BRPI0721103A2 - Lipase, método de determinação do desempenho da digestão in vitro de uma lipase em comparação com uma lipase de referência, uso de uma lipase ou de uma mistura de lipases, composição farmacêutica, e, método para o tratamento de doença - Google Patents
Lipase, método de determinação do desempenho da digestão in vitro de uma lipase em comparação com uma lipase de referência, uso de uma lipase ou de uma mistura de lipases, composição farmacêutica, e, método para o tratamento de doença Download PDFInfo
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- BRPI0721103A2 BRPI0721103A2 BRPI0721103-1A BRPI0721103A BRPI0721103A2 BR PI0721103 A2 BRPI0721103 A2 BR PI0721103A2 BR PI0721103 A BRPI0721103 A BR PI0721103A BR PI0721103 A2 BRPI0721103 A2 BR PI0721103A2
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- lipase
- seq
- protease
- amylase
- activity
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Classifications
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- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
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- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
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- A—HUMAN NECESSITIES
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
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- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/54—Mixtures of enzymes or proenzymes covered by more than a single one of groups A61K38/44 - A61K38/46 or A61K38/51 - A61K38/53
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- A—HUMAN NECESSITIES
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
- C12N9/20—Triglyceride splitting, e.g. by means of lipase
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
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Landscapes
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- Endocrinology (AREA)
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- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Detergent Compositions (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87119606P | 2006-12-21 | 2006-12-21 | |
| US60/871196 | 2006-12-21 | ||
| PCT/US2007/087168 WO2008079685A2 (en) | 2006-12-21 | 2007-12-12 | Lipase variants for pharmaceutical use |
Publications (1)
| Publication Number | Publication Date |
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| BRPI0721103A2 true BRPI0721103A2 (pt) | 2014-03-04 |
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| BRPI0721103-1A BRPI0721103A2 (pt) | 2006-12-21 | 2007-12-12 | Lipase, método de determinação do desempenho da digestão in vitro de uma lipase em comparação com uma lipase de referência, uso de uma lipase ou de uma mistura de lipases, composição farmacêutica, e, método para o tratamento de doença |
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| ATE407693T1 (de) | 2004-03-22 | 2008-09-15 | Solvay Pharm Gmbh | Orale pharmazeutische zusammensetzungen von produkten mit lipase, insbesondere von pankreatin,mit tensiden |
| BRPI0614914A2 (pt) | 2005-07-29 | 2011-04-19 | Solvay Pharm Gmbh | processos para a fabricação de pó de pancreatina esterilizada |
| US11266607B2 (en) | 2005-08-15 | 2022-03-08 | AbbVie Pharmaceuticals GmbH | Process for the manufacture and use of pancreatin micropellet cores |
| US9198871B2 (en) | 2005-08-15 | 2015-12-01 | Abbott Products Gmbh | Delayed release pancreatin compositions |
| US10072256B2 (en) | 2006-05-22 | 2018-09-11 | Abbott Products Gmbh | Process for separating and determining the viral load in a pancreatin sample |
| US8273348B2 (en) | 2006-12-21 | 2012-09-25 | Novozymes A/S | Lipase variants for pharmaceutical use |
| US20090217464A1 (en) * | 2008-02-29 | 2009-09-03 | Philip Frank Souter | Detergent composition comprising lipase |
| MX2010009464A (es) | 2008-02-29 | 2010-09-22 | Dsm Ip Assets Bv | Lipasas con alta especificidad hacia acidos grasos de cadena corta y usos de las mismas. |
| US9163203B2 (en) * | 2008-02-29 | 2015-10-20 | Novozymes A/S | Lipolytic enzyme variant with improved stability and polynucleotides encoding same |
| EP4159833A3 (en) | 2009-12-09 | 2023-07-26 | The Procter & Gamble Company | Fabric and home care products |
| CN103703139A (zh) | 2011-07-22 | 2014-04-02 | 诺维信北美公司 | 用于预处理纤维素材料和改进其水解的方法 |
| US8268305B1 (en) | 2011-09-23 | 2012-09-18 | Bio-Cat, Inc. | Method and compositions to reduce serum levels of triacylglycerides in human beings using a fungal lipase |
| ES2887576T3 (es) * | 2011-12-29 | 2021-12-23 | Novozymes As | Composiciones detergentes con variantes de lipasa |
| US9394530B2 (en) * | 2012-02-03 | 2016-07-19 | Novozymes A/S | Lipase variants and polynucleotides encoding same |
| CN107988181A (zh) * | 2012-04-02 | 2018-05-04 | 诺维信公司 | 脂肪酶变体以及编码其的多核苷酸 |
| EP2906691B1 (en) * | 2012-10-12 | 2021-01-27 | Danisco US Inc. | Compositions and methods comprising a lipolytic enzyme variant |
| CN105209612A (zh) * | 2013-05-14 | 2015-12-30 | 诺维信公司 | 洗涤剂组合物 |
| ES2956266T3 (es) * | 2013-07-19 | 2023-12-18 | Danisco Us Inc | Composiciones y procedimientos que comprenden una variante de enzima lipolítica |
| WO2016079305A1 (en) * | 2014-11-20 | 2016-05-26 | Novozymes A/S | Alicyclobacillus variants and polynucleotides encoding same |
| CN107002054A (zh) | 2014-12-05 | 2017-08-01 | 诺维信公司 | 脂肪酶变体以及编码它们的多核苷酸 |
| US11268076B2 (en) | 2014-12-09 | 2022-03-08 | Novozymes A/S | Lipase variants and polynucleotides encoding same |
| CN107864658A (zh) | 2015-04-07 | 2018-03-30 | 诺维信公司 | 用于选择具有脂肪酶活性的酶的方法 |
| WO2017001673A1 (en) * | 2015-07-01 | 2017-01-05 | Novozymes A/S | Methods of reducing odor |
| US10760037B2 (en) * | 2015-07-03 | 2020-09-01 | Novozymes A/S | Sulfite compositions |
| US11326152B2 (en) | 2016-07-18 | 2022-05-10 | Novozymes A/S | Lipase variants, polynucleotides encoding same and the use thereof |
| WO2018139634A1 (ja) * | 2017-01-30 | 2018-08-02 | 学校法人日本医科大学 | アデノ随伴ウイルス（ａａｖ）キャプシドタンパク質の変異体 |
| CA3073362A1 (en) | 2017-09-27 | 2019-04-04 | Novozymes A/S | Lipase variants and microcapsule compositions comprising such lipase variants |
| US11286443B2 (en) * | 2017-09-27 | 2022-03-29 | The Procter & Gamble Company | Detergent compositions comprising lipases |
| CN111801416A (zh) * | 2018-02-08 | 2020-10-20 | 诺维信公司 | 脂肪酶变体及其组合物 |
| US12269847B2 (en) * | 2018-08-16 | 2025-04-08 | Donaldson Company, Inc. | Genetically encoded polypeptide for affinity capture and purification of biologics |
| CN111334369B (zh) * | 2020-03-11 | 2022-10-21 | 陕西科技大学 | 一种酶法制备卵磷脂型pufa的方法 |
| CN115803083A (zh) * | 2020-06-24 | 2023-03-14 | 基利安股份公司 | 新脂肪酶 |
| US20240035005A1 (en) * | 2020-10-29 | 2024-02-01 | Novozymes A/S | Lipase variants and compositions comprising such lipase variants |
| CN113846074B (zh) * | 2021-10-20 | 2022-10-21 | 南京林业大学 | 一种疏棉状嗜热丝孢菌脂肪酶突变体g91c及其应用 |
| CN119630280A (zh) | 2022-05-14 | 2025-03-14 | 诺维信公司 | 用于预防、处理、抑制和/或消除植物病原性侵染和感染的组合物和方法 |
| WO2023247664A2 (en) * | 2022-06-24 | 2023-12-28 | Novozymes A/S | Lipase variants and compositions comprising such lipase variants |
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| DK173590D0 (da) | 1990-06-06 | 1990-07-19 | Novo Nordisk As | Rekombinante terapeutiske lipaser |
| DE69129988T2 (de) * | 1990-09-13 | 1999-03-18 | Novo Nordisk A/S, Bagsvaerd | Lipase-varianten |
| US5869438A (en) | 1990-09-13 | 1999-02-09 | Novo Nordisk A/S | Lipase variants |
| DK46693D0 (enExample) | 1993-04-23 | 1993-04-23 | Novo Nordisk As | |
| BR9107206A (pt) | 1990-12-05 | 1993-11-03 | Novo Nordisk As | Processo para produzir uma variante de proteina que evoca uma resposta imunogenica diminuida em animais,produtos obtidos,composicao e uso |
| JPH06507071A (ja) | 1991-05-01 | 1994-08-11 | ノボザイムス アクティーゼルスカブ | 安定化酵素 |
| DK39693D0 (da) | 1993-04-02 | 1993-04-02 | Novo Nordisk As | Enzym |
| US5866526A (en) | 1993-10-04 | 1999-02-02 | Novo Nordisk A/S | Enzyme preparation comprising a modified enzyme |
| DE69527835T2 (de) | 1994-02-22 | 2003-04-10 | Novozymes A/S, Bagsvaerd | Methode zur herstellung einer variante eines lipolytischen enzymes |
| AU3924095A (en) | 1994-11-24 | 1996-06-17 | Novo Nordisk A/S | A process for producing polypeptides with reduced allergenicity |
| WO1996017929A1 (en) | 1994-12-07 | 1996-06-13 | Novo Nordisk A/S | Polypeptide with reduced allergenicity |
| CN1165614C (zh) | 1995-01-26 | 2004-09-08 | 诺沃奇梅兹有限公司 | 含有木聚糖酶的动物饲料添加剂 |
| US6495357B1 (en) * | 1995-07-14 | 2002-12-17 | Novozyme A/S | Lipolytic enzymes |
| WO1997004078A1 (en) | 1995-07-14 | 1997-02-06 | Novo Nordisk A/S | A modified enzyme with lipolytic activity |
| DE69632538T2 (de) | 1995-08-11 | 2005-05-19 | Novozymes A/S | Neuartige lipolytische enzyme |
| CA2277618A1 (en) | 1997-01-10 | 1998-07-16 | Novo Nordisk A/S | Enzyme coupled with polymeric molecules for skin care |
| EP1017794A1 (en) | 1997-02-06 | 2000-07-12 | Novo Nordisk A/S | Polypeptide-polymer conjugates having added and/or removed attachment groups |
| WO1999000489A1 (en) | 1997-06-25 | 1999-01-07 | Novo Nordisk A/S | A modified polypeptide |
| AU3247699A (en) | 1998-02-17 | 1999-09-06 | Novo Nordisk A/S | Lipase variant |
| DE69931607T2 (de) * | 1998-02-17 | 2007-05-16 | Novozymes A/S | Lipasevariante |
| CA2346929A1 (en) | 1998-10-13 | 2000-04-20 | Novozymes A/S | A modified polypeptide with reduced immune response |
| CN1206237C (zh) | 1998-10-30 | 2005-06-15 | 诺沃奇梅兹有限公司 | 低免疫原性蛋白质变体 |
| JP2002531067A (ja) | 1998-10-30 | 2002-09-24 | ノボザイムス アクティーゼルスカブ | 低下したアレルゲン性を有するグリコシル化タンパク質 |
| US7312062B2 (en) * | 1998-11-27 | 2007-12-25 | Novozymes A/S | Lipolytic enzyme variants |
| WO2000032758A1 (en) | 1998-11-27 | 2000-06-08 | Novozymes A/S | Lipolytic enzyme variants |
| DE50002450D1 (de) | 1999-03-17 | 2003-07-10 | Solvay Pharm Gmbh | Enzyme zur behandlung von diabetes mellitus typ i |
| EP1171581A1 (en) | 1999-03-31 | 2002-01-16 | Novozymes A/S | Lipase variant |
| EP1428874B1 (en) | 1999-03-31 | 2013-12-18 | Novozymes A/S | Lipase variant |
| CN100429990C (zh) | 2000-02-08 | 2008-11-05 | Dsmip资产公司 | 酸-稳定性蛋白酶在动物饲料中的用途 |
| AU2001254620A1 (en) * | 2000-04-28 | 2001-11-12 | Novozymes A/S | Lipolytic enzyme variant |
| CA2431972C (en) | 2001-01-10 | 2012-10-23 | Novozymes A/S | Thermostable lipolytic enzyme variant |
| AR032392A1 (es) | 2001-01-19 | 2003-11-05 | Solvay Pharm Gmbh | Mezcla de enzimas, preparado farmaceutico y utilizacion de dicho preparado. |
| CA2432329C (en) | 2001-02-07 | 2012-04-10 | Novozymes A/S | Lipase variants |
| US20050255544A1 (en) | 2002-01-16 | 2005-11-17 | Novozymes A/S | Lipolytic enzyme variants and method for their production |
| BRPI0407108A (pt) | 2003-02-06 | 2006-01-24 | Novozymes As | Método para produzir uma imunoglobulina funcional humana |
| DK1625216T3 (da) * | 2003-05-09 | 2013-03-18 | Novozymes As | Lipolytiske enzymvarianter |
| WO2004111216A2 (en) * | 2003-06-19 | 2004-12-23 | Novozymes A/S | Phospholipase variants |
| US20060236414A1 (en) | 2003-06-19 | 2006-10-19 | Novozymes A/S | Proteases and methods for producing them |
| JP2007535913A (ja) | 2004-01-21 | 2007-12-13 | ノボザイムス アクティーゼルスカブ | ヘテロカリオン菌類又は菌類宿主細胞におけるモノクローナル抗体の生成 |
| ATE407693T1 (de) | 2004-03-22 | 2008-09-15 | Solvay Pharm Gmbh | Orale pharmazeutische zusammensetzungen von produkten mit lipase, insbesondere von pankreatin,mit tensiden |
| SI2198880T1 (sl) | 2004-10-14 | 2017-02-28 | Eli Lilly And Co. | Sestavki, ki vsebujejo lipazo, proteazo in amilazo, za zdravljenje pankreasne insuficience |
| WO2006084470A2 (en) | 2005-02-10 | 2006-08-17 | Novozymes A/S | Enzymatic enantioselective ester or amide hydrolysis or synthesis |
| RU2007149045A (ru) * | 2005-06-24 | 2009-07-10 | Новозимс А/С (Dk) | Липазы для фармацевтического применения |
| US8017351B2 (en) | 2005-06-24 | 2011-09-13 | Novozymes A/S | Amylases for pharmaceutical use |
| NZ563777A (en) | 2005-06-24 | 2010-08-27 | Novozymes As | Serine protease derived from Bacillus licheniformis optionally in combination with lipases and amylases for pharmaceutical use |
| WO2007080197A2 (en) * | 2006-01-16 | 2007-07-19 | Novozymes A/S | Immobilised enzymes |
| EP2371948B1 (en) * | 2006-01-23 | 2017-04-19 | Novozymes A/S | Lipase variants |
| JP2009523900A (ja) * | 2006-01-23 | 2009-06-25 | ザ プロクター アンド ギャンブル カンパニー | リパーゼと漂白剤触媒を含む組成物 |
| US8273348B2 (en) * | 2006-12-21 | 2012-09-25 | Novozymes A/S | Lipase variants for pharmaceutical use |
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2007
- 2007-12-12 US US12/519,868 patent/US8273348B2/en active Active
- 2007-12-12 EP EP12155317.6A patent/EP2455461B1/en active Active
- 2007-12-12 EP EP12155315A patent/EP2455460A3/en not_active Withdrawn
- 2007-12-12 RU RU2009128067/10A patent/RU2009128067A/ru not_active Application Discontinuation
- 2007-12-12 EP EP10172609.9A patent/EP2261328B1/en active Active
- 2007-12-12 CN CN200780051638.6A patent/CN101743308B/zh active Active
- 2007-12-12 CA CA2670643A patent/CA2670643C/en active Active
- 2007-12-12 WO PCT/US2007/087168 patent/WO2008079685A2/en not_active Ceased
- 2007-12-12 MX MX2009006597A patent/MX2009006597A/es not_active Application Discontinuation
- 2007-12-12 CN CN201510504893.8A patent/CN105112386A/zh active Pending
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- 2007-12-12 EP EP07869130A patent/EP2099907A2/en not_active Withdrawn
- 2007-12-12 KR KR1020097014850A patent/KR20090101930A/ko not_active Withdrawn
- 2007-12-12 BR BRPI0721103-1A patent/BRPI0721103A2/pt not_active IP Right Cessation
- 2007-12-18 TW TW096148377A patent/TW200829698A/zh unknown
- 2007-12-21 AR ARP070105859A patent/AR064494A1/es not_active Application Discontinuation
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2009
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