|
CA2674291C
(en)
*
|
2007-01-12 |
2015-11-24 |
Novartis Ag |
New process
|
|
AU2012202949B2
(en)
*
|
2008-01-17 |
2015-01-22 |
Novartis Ag |
Process and intermediates for the preparation of 5-biphenyl-4-yl-2-methylpentanoic acid derivatives
|
|
AR070176A1
(es)
*
|
2008-01-17 |
2010-03-17 |
Novartis Ag |
Procesos de sintesis de inhibidores de nep, compuestos intermediarios y uso de los mismos en la sintesis
|
|
ES2523734T3
(es)
|
2009-05-28 |
2014-12-01 |
Novartis Ag |
Derivados aminopropiónicos sustituidos como inhibidores de neprilisina
|
|
EP3048100A1
(en)
|
2009-05-28 |
2016-07-27 |
Novartis AG |
Substituted aminobutyric derivatives as neprilysin inhibitors
|
|
JO2967B1
(en)
|
2009-11-20 |
2016-03-15 |
نوفارتس ايه جي |
Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors
|
|
ES2550485T3
(es)
*
|
2010-01-22 |
2015-11-10 |
Novartis Ag |
Intermedios de inhibidores de la endopeptidasa neutra y método de preparación de los mismos
|
|
ES2608780T3
(es)
|
2010-08-23 |
2017-04-17 |
Novartis Ag |
Nuevo proceso para la preparación de intermediarios útiles para la elaboración de inhibidores de NEP
|
|
MX2013002150A
(es)
|
2010-08-23 |
2013-04-03 |
Novartis Ag |
Proceso para la preparacion de intermediarios para la elaboracion de inhibidores de nep.
|
|
US8673974B2
(en)
|
2010-11-16 |
2014-03-18 |
Novartis Ag |
Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors
|
|
US8993631B2
(en)
|
2010-11-16 |
2015-03-31 |
Novartis Ag |
Method of treating contrast-induced nephropathy
|
|
US8877815B2
(en)
*
|
2010-11-16 |
2014-11-04 |
Novartis Ag |
Substituted carbamoylcycloalkyl acetic acid derivatives as NEP
|
|
BR112013014952A2
(pt)
|
2010-12-15 |
2017-05-30 |
Theravance Inc |
inibidores de neprilisina
|
|
HRP20151115T1
(en)
|
2010-12-15 |
2015-11-20 |
Theravance Biopharma R&D Ip, Llc |
Neprilysin inhibitors
|
|
EP2675795B1
(en)
|
2011-02-17 |
2016-04-20 |
Theravance Biopharma R&D IP, LLC |
Substituted aminobutyric derivatives as neprilysin inhibitors
|
|
WO2012154249A1
(en)
|
2011-02-17 |
2012-11-15 |
Theravance, Inc. |
Substituted aminobutyric derivatives as neprilysin inhibitors
|
|
JP5959074B2
(ja)
|
2011-05-31 |
2016-08-02 |
セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー |
ネプリライシン阻害剤
|
|
CN103748070B
(zh)
|
2011-05-31 |
2015-06-24 |
施万生物制药研发Ip有限责任公司 |
脑啡肽酶抑制剂
|
|
EP2714660B1
(en)
|
2011-05-31 |
2018-09-26 |
Theravance Biopharma R&D IP, LLC |
Neprilysin inhibitors
|
|
TWI560172B
(en)
|
2011-11-02 |
2016-12-01 |
Theravance Biopharma R&D Ip Llc |
Neprilysin inhibitors
|
|
TWI562986B
(en)
*
|
2012-02-15 |
2016-12-21 |
Theravance Biopharma R&D Ip Llc |
Process for preparing 4-amino-5-biphenyl-4-yl-2-hydroxymethyl-2-methyl-pentanoic acid compounds
|
|
CN104350052B
(zh)
|
2012-05-31 |
2017-05-31 |
施万生物制药研发Ip有限责任公司 |
一氧化氮供体脑啡肽酶抑制剂
|
|
CA2873328A1
(en)
|
2012-06-08 |
2013-12-12 |
Theravance Biopharma R&D Ip, Llc |
Neprilysin inhibitors
|
|
RS55967B1
(sr)
|
2012-06-08 |
2017-09-29 |
Theravance Biopharma R&D Ip Llc |
Inhibitori neprilizina
|
|
SMT201700134T1
(it)
|
2012-08-08 |
2017-05-08 |
Theravance Biopharma R&D Ip Llc |
Inibitori della neprilisina
|
|
CN105073762B
(zh)
|
2013-02-14 |
2017-03-08 |
诺华股份有限公司 |
作为nep(中性内肽酶)抑制剂的取代的联苯丁酰膦酸衍生物
|
|
WO2014126972A1
(en)
|
2013-02-14 |
2014-08-21 |
Novartis Ag |
Substituted bisphenyl butanoic acid derivatives as nep inhibitors with improved in vivo efficacy
|
|
WO2014138053A1
(en)
|
2013-03-05 |
2014-09-12 |
Theravance Biopharma R&D Ip, Llc |
Neprilysin inhibitors
|
|
CN104230865B
(zh)
*
|
2013-06-13 |
2018-01-09 |
上海翰森生物医药科技有限公司 |
联芳基取代的4‑氨基丁酸衍生物及其制备方法和用途
|
|
CN105992763A
(zh)
|
2014-01-30 |
2016-10-05 |
施万生物制药研发Ip有限责任公司 |
脑啡肽酶抑制剂
|
|
SG11201606057PA
(en)
|
2014-01-30 |
2016-08-30 |
Theravance Biopharma R&D Ip Llc |
5-biphenyl-4-heteroarylcarbonylamino-pentanoic acid derivatives as neprilysin inhibitors
|
|
LT3218351T
(lt)
|
2014-11-14 |
2019-09-25 |
Zentiva K.S. |
Ahu-377 farmaciniu požiūriu priimtinų formų gavimo, atskyrimo ir gryninimo būdas
|
|
CN107074744B
(zh)
*
|
2014-12-03 |
2019-06-18 |
上海翰森生物医药科技有限公司 |
Nep抑制剂结晶型游离酸、钙盐多晶型及其制备方法和应用
|
|
CN104557600B
(zh)
*
|
2015-01-26 |
2016-05-04 |
苏州明锐医药科技有限公司 |
沙库比曲的制备方法
|
|
RU2726623C2
(ru)
|
2015-02-11 |
2020-07-15 |
ТЕРЕВАНС БАЙОФАРМА Ар энд Ди АйПи, ЭлЭлСи |
(2s,4r)-5-(5'-хлор-2'-фторбифенил-4-ил)-4-(этоксиоксалиламино)-2-гидроксиметил-2-метилпентановая кислота
|
|
TW201632493A
(zh)
|
2015-02-13 |
2016-09-16 |
諾華公司 |
新穎方法
|
|
RU2715241C2
(ru)
|
2015-02-19 |
2020-02-26 |
ТЕРЕВАНС БАЙОФАРМА Ар энд Ди АйПи, ЭлЭлСи |
(2r,4r)-5-(5′-хлор-2′-фторбифенил-4-ил)-2-гидрокси-4-[(5-метилоксазол-2-карбонил)амино]пентановая кислота
|
|
WO2016135751A1
(en)
|
2015-02-25 |
2016-09-01 |
Mylan Laboratories Limited |
Novel process for the preparation of sacubitril and its intermediates
|
|
CN106187808A
(zh)
*
|
2015-05-08 |
2016-12-07 |
苏州鹏旭医药科技有限公司 |
Ahu-377的制备方法、ahu-377中间体及ahu-377中间体的制备方法
|
|
CN104829514B
(zh)
*
|
2015-05-12 |
2017-10-03 |
江苏福瑞生物医药有限公司 |
一种药物中间体的合成方法
|
|
CN104926707B
(zh)
*
|
2015-05-12 |
2017-10-27 |
江苏福瑞生物医药有限公司 |
一种药物中间体的合成方法
|
|
CN104860894B
(zh)
*
|
2015-06-10 |
2017-05-17 |
北京博全健医药科技有限公司 |
一种抗心衰药lcz696的制备方法
|
|
WO2016203500A2
(en)
*
|
2015-06-19 |
2016-12-22 |
Actavis Group Ptc Ehf. |
Preparation of sacubitril or salt thereof and novel intermediates in the preparation of sacubitril
|
|
DK3317248T3
(da)
*
|
2015-07-02 |
2020-12-14 |
Novartis Ag |
Sacubitrilcalciumsalte
|
|
WO2017006254A1
(en)
|
2015-07-08 |
2017-01-12 |
Novartis Ag |
Drug combination comprising an angiotensin ii receptor antagonist, a neutral endopeptidase inhibitor and a mineralcorticoid receptor antagonist
|
|
CN105061263B
(zh)
*
|
2015-08-11 |
2017-03-15 |
苏州楚凯药业有限公司 |
一种nep抑制剂中间体的制备方法
|
|
CN105168205A
(zh)
*
|
2015-08-18 |
2015-12-23 |
泰力特医药（湖北）有限公司 |
一种血管紧张素ii受体和脑啡肽酶受体双重抑制剂lcz696的制备方法
|
|
WO2017033128A1
(en)
|
2015-08-25 |
2017-03-02 |
Novartis Ag |
Biphenyl-substitued 4-amino-butyric acid derivatives and their use in the synthesis of nep inhibitors
|
|
CN105130869B
(zh)
*
|
2015-09-07 |
2017-12-26 |
曾伟 |
一种Entresto中间体(S)‑5‑(联苯‑4‑羰基)吡咯烷‑2‑酮的合成方法
|
|
WO2017051326A1
(en)
|
2015-09-23 |
2017-03-30 |
Novartis Ag |
New processes and intermediates useful in synthesis of nep inhibitors
|
|
CN105348209B
(zh)
|
2015-12-09 |
2017-12-26 |
浙江天宇药业股份有限公司 |
一种抗心衰药lcz696的制备方法
|
|
CN105523964B
(zh)
*
|
2015-12-09 |
2017-05-24 |
苏州楚凯药业有限公司 |
一种抗心衰药物中间体的制备方法
|
|
US10377697B2
(en)
*
|
2015-12-10 |
2019-08-13 |
Novartis Ag |
Process and intermediates
|
|
BR112018011788A2
(pt)
|
2015-12-11 |
2018-12-04 |
Zentiva Ks |
formas sólidas de éster etílico de ácido (2r,4s)-5-(bifenil-4-il)-4-[(3-carboxipropionil)amino]-2-metil-pentanoico, seus sais e um método de preparação
|
|
CN106977415B
(zh)
*
|
2016-01-15 |
2021-03-26 |
广东东阳光药业有限公司 |
一种沙库必曲的中间体及其制备方法
|
|
CN105566194A
(zh)
*
|
2016-02-01 |
2016-05-11 |
张伯引 |
一种Sacubitril中间体的制备方法
|
|
EP3424899B1
(en)
*
|
2016-02-29 |
2022-05-11 |
Sunshine Lake Pharma Co., Ltd. |
Sacubitril intermediate and preparation method thereof
|
|
US10100021B2
(en)
|
2016-03-08 |
2018-10-16 |
Theravance Biopharma R&D Ip, Llc |
Crystalline(2S,4R)-5-(5′-chloro-2′-fluoro-[1,1′-biphenyl]-4-yl)-2-(ethoxymethyl)-4-(3-hydroxyisoxazole-5-carboxamido)-2-methylpentanoic acid and uses thereof
|
|
WO2017191620A1
(en)
*
|
2016-05-06 |
2017-11-09 |
Sun Pharmaceutical Industries Limited |
A crystalline form of a salt of sacubitril and a process of its preparation
|
|
CN105924355B
(zh)
*
|
2016-05-11 |
2018-08-17 |
浙江宏元药业有限公司 |
沙库比曲中间体及沙库比曲中间体和沙库比曲的制备方法
|
|
WO2018007919A1
(en)
|
2016-07-05 |
2018-01-11 |
Novartis Ag |
New process for early sacubitril intermediates
|
|
CN107602399B
(zh)
*
|
2016-07-11 |
2020-09-25 |
江西东邦药业有限公司 |
一种脑啡肽酶抑制剂中间体的制备方法
|
|
EP3500549B1
(en)
|
2016-08-17 |
2020-12-16 |
Novartis AG |
New processes and intermediates for nep inhibitor synthesis
|
|
CN106496055A
(zh)
*
|
2016-10-09 |
2017-03-15 |
杭州科巢生物科技有限公司 |
一种抗心衰新药的关键组分沙库比曲的新合成方法
|
|
US10857132B2
(en)
*
|
2016-10-10 |
2020-12-08 |
Laurus Labs Limited |
Stable amorphous form of sacubitril valsartan trisodium complex and processes for preparation thereof
|
|
CN110088079A
(zh)
|
2016-12-23 |
2019-08-02 |
诺华股份有限公司 |
用于早期沙卡布曲中间体的新方法
|
|
CN107311909A
(zh)
*
|
2017-06-22 |
2017-11-03 |
东南大学 |
一种lcz696杂质对照品的制备方法
|
|
CN109206419B
(zh)
*
|
2017-06-29 |
2023-07-14 |
上海迪赛诺化学制药有限公司 |
沙库比曲中间体及其制备方法和应用
|
|
WO2019110371A1
(en)
*
|
2017-12-05 |
2019-06-13 |
Basf Se |
Organic sulfonic acid salts of amino acid esters and process for their preparation
|
|
UY38072A
(es)
|
2018-02-07 |
2019-10-01 |
Novartis Ag |
Compuestos derivados de éster butanoico sustituido con bisfenilo como inhibidores de nep, composiciones y combinaciones de los mismos
|
|
CN110407733A
(zh)
*
|
2018-04-26 |
2019-11-05 |
鲁南制药集团股份有限公司 |
一种沙库巴曲杂质化合物
|
|
CN110551151A
(zh)
*
|
2018-05-30 |
2019-12-10 |
微宏动力系统（湖州）有限公司 |
一种磷酸酯或亚磷酸酯的制备方法、电解液及二次电池
|
|
CN108727213B
(zh)
*
|
2018-06-29 |
2021-06-08 |
中国科学院上海有机化学研究所 |
一种沙库必曲的制备方法
|
|
WO2020039394A1
(en)
|
2018-08-24 |
2020-02-27 |
Novartis Ag |
New drug combinations
|
|
CN109456212A
(zh)
*
|
2018-12-03 |
2019-03-12 |
康化（上海）新药研发有限公司 |
一种沙库比曲中间体的合成方法
|
|
CN109400504A
(zh)
*
|
2018-12-11 |
2019-03-01 |
重庆三圣实业股份有限公司 |
Lcz696中间体非对映异构体的分离纯化方法
|
|
WO2020144030A1
(en)
|
2019-01-08 |
2020-07-16 |
Basf Se |
Process for the preparation of organosulfate salts of amino acids esters
|
|
CN109912486B
(zh)
*
|
2019-04-25 |
2022-09-27 |
东北制药集团股份有限公司 |
一种联苯甲基内酰胺化合物的制备方法
|
|
CN110878039A
(zh)
*
|
2019-12-18 |
2020-03-13 |
株洲千金药业股份有限公司 |
一种沙库巴曲缬沙坦钠杂质的制备方法
|
|
JP7064527B2
(ja)
*
|
2020-05-01 |
2022-05-10 |
ノバルティス アーゲー |
サクビトリルカルシウム塩
|
|
KR20230035612A
(ko)
|
2020-07-09 |
2023-03-14 |
어드밴식스 레진즈 앤드 케미컬즈 엘엘씨 |
분지형 아미노산 계면활성제
|
|
US11787967B2
(en)
|
2020-07-13 |
2023-10-17 |
Advansix Resins & Chemicals Llc |
Branched amino acid surfactants for inks, paints, and adhesives
|
|
AU2021307397B2
(en)
|
2020-07-13 |
2024-06-13 |
Advansix Resins & Chemicals Llc |
Branched amino acid surfactants for use in healthcare products
|
|
US12071578B2
(en)
|
2020-07-13 |
2024-08-27 |
Advansix Resins & Chemicals Llc |
Branched amino acid surfactants for electronics products
|
|
MY207213A
(en)
|
2020-07-13 |
2025-02-06 |
Advansix Resins & Chemicals Llc |
Branched amino acid surfactants for personal care and cosmetic products
|
|
MX2023000568A
(es)
|
2020-07-13 |
2023-02-13 |
Advansix Resins & Chemicals Llc |
Tensioactivos de aminoacidos ramificados para la produccion de gas y petroleo.
|
|
JP7473736B2
(ja)
|
2020-07-13 |
2024-04-23 |
アドバンシックス・レジンズ・アンド・ケミカルズ・リミテッド・ライアビリティ・カンパニー |
クリーニング製品用分岐アミノ酸界面活性剤
|
|
CN115677521B
(zh)
*
|
2022-11-16 |
2024-02-02 |
迪嘉药业集团股份有限公司 |
一种高纯度沙库巴曲钙的制备方法
|
|
CN117447341B
(zh)
*
|
2023-09-06 |
2025-11-18 |
杭州国瑞生物科技有限公司 |
一种沙库巴曲缬沙坦钠中间体的精制方法
|
|
CN117756622A
(zh)
*
|
2023-12-21 |
2024-03-26 |
安徽皓元药业有限公司 |
一种沙库巴曲关键中间体的制备方法
|