|
US6410516B1
(en)
|
1986-01-09 |
2002-06-25 |
President & Fellows Of Harvard College |
Nuclear factors associated with transcriptional regulation
|
|
US5206152A
(en)
|
1988-04-08 |
1993-04-27 |
Arch Development Corporation |
Cloning and expression of early growth regulatory protein genes
|
|
DE3815221C2
(de)
|
1988-05-04 |
1995-06-29 |
Gradinger F Hermes Pharma |
Verwendung einer Retinol- und/oder Retinsäureester enthaltenden pharmazeutischen Zubereitung zur Inhalation zur Einwirkung auf die Schleimhäute des Tracheo-Bronchialtraktes einschließlich der Lungenalveolen
|
|
KR100225087B1
(ko)
|
1990-03-23 |
1999-10-15 |
한스 발터라벤 |
피타아제의 식물내 발현
|
|
US5272056A
(en)
|
1991-01-03 |
1993-12-21 |
The Research Foundation Of State University Of New York |
Modification of DNA and oligonucleotides using metal complexes of polyaza ligands
|
|
EP0580754A1
(en)
|
1991-04-18 |
1994-02-02 |
The Salk Institute For Biological Studies |
Oligodeoxynucleotides and oligonucleotides useful as decoys for proteins which selectively bind to defined dna sequences
|
|
FR2675803B1
(fr)
|
1991-04-25 |
1996-09-06 |
Genset Sa |
Oligonucleotides fermes, antisens et sens et leurs applications.
|
|
AU659482B2
(en)
|
1991-06-28 |
1995-05-18 |
Massachusetts Institute Of Technology |
Localized oligonucleotide therapy
|
|
WO1995004064A1
(en)
|
1993-07-29 |
1995-02-09 |
The Regents Of The University Of California |
Polynucleotide decoys that ihnibit mhc-ii expression and uses thereof
|
|
EP0732929B1
(en)
|
1993-10-29 |
2008-05-14 |
The Brigham And Women's Hospital, Inc. |
Therapeutic use of cis-element decoys in vivo
|
|
US6034234A
(en)
|
1994-11-17 |
2000-03-07 |
Taiho Pharmaceutical Co., Ltd. |
Double-stranded oligonucleotide and anticancer agent containing the same as active ingredient
|
|
WO1996029433A1
(en)
|
1995-03-23 |
1996-09-26 |
Research Foundation Of State University Of New York |
Rest protein and dna
|
|
DK0824588T3
(da)
|
1995-05-11 |
2004-08-16 |
Applied Research Systems |
Inhibitor af IL-6 aktivitet
|
|
DE69636997T2
(de)
|
1995-05-12 |
2007-07-12 |
Anges MG Inc., Ibaraki |
HEILUNG UND VORBEUGUNG VON DURCH NF-kappaB VERURSACHTEN ERKRANKUNGEN
|
|
GB9515356D0
(en)
|
1995-07-26 |
1995-09-20 |
Medical Res Council |
Improvements in or relating to delivery of nucleic acid
|
|
US6265389B1
(en)
|
1995-08-31 |
2001-07-24 |
Alkermes Controlled Therapeutics, Inc. |
Microencapsulation and sustained release of oligonucleotides
|
|
US6245747B1
(en)
|
1996-03-12 |
2001-06-12 |
The Board Of Regents Of The University Of Nebraska |
Targeted site specific antisense oligodeoxynucleotide delivery method
|
|
AU737926B2
(en)
|
1996-05-20 |
2001-09-06 |
Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The |
Oligonucleotides which specifically bind retroviral nucleocapsid proteins
|
|
US6022863A
(en)
|
1996-05-21 |
2000-02-08 |
Yale University |
Regulation of gene expression
|
|
JP3614866B2
(ja)
|
1997-06-12 |
2005-01-26 |
リサーチ コーポレイション テクノロジーズ，インコーポレイティド |
人工抗体ポリペプチド
|
|
JP4215219B2
(ja)
|
1997-07-04 |
2009-01-28 |
アンジェスＭｇ株式会社 |
脳保護剤
|
|
JP3667047B2
(ja)
|
1997-09-12 |
2005-07-06 |
キヤノン株式会社 |
人工核酸およびその製造方法、デオキシリボフラノース化合物、リボフラノース化合物およびこれらの製造方法
|
|
DE19742706B4
(de)
|
1997-09-26 |
2013-07-25 |
Pieris Proteolab Ag |
Lipocalinmuteine
|
|
US6376471B1
(en)
|
1997-10-10 |
2002-04-23 |
Johns Hopkins University |
Gene delivery compositions and methods
|
|
US6060310A
(en)
|
1997-11-24 |
2000-05-09 |
The United States Of America As Represented By The Department Of Health And Human Services |
Transcription factor decoy and tumor growth inhibitor
|
|
AU1656299A
(en)
|
1997-12-16 |
1999-07-05 |
University Of Saskatchewan |
Conductive metal-containing nucleic acids
|
|
AUPP221098A0
(en)
|
1998-03-06 |
1998-04-02 |
Diatech Pty Ltd |
V-like domain binding molecules
|
|
PL345207A1
(en)
|
1998-06-02 |
2001-12-03 |
Glaxo Group Ltd |
Gene therapy method
|
|
US6818626B1
(en)
|
1998-07-17 |
2004-11-16 |
Mirus Corporation |
Chelating systems for use in the delivery of compounds to cells
|
|
US6867289B1
(en)
|
1998-10-26 |
2005-03-15 |
Board Of Regents, The University Of Texas Systems |
Thio-modified aptamer synthetic methods and compositions
|
|
US6008048A
(en)
|
1998-12-04 |
1999-12-28 |
Isis Pharmaceuticals Inc. |
Antisense inhibition of EGR-1 expression
|
|
US7115396B2
(en)
|
1998-12-10 |
2006-10-03 |
Compound Therapeutics, Inc. |
Protein scaffolds for antibody mimics and other binding proteins
|
|
US7160869B2
(en)
|
1998-12-16 |
2007-01-09 |
University Of Saskatchewan |
Biologically active metal-containing nucleic acids
|
|
EP1141366B1
(en)
|
1998-12-23 |
2007-02-21 |
Genentech, Inc. |
Transfectacons comprising calcium phosphate and a nucleic acid
|
|
US6395029B1
(en)
|
1999-01-19 |
2002-05-28 |
The Children's Hospital Of Philadelphia |
Sustained delivery of polyionic bioactive agents
|
|
US6333408B1
(en)
|
1999-03-08 |
2001-12-25 |
Kureha Chemical Industry Co., Ltd. |
Oligonucleotides inhibitors of PAI-1 MRNA
|
|
FR2790955B1
(fr)
|
1999-03-19 |
2003-01-17 |
Assist Publ Hopitaux De Paris |
Utilisation d'oligonucleotides stabilises comme principe actif antitumoral
|
|
US6387620B1
(en)
|
1999-07-28 |
2002-05-14 |
Gilead Sciences, Inc. |
Transcription-free selex
|
|
CA2300328A1
(en)
|
1999-09-14 |
2001-03-14 |
Cardiogene Gentherap. Systeme Ag |
Modulating transcription of genes in vascular cells
|
|
US6927027B2
(en)
|
1999-12-21 |
2005-08-09 |
Ingeneus Corporation |
Nucleic acid multiplex formation
|
|
US6969704B1
(en)
|
2000-08-25 |
2005-11-29 |
The Trustees Of Columbia University In The City Of New York |
Methods for suppressing early growth response—1protein (Egr-1) to reduce vascular injury in a subject
|
|
JP5291279B2
(ja)
|
2000-09-08 |
2013-09-18 |
ウニヴェルジテート・チューリッヒ |
反復モジュールを含む反復タンパク質の集合体
|
|
US6376190B1
(en)
|
2000-09-22 |
2002-04-23 |
Somalogic, Inc. |
Modified SELEX processes without purified protein
|
|
DE10049549A1
(de)
*
|
2000-10-06 |
2002-05-02 |
Markus Hecker |
Modulation der Transkription pro-inflammatorischer Genprodukte
|
|
CA2462081A1
(en)
|
2000-10-11 |
2002-04-18 |
Laura Kragie |
Composition and method of alleviating adverse side effects and/or enhancing efficacy of agents that inhibit aromatase
|
|
US6596541B2
(en)
|
2000-10-31 |
2003-07-22 |
Regeneron Pharmaceuticals, Inc. |
Methods of modifying eukaryotic cells
|
|
AU2001292310A1
(en)
|
2000-11-24 |
2002-06-03 |
Chugai Seiyaku Kabushiki Kaisha |
Method of regulating the activity of expression product of gene transferred intoliving body
|
|
WO2002066071A2
(en)
|
2001-01-03 |
2002-08-29 |
Thomas Jefferson University |
Treatment of tissue fibrosis by blocking the sp1 transcription factor
|
|
US7060690B2
(en)
|
2001-01-22 |
2006-06-13 |
Genta Incorporated |
Methods and compositions for treating a cell-proliferative disorder using CRE decoy oligomers, BCL-2 antisense oligomers, and hybrid oligomers thereof
|
|
DE60225899T2
(de)
|
2001-02-20 |
2009-04-09 |
AnGes MG Inc., Ibaraki-shi |
TOPISCHE ANWENDUNG EINES NF-kB DECOYS ZUR BEHANDLUNG ATOPISCHER DERMATITIS
|
|
AU2002254132A1
(en)
|
2001-03-06 |
2002-09-19 |
Sierra Sciences, Inc. |
Methods and compositions for modulating telomerase reverse transcriptase (tert) expression
|
|
US20030166555A1
(en)
|
2001-04-02 |
2003-09-04 |
Alberini Cristina M. |
Methods and compositions for regulating memory consolidation
|
|
US20040175756A1
(en)
|
2001-04-26 |
2004-09-09 |
Avidia Research Institute |
Methods for using combinatorial libraries of monomer domains
|
|
US20050053973A1
(en)
|
2001-04-26 |
2005-03-10 |
Avidia Research Institute |
Novel proteins with targeted binding
|
|
JP4369662B2
(ja)
|
2001-04-26 |
2009-11-25 |
アビディア インコーポレイテッド |
単量体ドメインのコンビナトリアルライブラリー
|
|
EP1298141A1
(en)
|
2001-09-27 |
2003-04-02 |
Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts |
Interleukin-4 (IL-4) promoter sequences specifically interacting with IRF-1 and IRF-2
|
|
DE10148828B4
(de)
|
2001-10-04 |
2005-05-19 |
Avontec Gmbh |
Modulation der Expression STAT-1-abhängiger Gene
|
|
US6663880B1
(en)
|
2001-11-30 |
2003-12-16 |
Advanced Cardiovascular Systems, Inc. |
Permeabilizing reagents to increase drug delivery and a method of local delivery
|
|
JP2005519917A
(ja)
|
2002-02-01 |
2005-07-07 |
オメロス コーポレイション |
軟骨分解の全身阻害のための組成物および方法
|
|
US7244592B2
(en)
|
2002-03-07 |
2007-07-17 |
Dyax Corp. |
Ligand screening and discovery
|
|
CN1240439C
(zh)
|
2002-03-28 |
2006-02-08 |
南京凯基生物科技发展有限公司 |
肿瘤基因开关药物
|
|
CA2483505A1
(en)
|
2002-04-26 |
2003-11-06 |
Anges Mg, Inc. |
Circular dumbbell decoy oligodeoxynucleotides (cdodn) containing dna bindings sites of transcription
|
|
DE10242319A1
(de)
|
2002-09-12 |
2004-03-25 |
Avontec Gmbh |
Funkionelle Korrektur der-786C/T-Varianz des humanen eNOS-Gens
|
|
DE10257421A1
(de)
|
2002-12-09 |
2004-07-08 |
Grünenthal GmbH |
Regulatorische Elemente im 5'-Bereich des VR1-Gens
|
|
KR20140148502A
(ko)
|
2002-12-09 |
2014-12-31 |
아브락시스 바이오사이언스, 엘엘씨 |
약리학적 물질의 조성물 및 그 전달방법
|
|
JP2007528707A
(ja)
|
2003-06-30 |
2007-10-18 |
マサチューセッツ インスティテュート オブ テクノロジー |
統合失調症の診断および治療のための標的としてのｅｇｒ遺伝子
|
|
US20080233644A1
(en)
|
2003-09-12 |
2008-09-25 |
Helen Fillmore |
Chimeric Transcription Factor Decoy Oligonucleotides
|
|
WO2005062854A2
(en)
|
2003-12-19 |
2005-07-14 |
University Of Cincinnati |
Polyamides for nucleic acid delivery
|
|
JP2005336081A
(ja)
|
2004-05-26 |
2005-12-08 |
Anges Mg Inc |
Ｎｒ２ｂ−ｎｍｄａ受容体の再発現抑制剤
|
|
US7482158B2
(en)
|
2004-07-01 |
2009-01-27 |
Mathison Brian H |
Composite polynucleic acid therapeutics
|
|
WO2006012625A2
(en)
|
2004-07-22 |
2006-02-02 |
University Of Pittsburgh - Of The Commonwealth System Of Higher Education |
Stat3 decoy oligonucleotides and uses therefor
|
|
AU2005286640A1
(en)
|
2004-09-21 |
2006-03-30 |
Anesiva, Inc. |
Delivery of polynucleotides
|
|
AU2005288522B2
(en)
|
2004-09-28 |
2012-06-28 |
Quark Pharmaceuticals, Inc. |
Oligoribonucleotides and methods of use thereof for treatment of alopecia, acute renal failure and other diseases
|
|
WO2006043722A1
(ja)
|
2004-10-22 |
2006-04-27 |
Anges Mg, Inc. |
キメラ（ダブル）デコイ
|
|
US7585848B2
(en)
|
2005-01-11 |
2009-09-08 |
Rush University Medical Center |
Methods and compositions for treating, inhibiting and reversing disorders of the intervertebral disc
|
|
US8268572B2
(en)
|
2005-03-04 |
2012-09-18 |
Dana-Farber Cancer Institute, Inc. |
Methods to identify inhibitors of Runx1-mediated expression of nociceptive receptors and ion channels
|
|
ATE524546T1
(de)
|
2005-03-25 |
2011-09-15 |
Medtronic Inc |
Verwendung von anti-tnf oder anti-il1-rnai zur unterdrückung der wirkung entzündungsfördernder cytokine zur lokalen schmerzbehandlung
|
|
ES2845146T3
(es)
|
2006-10-09 |
2021-07-26 |
Neurofluidics Inc |
Sistema de purificación de líquido cefalorraquídeo
|
|
CA2682135A1
(en)
|
2007-04-17 |
2008-10-30 |
Baxter International Inc. |
Nucleic acid microparticles for pulmonary delivery
|
|
AU2014201462B2
(en)
|
2007-05-11 |
2016-09-29 |
Adynxx, Inc. |
Gene expression and pain
|
|
EP3199635B1
(en)
*
|
2007-05-11 |
2019-02-06 |
Adynxx, Inc. |
Gene expression and pain
|
|
GB0906130D0
(en)
*
|
2008-10-03 |
2009-05-20 |
Procrata Biosystems Ltd |
Transcription factor decoys
|
|
US8609617B2
(en)
*
|
2009-09-04 |
2013-12-17 |
University Of Miami |
KLF family members regulate intrinsic axon regeneration ability
|
|
KR20150039873A
(ko)
|
2010-08-20 |
2015-04-13 |
레플리코르 인코포레이티드 |
올리고뉴클레오타이드 킬레이트 복합체
|
|
EP2723865B1
(en)
|
2011-06-21 |
2019-03-27 |
Alnylam Pharmaceuticals, Inc. |
METHODS FOR DETERMINING ACTIVITY OF RNAi IN A SUBJECT
|
|
EP3257505A1
(en)
|
2011-07-20 |
2017-12-20 |
Hospira, Inc. |
Compositions comprising diclofenac for the treatment of post-operative pain
|
|
CN104487096B
(zh)
|
2012-05-10 |
2020-09-15 |
埃迪恩克斯股份有限公司 |
用于活性成分递送的配制物
|
|
CA2873529C
(en)
|
2012-05-18 |
2020-08-18 |
Replicor Inc. |
Oligonucleotide chelate complex-polypeptide compositions and methods
|
|
AU2015301491A1
(en)
|
2014-08-15 |
2017-02-02 |
Adynxx, Inc. |
Oligonucleotide decoys for the treatment of pain
|
|
US20200017853A1
(en)
|
2016-02-29 |
2020-01-16 |
Adynxx, Inc. |
Compositions and methods for pain amelioration via modification of gene expression
|
|
US20200405742A1
(en)
|
2018-02-23 |
2020-12-31 |
Adynxx Sub, Inc. |
Compositions and methods for pain amelioration in patient population that scores high on the pain catastrophizing scale
|