JP6705807B2 - 疼痛を治療するためのオリゴヌクレオチドデコイ - Google Patents

疼痛を治療するためのオリゴヌクレオチドデコイ Download PDF

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JP6705807B2
JP6705807B2 JP2017508487A JP2017508487A JP6705807B2 JP 6705807 B2 JP6705807 B2 JP 6705807B2 JP 2017508487 A JP2017508487 A JP 2017508487A JP 2017508487 A JP2017508487 A JP 2017508487A JP 6705807 B2 JP6705807 B2 JP 6705807B2
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transcription factor
oligonucleotide
pain
factor binding
klf9
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JP2017529834A5 (enExample
JP2017529834A (ja
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ジュリエン マメット
ジュリエン マメット
リック オーア
リック オーア
ドン マニング
ドン マニング
スコット ハリス
スコット ハリス
ウィリアム マーチン
ウィリアム マーチン
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エーダイニクス インコーポレイテッド
エーダイニクス インコーポレイテッド
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/13Decoys

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2017508487A 2014-08-15 2015-08-14 疼痛を治療するためのオリゴヌクレオチドデコイ Expired - Fee Related JP6705807B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462037996P 2014-08-15 2014-08-15
US62/037,996 2014-08-15
PCT/US2015/045268 WO2016025829A1 (en) 2014-08-15 2015-08-14 Oligonucleotide decoys for the treatment of pain

Related Child Applications (1)

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JP2020084841A Division JP2020141688A (ja) 2014-08-15 2020-05-14 疼痛を治療するためのオリゴヌクレオチドデコイ

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JP2017529834A JP2017529834A (ja) 2017-10-12
JP2017529834A5 JP2017529834A5 (enExample) 2018-09-13
JP6705807B2 true JP6705807B2 (ja) 2020-06-03

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JP2017508487A Expired - Fee Related JP6705807B2 (ja) 2014-08-15 2015-08-14 疼痛を治療するためのオリゴヌクレオチドデコイ
JP2020084841A Pending JP2020141688A (ja) 2014-08-15 2020-05-14 疼痛を治療するためのオリゴヌクレオチドデコイ

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US (2) US10287583B2 (enExample)
EP (2) EP3180434B1 (enExample)
JP (2) JP6705807B2 (enExample)
CN (1) CN106661578B (enExample)
AU (1) AU2015301491A1 (enExample)
BR (1) BR112017002629A2 (enExample)
CA (1) CA2957250A1 (enExample)
ES (1) ES2750689T3 (enExample)
PT (1) PT3180434T (enExample)
RU (1) RU2017108238A (enExample)
WO (1) WO2016025829A1 (enExample)

Families Citing this family (7)

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Publication number Priority date Publication date Assignee Title
JP5646320B2 (ja) 2007-05-11 2014-12-24 アダイニクス, インコーポレイテッド 遺伝子発現と疼痛
PT2846839T (pt) 2012-05-10 2019-05-29 Adynxx Inc Formulações para a administração de ingredientes ativos
PT3180434T (pt) 2014-08-15 2019-10-29 Adynxx Inc Chamarizes oligonucleotídicos para o tratamento da dor
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JP2022512489A (ja) * 2018-12-24 2022-02-04 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア キメラデコイを使用する脊柱症状の治療
US12031134B2 (en) 2020-08-13 2024-07-09 Nevada Research & Innovation Corporation KLF11 siRNA for treatment of diabetes and obesity
US20250011787A1 (en) 2021-10-21 2025-01-09 The J. David Gladstone Institutes, a testamentary trust established under the Will of J. David Glads Retroelement-generated transcription factor decoys

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Publication number Publication date
CA2957250A1 (en) 2016-02-18
US10287583B2 (en) 2019-05-14
AU2015301491A1 (en) 2017-02-02
BR112017002629A2 (pt) 2018-02-20
US20190276825A1 (en) 2019-09-12
PT3180434T (pt) 2019-10-29
RU2017108238A (ru) 2018-09-17
US10683502B2 (en) 2020-06-16
CN106661578A (zh) 2017-05-10
EP3626822A1 (en) 2020-03-25
EP3180434B1 (en) 2019-07-17
US20170247694A1 (en) 2017-08-31
WO2016025829A1 (en) 2016-02-18
RU2017108238A3 (enExample) 2019-09-18
JP2020141688A (ja) 2020-09-10
EP3180434A1 (en) 2017-06-21
ES2750689T3 (es) 2020-03-26
JP2017529834A (ja) 2017-10-12
CN106661578B (zh) 2020-08-04
EP3180434A4 (en) 2018-04-04

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