JP2010512795A5 - - Google Patents
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- Publication number
- JP2010512795A5 JP2010512795A5 JP2009543078A JP2009543078A JP2010512795A5 JP 2010512795 A5 JP2010512795 A5 JP 2010512795A5 JP 2009543078 A JP2009543078 A JP 2009543078A JP 2009543078 A JP2009543078 A JP 2009543078A JP 2010512795 A5 JP2010512795 A5 JP 2010512795A5
- Authority
- JP
- Japan
- Prior art keywords
- lipase
- seq
- amylase
- protease
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000004367 Lipase Substances 0.000 claims 11
- 102000004882 Lipase Human genes 0.000 claims 11
- 108090001060 Lipase Proteins 0.000 claims 11
- 235000019421 lipase Nutrition 0.000 claims 11
- 239000004382 Amylase Substances 0.000 claims 10
- 102000013142 Amylases Human genes 0.000 claims 10
- 108010065511 Amylases Proteins 0.000 claims 10
- 108091005804 Peptidases Proteins 0.000 claims 10
- 239000004365 Protease Substances 0.000 claims 10
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 10
- 235000019418 amylase Nutrition 0.000 claims 10
- 150000001413 amino acids Chemical class 0.000 claims 9
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 102220479102 CD59 glycoprotein_N33Q_mutation Human genes 0.000 claims 3
- 238000006467 substitution reaction Methods 0.000 claims 2
- 201000003883 Cystic fibrosis Diseases 0.000 claims 1
- 208000035467 Pancreatic insufficiency Diseases 0.000 claims 1
- 206010033645 Pancreatitis Diseases 0.000 claims 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
- 230000001079 digestive effect Effects 0.000 claims 1
- 208000010643 digestive system disease Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 235000019626 lipase activity Nutrition 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 102200012371 rs879255637 Human genes 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87119606P | 2006-12-21 | 2006-12-21 | |
| US60/871,196 | 2006-12-21 | ||
| PCT/US2007/087168 WO2008079685A2 (en) | 2006-12-21 | 2007-12-12 | Lipase variants for pharmaceutical use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010512795A JP2010512795A (ja) | 2010-04-30 |
| JP2010512795A5 true JP2010512795A5 (enExample) | 2011-02-03 |
| JP5406040B2 JP5406040B2 (ja) | 2014-02-05 |
Family
ID=38043020
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009543078A Active JP5406040B2 (ja) | 2006-12-21 | 2007-12-12 | 医薬使用のためのリパーゼ変異体 |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US8273348B2 (enExample) |
| EP (6) | EP2455461B1 (enExample) |
| JP (1) | JP5406040B2 (enExample) |
| KR (1) | KR20090101930A (enExample) |
| CN (2) | CN101743308B (enExample) |
| AR (1) | AR064494A1 (enExample) |
| AU (1) | AU2007337150A1 (enExample) |
| BR (1) | BRPI0721103A2 (enExample) |
| CA (3) | CA2670643C (enExample) |
| IL (1) | IL198893A0 (enExample) |
| MX (1) | MX2009006597A (enExample) |
| NO (1) | NO20092729L (enExample) |
| RU (1) | RU2009128067A (enExample) |
| TW (1) | TW200829698A (enExample) |
| WO (1) | WO2008079685A2 (enExample) |
| ZA (1) | ZA200903598B (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE407693T1 (de) | 2004-03-22 | 2008-09-15 | Solvay Pharm Gmbh | Orale pharmazeutische zusammensetzungen von produkten mit lipase, insbesondere von pankreatin,mit tensiden |
| BRPI0614914A2 (pt) | 2005-07-29 | 2011-04-19 | Solvay Pharm Gmbh | processos para a fabricação de pó de pancreatina esterilizada |
| US11266607B2 (en) | 2005-08-15 | 2022-03-08 | AbbVie Pharmaceuticals GmbH | Process for the manufacture and use of pancreatin micropellet cores |
| US9198871B2 (en) | 2005-08-15 | 2015-12-01 | Abbott Products Gmbh | Delayed release pancreatin compositions |
| US10072256B2 (en) | 2006-05-22 | 2018-09-11 | Abbott Products Gmbh | Process for separating and determining the viral load in a pancreatin sample |
| US8273348B2 (en) | 2006-12-21 | 2012-09-25 | Novozymes A/S | Lipase variants for pharmaceutical use |
| US20090217464A1 (en) * | 2008-02-29 | 2009-09-03 | Philip Frank Souter | Detergent composition comprising lipase |
| MX2010009464A (es) | 2008-02-29 | 2010-09-22 | Dsm Ip Assets Bv | Lipasas con alta especificidad hacia acidos grasos de cadena corta y usos de las mismas. |
| US9163203B2 (en) * | 2008-02-29 | 2015-10-20 | Novozymes A/S | Lipolytic enzyme variant with improved stability and polynucleotides encoding same |
| EP4159833A3 (en) | 2009-12-09 | 2023-07-26 | The Procter & Gamble Company | Fabric and home care products |
| CN103703139A (zh) | 2011-07-22 | 2014-04-02 | 诺维信北美公司 | 用于预处理纤维素材料和改进其水解的方法 |
| US8268305B1 (en) | 2011-09-23 | 2012-09-18 | Bio-Cat, Inc. | Method and compositions to reduce serum levels of triacylglycerides in human beings using a fungal lipase |
| ES2887576T3 (es) * | 2011-12-29 | 2021-12-23 | Novozymes As | Composiciones detergentes con variantes de lipasa |
| US9394530B2 (en) * | 2012-02-03 | 2016-07-19 | Novozymes A/S | Lipase variants and polynucleotides encoding same |
| CN107988181A (zh) * | 2012-04-02 | 2018-05-04 | 诺维信公司 | 脂肪酶变体以及编码其的多核苷酸 |
| EP2906691B1 (en) * | 2012-10-12 | 2021-01-27 | Danisco US Inc. | Compositions and methods comprising a lipolytic enzyme variant |
| CN105209612A (zh) * | 2013-05-14 | 2015-12-30 | 诺维信公司 | 洗涤剂组合物 |
| ES2956266T3 (es) * | 2013-07-19 | 2023-12-18 | Danisco Us Inc | Composiciones y procedimientos que comprenden una variante de enzima lipolítica |
| WO2016079305A1 (en) * | 2014-11-20 | 2016-05-26 | Novozymes A/S | Alicyclobacillus variants and polynucleotides encoding same |
| CN107002054A (zh) | 2014-12-05 | 2017-08-01 | 诺维信公司 | 脂肪酶变体以及编码它们的多核苷酸 |
| US11268076B2 (en) | 2014-12-09 | 2022-03-08 | Novozymes A/S | Lipase variants and polynucleotides encoding same |
| CN107864658A (zh) | 2015-04-07 | 2018-03-30 | 诺维信公司 | 用于选择具有脂肪酶活性的酶的方法 |
| WO2017001673A1 (en) * | 2015-07-01 | 2017-01-05 | Novozymes A/S | Methods of reducing odor |
| US10760037B2 (en) * | 2015-07-03 | 2020-09-01 | Novozymes A/S | Sulfite compositions |
| US11326152B2 (en) | 2016-07-18 | 2022-05-10 | Novozymes A/S | Lipase variants, polynucleotides encoding same and the use thereof |
| WO2018139634A1 (ja) * | 2017-01-30 | 2018-08-02 | 学校法人日本医科大学 | アデノ随伴ウイルス（ａａｖ）キャプシドタンパク質の変異体 |
| CA3073362A1 (en) | 2017-09-27 | 2019-04-04 | Novozymes A/S | Lipase variants and microcapsule compositions comprising such lipase variants |
| US11286443B2 (en) * | 2017-09-27 | 2022-03-29 | The Procter & Gamble Company | Detergent compositions comprising lipases |
| CN111801416A (zh) * | 2018-02-08 | 2020-10-20 | 诺维信公司 | 脂肪酶变体及其组合物 |
| US12269847B2 (en) * | 2018-08-16 | 2025-04-08 | Donaldson Company, Inc. | Genetically encoded polypeptide for affinity capture and purification of biologics |
| CN111334369B (zh) * | 2020-03-11 | 2022-10-21 | 陕西科技大学 | 一种酶法制备卵磷脂型pufa的方法 |
| CN115803083A (zh) * | 2020-06-24 | 2023-03-14 | 基利安股份公司 | 新脂肪酶 |
| US20240035005A1 (en) * | 2020-10-29 | 2024-02-01 | Novozymes A/S | Lipase variants and compositions comprising such lipase variants |
| CN113846074B (zh) * | 2021-10-20 | 2022-10-21 | 南京林业大学 | 一种疏棉状嗜热丝孢菌脂肪酶突变体g91c及其应用 |
| CN119630280A (zh) | 2022-05-14 | 2025-03-14 | 诺维信公司 | 用于预防、处理、抑制和/或消除植物病原性侵染和感染的组合物和方法 |
| WO2023247664A2 (en) * | 2022-06-24 | 2023-12-28 | Novozymes A/S | Lipase variants and compositions comprising such lipase variants |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK173590D0 (da) | 1990-06-06 | 1990-07-19 | Novo Nordisk As | Rekombinante terapeutiske lipaser |
| DE69129988T2 (de) * | 1990-09-13 | 1999-03-18 | Novo Nordisk A/S, Bagsvaerd | Lipase-varianten |
| US5869438A (en) | 1990-09-13 | 1999-02-09 | Novo Nordisk A/S | Lipase variants |
| DK46693D0 (enExample) | 1993-04-23 | 1993-04-23 | Novo Nordisk As | |
| BR9107206A (pt) | 1990-12-05 | 1993-11-03 | Novo Nordisk As | Processo para produzir uma variante de proteina que evoca uma resposta imunogenica diminuida em animais,produtos obtidos,composicao e uso |
| JPH06507071A (ja) | 1991-05-01 | 1994-08-11 | ノボザイムス アクティーゼルスカブ | 安定化酵素 |
| DK39693D0 (da) | 1993-04-02 | 1993-04-02 | Novo Nordisk As | Enzym |
| US5866526A (en) | 1993-10-04 | 1999-02-02 | Novo Nordisk A/S | Enzyme preparation comprising a modified enzyme |
| DE69527835T2 (de) | 1994-02-22 | 2003-04-10 | Novozymes A/S, Bagsvaerd | Methode zur herstellung einer variante eines lipolytischen enzymes |
| AU3924095A (en) | 1994-11-24 | 1996-06-17 | Novo Nordisk A/S | A process for producing polypeptides with reduced allergenicity |
| WO1996017929A1 (en) | 1994-12-07 | 1996-06-13 | Novo Nordisk A/S | Polypeptide with reduced allergenicity |
| CN1165614C (zh) | 1995-01-26 | 2004-09-08 | 诺沃奇梅兹有限公司 | 含有木聚糖酶的动物饲料添加剂 |
| US6495357B1 (en) * | 1995-07-14 | 2002-12-17 | Novozyme A/S | Lipolytic enzymes |
| WO1997004078A1 (en) | 1995-07-14 | 1997-02-06 | Novo Nordisk A/S | A modified enzyme with lipolytic activity |
| DE69632538T2 (de) | 1995-08-11 | 2005-05-19 | Novozymes A/S | Neuartige lipolytische enzyme |
| CA2277618A1 (en) | 1997-01-10 | 1998-07-16 | Novo Nordisk A/S | Enzyme coupled with polymeric molecules for skin care |
| EP1017794A1 (en) | 1997-02-06 | 2000-07-12 | Novo Nordisk A/S | Polypeptide-polymer conjugates having added and/or removed attachment groups |
| WO1999000489A1 (en) | 1997-06-25 | 1999-01-07 | Novo Nordisk A/S | A modified polypeptide |
| AU3247699A (en) | 1998-02-17 | 1999-09-06 | Novo Nordisk A/S | Lipase variant |
| DE69931607T2 (de) * | 1998-02-17 | 2007-05-16 | Novozymes A/S | Lipasevariante |
| CA2346929A1 (en) | 1998-10-13 | 2000-04-20 | Novozymes A/S | A modified polypeptide with reduced immune response |
| CN1206237C (zh) | 1998-10-30 | 2005-06-15 | 诺沃奇梅兹有限公司 | 低免疫原性蛋白质变体 |
| JP2002531067A (ja) | 1998-10-30 | 2002-09-24 | ノボザイムス アクティーゼルスカブ | 低下したアレルゲン性を有するグリコシル化タンパク質 |
| US7312062B2 (en) * | 1998-11-27 | 2007-12-25 | Novozymes A/S | Lipolytic enzyme variants |
| WO2000032758A1 (en) | 1998-11-27 | 2000-06-08 | Novozymes A/S | Lipolytic enzyme variants |
| DE50002450D1 (de) | 1999-03-17 | 2003-07-10 | Solvay Pharm Gmbh | Enzyme zur behandlung von diabetes mellitus typ i |
| EP1171581A1 (en) | 1999-03-31 | 2002-01-16 | Novozymes A/S | Lipase variant |
| EP1428874B1 (en) | 1999-03-31 | 2013-12-18 | Novozymes A/S | Lipase variant |
| CN100429990C (zh) | 2000-02-08 | 2008-11-05 | Dsmip资产公司 | 酸-稳定性蛋白酶在动物饲料中的用途 |
| AU2001254620A1 (en) * | 2000-04-28 | 2001-11-12 | Novozymes A/S | Lipolytic enzyme variant |
| CA2431972C (en) | 2001-01-10 | 2012-10-23 | Novozymes A/S | Thermostable lipolytic enzyme variant |
| AR032392A1 (es) | 2001-01-19 | 2003-11-05 | Solvay Pharm Gmbh | Mezcla de enzimas, preparado farmaceutico y utilizacion de dicho preparado. |
| CA2432329C (en) | 2001-02-07 | 2012-04-10 | Novozymes A/S | Lipase variants |
| US20050255544A1 (en) | 2002-01-16 | 2005-11-17 | Novozymes A/S | Lipolytic enzyme variants and method for their production |
| BRPI0407108A (pt) | 2003-02-06 | 2006-01-24 | Novozymes As | Método para produzir uma imunoglobulina funcional humana |
| DK1625216T3 (da) * | 2003-05-09 | 2013-03-18 | Novozymes As | Lipolytiske enzymvarianter |
| WO2004111216A2 (en) * | 2003-06-19 | 2004-12-23 | Novozymes A/S | Phospholipase variants |
| US20060236414A1 (en) | 2003-06-19 | 2006-10-19 | Novozymes A/S | Proteases and methods for producing them |
| JP2007535913A (ja) | 2004-01-21 | 2007-12-13 | ノボザイムス アクティーゼルスカブ | ヘテロカリオン菌類又は菌類宿主細胞におけるモノクローナル抗体の生成 |
| ATE407693T1 (de) | 2004-03-22 | 2008-09-15 | Solvay Pharm Gmbh | Orale pharmazeutische zusammensetzungen von produkten mit lipase, insbesondere von pankreatin,mit tensiden |
| SI2198880T1 (sl) | 2004-10-14 | 2017-02-28 | Eli Lilly And Co. | Sestavki, ki vsebujejo lipazo, proteazo in amilazo, za zdravljenje pankreasne insuficience |
| WO2006084470A2 (en) | 2005-02-10 | 2006-08-17 | Novozymes A/S | Enzymatic enantioselective ester or amide hydrolysis or synthesis |
| RU2007149045A (ru) * | 2005-06-24 | 2009-07-10 | Новозимс А/С (Dk) | Липазы для фармацевтического применения |
| US8017351B2 (en) | 2005-06-24 | 2011-09-13 | Novozymes A/S | Amylases for pharmaceutical use |
| NZ563777A (en) | 2005-06-24 | 2010-08-27 | Novozymes As | Serine protease derived from Bacillus licheniformis optionally in combination with lipases and amylases for pharmaceutical use |
| WO2007080197A2 (en) * | 2006-01-16 | 2007-07-19 | Novozymes A/S | Immobilised enzymes |
| EP2371948B1 (en) * | 2006-01-23 | 2017-04-19 | Novozymes A/S | Lipase variants |
| JP2009523900A (ja) * | 2006-01-23 | 2009-06-25 | ザ プロクター アンド ギャンブル カンパニー | リパーゼと漂白剤触媒を含む組成物 |
| US8273348B2 (en) * | 2006-12-21 | 2012-09-25 | Novozymes A/S | Lipase variants for pharmaceutical use |
-
2007
- 2007-12-12 US US12/519,868 patent/US8273348B2/en active Active
- 2007-12-12 EP EP12155317.6A patent/EP2455461B1/en active Active
- 2007-12-12 EP EP12155315A patent/EP2455460A3/en not_active Withdrawn
- 2007-12-12 RU RU2009128067/10A patent/RU2009128067A/ru not_active Application Discontinuation
- 2007-12-12 EP EP10172609.9A patent/EP2261328B1/en active Active
- 2007-12-12 CN CN200780051638.6A patent/CN101743308B/zh active Active
- 2007-12-12 CA CA2670643A patent/CA2670643C/en active Active
- 2007-12-12 WO PCT/US2007/087168 patent/WO2008079685A2/en not_active Ceased
- 2007-12-12 MX MX2009006597A patent/MX2009006597A/es not_active Application Discontinuation
- 2007-12-12 CN CN201510504893.8A patent/CN105112386A/zh active Pending
- 2007-12-12 CA CA2961041A patent/CA2961041C/en active Active
- 2007-12-12 JP JP2009543078A patent/JP5406040B2/ja active Active
- 2007-12-12 CA CA3081308A patent/CA3081308C/en active Active
- 2007-12-12 AU AU2007337150A patent/AU2007337150A1/en not_active Abandoned
- 2007-12-12 EP EP12155294.7A patent/EP2455459B1/en active Active
- 2007-12-12 EP EP12155319.2A patent/EP2455462B1/en active Active
- 2007-12-12 EP EP07869130A patent/EP2099907A2/en not_active Withdrawn
- 2007-12-12 KR KR1020097014850A patent/KR20090101930A/ko not_active Withdrawn
- 2007-12-12 BR BRPI0721103-1A patent/BRPI0721103A2/pt not_active IP Right Cessation
- 2007-12-18 TW TW096148377A patent/TW200829698A/zh unknown
- 2007-12-21 AR ARP070105859A patent/AR064494A1/es not_active Application Discontinuation
-
2009
- 2009-05-21 IL IL198893A patent/IL198893A0/en unknown
- 2009-05-25 ZA ZA200903598A patent/ZA200903598B/xx unknown
- 2009-07-20 NO NO20092729A patent/NO20092729L/no not_active Application Discontinuation
-
2012
- 2012-08-16 US US13/587,043 patent/US9029115B2/en active Active
-
2015
- 2015-04-06 US US14/679,563 patent/US9539311B2/en active Active
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