JP2017529834A5 - - Google Patents
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- JP2017529834A5 JP2017529834A5 JP2017508487A JP2017508487A JP2017529834A5 JP 2017529834 A5 JP2017529834 A5 JP 2017529834A5 JP 2017508487 A JP2017508487 A JP 2017508487A JP 2017508487 A JP2017508487 A JP 2017508487A JP 2017529834 A5 JP2017529834 A5 JP 2017529834A5
- Authority
- JP
- Japan
- Prior art keywords
- transcription factor
- factor binding
- oligonucleotide
- oligonucleotide decoy
- binding site
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108091034117 Oligonucleotide Proteins 0.000 claims description 50
- 108091023040 Transcription factor Proteins 0.000 claims description 46
- 102000040945 Transcription factor Human genes 0.000 claims description 46
- 101001139112 Homo sapiens Krueppel-like factor 9 Proteins 0.000 claims description 23
- 102100020684 Krueppel-like factor 9 Human genes 0.000 claims description 22
- 238000000034 method Methods 0.000 claims description 22
- 239000003814 drug Substances 0.000 claims description 20
- 229940124597 therapeutic agent Drugs 0.000 claims description 20
- 208000002193 Pain Diseases 0.000 claims description 16
- 101001046599 Homo sapiens Krueppel-like factor 15 Proteins 0.000 claims description 15
- 101001139126 Homo sapiens Krueppel-like factor 6 Proteins 0.000 claims description 15
- 102100022328 Krueppel-like factor 15 Human genes 0.000 claims description 15
- 102100020679 Krueppel-like factor 6 Human genes 0.000 claims description 15
- 238000012286 ELISA Assay Methods 0.000 claims description 12
- 230000008055 nociceptive signaling Effects 0.000 claims description 6
- 239000002773 nucleotide Substances 0.000 claims description 6
- 125000003729 nucleotide group Chemical group 0.000 claims description 6
- 230000003287 optical effect Effects 0.000 claims description 6
- 101001046587 Homo sapiens Krueppel-like factor 1 Proteins 0.000 claims description 5
- 101001006895 Homo sapiens Krueppel-like factor 11 Proteins 0.000 claims description 5
- 101001006886 Homo sapiens Krueppel-like factor 12 Proteins 0.000 claims description 5
- 101001046564 Homo sapiens Krueppel-like factor 13 Proteins 0.000 claims description 5
- 101001046596 Homo sapiens Krueppel-like factor 14 Proteins 0.000 claims description 5
- 101001046589 Homo sapiens Krueppel-like factor 17 Proteins 0.000 claims description 5
- 101001139146 Homo sapiens Krueppel-like factor 2 Proteins 0.000 claims description 5
- 101001139136 Homo sapiens Krueppel-like factor 3 Proteins 0.000 claims description 5
- 101001139134 Homo sapiens Krueppel-like factor 4 Proteins 0.000 claims description 5
- 101001139130 Homo sapiens Krueppel-like factor 5 Proteins 0.000 claims description 5
- 101001139115 Homo sapiens Krueppel-like factor 8 Proteins 0.000 claims description 5
- 101000868883 Homo sapiens Transcription factor Sp6 Proteins 0.000 claims description 5
- 102100022248 Krueppel-like factor 1 Human genes 0.000 claims description 5
- 102100027797 Krueppel-like factor 11 Human genes 0.000 claims description 5
- 102100027792 Krueppel-like factor 12 Human genes 0.000 claims description 5
- 102100022254 Krueppel-like factor 13 Human genes 0.000 claims description 5
- 102100022329 Krueppel-like factor 14 Human genes 0.000 claims description 5
- 102100022249 Krueppel-like factor 17 Human genes 0.000 claims description 5
- 102100020675 Krueppel-like factor 2 Human genes 0.000 claims description 5
- 102100020678 Krueppel-like factor 3 Human genes 0.000 claims description 5
- 102100020677 Krueppel-like factor 4 Human genes 0.000 claims description 5
- 102100020680 Krueppel-like factor 5 Human genes 0.000 claims description 5
- 102100020691 Krueppel-like factor 8 Human genes 0.000 claims description 5
- 208000004296 neuralgia Diseases 0.000 claims description 5
- 208000021722 neuropathic pain Diseases 0.000 claims description 5
- 230000035897 transcription Effects 0.000 claims description 5
- 238000013518 transcription Methods 0.000 claims description 5
- 206010061218 Inflammation Diseases 0.000 claims description 4
- 230000004054 inflammatory process Effects 0.000 claims description 4
- 208000000094 Chronic Pain Diseases 0.000 claims description 2
- 210000003169 central nervous system Anatomy 0.000 claims description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 2
- 208000035475 disorder Diseases 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 108090000623 proteins and genes Proteins 0.000 claims description 2
- -1 K LF7 Proteins 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 101001006892 Homo sapiens Krueppel-like factor 10 Proteins 0.000 description 4
- 101001046593 Homo sapiens Krueppel-like factor 16 Proteins 0.000 description 4
- 102100027798 Krueppel-like factor 10 Human genes 0.000 description 4
- 102100022324 Krueppel-like factor 16 Human genes 0.000 description 4
- 101001139117 Homo sapiens Krueppel-like factor 7 Proteins 0.000 description 1
- 102100020692 Krueppel-like factor 7 Human genes 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000002103 transcriptional effect Effects 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462037996P | 2014-08-15 | 2014-08-15 | |
| US62/037,996 | 2014-08-15 | ||
| PCT/US2015/045268 WO2016025829A1 (en) | 2014-08-15 | 2015-08-14 | Oligonucleotide decoys for the treatment of pain |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020084841A Division JP2020141688A (ja) | 2014-08-15 | 2020-05-14 | 疼痛を治療するためのオリゴヌクレオチドデコイ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017529834A JP2017529834A (ja) | 2017-10-12 |
| JP2017529834A5 true JP2017529834A5 (enExample) | 2018-09-13 |
| JP6705807B2 JP6705807B2 (ja) | 2020-06-03 |
Family
ID=55304669
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017508487A Expired - Fee Related JP6705807B2 (ja) | 2014-08-15 | 2015-08-14 | 疼痛を治療するためのオリゴヌクレオチドデコイ |
| JP2020084841A Pending JP2020141688A (ja) | 2014-08-15 | 2020-05-14 | 疼痛を治療するためのオリゴヌクレオチドデコイ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020084841A Pending JP2020141688A (ja) | 2014-08-15 | 2020-05-14 | 疼痛を治療するためのオリゴヌクレオチドデコイ |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US10287583B2 (enExample) |
| EP (2) | EP3626822A1 (enExample) |
| JP (2) | JP6705807B2 (enExample) |
| CN (1) | CN106661578B (enExample) |
| AU (1) | AU2015301491A1 (enExample) |
| BR (1) | BR112017002629A2 (enExample) |
| CA (1) | CA2957250A1 (enExample) |
| ES (1) | ES2750689T3 (enExample) |
| PT (1) | PT3180434T (enExample) |
| RU (1) | RU2017108238A (enExample) |
| WO (1) | WO2016025829A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3199635B1 (en) | 2007-05-11 | 2019-02-06 | Adynxx, Inc. | Gene expression and pain |
| CA2872901A1 (en) | 2012-05-10 | 2013-11-14 | Adynxx, Inc. | Formulations for the delivery of active ingredients |
| CA2957250A1 (en) | 2014-08-15 | 2016-02-18 | Adynxx, Inc. | Oligonucleotide decoys for the treatment of pain |
| FR3029450B1 (fr) * | 2014-12-03 | 2017-11-03 | Pole De Plasturgie De Lest | Dispositif de moulage pour la fabrication de pieces en materiau composite a partir de resine polymere liquide par injection haute pression. |
| CN113453695A (zh) * | 2018-12-24 | 2021-09-28 | 加州大学评议会 | 用嵌合体诱饵治疗脊柱病症 |
| CN116096382A (zh) * | 2020-08-13 | 2023-05-09 | 内华达研究与创新公司 | 用于治疗糖尿病和肥胖症的KLF11 siRNA |
| WO2023070072A1 (en) | 2021-10-21 | 2023-04-27 | The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone | Retroelement-generated transcription factor decoys |
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2015
- 2015-08-14 CA CA2957250A patent/CA2957250A1/en not_active Abandoned
- 2015-08-14 RU RU2017108238A patent/RU2017108238A/ru not_active Application Discontinuation
- 2015-08-14 AU AU2015301491A patent/AU2015301491A1/en not_active Abandoned
- 2015-08-14 EP EP19186119.4A patent/EP3626822A1/en not_active Withdrawn
- 2015-08-14 WO PCT/US2015/045268 patent/WO2016025829A1/en not_active Ceased
- 2015-08-14 JP JP2017508487A patent/JP6705807B2/ja not_active Expired - Fee Related
- 2015-08-14 PT PT158320838T patent/PT3180434T/pt unknown
- 2015-08-14 BR BR112017002629-5A patent/BR112017002629A2/pt not_active Application Discontinuation
- 2015-08-14 US US15/504,191 patent/US10287583B2/en not_active Expired - Fee Related
- 2015-08-14 ES ES15832083T patent/ES2750689T3/es active Active
- 2015-08-14 CN CN201580042835.6A patent/CN106661578B/zh not_active Expired - Fee Related
- 2015-08-14 EP EP15832083.8A patent/EP3180434B1/en not_active Not-in-force
-
2019
- 2019-03-19 US US16/358,013 patent/US10683502B2/en not_active Expired - Fee Related
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2020
- 2020-05-14 JP JP2020084841A patent/JP2020141688A/ja active Pending
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