | Methods and compositions for regulation of metabolic disorders |
WO2014130955A1 (en) | 2013-02-25 | 2014-08-28 | Sangamo Biosciences, Inc. | Methods and compositions for enhancing nuclease-mediated gene disruption |
US10030067B2 (en) * | 2013-03-15 | 2018-07-24 | University Of Florida Research Foundation, Incorporated | Compounds for treating neurodegenerative proteinopathies |
CN105899665B (zh) | 2013-10-17 | 2019-10-22 | 桑格摩生物科学股份有限公司 | 用于核酸酶介导的基因组工程改造的递送方法和组合物 |
CA2926078C (en) | 2013-10-17 | 2021-11-16 | Sangamo Biosciences, Inc. | Delivery methods and compositions for nuclease-mediated genome engineering in hematopoietic stem cells |
MX358066B (es) | 2013-11-04 | 2018-08-03 | Dow Agrosciences Llc | Óptimos loci de soya. |
EP3066109A4 (de) | 2013-11-04 | 2017-11-29 | Dow AgroSciences LLC | Optimale sojabohnen-loci |
CA2928666C (en) | 2013-11-04 | 2023-05-23 | Dow Agrosciences Llc | Optimal maize loci for targeted genome modification |
AU2014341927B2 (en) | 2013-11-04 | 2017-12-14 | Corteva Agriscience Llc | Optimal maize loci |
CA2929179A1 (en) | 2013-11-11 | 2015-05-14 | Sangamo Biosciences, Inc. | Htt genetic repressor, viral vector, and uses thereof |
DK3068881T3 (en) | 2013-11-13 | 2019-04-15 | Childrens Medical Center | NUCLEASE-MEDIATED REGULATION OF GENEPRESSION |
US9771403B2 (en) | 2013-12-09 | 2017-09-26 | Sangamo Therapeutics, Inc. | Methods and compositions for treating hemophilia |
US10072066B2 (en) | 2014-02-03 | 2018-09-11 | Sangamo Therapeutics, Inc. | Methods and compositions for treatment of a beta thalessemia |
US10370680B2 (en) | 2014-02-24 | 2019-08-06 | Sangamo Therapeutics, Inc. | Method of treating factor IX deficiency using nuclease-mediated targeted integration |
US9624498B2 (en) | 2014-03-18 | 2017-04-18 | Sangamo Biosciences, Inc. | Methods and compositions for regulation of zinc finger protein expression |
NZ728159A (en) | 2014-07-14 | 2018-08-31 | Univ Washington State | Nanos2 knock-out that ablates germline cells |
MA40253A (fr) | 2014-07-15 | 2017-05-24 | Juno Therapeutics Inc | Cellules modifiées pour thérapie cellulaire adoptive |
US9816074B2 (en) | 2014-07-25 | 2017-11-14 | Sangamo Therapeutics, Inc. | Methods and compositions for modulating nuclease-mediated genome engineering in hematopoietic stem cells |
WO2016014837A1 (en) | 2014-07-25 | 2016-01-28 | Sangamo Biosciences, Inc. | Gene editing for hiv gene therapy |
WO2016019144A2 (en) | 2014-07-30 | 2016-02-04 | Sangamo Biosciences, Inc. | Gene correction of scid-related genes in hematopoietic stem and progenitor cells |
EP3878948A1 (de) | 2014-09-16 | 2021-09-15 | Sangamo Therapeutics, Inc. | Verfahren und zusammensetzungen für nukleasevermitteltes genom-engineering und korrektur bei hämotopoietischen stammzellen |
RU2558294C1 (ru) | 2014-09-16 | 2015-07-27 | Общество с ограниченной ответственностью "НекстГен" | Кодон-оптимизированная рекомбинантная плазмида, способ стимуляции регенерации периферического нерва, способ лечения поврежденного нерва человека |
US10889834B2 (en) | 2014-12-15 | 2021-01-12 | Sangamo Therapeutics, Inc. | Methods and compositions for enhancing targeted transgene integration |
WO2016118726A2 (en) | 2015-01-21 | 2016-07-28 | Sangamo Biosciences, Inc. | Methods and compositions for identification of highly specific nucleases |
ES2959608T3 (es) | 2015-04-03 | 2024-02-27 | Dana Farber Cancer Inst Inc | Composición y métodos de edición del genoma de células B |
IL284707B2 (en) | 2015-05-12 | 2024-01-01 | Sangamo Therapeutics Inc | Regulation of nuclease-mediated gene expression |
US9957501B2 (en) | 2015-06-18 | 2018-05-01 | Sangamo Therapeutics, Inc. | Nuclease-mediated regulation of gene expression |
EP3322297A4 (de) | 2015-07-13 | 2019-04-17 | Sangamo Therapeutics, Inc. | Freisetzungsverfahren und zusammensetzungen für nukleasevermitteltes genomengineering |
MA42895A (fr) | 2015-07-15 | 2018-05-23 | Juno Therapeutics Inc | Cellules modifiées pour thérapie cellulaire adoptive |
CN109475107A (zh) | 2015-08-06 | 2019-03-15 | 密苏里大学管理者 | 具有修饰的cd163基因的抗病原体动物 |
CA3008413A1 (en) | 2015-12-18 | 2017-06-22 | Sangamo Therapeutics, Inc. | Targeted disruption of the t cell receptor |
EA201891212A1 (ru) | 2015-12-18 | 2019-01-31 | Сангамо Терапьютикс, Инк. | Адресная дезорганизация клеточного рецептора гкгс |
SG11201805680SA (en) | 2016-01-15 | 2018-07-30 | Sangamo Therapeutics Inc | Methods and compositions for the treatment of neurologic disease |
ES2901215T3 (es) | 2016-05-27 | 2022-03-21 | Aadigen Llc | Péptidos y nanopartículas para la liberación intracelular de moléculas de edición del genoma |
AU2017295720B2 (en) | 2016-07-13 | 2021-07-22 | Vertex Pharmaceuticals Incorporated | Methods, compositions and kits for increasing genome editing efficiency |
EP3504327B1 (de) | 2016-08-24 | 2021-10-06 | Sangamo Therapeutics, Inc. | Manipulierte zielspezifische nukleasen |
PL3504229T3 (pl) | 2016-08-24 | 2022-04-19 | Sangamo Therapeutics, Inc. | Regulacja ekspresji genów przy użyciu nukleaz poddanych inżynierii |
EP3523422A1 (de) | 2016-10-05 | 2019-08-14 | FUJIFILM Cellular Dynamics, Inc. | Erzeugung reifer linien aus induzierten pluripotenten stammzellen mit mecp2-unterbrechung |
MA46649A (fr) | 2016-10-13 | 2019-08-21 | Juno Therapeutics Inc | Méthodes et compositions d'immunothérapie impliquant des modulateurs de la voie métabolique du tryptophane |
BR112019007210A2 (pt) | 2016-10-20 | 2019-08-13 | Sangamo Therapeutics Inc | métodos e composições para o tratamento da doença de fabry |
WO2018081775A1 (en) | 2016-10-31 | 2018-05-03 | Sangamo Therapeutics, Inc. | Gene correction of scid-related genes in hematopoietic stem and progenitor cells |
CA3045323A1 (en) | 2016-12-02 | 2018-06-07 | Juno Therapeutics, Inc. | Engineered b cells and related compositions and methods |
MA49610A (fr) | 2016-12-08 | 2020-05-27 | Univ Case Western Reserve | Procédés et compositions pour améliorer la production de myéline fonctionnelle |
IL301115A (en) | 2017-04-28 | 2023-05-01 | Acuitas Therapeutics Inc | New lipid carbonyl and lipid nanoparticle formulations for delivery of nucleic acids |
CA3059793A1 (en) | 2017-05-03 | 2018-11-08 | Sangamo Therapeutics, Inc. | Methods and compositions for modification of a cystic fibrosis transmembrane conductance regulator (cftr) gene |
US11512287B2 (en) | 2017-06-16 | 2022-11-29 | Sangamo Therapeutics, Inc. | Targeted disruption of T cell and/or HLA receptors |
CA3079748A1 (en) | 2017-11-09 | 2019-05-16 | Sangamo Therapeutics, Inc. | Genetic modification of cytokine inducible sh2-containing protein (cish) gene |
JP2019103139A (ja) * | 2017-11-28 | 2019-06-24 | 芳樹 前澤 | コールセンター業務システム |
EA202091708A1 (ru) | 2018-01-17 | 2020-11-10 | Вертекс Фармасьютикалз Инкорпорейтед | Ингибиторы днк-пк |
BR112020013626A2 (pt) | 2018-01-17 | 2020-12-01 | Vertex Pharmaceuticals Incorporated | compostos de quinoxalinona, composições, métodos e kits para aumentar a eficiência de edição de genoma |
WO2019143675A1 (en) | 2018-01-17 | 2019-07-25 | Vertex Pharmaceuticals Incorporated | Dna-pk inhibitors |
CA3089587A1 (en) | 2018-02-08 | 2019-08-15 | Sangamo Therapeutics, Inc. | Engineered target specific nucleases |
US11690921B2 (en) | 2018-05-18 | 2023-07-04 | Sangamo Therapeutics, Inc. | Delivery of target specific nucleases |
IL280951B1 (en) | 2018-08-23 | 2024-04-01 | Sangamo Therapeutics Inc | Engineered target-specific base editors |
WO2020051283A1 (en) | 2018-09-05 | 2020-03-12 | The Regents Of The University Of California | Generation of heritably gene-edited plants without tissue culture |
CA3111711A1 (en) | 2018-09-18 | 2020-03-26 | Sangamo Therapeutics, Inc. | Programmed cell death 1 (pd1) specific nucleases |
CN113474328A (zh) | 2019-01-11 | 2021-10-01 | 爱康泰生治疗公司 | 用于脂质纳米颗粒递送活性剂的脂质 |
AU2019428629A1 (en) | 2019-02-06 | 2021-01-28 | Sangamo Therapeutics, Inc. | Method for the treatment of mucopolysaccharidosis type I |
MX2021012152A (es) | 2019-04-02 | 2021-11-03 | Sangamo Therapeutics Inc | Metodos para el tratamiento de beta-talasemia. |
CN113966401A (zh) | 2019-04-10 | 2022-01-21 | 犹他大学研究基金会 | 用于治疗amd的htra1调节 |
JP2022543112A (ja) | 2019-08-01 | 2022-10-07 | サナ バイオテクノロジー,インコーポレイテッド | Dux4発現細胞およびそれらの使用 |
JP2022546317A (ja) | 2019-08-23 | 2022-11-04 | サナ バイオテクノロジー,インコーポレイテッド | Cd24発現細胞およびそれらの用途 |
AU2020376048A1 (en) | 2019-11-01 | 2022-06-02 | Sangamo Therapeutics, Inc. | Compositions and methods for genome engineering |
EP4125961A1 (de) | 2020-03-25 | 2023-02-08 | Sana Biotechnology, Inc. | Hypoimmunogene nervenzellen zur behandlung von neurologischen erkrankungen und zuständen |
EP4146812A1 (de) | 2020-05-06 | 2023-03-15 | Cellectis S.A. | Verfahren zur gezielten einführung exogener sequenzen in zelluläre genome |
CA3177621A1 (en) | 2020-05-06 | 2021-11-11 | Alexandre Juillerat | Methods to genetically modify cells for delivery of therapeutic proteins |
WO2021236852A1 (en) | 2020-05-20 | 2021-11-25 | Sana Biotechnology, Inc. | Methods and compositions for treatment of viral infections |
WO2022016070A1 (en) | 2020-07-16 | 2022-01-20 | Acuitas Therapeutics, Inc. | Cationic lipids for use in lipid nanoparticles |
AU2021325941A1 (en) | 2020-08-13 | 2023-03-09 | Sana Biotechnology, Inc. | Methods of treating sensitized patients with hypoimmunogenic cells, and associated methods and compositions |
EP4204545A2 (de) | 2020-08-25 | 2023-07-05 | Kite Pharma, Inc. | T-zellen mit verbesserter funktionalität |
WO2022101641A1 (en) | 2020-11-16 | 2022-05-19 | Pig Improvement Company Uk Limited | Influenza a-resistant animals having edited anp32 genes |
JP2024501971A (ja) | 2020-12-31 | 2024-01-17 | サナ バイオテクノロジー,インコーポレイテッド | Car-t活性を調節するための方法及び組成物 |
AU2022283291A1 (en) | 2021-05-27 | 2023-11-02 | Sana Biotechnology, Inc. | Hypoimmunogenic cells comprising engineered hla-e or hla-g |
AU2022309875A1 (en) | 2021-07-14 | 2024-01-25 | Sana Biotechnology, Inc. | Altered expression of y chromosome-linked antigens in hypoimmunogenic cells |
AU2022325955A1 (en) | 2021-08-11 | 2024-02-08 | Sana Biotechnology, Inc. | Genetically modified cells for allogeneic cell therapy to reduce instant blood mediated inflammatory reactions |
WO2023019227A1 (en) | 2021-08-11 | 2023-02-16 | Sana Biotechnology, Inc. | Genetically modified cells for allogeneic cell therapy to reduce complement-mediated inflammatory reactions |
AU2022326565A1 (en) | 2021-08-11 | 2024-02-08 | Sana Biotechnology, Inc. | Genetically modified cells for allogeneic cell therapy |
KR20240053673A (ko) | 2021-08-11 | 2024-04-24 | 사나 바이오테크놀로지, 인크. | 저면역원성 세포 내 유전자 발현을 변경하기 위한 유도성 시스템 |
CA3227108A1 (en) | 2021-08-11 | 2023-02-16 | Xiaomeng HU | Genetically modified primary cells for allogeneic cell therapy |
WO2023069790A1 (en) | 2021-10-22 | 2023-04-27 | Sana Biotechnology, Inc. | Methods of engineering allogeneic t cells with a transgene in a tcr locus and associated compositions and methods |
WO2023081756A1 (en) | 2021-11-03 | 2023-05-11 | The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone | Precise genome editing using retrons |
WO2023105244A1 (en) | 2021-12-10 | 2023-06-15 | Pig Improvement Company Uk Limited | Editing tmprss2/4 for disease resistance in livestock |
CA3241438A1 (en) | 2021-12-23 | 2023-06-29 | Sana Biotechnology, Inc. | Chimeric antigen receptor (car) t cells for treating autoimmune disease and associated methods |
WO2023141602A2 (en) | 2022-01-21 | 2023-07-27 | Renagade Therapeutics Management Inc. | Engineered retrons and methods of use |
WO2023154578A1 (en) | 2022-02-14 | 2023-08-17 | Sana Biotechnology, Inc. | Methods of treating patients exhibiting a prior failed therapy with hypoimmunogenic cells |
WO2023158836A1 (en) | 2022-02-17 | 2023-08-24 | Sana Biotechnology, Inc. | Engineered cd47 proteins and uses thereof |
WO2023173123A1 (en) | 2022-03-11 | 2023-09-14 | Sana Biotechnology, Inc. | Genetically modified cells and compositions and uses thereof |
WO2024013514A2 (en) | 2022-07-15 | 2024-01-18 | Pig Improvement Company Uk Limited | Gene edited livestock animals having coronavirus resistance |
WO2024044723A1 (en) | 2022-08-25 | 2024-02-29 | Renagade Therapeutics Management Inc. | Engineered retrons and methods of use |
Family Cites Families (79)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4217344A (en) * | 1976-06-23 | 1980-08-12 | L'oreal | Compositions containing aqueous dispersions of lipid spheres |
US4235871A (en) * | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
US4186183A (en) * | 1978-03-29 | 1980-01-29 | The United States Of America As Represented By The Secretary Of The Army | Liposome carriers in chemotherapy of leishmaniasis |
US4261975A (en) * | 1979-09-19 | 1981-04-14 | Merck & Co., Inc. | Viral liposome particle |
US4485054A (en) * | 1982-10-04 | 1984-11-27 | Lipoderm Pharmaceuticals Limited | Method of encapsulating biologically active materials in multilamellar lipid vesicles (MLV) |
US4603044A (en) * | 1983-01-06 | 1986-07-29 | Technology Unlimited, Inc. | Hepatocyte Directed Vesicle delivery system |
US4501728A (en) * | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
US4897355A (en) * | 1985-01-07 | 1990-01-30 | Syntex (U.S.A.) Inc. | N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
US4946787A (en) * | 1985-01-07 | 1990-08-07 | Syntex (U.S.A.) Inc. | N-(ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
US5049386A (en) * | 1985-01-07 | 1991-09-17 | Syntex (U.S.A.) Inc. | N-ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)Alk-1-YL-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
US4797368A (en) * | 1985-03-15 | 1989-01-10 | The United States Of America As Represented By The Department Of Health And Human Services | Adeno-associated virus as eukaryotic expression vector |
US4774085A (en) * | 1985-07-09 | 1988-09-27 | 501 Board of Regents, Univ. of Texas | Pharmaceutical administration systems containing a mixture of immunomodulators |
US5422251A (en) * | 1986-11-26 | 1995-06-06 | Princeton University | Triple-stranded nucleic acids |
US4837028A (en) * | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
US5674722A (en) * | 1987-12-11 | 1997-10-07 | Somatix Therapy Corporation | Genetic modification of endothelial cells |
US6001350A (en) * | 1987-12-11 | 1999-12-14 | Somatix Therapy Corp | Genetic modification of endothelial cells |
US5176996A (en) * | 1988-12-20 | 1993-01-05 | Baylor College Of Medicine | Method for making synthetic oligonucleotides which bind specifically to target sites on duplex DNA molecules, by forming a colinear triplex, the synthetic oligonucleotides and methods of use |
US4957773A (en) * | 1989-02-13 | 1990-09-18 | Syracuse University | Deposition of boron-containing films from decaborane |
US5693622A (en) * | 1989-03-21 | 1997-12-02 | Vical Incorporated | Expression of exogenous polynucleotide sequences cardiac muscle of a mammal |
US5328470A (en) * | 1989-03-31 | 1994-07-12 | The Regents Of The University Of Michigan | Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor |
US5698531A (en) * | 1989-03-31 | 1997-12-16 | The Regents Of The University Of Michigan | Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor |
US5210015A (en) * | 1990-08-06 | 1993-05-11 | Hoffman-La Roche Inc. | Homogeneous assay system using the nuclease activity of a nucleic acid polymerase |
US5817491A (en) * | 1990-09-21 | 1998-10-06 | The Regents Of The University Of California | VSV G pseusdotyped retroviral vectors |
US5849571A (en) * | 1990-10-10 | 1998-12-15 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Latency active herpes virus promoters and their use |
US5849572A (en) * | 1990-10-10 | 1998-12-15 | Regents Of The University Of Michigan | HSV-1 vector containing a lat promoter |
US5173414A (en) * | 1990-10-30 | 1992-12-22 | Applied Immune Sciences, Inc. | Production of recombinant adeno-associated virus vectors |
US5503022A (en) * | 1993-01-25 | 1996-04-02 | Barone; Larry A. | Marine impeller tester |
US5797960A (en) * | 1993-02-22 | 1998-08-25 | Stevens; John H. | Method and apparatus for thoracoscopic intracardiac procedures |
US5538848A (en) * | 1994-11-16 | 1996-07-23 | Applied Biosystems Division, Perkin-Elmer Corp. | Method for detecting nucleic acid amplification using self-quenching fluorescence probe |
US6140466A (en) * | 1994-01-18 | 2000-10-31 | The Scripps Research Institute | Zinc finger protein derivatives and methods therefor |
US5585245A (en) * | 1994-04-22 | 1996-12-17 | California Institute Of Technology | Ubiquitin-based split protein sensor |
JP4118327B2 (ja) * | 1994-08-20 | 2008-07-16 | ゲンダック・リミテッド | Dna認識のための結合タンパク質におけるまたはそれに関連する改良 |
US5789538A (en) * | 1995-02-03 | 1998-08-04 | Massachusetts Institute Of Technology | Zinc finger proteins with high affinity new DNA binding specificities |
US5928939A (en) * | 1995-03-01 | 1999-07-27 | Ludwig Institute For Cancer Research | Vascular endothelial growth factor-b and dna coding therefor |
US5797870A (en) * | 1995-06-07 | 1998-08-25 | Indiana University Foundation | Pericardial delivery of therapeutic and diagnostic agents |
US5840059A (en) * | 1995-06-07 | 1998-11-24 | Cardiogenesis Corporation | Therapeutic and diagnostic agent delivery |
US6344445B1 (en) * | 1995-10-19 | 2002-02-05 | Cantab Pharmaceutical Research Limited | Herpes virus vectors and their uses |
DE69631490T2 (de) * | 1995-11-09 | 2004-10-07 | Univ Massachusetts Boston | Wiederherstellung der gewebeoberfläche mit zusammensetzungen aus hydrogel-zellen |
US5941868A (en) * | 1995-12-22 | 1999-08-24 | Localmed, Inc. | Localized intravascular delivery of growth factors for promotion of angiogenesis |
US6261552B1 (en) * | 1997-05-22 | 2001-07-17 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Herpes simplex virus vectors |
US5928638A (en) * | 1996-06-17 | 1999-07-27 | Systemix, Inc. | Methods for gene transfer |
GB9615794D0 (en) * | 1996-07-26 | 1996-09-04 | Medical Res Council | Mutant herpes simplex virus strains and uses thereof |
US5976164A (en) * | 1996-09-13 | 1999-11-02 | Eclipse Surgical Technologies, Inc. | Method and apparatus for myocardial revascularization and/or biopsy of the heart |
WO1998017815A1 (en) * | 1996-10-17 | 1998-04-30 | Oxford Biomedica (Uk) Limited | Retroviral vectors |
US5931810A (en) * | 1996-12-05 | 1999-08-03 | Comedicus Incorporated | Method for accessing the pericardial space |
US6067988A (en) * | 1996-12-26 | 2000-05-30 | Eclipse Surgical Technologies, Inc. | Method for creation of drug delivery and/or stimulation pockets in myocardium |
US5925012A (en) * | 1996-12-27 | 1999-07-20 | Eclipse Surgical Technologies, Inc. | Laser assisted drug delivery |
US5999678A (en) * | 1996-12-27 | 1999-12-07 | Eclipse Surgical Technologies, Inc. | Laser delivery means adapted for drug delivery |
US20030219409A1 (en) * | 1997-01-10 | 2003-11-27 | Biovex Limited | Eukaryotic gene expression cassette and uses thereof |
US5993443A (en) * | 1997-02-03 | 1999-11-30 | Eclipse Surgical Technologies, Inc. | Revascularization with heartbeat verification |
US6045565A (en) * | 1997-11-04 | 2000-04-04 | Scimed Life Systems, Inc. | Percutaneous myocardial revascularization growth factor mediums and method |
US6086582A (en) * | 1997-03-13 | 2000-07-11 | Altman; Peter A. | Cardiac drug delivery system |
US5893839A (en) * | 1997-03-13 | 1999-04-13 | Advanced Research And Technology Institute, Inc. | Timed-release localized drug delivery by percutaneous administration |
US5968010A (en) * | 1997-04-30 | 1999-10-19 | Beth Israel Deaconess Medical Center, Inc. | Method for transvenously accessing the pericardial space via the right atrium |
US5863736A (en) * | 1997-05-23 | 1999-01-26 | Becton, Dickinson And Company | Method, apparatus and computer program products for determining quantities of nucleic acid sequences in samples |
GB9710809D0 (en) * | 1997-05-23 | 1997-07-23 | Medical Res Council | Nucleic acid binding proteins |
US6007408A (en) * | 1997-08-21 | 1999-12-28 | Micron Technology, Inc. | Method and apparatus for endpointing mechanical and chemical-mechanical polishing of substrates |
US5972013A (en) * | 1997-09-19 | 1999-10-26 | Comedicus Incorporated | Direct pericardial access device with deflecting mechanism and method |
US6050986A (en) * | 1997-12-01 | 2000-04-18 | Scimed Life Systems, Inc. | Catheter system for the delivery of a low volume liquid bolus |
US5994136A (en) * | 1997-12-12 | 1999-11-30 | Cell Genesys, Inc. | Method and means for producing high titer, safe, recombinant lentivirus vectors |
GB9801930D0 (en) * | 1998-01-29 | 1998-03-25 | Univ London | Mutant herpes simplex viruses and uses thereof |
US5997509A (en) * | 1998-03-06 | 1999-12-07 | Cornell Research Foundation, Inc. | Minimally invasive gene therapy delivery device and method |
US6066123A (en) * | 1998-04-09 | 2000-05-23 | The Board Of Trustees Of The Leland Stanford Junior University | Enhancement of bioavailability by use of focused energy delivery to a target tissue |
US20040063094A1 (en) * | 1998-05-20 | 2004-04-01 | Biovex Limited | Mutant herpes simplex viruses and uses thereof |
US6048332A (en) * | 1998-10-09 | 2000-04-11 | Ave Connaught | Dimpled porous infusion balloon |
US6140081A (en) * | 1998-10-16 | 2000-10-31 | The Scripps Research Institute | Zinc finger binding domains for GNN |
US6453242B1 (en) * | 1999-01-12 | 2002-09-17 | Sangamo Biosciences, Inc. | Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites |
US6534261B1 (en) * | 1999-01-12 | 2003-03-18 | Sangamo Biosciences, Inc. | Regulation of endogenous gene expression in cells using zinc finger proteins |
US7030215B2 (en) * | 1999-03-24 | 2006-04-18 | Sangamo Biosciences, Inc. | Position dependent recognition of GNN nucleotide triplets by zinc fingers |
GB9930418D0 (en) * | 1999-12-22 | 2000-02-16 | Neurovex Ltd | Replication incompetent herpes virus vectors |
GB9930419D0 (en) * | 1999-12-22 | 2000-02-16 | Neurovex Ltd | Replication incompetent herpes virus vectors |
US7223593B2 (en) * | 2000-01-21 | 2007-05-29 | Biovex Limited | Herpes virus strains for gene therapy |
GB0001476D0 (en) * | 2000-01-21 | 2000-03-15 | Neurovex Ltd | Herpes virus strains |
US20020061512A1 (en) * | 2000-02-18 | 2002-05-23 | Kim Jin-Soo | Zinc finger domains and methods of identifying same |
EP1276865B1 (de) * | 2000-04-28 | 2014-05-21 | Sangamo BioSciences, Inc. | Verfahren zur bindung eines exogenen moleküls an zelluläres chromatin |
AU2884102A (en) * | 2000-12-07 | 2002-06-18 | Sangamo Biosciences Inc | Regulation of angiogenesis with zinc finger proteins |
US7067317B2 (en) * | 2000-12-07 | 2006-06-27 | Sangamo Biosciences, Inc. | Regulation of angiogenesis with zinc finger proteins |
CA2435394C (en) * | 2001-01-22 | 2018-01-09 | Sangamo Biosciences, Inc. | Modified zinc finger binding proteins |
WO2004053130A1 (en) * | 2002-12-09 | 2004-06-24 | Toolgen, Inc. | Regulatory zinc finger proteins |
-
2005
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US20110281937A1 (en) | 2011-11-17 |
AU2010212293B2 (en) | 2012-07-19 |
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EP1732614A2 (de) | 2006-12-20 |
ES2315859T3 (es) | 2009-04-01 |
EP1732614B1 (de) | 2008-12-24 |
JP4903689B2 (ja) | 2012-03-28 |
WO2005099771A2 (en) | 2005-10-27 |
JP2007532567A (ja) | 2007-11-15 |
AU2005232665B2 (en) | 2010-05-13 |
US20100256221A1 (en) | 2010-10-07 |
AU2005232665A1 (en) | 2005-10-27 |
HK1095761A1 (en) | 2007-05-18 |
CA2561714A1 (en) | 2005-10-27 |
US20050267061A1 (en) | 2005-12-01 |
DE602005011943D1 (de) | 2009-02-05 |
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