TW200829698A - Lipase variants for pharmaceutical use - Google Patents
Lipase variants for pharmaceutical use Download PDFInfo
- Publication number
- TW200829698A TW200829698A TW096148377A TW96148377A TW200829698A TW 200829698 A TW200829698 A TW 200829698A TW 096148377 A TW096148377 A TW 096148377A TW 96148377 A TW96148377 A TW 96148377A TW 200829698 A TW200829698 A TW 200829698A
- Authority
- TW
- Taiwan
- Prior art keywords
- lipase
- seq
- amino acid
- enzyme
- activity
- Prior art date
Links
- 108090001060 Lipase Proteins 0.000 title claims abstract description 240
- 102000004882 Lipase Human genes 0.000 title claims abstract description 240
- 239000004367 Lipase Substances 0.000 title claims abstract description 239
- 235000019421 lipase Nutrition 0.000 title claims abstract description 239
- 150000001413 amino acids Chemical class 0.000 claims abstract description 56
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims abstract description 50
- 108091005804 Peptidases Proteins 0.000 claims abstract description 27
- 239000004365 Protease Substances 0.000 claims abstract description 27
- 239000003833 bile salt Substances 0.000 claims abstract description 26
- 230000029087 digestion Effects 0.000 claims abstract description 24
- 230000000694 effects Effects 0.000 claims abstract description 22
- 238000000034 method Methods 0.000 claims abstract description 21
- 102000057297 Pepsin A Human genes 0.000 claims abstract description 19
- 108090000284 Pepsin A Proteins 0.000 claims abstract description 19
- 229940111202 pepsin Drugs 0.000 claims abstract description 19
- 239000004382 Amylase Substances 0.000 claims abstract description 18
- 102000013142 Amylases Human genes 0.000 claims abstract description 18
- 108010065511 Amylases Proteins 0.000 claims abstract description 18
- 235000019418 amylase Nutrition 0.000 claims abstract description 18
- 238000000338 in vitro Methods 0.000 claims abstract description 17
- 230000001079 digestive effect Effects 0.000 claims abstract description 9
- 201000003883 Cystic fibrosis Diseases 0.000 claims abstract description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 7
- 208000035475 disorder Diseases 0.000 claims abstract description 7
- 206010033645 Pancreatitis Diseases 0.000 claims abstract description 6
- 208000035467 Pancreatic insufficiency Diseases 0.000 claims abstract description 5
- 238000006731 degradation reaction Methods 0.000 claims abstract description 4
- 206010012601 diabetes mellitus Diseases 0.000 claims abstract description 4
- 102220479102 CD59 glycoprotein_N33Q_mutation Human genes 0.000 claims description 1609
- 102220097791 rs201753350 Human genes 0.000 claims description 549
- 102220598657 5-hydroxytryptamine receptor 1E_D27R_mutation Human genes 0.000 claims description 270
- 102220104423 rs63749907 Human genes 0.000 claims description 141
- 102220606460 C-reactive protein_G163V_mutation Human genes 0.000 claims description 100
- 102220052839 rs73113102 Human genes 0.000 claims description 94
- 102220254290 rs1553156175 Human genes 0.000 claims description 71
- 102220257095 rs587779102 Human genes 0.000 claims description 63
- 238000006467 substitution reaction Methods 0.000 claims description 55
- 102200108133 rs201753350 Human genes 0.000 claims description 51
- 102220105300 rs879254420 Human genes 0.000 claims description 48
- 229910052727 yttrium Inorganic materials 0.000 claims description 35
- 102220056648 rs730881059 Human genes 0.000 claims description 34
- 102220021416 rs80357110 Human genes 0.000 claims description 29
- 229910052720 vanadium Inorganic materials 0.000 claims description 27
- 102000035195 Peptidases Human genes 0.000 claims description 26
- 235000005911 diet Nutrition 0.000 claims description 24
- 102000004190 Enzymes Human genes 0.000 claims description 23
- 108090000790 Enzymes Proteins 0.000 claims description 23
- 102220475917 Oligophrenin-1_G91V_mutation Human genes 0.000 claims description 23
- 230000037213 diet Effects 0.000 claims description 23
- 229940088598 enzyme Drugs 0.000 claims description 23
- 102200101939 rs72554338 Human genes 0.000 claims description 23
- 229910052717 sulfur Inorganic materials 0.000 claims description 22
- 102220412429 c.297A>C Human genes 0.000 claims description 21
- 229910052698 phosphorus Inorganic materials 0.000 claims description 21
- 229910052721 tungsten Inorganic materials 0.000 claims description 20
- 235000019626 lipase activity Nutrition 0.000 claims description 19
- 102220105121 rs150066950 Human genes 0.000 claims description 19
- 102220083998 rs551990619 Human genes 0.000 claims description 18
- 230000006872 improvement Effects 0.000 claims description 17
- 102220487741 Protein eyes shut homolog_D27N_mutation Human genes 0.000 claims description 16
- 229910052757 nitrogen Inorganic materials 0.000 claims description 16
- 229910052739 hydrogen Inorganic materials 0.000 claims description 15
- 102200110982 rs28931568 Human genes 0.000 claims description 15
- 102220041676 rs587779102 Human genes 0.000 claims description 15
- 102220020884 rs80356880 Human genes 0.000 claims description 15
- 239000000203 mixture Substances 0.000 claims description 14
- 102220276634 rs1553131563 Human genes 0.000 claims description 14
- 102220536108 Serine/threonine-protein kinase OSR1_K46M_mutation Human genes 0.000 claims description 13
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 13
- 102200121669 rs104894915 Human genes 0.000 claims description 13
- 108090000623 proteins and genes Proteins 0.000 claims description 12
- 102220552927 Fidgetin-like protein 1_G163H_mutation Human genes 0.000 claims description 11
- 102220564804 Killer cell immunoglobulin-like receptor 2DL2_N73D_mutation Human genes 0.000 claims description 11
- 102220593678 Stromal interaction molecule 1_E87Q_mutation Human genes 0.000 claims description 11
- 102220245301 rs1555596673 Human genes 0.000 claims description 11
- 102200027496 rs63751429 Human genes 0.000 claims description 11
- 102220330013 rs78488639 Human genes 0.000 claims description 11
- 210000002784 stomach Anatomy 0.000 claims description 11
- 239000002253 acid Substances 0.000 claims description 10
- 102000004169 proteins and genes Human genes 0.000 claims description 10
- 102220198277 rs1057519874 Human genes 0.000 claims description 10
- 102220204637 rs137852883 Human genes 0.000 claims description 10
- 102220045389 rs587782063 Human genes 0.000 claims description 10
- 102220360655 c.170A>G Human genes 0.000 claims description 9
- 102220536901 PRKC apoptosis WT1 regulator protein_L69I_mutation Human genes 0.000 claims description 8
- 235000021588 free fatty acids Nutrition 0.000 claims description 8
- 101150025207 VPK2 gene Proteins 0.000 claims description 7
- 101100049497 Variola virus (isolate Human/India/Ind3/1967) C14L gene Proteins 0.000 claims description 7
- 102200006121 rs1060501260 Human genes 0.000 claims description 7
- 102200131348 rs57983345 Human genes 0.000 claims description 7
- 102220059022 rs786201869 Human genes 0.000 claims description 7
- 102200158370 rs868333 Human genes 0.000 claims description 7
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 6
- 102220600976 Syndecan-4_N26A_mutation Human genes 0.000 claims description 6
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims description 6
- 102200158812 rs104894225 Human genes 0.000 claims description 6
- 102220082775 rs144148008 Human genes 0.000 claims description 6
- 102220184188 rs758665573 Human genes 0.000 claims description 6
- 102220087418 rs864622444 Human genes 0.000 claims description 6
- 102220104592 rs879254078 Human genes 0.000 claims description 6
- 102220524143 Cadherin-24_N26I_mutation Human genes 0.000 claims description 5
- 102220515651 Insulin-like growth factor I_R84E_mutation Human genes 0.000 claims description 5
- 102220593541 PMS1 protein homolog 1_N11D_mutation Human genes 0.000 claims description 5
- 102220474144 Phosphatidylcholine-sterol acyltransferase_T37M_mutation Human genes 0.000 claims description 5
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims description 5
- 239000000872 buffer Substances 0.000 claims description 5
- 239000003085 diluting agent Substances 0.000 claims description 5
- 102200161847 rs104894126 Human genes 0.000 claims description 5
- 102200116704 rs77587352 Human genes 0.000 claims description 5
- 102220125026 rs886043836 Human genes 0.000 claims description 5
- 239000000243 solution Substances 0.000 claims description 5
- 239000007983 Tris buffer Substances 0.000 claims description 4
- 102200080817 rs104894869 Human genes 0.000 claims description 4
- 102200027488 rs63749907 Human genes 0.000 claims description 4
- 102220028139 rs80357084 Human genes 0.000 claims description 4
- 239000000126 substance Substances 0.000 claims description 4
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims description 4
- 102220560906 Ataxin-2_N73Y_mutation Human genes 0.000 claims description 3
- 239000005711 Benzoic acid Substances 0.000 claims description 3
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 3
- 102220642119 Lipoma-preferred partner_D96R_mutation Human genes 0.000 claims description 3
- 102220508063 Mitochondrial folate transporter/carrier_G91R_mutation Human genes 0.000 claims description 3
- 102220526321 NHP2-like protein 1_G38K_mutation Human genes 0.000 claims description 3
- 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 claims description 3
- 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 claims description 3
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 claims description 3
- 102220616017 Sterile alpha motif domain-containing protein 5_D96Y_mutation Human genes 0.000 claims description 3
- 150000001412 amines Chemical class 0.000 claims description 3
- 125000003277 amino group Chemical group 0.000 claims description 3
- 239000001110 calcium chloride Substances 0.000 claims description 3
- 229910001628 calcium chloride Inorganic materials 0.000 claims description 3
- 235000011148 calcium chloride Nutrition 0.000 claims description 3
- 238000004364 calculation method Methods 0.000 claims description 3
- 230000015556 catabolic process Effects 0.000 claims description 3
- 239000003814 drug Substances 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 239000008194 pharmaceutical composition Substances 0.000 claims description 3
- 102200102592 rs104893740 Human genes 0.000 claims description 3
- 102220229111 rs759454598 Human genes 0.000 claims description 3
- 239000001632 sodium acetate Substances 0.000 claims description 3
- 235000017281 sodium acetate Nutrition 0.000 claims description 3
- 239000000758 substrate Substances 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 102220600243 Cerebellin-2_N23Q_mutation Human genes 0.000 claims description 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims description 2
- UEZVMMHDMIWARA-UHFFFAOYSA-N Metaphosphoric acid Chemical compound OP(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-N 0.000 claims description 2
- 229920004890 Triton X-100 Polymers 0.000 claims description 2
- 238000013019 agitation Methods 0.000 claims description 2
- 231100000673 dose–response relationship Toxicity 0.000 claims description 2
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims description 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 claims description 2
- 102220057725 rs374836770 Human genes 0.000 claims 12
- 102220644676 Galectin-related protein_D96L_mutation Human genes 0.000 claims 7
- 239000000843 powder Substances 0.000 claims 5
- 102220473558 ADP-ribosylation factor-like protein 2-binding protein_E56A_mutation Human genes 0.000 claims 4
- 102220517768 Methyl-CpG-binding domain protein 3-like 2B_D27Y_mutation Human genes 0.000 claims 3
- 102220496421 Zinc finger CCHC domain-containing protein 24_E43V_mutation Human genes 0.000 claims 3
- 102220277043 rs1553408229 Human genes 0.000 claims 3
- 102220312400 rs1555802310 Human genes 0.000 claims 3
- 102200084990 rs199422124 Human genes 0.000 claims 3
- 102220568523 Clustered mitochondria protein homolog_E99S_mutation Human genes 0.000 claims 2
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims 2
- 102220500768 Protein N-lysine methyltransferase METTL21D_D96V_mutation Human genes 0.000 claims 2
- 102220363768 c.76A>C Human genes 0.000 claims 2
- 102200068777 rs1805005 Human genes 0.000 claims 2
- 102200097285 rs199473487 Human genes 0.000 claims 2
- 102220271537 rs200383861 Human genes 0.000 claims 2
- 102220041065 rs200979664 Human genes 0.000 claims 2
- 102200028671 rs3765620 Human genes 0.000 claims 2
- 102200006128 rs559848002 Human genes 0.000 claims 2
- 102200058234 rs80338731 Human genes 0.000 claims 2
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims 1
- 241000283690 Bos taurus Species 0.000 claims 1
- 102000014914 Carrier Proteins Human genes 0.000 claims 1
- 108090000317 Chymotrypsin Proteins 0.000 claims 1
- 206010016654 Fibrosis Diseases 0.000 claims 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 101710084378 Lipase 2 Proteins 0.000 claims 1
- 239000005642 Oleic acid Substances 0.000 claims 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims 1
- 235000010627 Phaseolus vulgaris Nutrition 0.000 claims 1
- 244000046052 Phaseolus vulgaris Species 0.000 claims 1
- 108091006629 SLC13A2 Proteins 0.000 claims 1
- 108091008324 binding proteins Proteins 0.000 claims 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 229960002376 chymotrypsin Drugs 0.000 claims 1
- 208000031513 cyst Diseases 0.000 claims 1
- 230000007812 deficiency Effects 0.000 claims 1
- 230000028023 exocytosis Effects 0.000 claims 1
- 230000004761 fibrosis Effects 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims 1
- VIKNJXKGJWUCNN-XGXHKTLJSA-N norethisterone Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 VIKNJXKGJWUCNN-XGXHKTLJSA-N 0.000 claims 1
- 102220099510 rs878853826 Human genes 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 239000002689 soil Substances 0.000 claims 1
- 241001515965 unidentified phage Species 0.000 claims 1
- 239000000052 vinegar Substances 0.000 claims 1
- 235000021419 vinegar Nutrition 0.000 claims 1
- 230000009278 visceral effect Effects 0.000 claims 1
- 229940093761 bile salts Drugs 0.000 abstract description 9
- 241000223258 Thermomyces lanuginosus Species 0.000 abstract description 7
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
- 229940040461 lipase Drugs 0.000 description 162
- 235000001014 amino acid Nutrition 0.000 description 39
- 229940024606 amino acid Drugs 0.000 description 37
- 239000000523 sample Substances 0.000 description 18
- 239000003925 fat Substances 0.000 description 13
- 235000019197 fats Nutrition 0.000 description 13
- 235000019419 proteases Nutrition 0.000 description 9
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 8
- 235000003704 aspartic acid Nutrition 0.000 description 7
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 7
- 125000000539 amino acid group Chemical group 0.000 description 6
- 238000006243 chemical reaction Methods 0.000 description 6
- 229920001184 polypeptide Polymers 0.000 description 6
- 102000004196 processed proteins & peptides Human genes 0.000 description 6
- 108090000765 processed proteins & peptides Proteins 0.000 description 6
- 235000018102 proteins Nutrition 0.000 description 6
- 238000012217 deletion Methods 0.000 description 5
- 230000037430 deletion Effects 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 238000004448 titration Methods 0.000 description 5
- 241000223198 Humicola Species 0.000 description 4
- 102100023105 Sialin Human genes 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 150000001720 carbohydrates Chemical class 0.000 description 4
- 235000014633 carbohydrates Nutrition 0.000 description 4
- 238000011534 incubation Methods 0.000 description 4
- 102220279229 rs1554893808 Human genes 0.000 description 4
- 102100031415 Hepatic triacylglycerol lipase Human genes 0.000 description 3
- 108010013563 Lipoprotein Lipase Proteins 0.000 description 3
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 3
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 3
- 230000008033 biological extinction Effects 0.000 description 3
- 238000010790 dilution Methods 0.000 description 3
- 239000012895 dilution Substances 0.000 description 3
- 238000001727 in vivo Methods 0.000 description 3
- 239000002609 medium Substances 0.000 description 3
- 150000003904 phospholipids Chemical class 0.000 description 3
- 230000002829 reductive effect Effects 0.000 description 3
- 239000004475 Arginine Substances 0.000 description 2
- 241001337994 Cryptococcus <scale insect> Species 0.000 description 2
- 241000233866 Fungi Species 0.000 description 2
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerol Natural products OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 102100037611 Lysophospholipase Human genes 0.000 description 2
- 240000004371 Panax ginseng Species 0.000 description 2
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 2
- 235000003140 Panax quinquefolius Nutrition 0.000 description 2
- 102100035200 Phospholipase A and acyltransferase 4 Human genes 0.000 description 2
- 241000228341 Talaromyces Species 0.000 description 2
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 2
- 238000012937 correction Methods 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 235000008434 ginseng Nutrition 0.000 description 2
- 235000013922 glutamic acid Nutrition 0.000 description 2
- 239000004220 glutamic acid Substances 0.000 description 2
- 239000001963 growth medium Substances 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 235000013336 milk Nutrition 0.000 description 2
- 239000008267 milk Substances 0.000 description 2
- 210000004080 milk Anatomy 0.000 description 2
- 230000035772 mutation Effects 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 235000019198 oils Nutrition 0.000 description 2
- 238000011218 seed culture Methods 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 2
- DRCWOKJLSQUJPZ-DZGCQCFKSA-N (4ar,9as)-n-ethyl-1,4,9,9a-tetrahydrofluoren-4a-amine Chemical compound C1C2=CC=CC=C2[C@]2(NCC)[C@H]1CC=CC2 DRCWOKJLSQUJPZ-DZGCQCFKSA-N 0.000 description 1
- KSEBMYQBYZTDHS-HWKANZROSA-M (E)-Ferulic acid Natural products COC1=CC(\C=C\C([O-])=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-M 0.000 description 1
- -1 1,1,3,3-tetramethylbutyl)-phenyl group Chemical group 0.000 description 1
- ZUPZIBXPMSNWDP-UHFFFAOYSA-N 2-(2,3-dihydroxypropoxy)ethyl-trimethylazanium Chemical compound C[N+](C)(C)CCOCC(O)CO ZUPZIBXPMSNWDP-UHFFFAOYSA-N 0.000 description 1
- GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 description 1
- GNFTZDOKVXKIBK-UHFFFAOYSA-N 3-(2-methoxyethoxy)benzohydrazide Chemical compound COCCOC1=CC=CC(C(=O)NN)=C1 GNFTZDOKVXKIBK-UHFFFAOYSA-N 0.000 description 1
- UHPMCKVQTMMPCG-UHFFFAOYSA-N 5,8-dihydroxy-2-methoxy-6-methyl-7-(2-oxopropyl)naphthalene-1,4-dione Chemical compound CC1=C(CC(C)=O)C(O)=C2C(=O)C(OC)=CC(=O)C2=C1O UHPMCKVQTMMPCG-UHFFFAOYSA-N 0.000 description 1
- 241000235349 Ascomycota Species 0.000 description 1
- 241000228212 Aspergillus Species 0.000 description 1
- 241000223651 Aureobasidium Species 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 241000222120 Candida <Saccharomycetales> Species 0.000 description 1
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- 244000241257 Cucumis melo Species 0.000 description 1
- 235000015510 Cucumis melo subsp melo Nutrition 0.000 description 1
- OTMSDBZUPAUEDD-UHFFFAOYSA-N Ethane Chemical group CC OTMSDBZUPAUEDD-UHFFFAOYSA-N 0.000 description 1
- 241000221207 Filobasidium Species 0.000 description 1
- 241000223218 Fusarium Species 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 101001008429 Homo sapiens Nucleobindin-2 Proteins 0.000 description 1
- 241000171741 Humicola fuscoatra Species 0.000 description 1
- 241000223199 Humicola grisea Species 0.000 description 1
- 241001350650 Humicola lutea Species 0.000 description 1
- 241001373560 Humicola sp. Species 0.000 description 1
- 102000004157 Hydrolases Human genes 0.000 description 1
- 108090000604 Hydrolases Proteins 0.000 description 1
- 241000235649 Kluyveromyces Species 0.000 description 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
- 102000017055 Lipoprotein Lipase Human genes 0.000 description 1
- 108020002496 Lysophospholipase Proteins 0.000 description 1
- 241001344133 Magnaporthe Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 229920003091 Methocel™ Polymers 0.000 description 1
- 102000014171 Milk Proteins Human genes 0.000 description 1
- 108010011756 Milk Proteins Proteins 0.000 description 1
- 241000235395 Mucor Species 0.000 description 1
- 241000226677 Myceliophthora Species 0.000 description 1
- 241000233892 Neocallimastix Species 0.000 description 1
- 241000221960 Neurospora Species 0.000 description 1
- 102100027441 Nucleobindin-2 Human genes 0.000 description 1
- 238000013494 PH determination Methods 0.000 description 1
- 241001236817 Paecilomyces <Clavicipitaceae> Species 0.000 description 1
- 108010058864 Phospholipases A2 Proteins 0.000 description 1
- 241000235648 Pichia Species 0.000 description 1
- 241000235379 Piromyces Species 0.000 description 1
- 102000029797 Prion Human genes 0.000 description 1
- 108091000054 Prion Proteins 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- 241000030452 Rasamsonia byssochlamydoides Species 0.000 description 1
- 241000235070 Saccharomyces Species 0.000 description 1
- 241000222480 Schizophyllum Species 0.000 description 1
- 241000235346 Schizosaccharomyces Species 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- 241000228178 Thermoascus Species 0.000 description 1
- 241000223257 Thermomyces Species 0.000 description 1
- 241001261109 Thermomyces ibadanensis Species 0.000 description 1
- 241000650705 Thermomyces verrucosus Species 0.000 description 1
- 241001494489 Thielavia Species 0.000 description 1
- 241001149964 Tolypocladium Species 0.000 description 1
- 241000223259 Trichoderma Species 0.000 description 1
- 241000209140 Triticum Species 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- YKHUTMGNPUIXEN-UHFFFAOYSA-N [Ru].[O-][N+]#N Chemical group [Ru].[O-][N+]#N YKHUTMGNPUIXEN-UHFFFAOYSA-N 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 229940009098 aspartate Drugs 0.000 description 1
- 235000013405 beer Nutrition 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 150000001732 carboxylic acid derivatives Chemical group 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
- 235000021240 caseins Nutrition 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229960001231 choline Drugs 0.000 description 1
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 1
- 230000002759 chromosomal effect Effects 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 239000012228 culture supernatant Substances 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- KSEBMYQBYZTDHS-HWKANZROSA-N ferulic acid Chemical compound COC1=CC(\C=C\C(O)=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-N 0.000 description 1
- 229940114124 ferulic acid Drugs 0.000 description 1
- KSEBMYQBYZTDHS-UHFFFAOYSA-N ferulic acid Natural products COC1=CC(C=CC(O)=O)=CC=C1O KSEBMYQBYZTDHS-UHFFFAOYSA-N 0.000 description 1
- 235000001785 ferulic acid Nutrition 0.000 description 1
- 235000013312 flour Nutrition 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 229930182830 galactose Natural products 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 229960000310 isoleucine Drugs 0.000 description 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 1
- 125000000741 isoleucyl group Chemical group [H]N([H])C(C(C([H])([H])[H])C([H])([H])C([H])([H])[H])C(=O)O* 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000008774 maternal effect Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 108010020132 microbial serine proteinases Proteins 0.000 description 1
- 235000021239 milk protein Nutrition 0.000 description 1
- VYGYNVZNSSTDLJ-HKCOAVLJSA-N monorden Natural products CC1CC2OC2C=C/C=C/C(=O)CC3C(C(=CC(=C3Cl)O)O)C(=O)O1 VYGYNVZNSSTDLJ-HKCOAVLJSA-N 0.000 description 1
- 230000002536 noncholinergic effect Effects 0.000 description 1
- 229940049964 oleate Drugs 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 230000001175 peptic effect Effects 0.000 description 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
- 229920001592 potato starch Polymers 0.000 description 1
- 244000144977 poultry Species 0.000 description 1
- 235000013594 poultry meat Nutrition 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000006041 probiotic Substances 0.000 description 1
- 230000000529 probiotic effect Effects 0.000 description 1
- 235000018291 probiotics Nutrition 0.000 description 1
- 150000003180 prostaglandins Chemical class 0.000 description 1
- 102220205885 rs1057524159 Human genes 0.000 description 1
- 102220022307 rs80357066 Human genes 0.000 description 1
- 102220095343 rs876660671 Human genes 0.000 description 1
- 210000004767 rumen Anatomy 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000009469 supplementation Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- QURCVMIEKCOAJU-UHFFFAOYSA-N trans-isoferulic acid Natural products COC1=CC=C(C=CC(O)=O)C=C1O QURCVMIEKCOAJU-UHFFFAOYSA-N 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 208000014001 urinary system disease Diseases 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/54—Mixtures of enzymes or proenzymes covered by more than a single one of groups A61K38/44 - A61K38/46 or A61K38/51 - A61K38/53
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
- C12N9/20—Triglyceride splitting, e.g. by means of lipase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/01—Carboxylic ester hydrolases (3.1.1)
- C12Y301/01003—Triacylglycerol lipase (3.1.1.3)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Nutrition Science (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Detergent Compositions (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87119606P | 2006-12-21 | 2006-12-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW200829698A true TW200829698A (en) | 2008-07-16 |
Family
ID=38043020
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW096148377A TW200829698A (en) | 2006-12-21 | 2007-12-18 | Lipase variants for pharmaceutical use |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US8273348B2 (enExample) |
| EP (6) | EP2455459B1 (enExample) |
| JP (1) | JP5406040B2 (enExample) |
| KR (1) | KR20090101930A (enExample) |
| CN (2) | CN105112386A (enExample) |
| AR (1) | AR064494A1 (enExample) |
| AU (1) | AU2007337150A1 (enExample) |
| BR (1) | BRPI0721103A2 (enExample) |
| CA (3) | CA2961041C (enExample) |
| IL (1) | IL198893A0 (enExample) |
| MX (1) | MX2009006597A (enExample) |
| NO (1) | NO20092729L (enExample) |
| RU (1) | RU2009128067A (enExample) |
| TW (1) | TW200829698A (enExample) |
| WO (1) | WO2008079685A2 (enExample) |
| ZA (1) | ZA200903598B (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI903491B (zh) * | 2024-05-09 | 2025-11-01 | 國立高雄科技大學 | 水體與沉積物通量培養系統 |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2560613C (en) | 2004-03-22 | 2015-11-24 | Solvay Pharmaceuticals Gmbh | Oral pharmaceutical compositions of lipase-containing products, in particular of pancreatin, containing surfactants |
| HUE031042T2 (en) | 2005-07-29 | 2017-06-28 | Abbott Laboratories Gmbh | Methods for producing pancreatin powder with low viral content |
| US9198871B2 (en) | 2005-08-15 | 2015-12-01 | Abbott Products Gmbh | Delayed release pancreatin compositions |
| US11266607B2 (en) | 2005-08-15 | 2022-03-08 | AbbVie Pharmaceuticals GmbH | Process for the manufacture and use of pancreatin micropellet cores |
| US10072256B2 (en) | 2006-05-22 | 2018-09-11 | Abbott Products Gmbh | Process for separating and determining the viral load in a pancreatin sample |
| KR20090101930A (ko) * | 2006-12-21 | 2009-09-29 | 노보자임스 에이/에스 | 약학적 사용을 위한 리파아제 변형체 |
| MX2010009077A (es) * | 2008-02-29 | 2010-09-24 | Novozymes As | Variante de enzima lipolitica con estabilidad mejorada y polinucleotidos que codifican para la misma. |
| US8637101B2 (en) | 2008-02-29 | 2014-01-28 | Dsm Ip Assets B.V. | Lipases with high specificity towards short chain fatty acids and uses thereof |
| AR070498A1 (es) * | 2008-02-29 | 2010-04-07 | Procter & Gamble | Composicion detergente que comprende lipasa |
| CN102652175B (zh) | 2009-12-09 | 2016-02-10 | 宝洁公司 | 织物和家居护理产品 |
| EP2734633B1 (en) | 2011-07-22 | 2019-05-01 | Novozymes North America, Inc. | Processes for pretreating cellulosic material and improving hydrolysis thereof |
| US8268305B1 (en) | 2011-09-23 | 2012-09-18 | Bio-Cat, Inc. | Method and compositions to reduce serum levels of triacylglycerides in human beings using a fungal lipase |
| CN110777016A (zh) * | 2011-12-29 | 2020-02-11 | 诺维信公司 | 具有脂肪酶变体的洗涤剂组合物 |
| CN104080908B (zh) * | 2012-02-03 | 2018-02-06 | 诺维信公司 | 脂肪酶变体以及编码它们的多核苷酸 |
| CN107988181A (zh) | 2012-04-02 | 2018-05-04 | 诺维信公司 | 脂肪酶变体以及编码其的多核苷酸 |
| EP3842531A1 (en) * | 2012-10-12 | 2021-06-30 | Danisco US Inc. | Compositions and method comprising a lipolytic enzyme variant |
| EP4717756A2 (en) | 2013-05-14 | 2026-04-01 | Novozymes A/S | Lipase variants and detergent compositions |
| EP3696264B1 (en) * | 2013-07-19 | 2023-06-28 | Danisco US Inc. | Compositions and methods comprising a lipolytic enzyme variant |
| WO2016079305A1 (en) * | 2014-11-20 | 2016-05-26 | Novozymes A/S | Alicyclobacillus variants and polynucleotides encoding same |
| WO2016087401A1 (en) * | 2014-12-05 | 2016-06-09 | Novozymes A/S | Lipase variants and polynucleotides encoding same |
| US11268076B2 (en) * | 2014-12-09 | 2022-03-08 | Novozymes A/S | Lipase variants and polynucleotides encoding same |
| WO2016164596A2 (en) | 2015-04-07 | 2016-10-13 | Novozymes A/S | Methods for selecting enzymes having lipase activity |
| MX394221B (es) * | 2015-07-01 | 2025-03-24 | Novozymes As | Metodos de reduccion de olor. |
| CN107995922B (zh) * | 2015-07-03 | 2021-12-28 | 诺维信公司 | 在亚硫酸盐的存在下具有改进的稳定性的洗涤剂组合物 |
| EP3485008B1 (en) * | 2016-07-18 | 2024-01-31 | Novozymes A/S | Lipase variants, polynucleotides encoding same and the use thereof |
| EP3575398A4 (en) * | 2017-01-30 | 2020-11-11 | Nippon Medical School Foundation | ADENO-ASSOCIATED VIRUS (AAV) CAPSIDE PROTEIN MUTANT |
| EP4567094A3 (en) * | 2017-09-27 | 2026-01-07 | Novozymes A/S | Lipase variants and microcapsule compositions comprising such lipase variants |
| JP7114697B2 (ja) | 2017-09-27 | 2022-08-08 | ザ プロクター アンド ギャンブル カンパニー | リパーゼを含む洗剤組成物 |
| EP3749759A1 (en) * | 2018-02-08 | 2020-12-16 | Novozymes A/S | Lipase variants and compositions thereof |
| US12269847B2 (en) * | 2018-08-16 | 2025-04-08 | Donaldson Company, Inc. | Genetically encoded polypeptide for affinity capture and purification of biologics |
| CN111334369B (zh) * | 2020-03-11 | 2022-10-21 | 陕西科技大学 | 一种酶法制备卵磷脂型pufa的方法 |
| CN115803083A (zh) * | 2020-06-24 | 2023-03-14 | 基利安股份公司 | 新脂肪酶 |
| JP2023547450A (ja) * | 2020-10-29 | 2023-11-10 | ノボザイムス アクティーゼルスカブ | リパーゼ変異体及びそのようなリパーゼ変異体を含む組成物 |
| CN113846074B (zh) * | 2021-10-20 | 2022-10-21 | 南京林业大学 | 一种疏棉状嗜热丝孢菌脂肪酶突变体g91c及其应用 |
| CN116732002A (zh) * | 2022-03-01 | 2023-09-12 | 中国科学院天津工业生物技术研究所 | 一种耐受表面活性剂的脂肪酶变体及其应用 |
| EP4525615A2 (en) | 2022-05-14 | 2025-03-26 | Novozymes A/S | Compositions and methods for preventing, treating, supressing and/or eliminating phytopathogenic infestations and infections |
| EP4544015A2 (en) * | 2022-06-24 | 2025-04-30 | Novozymes A/S | Lipase variants and compositions comprising such lipase variants |
| CN121874157A (zh) * | 2023-12-01 | 2026-04-17 | 青岛蔚蓝生物集团有限公司 | 一种脂肪酶突变体 |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK173590D0 (da) * | 1990-06-06 | 1990-07-19 | Novo Nordisk As | Rekombinante terapeutiske lipaser |
| US5869438A (en) | 1990-09-13 | 1999-02-09 | Novo Nordisk A/S | Lipase variants |
| DK46693D0 (enExample) * | 1993-04-23 | 1993-04-23 | Novo Nordisk As | |
| AU657278B2 (en) | 1990-09-13 | 1995-03-09 | Novo Nordisk A/S | Lipase variants |
| FI932561L (fi) | 1990-12-05 | 1993-06-04 | Novo Nordisk As | Proteiner med foeraendrade epitoper och foerfaranden foer deras framstaellning |
| FI934812A0 (fi) | 1991-05-01 | 1993-10-29 | Novo Nordisk As | Stabiliserade entzymer |
| DK39693D0 (da) | 1993-04-02 | 1993-04-02 | Novo Nordisk As | Enzym |
| AU7807394A (en) | 1993-10-04 | 1995-05-01 | Novo Nordisk A/S | An enzyme preparation comprising a modified enzyme |
| DE69527835T2 (de) | 1994-02-22 | 2003-04-10 | Novozymes A/S, Bagsvaerd | Methode zur herstellung einer variante eines lipolytischen enzymes |
| WO1996016177A1 (en) | 1994-11-24 | 1996-05-30 | Novo Nordisk A/S | A process for producing polypeptides with reduced allergenicity |
| FI972443A7 (fi) | 1994-12-07 | 1997-06-09 | Novozymes As | Polypeptidi, jonka allergeenisuus on vähentynyt |
| CN1165614C (zh) | 1995-01-26 | 2004-09-08 | 诺沃奇梅兹有限公司 | 含有木聚糖酶的动物饲料添加剂 |
| EP0839186B1 (en) | 1995-07-14 | 2004-11-10 | Novozymes A/S | A modified enzyme with lipolytic activity |
| US6495357B1 (en) * | 1995-07-14 | 2002-12-17 | Novozyme A/S | Lipolytic enzymes |
| AU6655196A (en) | 1995-08-11 | 1997-03-12 | Novo Nordisk A/S | Novel lipolytic enzymes |
| CA2277618A1 (en) | 1997-01-10 | 1998-07-16 | Novo Nordisk A/S | Enzyme coupled with polymeric molecules for skin care |
| JP2001511162A (ja) | 1997-02-06 | 2001-08-07 | ノボ ノルディスク アクティーゼルスカブ | 付加され、そして／又は除去された付着基を有するポリペプチド−ポリマー結合体 |
| ATE375387T1 (de) | 1997-06-25 | 2007-10-15 | Novozymes As | Modifiziertes polypeptid |
| AU3247699A (en) | 1998-02-17 | 1999-09-06 | Novo Nordisk A/S | Lipase variant |
| ATE328070T1 (de) * | 1998-02-17 | 2006-06-15 | Novozymes As | Lipasevariante |
| AU6078899A (en) | 1998-10-13 | 2000-05-01 | Novozymes A/S | A modified polypeptide with reduced immune response |
| ATE365210T1 (de) | 1998-10-30 | 2007-07-15 | Novozymes As | Glykosylierte proteine mit reduzierter allergenität |
| ES2220114T3 (es) | 1998-10-30 | 2004-12-01 | Novozymes A/S | Variantes de proteinas poco alergenicas. |
| US7312062B2 (en) * | 1998-11-27 | 2007-12-25 | Novozymes A/S | Lipolytic enzyme variants |
| NZ511340A (en) | 1998-11-27 | 2003-07-25 | Novozymes As | Lipolytic enzyme variants |
| ATE242003T1 (de) | 1999-03-17 | 2003-06-15 | Solvay Pharm Gmbh | Enzyme zur behandlung von diabetes mellitus typ i |
| AU3420100A (en) | 1999-03-31 | 2000-10-23 | Novozymes A/S | Lipase variant |
| DK1428874T3 (en) * | 1999-03-31 | 2014-03-10 | Novozymes As | lipase variant |
| CA2395266C (en) | 2000-02-08 | 2009-04-14 | F. Hoffmann-La Roche Ag | Use of acid-stable subtilisin proteases in animal feed |
| EP1280817A2 (en) * | 2000-04-28 | 2003-02-05 | Novozymes A/S | Production and use of protein variants having modified immunogenecity |
| AU2002219020B2 (en) * | 2001-01-10 | 2007-05-24 | Novozymes A/S | Thermostable lipolytic enzyme variant |
| AR032392A1 (es) | 2001-01-19 | 2003-11-05 | Solvay Pharm Gmbh | Mezcla de enzimas, preparado farmaceutico y utilizacion de dicho preparado. |
| JP4287149B2 (ja) | 2001-02-07 | 2009-07-01 | ノボザイムス アクティーゼルスカブ | リパーゼ変異体 |
| EP1468084A1 (en) * | 2002-01-16 | 2004-10-20 | Novozymes A/S | Lipolytic enzyme variants and method for their production |
| US20060234340A1 (en) | 2003-02-06 | 2006-10-19 | Novozymes A/S | Human heavy chain antibody expression in flamentous fungi |
| CA2523400C (en) | 2003-05-09 | 2015-03-17 | Novozymes A/S | Variant lipolytic enzymes |
| EP1639107B1 (en) | 2003-06-19 | 2013-08-14 | Novozymes A/S | Improved proteases and methods for producing them |
| US20060251763A1 (en) | 2003-06-19 | 2006-11-09 | Patkar Shamkant A | Phospholipase variants |
| JP2007535913A (ja) | 2004-01-21 | 2007-12-13 | ノボザイムス アクティーゼルスカブ | ヘテロカリオン菌類又は菌類宿主細胞におけるモノクローナル抗体の生成 |
| CA2560613C (en) | 2004-03-22 | 2015-11-24 | Solvay Pharmaceuticals Gmbh | Oral pharmaceutical compositions of lipase-containing products, in particular of pancreatin, containing surfactants |
| PT1809320E (pt) | 2004-10-14 | 2010-10-25 | Altus Pharmaceuticals Inc | Composições contendo lipase, protease e amilase para o tratamento de insuficiência pancreática |
| EP1851311A2 (en) | 2005-02-10 | 2007-11-07 | Novozymes A/S | Enzymatic enantioselective ester or amide hydrolysis or synthesis |
| AU2006261444A1 (en) | 2005-06-24 | 2006-12-28 | Novozymes A/S | Amylases for pharmaceutical use |
| CN101208429A (zh) * | 2005-06-24 | 2008-06-25 | 诺维信公司 | 用于药物用途的脂肪酶 |
| NZ563777A (en) | 2005-06-24 | 2010-08-27 | Novozymes As | Serine protease derived from Bacillus licheniformis optionally in combination with lipases and amylases for pharmaceutical use |
| WO2007080197A2 (en) * | 2006-01-16 | 2007-07-19 | Novozymes A/S | Immobilised enzymes |
| EP1979456A2 (en) * | 2006-01-23 | 2008-10-15 | The Procter & Gamble Company | A composition comprising a lipase and a bleach catalyst |
| CN101370933B (zh) * | 2006-01-23 | 2015-11-25 | 诺维信公司 | 脂肪酶变体 |
| KR20090101930A (ko) * | 2006-12-21 | 2009-09-29 | 노보자임스 에이/에스 | 약학적 사용을 위한 리파아제 변형체 |
-
2007
- 2007-12-12 KR KR1020097014850A patent/KR20090101930A/ko not_active Withdrawn
- 2007-12-12 JP JP2009543078A patent/JP5406040B2/ja active Active
- 2007-12-12 EP EP12155294.7A patent/EP2455459B1/en active Active
- 2007-12-12 RU RU2009128067/10A patent/RU2009128067A/ru not_active Application Discontinuation
- 2007-12-12 CA CA2961041A patent/CA2961041C/en active Active
- 2007-12-12 WO PCT/US2007/087168 patent/WO2008079685A2/en not_active Ceased
- 2007-12-12 CN CN201510504893.8A patent/CN105112386A/zh active Pending
- 2007-12-12 AU AU2007337150A patent/AU2007337150A1/en not_active Abandoned
- 2007-12-12 CA CA2670643A patent/CA2670643C/en active Active
- 2007-12-12 EP EP12155319.2A patent/EP2455462B1/en active Active
- 2007-12-12 US US12/519,868 patent/US8273348B2/en active Active
- 2007-12-12 MX MX2009006597A patent/MX2009006597A/es not_active Application Discontinuation
- 2007-12-12 CN CN200780051638.6A patent/CN101743308B/zh active Active
- 2007-12-12 EP EP10172609.9A patent/EP2261328B1/en active Active
- 2007-12-12 EP EP12155315A patent/EP2455460A3/en not_active Withdrawn
- 2007-12-12 EP EP07869130A patent/EP2099907A2/en not_active Withdrawn
- 2007-12-12 CA CA3081308A patent/CA3081308C/en active Active
- 2007-12-12 BR BRPI0721103-1A patent/BRPI0721103A2/pt not_active IP Right Cessation
- 2007-12-12 EP EP12155317.6A patent/EP2455461B1/en active Active
- 2007-12-18 TW TW096148377A patent/TW200829698A/zh unknown
- 2007-12-21 AR ARP070105859A patent/AR064494A1/es not_active Application Discontinuation
-
2009
- 2009-05-21 IL IL198893A patent/IL198893A0/en unknown
- 2009-05-25 ZA ZA200903598A patent/ZA200903598B/xx unknown
- 2009-07-20 NO NO20092729A patent/NO20092729L/no not_active Application Discontinuation
-
2012
- 2012-08-16 US US13/587,043 patent/US9029115B2/en active Active
-
2015
- 2015-04-06 US US14/679,563 patent/US9539311B2/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI903491B (zh) * | 2024-05-09 | 2025-11-01 | 國立高雄科技大學 | 水體與沉積物通量培養系統 |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| TW200829698A (en) | Lipase variants for pharmaceutical use | |
| US20090047266A1 (en) | Lipases for Pharmaceutical Use | |
| CZ20031900A3 (cs) | Směs mikrobiálních enzymů | |
| US8455235B2 (en) | Protease variants for pharmaceutical use | |
| AU2013203500B2 (en) | Lipase variants for pharmaceutical use | |
| AU2013200626B2 (en) | Lipase variants for pharmaceutical use | |
| HK1141553A (en) | Lipase variants for pharmaceutical use | |
| HK1145697A (en) | Protease variants for pharmaceutical use | |
| HK1113174A (en) | Lipases for pharmaceutical use |