JP2010512795A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2010512795A5 JP2010512795A5 JP2009543078A JP2009543078A JP2010512795A5 JP 2010512795 A5 JP2010512795 A5 JP 2010512795A5 JP 2009543078 A JP2009543078 A JP 2009543078A JP 2009543078 A JP2009543078 A JP 2009543078A JP 2010512795 A5 JP2010512795 A5 JP 2010512795A5
- Authority
- JP
- Japan
- Prior art keywords
- lipase
- seq
- amylase
- protease
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000004367 Lipase Substances 0.000 claims 11
- 102000004882 Lipase Human genes 0.000 claims 11
- 108090001060 Lipase Proteins 0.000 claims 11
- 235000019421 lipase Nutrition 0.000 claims 11
- 239000004382 Amylase Substances 0.000 claims 10
- 102000013142 Amylases Human genes 0.000 claims 10
- 108010065511 Amylases Proteins 0.000 claims 10
- 108091005804 Peptidases Proteins 0.000 claims 10
- 239000004365 Protease Substances 0.000 claims 10
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 10
- 235000019418 amylase Nutrition 0.000 claims 10
- 150000001413 amino acids Chemical class 0.000 claims 9
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 102220479102 CD59 glycoprotein_N33Q_mutation Human genes 0.000 claims 3
- 238000006467 substitution reaction Methods 0.000 claims 2
- 201000003883 Cystic fibrosis Diseases 0.000 claims 1
- 208000035467 Pancreatic insufficiency Diseases 0.000 claims 1
- 206010033645 Pancreatitis Diseases 0.000 claims 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
- 230000001079 digestive effect Effects 0.000 claims 1
- 208000010643 digestive system disease Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 235000019626 lipase activity Nutrition 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 102200012371 rs879255637 Human genes 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87119606P | 2006-12-21 | 2006-12-21 | |
| US60/871,196 | 2006-12-21 | ||
| PCT/US2007/087168 WO2008079685A2 (en) | 2006-12-21 | 2007-12-12 | Lipase variants for pharmaceutical use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010512795A JP2010512795A (ja) | 2010-04-30 |
| JP2010512795A5 true JP2010512795A5 (enExample) | 2011-02-03 |
| JP5406040B2 JP5406040B2 (ja) | 2014-02-05 |
Family
ID=38043020
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009543078A Active JP5406040B2 (ja) | 2006-12-21 | 2007-12-12 | 医薬使用のためのリパーゼ変異体 |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US8273348B2 (enExample) |
| EP (6) | EP2455461B1 (enExample) |
| JP (1) | JP5406040B2 (enExample) |
| KR (1) | KR20090101930A (enExample) |
| CN (2) | CN105112386A (enExample) |
| AR (1) | AR064494A1 (enExample) |
| AU (1) | AU2007337150A1 (enExample) |
| BR (1) | BRPI0721103A2 (enExample) |
| CA (3) | CA2961041C (enExample) |
| IL (1) | IL198893A0 (enExample) |
| MX (1) | MX2009006597A (enExample) |
| NO (1) | NO20092729L (enExample) |
| RU (1) | RU2009128067A (enExample) |
| TW (1) | TW200829698A (enExample) |
| WO (1) | WO2008079685A2 (enExample) |
| ZA (1) | ZA200903598B (enExample) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5032300B2 (ja) | 2004-03-22 | 2012-09-26 | アボット プロダクツ ゲゼルシャフト ミット ベシュレンクテル ハフツング | 界面活性剤を含有している、リパーゼを含有する生成物の、とりわけパンクレアチンの経口医薬組成物 |
| EP2278002B1 (en) | 2005-07-29 | 2017-07-12 | Abbott Laboratories GmbH | Pancreatin with reduced viral content |
| US9198871B2 (en) | 2005-08-15 | 2015-12-01 | Abbott Products Gmbh | Delayed release pancreatin compositions |
| US11266607B2 (en) | 2005-08-15 | 2022-03-08 | AbbVie Pharmaceuticals GmbH | Process for the manufacture and use of pancreatin micropellet cores |
| US10072256B2 (en) | 2006-05-22 | 2018-09-11 | Abbott Products Gmbh | Process for separating and determining the viral load in a pancreatin sample |
| WO2008079685A2 (en) * | 2006-12-21 | 2008-07-03 | Novozymes A/S | Lipase variants for pharmaceutical use |
| JP2011513539A (ja) * | 2008-02-29 | 2011-04-28 | ザ プロクター アンド ギャンブル カンパニー | リパーゼを含む洗剤組成物 |
| MX2010009464A (es) | 2008-02-29 | 2010-09-22 | Dsm Ip Assets Bv | Lipasas con alta especificidad hacia acidos grasos de cadena corta y usos de las mismas. |
| EP2250258B1 (en) * | 2008-02-29 | 2017-01-04 | Novozymes A/S | Lipolytic enzyme variant with improved stability and polynucleotides encoding same |
| CA2782613C (en) | 2009-12-09 | 2016-08-23 | The Procter & Gamble Company | Fabric and home care products |
| US20140147895A1 (en) | 2011-07-22 | 2014-05-29 | Novozymes A/S | Processes for Pretreating Cellulosic Material and Improving Hydrolysis Thereof |
| US8268305B1 (en) | 2011-09-23 | 2012-09-18 | Bio-Cat, Inc. | Method and compositions to reduce serum levels of triacylglycerides in human beings using a fungal lipase |
| ES2680145T3 (es) * | 2011-12-29 | 2018-09-04 | Novozymes A/S | Composiciones detergentes con variantes de lipasa |
| US9394530B2 (en) * | 2012-02-03 | 2016-07-19 | Novozymes A/S | Lipase variants and polynucleotides encoding same |
| WO2013149858A1 (en) | 2012-04-02 | 2013-10-10 | Novozymes A/S | Lipase variants and polynucleotides encoding same |
| CA2887898A1 (en) * | 2012-10-12 | 2014-04-17 | Danisco Us Inc. | Compositions and methods comprising a lipolytic enzyme variant |
| CN115521831A (zh) * | 2013-05-14 | 2022-12-27 | 诺维信公司 | 洗涤剂组合物 |
| ES2956266T3 (es) * | 2013-07-19 | 2023-12-18 | Danisco Us Inc | Composiciones y procedimientos que comprenden una variante de enzima lipolítica |
| EP3221447A1 (en) * | 2014-11-20 | 2017-09-27 | Novozymes A/S | Alicyclobacillus variants and polynucleotides encoding same |
| US10457921B2 (en) | 2014-12-05 | 2019-10-29 | Novozymes A/S | Lipase variants and polynucleotides encoding same |
| MX382218B (es) * | 2014-12-09 | 2025-03-13 | Novozymes As | Variantes de lipasa y polinucleotidos que las codifican. |
| EP3280818A2 (en) | 2015-04-07 | 2018-02-14 | Novozymes A/S | Methods for selecting enzymes having lipase activity |
| EP3317407B1 (en) * | 2015-07-01 | 2021-05-19 | Novozymes A/S | Methods of reducing odor |
| US10760037B2 (en) * | 2015-07-03 | 2020-09-01 | Novozymes A/S | Sulfite compositions |
| US11326152B2 (en) | 2016-07-18 | 2022-05-10 | Novozymes A/S | Lipase variants, polynucleotides encoding same and the use thereof |
| JP7081767B2 (ja) * | 2017-01-30 | 2022-06-07 | 学校法人日本医科大学 | アデノ随伴ウイルス（ａａｖ）キャプシドタンパク質の変異体 |
| MX2020003779A (es) * | 2017-09-27 | 2020-08-03 | Procter & Gamble | Composiciones detergentes que comprenden lipasas. |
| JP7317811B2 (ja) * | 2017-09-27 | 2023-07-31 | ノボザイムス アクティーゼルスカブ | リパーゼ変異体及びかかるリパーゼ変異体を含むマイクロカプセル組成物 |
| WO2019154952A1 (en) * | 2018-02-08 | 2019-08-15 | Novozymes A/S | Lipase variants and compositions thereof |
| WO2020037100A1 (en) * | 2018-08-16 | 2020-02-20 | Isolere Bio, Inc. | Genetically encoded polypeptide for affinity capture and purification of biologics |
| CN111334369B (zh) * | 2020-03-11 | 2022-10-21 | 陕西科技大学 | 一种酶法制备卵磷脂型pufa的方法 |
| US12467042B2 (en) * | 2020-06-24 | 2025-11-11 | Dermapharm Aktiengesellschaft | Lipase enzyme |
| EP4237552A2 (en) * | 2020-10-29 | 2023-09-06 | Novozymes A/S | Lipase variants and compositions comprising such lipase variants |
| CN113846074B (zh) * | 2021-10-20 | 2022-10-21 | 南京林业大学 | 一种疏棉状嗜热丝孢菌脂肪酶突变体g91c及其应用 |
| AU2023272468A1 (en) | 2022-05-14 | 2024-11-14 | Novonesis Plant Biosolutions A/S | Compositions and methods for preventing, treating, supressing and/or eliminating phytopathogenic infestations and infections |
| CN119522274A (zh) * | 2022-06-24 | 2025-02-25 | 诺维信公司 | 脂肪酶变体和包含这样的脂肪酶变体的组合物 |
| CN120082537A (zh) * | 2023-12-01 | 2025-06-03 | 青岛蔚蓝生物集团有限公司 | 一种脂肪酶突变体 |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK173590D0 (da) | 1990-06-06 | 1990-07-19 | Novo Nordisk As | Rekombinante terapeutiske lipaser |
| DK46693D0 (enExample) | 1993-04-23 | 1993-04-23 | Novo Nordisk As | |
| US5869438A (en) | 1990-09-13 | 1999-02-09 | Novo Nordisk A/S | Lipase variants |
| JP3469234B2 (ja) * | 1990-09-13 | 2003-11-25 | ノボザイムス アクティーゼルスカブ | リパーゼ変異体 |
| DE69130113T2 (de) | 1990-12-05 | 1999-05-12 | Novo Nordisk A/S, Bagsvaerd | Proteine mit geänderten epitopen und verfahren zur deren herstellung |
| ATE169678T1 (de) | 1991-05-01 | 1998-08-15 | Novo Nordisk As | Stabilisierte enzyme |
| DK39693D0 (da) | 1993-04-02 | 1993-04-02 | Novo Nordisk As | Enzym |
| BR9407752A (pt) | 1993-10-04 | 1997-03-04 | Novo Nordisk As | Preparaçao de enzima aditivo detergente composiçao detergente processo para o tratamento de fibras lignocelulósicas |
| AU1806795A (en) | 1994-02-22 | 1995-09-04 | Novo Nordisk A/S | A method of preparing a variant of a lipolytic enzyme |
| JPH10509324A (ja) | 1994-11-24 | 1998-09-14 | ノボ ノルディスク アクティーゼルスカブ | 抑制されたアレルゲン性を有するポリペプチドの製造のための方法 |
| AU697440B2 (en) | 1994-12-07 | 1998-10-08 | Novozymes A/S | Polypeptide with reduced allergenicity |
| CA2209617C (en) | 1995-01-26 | 2002-05-28 | Novo Nordisk A/S | Animal feed additives comprising xylanase |
| WO1997004079A1 (en) | 1995-07-14 | 1997-02-06 | Novo Nordisk A/S | A modified enzyme with lipolytic activity |
| US6495357B1 (en) * | 1995-07-14 | 2002-12-17 | Novozyme A/S | Lipolytic enzymes |
| CN1192780B (zh) | 1995-08-11 | 2010-08-04 | 诺沃奇梅兹有限公司 | 新的脂解酶 |
| JP2002510963A (ja) | 1997-01-10 | 2002-04-09 | ノボザイムス アクティーゼルスカブ | スキンケア用酵素修飾体 |
| JP2001511162A (ja) | 1997-02-06 | 2001-08-07 | ノボ ノルディスク アクティーゼルスカブ | 付加され、そして／又は除去された付着基を有するポリペプチド−ポリマー結合体 |
| JP2002516615A (ja) | 1997-06-25 | 2002-06-04 | ノボザイムス アクティーゼルスカブ | 変性ポリペプチド |
| ATE328070T1 (de) * | 1998-02-17 | 2006-06-15 | Novozymes As | Lipasevariante |
| AU3247699A (en) | 1998-02-17 | 1999-09-06 | Novo Nordisk A/S | Lipase variant |
| WO2000022103A1 (en) | 1998-10-13 | 2000-04-20 | Novozymes A/S | A modified polypeptide with reduced immune response |
| DE69938435D1 (de) | 1998-10-30 | 2008-05-08 | Novozymes As | Niedrigallergene Proteinvarianten |
| CA2348822A1 (en) | 1998-10-30 | 2000-05-11 | Novozymes A/S | Glycosylated proteins having reduced allergenicity |
| EP1131416B1 (en) | 1998-11-27 | 2009-09-02 | Novozymes A/S | Lipolytic enzyme variants |
| US7312062B2 (en) * | 1998-11-27 | 2007-12-25 | Novozymes A/S | Lipolytic enzyme variants |
| TR200102784T2 (tr) | 1999-03-17 | 2002-04-22 | Solvay Pharmaceuticals Gmbh | Diyabet tedavisi için ilaç |
| EP1171581A1 (en) * | 1999-03-31 | 2002-01-16 | Novozymes A/S | Lipase variant |
| EP2278000A1 (en) * | 1999-03-31 | 2011-01-26 | Novozymes A/S | Lipase variant |
| WO2001058276A2 (en) | 2000-02-08 | 2001-08-16 | F Hoffmann-La Roche Ag | Use of acid-stable proteases in animal feed |
| WO2001083761A1 (en) | 2000-04-28 | 2001-11-08 | Novozymes A/S | Laccase mutants |
| DE60231700D1 (de) * | 2001-01-10 | 2009-05-07 | Novozymes As | Variante eines lipolytischen enzyms |
| AR032392A1 (es) | 2001-01-19 | 2003-11-05 | Solvay Pharm Gmbh | Mezcla de enzimas, preparado farmaceutico y utilizacion de dicho preparado. |
| CN1491278A (zh) | 2001-02-07 | 2004-04-21 | ŵά�Ź�˾ | 脂酶变体 |
| EP1468084A1 (en) * | 2002-01-16 | 2004-10-20 | Novozymes A/S | Lipolytic enzyme variants and method for their production |
| JP2007506405A (ja) | 2003-02-06 | 2007-03-22 | ノボザイムス アクティーゼルスカブ | 糸状菌におけるヒトｈ鎖抗体の発現 |
| EP2270139B1 (en) * | 2003-05-09 | 2016-07-27 | Novozymes A/S | Variant lipolytic enzymes |
| US20060236414A1 (en) | 2003-06-19 | 2006-10-19 | Novozymes A/S | Proteases and methods for producing them |
| EP1639102A2 (en) * | 2003-06-19 | 2006-03-29 | Novozymes A/S | Phospholipase variants |
| AR047440A1 (es) | 2004-01-21 | 2006-01-18 | Novozymes As | Produccion de un anticuerpo monoclonal en un hongo heterocarion o una celula huesped fungal |
| JP5032300B2 (ja) | 2004-03-22 | 2012-09-26 | アボット プロダクツ ゲゼルシャフト ミット ベシュレンクテル ハフツング | 界面活性剤を含有している、リパーゼを含有する生成物の、とりわけパンクレアチンの経口医薬組成物 |
| DK1809320T3 (da) | 2004-10-14 | 2010-11-15 | Cystic Fibrosis Foundation The | Præparater indeholdende lipase, protease og amylase til behandling af pankreatisk insufficiens |
| US20080138856A1 (en) | 2005-02-10 | 2008-06-12 | Novozymes A/S | Enzymatic Enantioselective Ester or Amide Hydrolysis or Synthesis |
| KR20080017025A (ko) * | 2005-06-24 | 2008-02-25 | 노보자임스 에이/에스 | 약학적 용도의 리파제 |
| MX2007015471A (es) | 2005-06-24 | 2008-04-04 | Novozymes As | Amilasas para uso farmaceutico. |
| JP2008546395A (ja) | 2005-06-24 | 2008-12-25 | ノボザイムス アクティーゼルスカブ | 医薬使用のためのプロテアーゼ |
| WO2007080197A2 (en) * | 2006-01-16 | 2007-07-19 | Novozymes A/S | Immobilised enzymes |
| CN105296445B (zh) * | 2006-01-23 | 2022-05-10 | 诺维信公司 | 脂肪酶变体 |
| CA2635927A1 (en) * | 2006-01-23 | 2007-08-02 | The Procter And Gamble Company | A composition comprising a lipase and a bleach catalyst |
| WO2008079685A2 (en) * | 2006-12-21 | 2008-07-03 | Novozymes A/S | Lipase variants for pharmaceutical use |
-
2007
- 2007-12-12 WO PCT/US2007/087168 patent/WO2008079685A2/en not_active Ceased
- 2007-12-12 EP EP12155317.6A patent/EP2455461B1/en active Active
- 2007-12-12 EP EP10172609.9A patent/EP2261328B1/en active Active
- 2007-12-12 CN CN201510504893.8A patent/CN105112386A/zh active Pending
- 2007-12-12 EP EP12155315A patent/EP2455460A3/en not_active Withdrawn
- 2007-12-12 MX MX2009006597A patent/MX2009006597A/es not_active Application Discontinuation
- 2007-12-12 JP JP2009543078A patent/JP5406040B2/ja active Active
- 2007-12-12 BR BRPI0721103-1A patent/BRPI0721103A2/pt not_active IP Right Cessation
- 2007-12-12 CA CA2961041A patent/CA2961041C/en active Active
- 2007-12-12 CA CA2670643A patent/CA2670643C/en active Active
- 2007-12-12 US US12/519,868 patent/US8273348B2/en active Active
- 2007-12-12 KR KR1020097014850A patent/KR20090101930A/ko not_active Withdrawn
- 2007-12-12 EP EP07869130A patent/EP2099907A2/en not_active Withdrawn
- 2007-12-12 EP EP12155294.7A patent/EP2455459B1/en active Active
- 2007-12-12 EP EP12155319.2A patent/EP2455462B1/en active Active
- 2007-12-12 CN CN200780051638.6A patent/CN101743308B/zh active Active
- 2007-12-12 CA CA3081308A patent/CA3081308C/en active Active
- 2007-12-12 RU RU2009128067/10A patent/RU2009128067A/ru not_active Application Discontinuation
- 2007-12-12 AU AU2007337150A patent/AU2007337150A1/en not_active Abandoned
- 2007-12-18 TW TW096148377A patent/TW200829698A/zh unknown
- 2007-12-21 AR ARP070105859A patent/AR064494A1/es not_active Application Discontinuation
-
2009
- 2009-05-21 IL IL198893A patent/IL198893A0/en unknown
- 2009-05-25 ZA ZA200903598A patent/ZA200903598B/xx unknown
- 2009-07-20 NO NO20092729A patent/NO20092729L/no not_active Application Discontinuation
-
2012
- 2012-08-16 US US13/587,043 patent/US9029115B2/en active Active
-
2015
- 2015-04-06 US US14/679,563 patent/US9539311B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2010512795A5 (enExample) | ||
| RU2008102650A (ru) | Амилазы для фармацевтического применения | |
| RU2007149045A (ru) | Липазы для фармацевтического применения | |
| RU2006145899A (ru) | Ферменты для фармацевтического применения | |
| JP2016505539A5 (enExample) | ||
| HRP20190918T1 (hr) | Ciljani terapeutski fuzijski proteini lizosomskog enzima i njihova upotreba | |
| JP2012176978A5 (enExample) | ||
| NO20092729L (no) | Lipasevarianter for farmasoytisk anvendelse | |
| WO2015038892A1 (en) | Polynucleotide compositions containing amino acids | |
| RU2001126526A (ru) | Лекарственное средство, предназначенное для лечения диабета | |
| JP2008536483A5 (enExample) | ||
| RS55230B1 (sr) | Himerni polipeptidi i njihova primena u bakterijskoj dekolonizaciji | |
| JP2012115277A5 (enExample) | ||
| Xu et al. | Breaking genetic shackles: The advance of base editing in genetic disorder treatment | |
| JP2014513952A5 (enExample) | ||
| JP2017529326A5 (enExample) | ||
| JP2011504366A5 (enExample) | ||
| JP2012521366A5 (enExample) | ||
| JP2014529399A5 (enExample) | ||
| RU2008102738A (ru) | Протеазы для фармацевтического применения | |
| RU2010127329A (ru) | Варианты протеаз для фармацевтического применения | |
| JP2020105169A5 (enExample) | ||
| JP2008541776A5 (enExample) | ||
| JP2014515595A5 (enExample) | ||
| WO2010086867A3 (en) | Peptides, pharmaceutical compositions comprising same and uses thereof |