JP2010512795A5 - - Google Patents
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- Publication number
- JP2010512795A5 JP2010512795A5 JP2009543078A JP2009543078A JP2010512795A5 JP 2010512795 A5 JP2010512795 A5 JP 2010512795A5 JP 2009543078 A JP2009543078 A JP 2009543078A JP 2009543078 A JP2009543078 A JP 2009543078A JP 2010512795 A5 JP2010512795 A5 JP 2010512795A5
- Authority
- JP
- Japan
- Prior art keywords
- lipase
- seq
- amylase
- protease
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000004367 Lipase Substances 0.000 claims 11
- 229940040461 Lipase Drugs 0.000 claims 11
- 102000004882 lipase Human genes 0.000 claims 11
- 235000019421 lipase Nutrition 0.000 claims 11
- 108090001060 lipase Proteins 0.000 claims 11
- 239000004382 Amylase Substances 0.000 claims 10
- 102000013142 Amylases Human genes 0.000 claims 10
- 108010065511 Amylases Proteins 0.000 claims 10
- 102000033147 ERVK-25 Human genes 0.000 claims 10
- 108091005771 Peptidases Proteins 0.000 claims 10
- 239000004365 Protease Substances 0.000 claims 10
- 235000019418 amylase Nutrition 0.000 claims 10
- 150000001413 amino acids Chemical class 0.000 claims 9
- 239000000203 mixture Substances 0.000 claims 6
- 102200048594 CD59 N33Q Human genes 0.000 claims 3
- 206010012601 Diabetes mellitus Diseases 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- 208000005407 Digestive System Disease Diseases 0.000 claims 1
- 102200012371 PRDM12 D31Y Human genes 0.000 claims 1
- 206010033628 Pancreatic insufficiency Diseases 0.000 claims 1
- 206010033645 Pancreatitis Diseases 0.000 claims 1
- 201000003883 cystic fibrosis Diseases 0.000 claims 1
- 230000001079 digestive Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 235000019626 lipase activity Nutrition 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000546 pharmaceutic aid Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
Claims (9)
- 医療用リパーゼであって、
（ａ）配列番号：２のアミノ酸１〜269の配列に対して少なくとも50％の同一性を有し；
（ｂ）リパーゼ活性を有し；そして
（ｃ）配列番号：２のアミノ酸１〜269の配列に比べて、置換N33Q、T231R、N233R及びD254Sを含み、そして配列番号：２のN33Q＋T231R＋N233Rである参照リパーゼに比べて改良された消化性能を有する；
ことを特徴とするリパーゼ。 - 配列番号：２のアミノ酸１〜269の配列に対して置換：N33Q＋G91T＋K98I＋T114I＋G163K＋T231R＋N233R＋D254Sを含む、請求項１に記載のリパーゼ。
- プロテアーゼ及び／又はアミラーゼとの組み合わせにおける、請求項１又は２に記載のリパーゼ。
- 請求項３に記載のプロテアーゼ及び／又はアミラーゼとの組み合わせにおけるリパーゼにおいて、
（i）当該プロテアーゼが、
ａ）配列番号：３のアミノ酸１〜274の配列を有するプロテアーゼ；
ｂ）配列番号：４のアミノ酸１〜188の配列を有するプロテアーゼ；及び
ｃ）配列番号：５のアミノ酸１〜188の配列を有するプロテアーゼ、
から成る群から選択されるプロテアーゼに対して少なくとも70％の同一性を有し；
（ii）前記アミラーゼが、
ａ）配列番号：６のアミノ酸１〜481の配列を有するアミラーゼ；
ｂ）配列番号：７のアミノ酸１〜481の配列を有するアミラーゼ；
ｃ）配列番号：８のアミノ酸１〜483の配列を有するアミラーゼ、
から成る群から選択されるアミラーゼに対して少なくとも70％の同一性を有する、
ことを特徴とする請求項３に記載のリパーゼ。 - 少なくとも１種の医薬として許容される賦形剤と共に、請求項１又は２に記載のリパーゼ又はリパーゼ混合物を含んで成る医薬組成物。
- プロテアーゼ及び／又はアミラーゼを更に含んで成る、請求項５に記載の組成物。
- 前記プロテアーゼ及び／又はアミラーゼが請求項４に記載したとおりでる、請求項６に記載の組成物。
- 消化系疾患、膵臓外分泌不全、膵炎、嚢胞性繊維症、I型糖尿病及び／又はII型糖尿病の治療のための医薬の製造における、請求項１又は２に記載のリパーゼ又はリパーゼ混合物の使用。
- アミラーゼ及び／又はプロテアーゼの使用をさらに含む、請求項８に記載の使用。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87119606P | 2006-12-21 | 2006-12-21 | |
| US60/871,196 | 2006-12-21 | ||
| PCT/US2007/087168 WO2008079685A2 (en) | 2006-12-21 | 2007-12-12 | Lipase variants for pharmaceutical use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010512795A JP2010512795A (ja) | 2010-04-30 |
| JP2010512795A5 true JP2010512795A5 (ja) | 2011-02-03 |
| JP5406040B2 JP5406040B2 (ja) | 2014-02-05 |
Family
ID=38043020
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009543078A Active JP5406040B2 (ja) | 2006-12-21 | 2007-12-12 | 医薬使用のためのリパーゼ変異体 |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US8273348B2 (ja) |
| EP (6) | EP2455462B1 (ja) |
| JP (1) | JP5406040B2 (ja) |
| KR (1) | KR20090101930A (ja) |
| CN (2) | CN105112386A (ja) |
| AR (1) | AR064494A1 (ja) |
| AU (1) | AU2007337150A1 (ja) |
| BR (1) | BRPI0721103A2 (ja) |
| CA (3) | CA3081308C (ja) |
| IL (1) | IL198893A0 (ja) |
| MX (1) | MX2009006597A (ja) |
| NO (1) | NO20092729L (ja) |
| RU (1) | RU2009128067A (ja) |
| TW (1) | TW200829698A (ja) |
| WO (1) | WO2008079685A2 (ja) |
| ZA (1) | ZA200903598B (ja) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005092370A1 (en) | 2004-03-22 | 2005-10-06 | Solvay Pharmaceuticals Gmbh | Oral pharmaceutical compositions of lipase-containing products, in particular of pancreatin, containing surfactants |
| HUE034739T2 (en) | 2005-07-29 | 2018-02-28 | Abbott Laboratories Gmbh | Reduced viral pancreatin |
| US9198871B2 (en) | 2005-08-15 | 2015-12-01 | Abbott Products Gmbh | Delayed release pancreatin compositions |
| US11266607B2 (en) | 2005-08-15 | 2022-03-08 | AbbVie Pharmaceuticals GmbH | Process for the manufacture and use of pancreatin micropellet cores |
| US10072256B2 (en) | 2006-05-22 | 2018-09-11 | Abbott Products Gmbh | Process for separating and determining the viral load in a pancreatin sample |
| WO2008079685A2 (en) * | 2006-12-21 | 2008-07-03 | Novozymes A/S | Lipase variants for pharmaceutical use |
| WO2009106553A2 (en) * | 2008-02-29 | 2009-09-03 | Novozymes A/S | Lipolytic enzyme variant with improved stability and polynucleotides encoding same |
| MX2010009464A (es) | 2008-02-29 | 2010-09-22 | Dsm Ip Assets Bv | Lipasas con alta especificidad hacia acidos grasos de cadena corta y usos de las mismas. |
| CN102112602A (zh) * | 2008-02-29 | 2011-06-29 | 宝洁公司 | 包含脂肪酶的洗涤剂组合物 |
| US20140147895A1 (en) | 2011-07-22 | 2014-05-29 | Novozymes A/S | Processes for Pretreating Cellulosic Material and Improving Hydrolysis Thereof |
| US8268305B1 (en) | 2011-09-23 | 2012-09-18 | Bio-Cat, Inc. | Method and compositions to reduce serum levels of triacylglycerides in human beings using a fungal lipase |
| EP2798053B1 (en) * | 2011-12-29 | 2018-05-16 | Novozymes A/S | Detergent compositions with lipase variants |
| CN108148823B (zh) | 2012-02-03 | 2023-03-14 | 诺维信公司 | 脂肪酶变体以及编码它们的多核苷酸 |
| EP2834353B1 (en) * | 2012-04-02 | 2017-07-19 | Novozymes A/S | Lipase variants and polynucleotides encoding same |
| EP3842531A1 (en) * | 2012-10-12 | 2021-06-30 | Danisco US Inc. | Compositions and method comprising a lipolytic enzyme variant |
| AR096270A1 (es) * | 2013-05-14 | 2015-12-16 | Novozymes As | Composiciones detergentes |
| MX371497B (es) * | 2013-07-19 | 2020-01-31 | Danisco Us Inc | Composiciones y metodos que comprenden una variante de enzima lipolitica. |
| US10287562B2 (en) * | 2014-11-20 | 2019-05-14 | Novoszymes A/S | Alicyclobacillus variants and polynucleotides encoding same |
| WO2016087401A1 (en) * | 2014-12-05 | 2016-06-09 | Novozymes A/S | Lipase variants and polynucleotides encoding same |
| WO2016091870A1 (en) * | 2014-12-09 | 2016-06-16 | Novozymes A/S | Lipase variants and polynucleotides encoding same |
| CN107864658A (zh) | 2015-04-07 | 2018-03-30 | 诺维信公司 | 用于选择具有脂肪酶活性的酶的方法 |
| EP3317389B1 (en) * | 2015-07-03 | 2019-04-10 | Novozymes A/S | Detergent compositions with improved stability in the presence of sulfites |
| US11028131B2 (en) * | 2017-01-30 | 2021-06-08 | Nippon Medical School Foundation | Mutant of adeno-associated virus (AAV) capsid protein |
| WO2019063499A1 (en) * | 2017-09-27 | 2019-04-04 | Novozymes A/S | LIPASE VARIANTS AND MICROCAPSULE COMPOSITIONS COMPRISING SUCH VARIANTS OF LIPASE |
| MX2020003779A (es) | 2017-09-27 | 2020-08-03 | Procter & Gamble | Composiciones detergentes que comprenden lipasas. |
| US20210071157A1 (en) * | 2018-02-08 | 2021-03-11 | Novozymes A/S | Lipase Variants and Compositions Thereof |
| CN111334369B (zh) * | 2020-03-11 | 2022-10-21 | 陕西科技大学 | 一种酶法制备卵磷脂型pufa的方法 |
| JP2023547450A (ja) * | 2020-10-29 | 2023-11-10 | ノボザイムス アクティーゼルスカブ | リパーゼ変異体及びそのようなリパーゼ変異体を含む組成物 |
| CN113846074B (zh) * | 2021-10-20 | 2022-10-21 | 南京林业大学 | 一种疏棉状嗜热丝孢菌脂肪酶突变体g91c及其应用 |
| WO2023225459A2 (en) | 2022-05-14 | 2023-11-23 | Novozymes A/S | Compositions and methods for preventing, treating, supressing and/or eliminating phytopathogenic infestations and infections |
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|---|---|---|---|---|
| DK173590D0 (da) | 1990-06-06 | 1990-07-19 | Novo Nordisk As | Rekombinante terapeutiske lipaser |
| DK46693D0 (ja) | 1993-04-23 | 1993-04-23 | Novo Nordisk As | |
| JP3469234B2 (ja) * | 1990-09-13 | 2003-11-25 | ノボザイムス アクティーゼルスカブ | リパーゼ変異体 |
| US5869438A (en) | 1990-09-13 | 1999-02-09 | Novo Nordisk A/S | Lipase variants |
| BR9107206A (pt) | 1990-12-05 | 1993-11-03 | Novo Nordisk As | Processo para produzir uma variante de proteina que evoca uma resposta imunogenica diminuida em animais,produtos obtidos,composicao e uso |
| DK0585285T3 (da) | 1991-05-01 | 1999-05-10 | Novo Nordisk As | Stabiliserede enzymer |
| DK39693D0 (da) | 1993-04-02 | 1993-04-02 | Novo Nordisk As | Enzym |
| CN1134726A (zh) | 1993-10-04 | 1996-10-30 | 诺沃挪第克公司 | 一种包含修饰酶的酶制剂 |
| JP3553958B2 (ja) | 1994-02-22 | 2004-08-11 | ノボザイムス アクティーゼルスカブ | 脂質分解酵素の変異体の製造方法 |
| AU3924095A (en) | 1994-11-24 | 1996-06-17 | Novo Nordisk A/S | A process for producing polypeptides with reduced allergenicity |
| CA2206852A1 (en) | 1994-12-07 | 1996-06-13 | Novo Nordisk A/S | Polypeptide with reduced allergenicity |
| ATE210180T1 (de) | 1995-01-26 | 2001-12-15 | Novozymes As | Xylanase beinhaltende futterzusätze für tiere |
| CN1193346A (zh) | 1995-07-14 | 1998-09-16 | 诺沃挪第克公司 | 一种具有脂解活性的修饰酶 |
| WO1997007202A1 (en) | 1995-08-11 | 1997-02-27 | Novo Nordisk A/S | Novel lipolytic enzymes |
| US6495357B1 (en) | 1995-07-14 | 2002-12-17 | Novozyme A/S | Lipolytic enzymes |
| CN1253585A (zh) | 1997-01-10 | 2000-05-17 | 诺沃挪第克公司 | 一种用于皮肤护理的被修饰酶 |
| AU740207B2 (en) | 1997-02-06 | 2001-11-01 | Novozymes A/S | Polypeptide-polymer conjugates having added and/or removed attachment groups |
| WO1999000489A1 (en) | 1997-06-25 | 1999-01-07 | Novo Nordisk A/S | A modified polypeptide |
| ATE328070T1 (de) * | 1998-02-17 | 2006-06-15 | Novozymes As | Lipasevariante |
| AU3247699A (en) | 1998-02-17 | 1999-09-06 | Novo Nordisk A/S | Lipase variant |
| WO2000022103A1 (en) | 1998-10-13 | 2000-04-20 | Novozymes A/S | A modified polypeptide with reduced immune response |
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| ATE263778T1 (de) | 1998-10-30 | 2004-04-15 | Novozymes As | Niedrigallergene proteinvarianten |
| EP1131416B1 (en) | 1998-11-27 | 2009-09-02 | Novozymes A/S | Lipolytic enzyme variants |
| US7312062B2 (en) * | 1998-11-27 | 2007-12-25 | Novozymes A/S | Lipolytic enzyme variants |
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| EP2278000A1 (en) * | 1999-03-31 | 2011-01-26 | Novozymes A/S | Lipase variant |
| EP1171581A1 (en) * | 1999-03-31 | 2002-01-16 | Novozymes A/S | Lipase variant |
| MXPA02007614A (es) | 2000-02-08 | 2002-12-13 | Hoffmann La Roche | Uso de proteasas subtilisinas estables en acido para alimento de animales. |
| EP2258852A1 (en) * | 2000-04-28 | 2010-12-08 | Novozymes A/S | Lipolytic enzyme variant |
| WO2002055679A2 (en) * | 2001-01-10 | 2002-07-18 | Novozymes A/S | Thermostable lipolytic enzyme variant |
| AR032392A1 (es) | 2001-01-19 | 2003-11-05 | Solvay Pharm Gmbh | Mezcla de enzimas, preparado farmaceutico y utilizacion de dicho preparado. |
| WO2002062973A2 (en) | 2001-02-07 | 2002-08-15 | Novozymes A/S | Lipase variants |
| CA2467415C (en) * | 2002-01-16 | 2014-03-11 | Novozymes A/S | Lipolytic enzyme variants and method for their production |
| CN1756767A (zh) | 2003-02-06 | 2006-04-05 | 诺和酶股份有限公司 | 在丝状真菌中表达人重链抗体 |
| DK2270139T3 (en) * | 2003-05-09 | 2016-11-07 | Novozymes As | Lipolytic Enzyme Variants |
| US20060236414A1 (en) | 2003-06-19 | 2006-10-19 | Novozymes A/S | Proteases and methods for producing them |
| US20060251763A1 (en) | 2003-06-19 | 2006-11-09 | Patkar Shamkant A | Phospholipase variants |
| WO2005070962A1 (en) | 2004-01-21 | 2005-08-04 | Novozymes A/S | Production of a monoclonal antibody in a heterokaryon fungus or in a fungal host cell |
| WO2005092370A1 (en) | 2004-03-22 | 2005-10-06 | Solvay Pharmaceuticals Gmbh | Oral pharmaceutical compositions of lipase-containing products, in particular of pancreatin, containing surfactants |
| PT1809320E (pt) | 2004-10-14 | 2010-10-25 | Altus Pharmaceuticals Inc | Composições contendo lipase, protease e amilase para o tratamento de insuficiência pancreática |
| US20080138856A1 (en) | 2005-02-10 | 2008-06-12 | Novozymes A/S | Enzymatic Enantioselective Ester or Amide Hydrolysis or Synthesis |
| AU2006261442A1 (en) * | 2005-06-24 | 2006-12-28 | Novozymes A/S | Lipases for pharmaceutical use |
| EP1896057A2 (en) | 2005-06-24 | 2008-03-12 | Novozymes A/S | Amylases for pharmaceutical use |
| JP2008546395A (ja) | 2005-06-24 | 2008-12-25 | ノボザイムス アクティーゼルスカブ | 医薬使用のためのプロテアーゼ |
| WO2007080197A2 (en) * | 2006-01-16 | 2007-07-19 | Novozymes A/S | Immobilised enzymes |
| ES2629332T3 (es) * | 2006-01-23 | 2017-08-08 | Novozymes A/S | Variantes de lipasa |
| EP1979456A2 (en) * | 2006-01-23 | 2008-10-15 | The Procter & Gamble Company | A composition comprising a lipase and a bleach catalyst |
| WO2008079685A2 (en) * | 2006-12-21 | 2008-07-03 | Novozymes A/S | Lipase variants for pharmaceutical use |
-
2007
- 2007-12-12 WO PCT/US2007/087168 patent/WO2008079685A2/en active Application Filing
- 2007-12-12 JP JP2009543078A patent/JP5406040B2/ja active Active
- 2007-12-12 CA CA3081308A patent/CA3081308C/en active Active
- 2007-12-12 RU RU2009128067/10A patent/RU2009128067A/ru not_active Application Discontinuation
- 2007-12-12 CN CN201510504893.8A patent/CN105112386A/zh active Pending
- 2007-12-12 AU AU2007337150A patent/AU2007337150A1/en not_active Abandoned
- 2007-12-12 KR KR1020097014850A patent/KR20090101930A/ko not_active Application Discontinuation
- 2007-12-12 CA CA2670643A patent/CA2670643C/en active Active
- 2007-12-12 CN CN200780051638.6A patent/CN101743308B/zh active Active
- 2007-12-12 EP EP12155319.2A patent/EP2455462B1/en active Active
- 2007-12-12 US US12/519,868 patent/US8273348B2/en active Active
- 2007-12-12 MX MX2009006597A patent/MX2009006597A/es not_active Application Discontinuation
- 2007-12-12 EP EP12155317.6A patent/EP2455461B1/en active Active
- 2007-12-12 EP EP12155294.7A patent/EP2455459B1/en active Active
- 2007-12-12 EP EP07869130A patent/EP2099907A2/en not_active Withdrawn
- 2007-12-12 BR BRPI0721103-1A patent/BRPI0721103A2/pt not_active IP Right Cessation
- 2007-12-12 CA CA2961041A patent/CA2961041C/en active Active
- 2007-12-12 EP EP10172609.9A patent/EP2261328B1/en active Active
- 2007-12-12 EP EP12155315A patent/EP2455460A3/en not_active Withdrawn
- 2007-12-18 TW TW096148377A patent/TW200829698A/zh unknown
- 2007-12-21 AR ARP070105859A patent/AR064494A1/es not_active Application Discontinuation
-
2009
- 2009-05-21 IL IL198893A patent/IL198893A0/en unknown
- 2009-05-25 ZA ZA200903598A patent/ZA200903598B/xx unknown
- 2009-07-20 NO NO20092729A patent/NO20092729L/no not_active Application Discontinuation
-
2012
- 2012-08-16 US US13/587,043 patent/US9029115B2/en active Active
-
2015
- 2015-04-06 US US14/679,563 patent/US9539311B2/en active Active
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