TW200829698A - Lipase variants for pharmaceutical use - Google Patents
Lipase variants for pharmaceutical use Download PDFInfo
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- TW200829698A TW200829698A TW096148377A TW96148377A TW200829698A TW 200829698 A TW200829698 A TW 200829698A TW 096148377 A TW096148377 A TW 096148377A TW 96148377 A TW96148377 A TW 96148377A TW 200829698 A TW200829698 A TW 200829698A
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- lipase
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| HUE031042T2 (en) | 2005-07-29 | 2017-06-28 | Abbott Laboratories Gmbh | Methods for producing pancreatin powder with low viral content |
| US9198871B2 (en) | 2005-08-15 | 2015-12-01 | Abbott Products Gmbh | Delayed release pancreatin compositions |
| US11266607B2 (en) | 2005-08-15 | 2022-03-08 | AbbVie Pharmaceuticals GmbH | Process for the manufacture and use of pancreatin micropellet cores |
| US10072256B2 (en) | 2006-05-22 | 2018-09-11 | Abbott Products Gmbh | Process for separating and determining the viral load in a pancreatin sample |
| US8273348B2 (en) * | 2006-12-21 | 2012-09-25 | Novozymes A/S | Lipase variants for pharmaceutical use |
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| CN101990573B (zh) * | 2008-02-29 | 2014-01-22 | 诺维信公司 | 具有改进的稳定性的脂肪分解酶变体及编码该变体的多核苷酸 |
| MX2012006616A (es) | 2009-12-09 | 2012-06-21 | Procter & Gamble | Productos para el cuidado de las telas y el hogar. |
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| CN110093330B (zh) * | 2012-10-12 | 2023-11-28 | 丹尼斯科美国公司 | 包含脂解酶变体的组合物和方法 |
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| EP3696264B1 (en) * | 2013-07-19 | 2023-06-28 | Danisco US Inc. | Compositions and methods comprising a lipolytic enzyme variant |
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| WO2016091870A1 (en) * | 2014-12-09 | 2016-06-16 | Novozymes A/S | Lipase variants and polynucleotides encoding same |
| EP3280818A2 (en) | 2015-04-07 | 2018-02-14 | Novozymes A/S | Methods for selecting enzymes having lipase activity |
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| WO2018015295A1 (en) | 2016-07-18 | 2018-01-25 | Novozymes A/S | Lipase variants, polynucleotides encoding same and the use thereof |
| EP3575398A4 (en) * | 2017-01-30 | 2020-11-11 | Nippon Medical School Foundation | ADENO-ASSOCIATED VIRUS (AAV) CAPSIDE PROTEIN MUTANT |
| CA3072932C (en) | 2017-09-27 | 2023-09-26 | The Procter & Gamble Company | Detergent compositions comprising lipases |
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| CN111757930A (zh) * | 2018-02-08 | 2020-10-09 | 诺维信公司 | 脂肪酶变体及其组合物 |
| CA3109082A1 (en) * | 2018-08-16 | 2020-02-20 | Isolere Bio, Inc. | Genetically encoded polypeptide for affinity capture and purification of biologics |
| CN111334369B (zh) * | 2020-03-11 | 2022-10-21 | 陕西科技大学 | 一种酶法制备卵磷脂型pufa的方法 |
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| CN113846074B (zh) * | 2021-10-20 | 2022-10-21 | 南京林业大学 | 一种疏棉状嗜热丝孢菌脂肪酶突变体g91c及其应用 |
| CN116732002A (zh) * | 2022-03-01 | 2023-09-12 | 中国科学院天津工业生物技术研究所 | 一种耐受表面活性剂的脂肪酶变体及其应用 |
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| CN120082537B (zh) * | 2023-12-01 | 2026-03-17 | 青岛蔚蓝生物集团有限公司 | 一种脂肪酶突变体 |
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| DK0548228T3 (da) * | 1990-09-13 | 1999-05-10 | Novo Nordisk As | Lipasevarianter |
| CA2095852C (en) | 1990-12-05 | 2001-05-08 | Uffe Lovborg | Proteins with changed epitopes and methods for the production thereof |
| JPH06507071A (ja) | 1991-05-01 | 1994-08-11 | ノボザイムス アクティーゼルスカブ | 安定化酵素 |
| DK39693D0 (da) | 1993-04-02 | 1993-04-02 | Novo Nordisk As | Enzym |
| WO1995009909A1 (en) | 1993-10-04 | 1995-04-13 | Novo Nordisk A/S | An enzyme preparation comprising a modified enzyme |
| MX9603542A (es) | 1994-02-22 | 1997-03-29 | Novo Nordisk As | Metodo para preparar una variante de una enzima lipolitica. |
| AU3924095A (en) | 1994-11-24 | 1996-06-17 | Novo Nordisk A/S | A process for producing polypeptides with reduced allergenicity |
| AU697440B2 (en) | 1994-12-07 | 1998-10-08 | Novozymes A/S | Polypeptide with reduced allergenicity |
| EP0805856B2 (en) | 1995-01-26 | 2009-04-01 | Novozymes A/S | Animal feed additives comprising xylanase |
| EP0839186B1 (en) | 1995-07-14 | 2004-11-10 | Novozymes A/S | A modified enzyme with lipolytic activity |
| US6495357B1 (en) | 1995-07-14 | 2002-12-17 | Novozyme A/S | Lipolytic enzymes |
| JP4068142B2 (ja) | 1995-08-11 | 2008-03-26 | ノボザイムス アクティーゼルスカブ | 新規の脂肪分解酵素 |
| JP2002510963A (ja) | 1997-01-10 | 2002-04-09 | ノボザイムス アクティーゼルスカブ | スキンケア用酵素修飾体 |
| JP2001511162A (ja) | 1997-02-06 | 2001-08-07 | ノボ ノルディスク アクティーゼルスカブ | 付加され、そして／又は除去された付着基を有するポリペプチド−ポリマー結合体 |
| WO1999000489A1 (en) | 1997-06-25 | 1999-01-07 | Novo Nordisk A/S | A modified polypeptide |
| AU3247699A (en) | 1998-02-17 | 1999-09-06 | Novo Nordisk A/S | Lipase variant |
| ATE328070T1 (de) * | 1998-02-17 | 2006-06-15 | Novozymes As | Lipasevariante |
| CN1323345A (zh) | 1998-10-13 | 2001-11-21 | 诺沃奇梅兹有限公司 | 具有降低的免疫应答的修饰多肽 |
| JP2003500003A (ja) | 1998-10-30 | 2003-01-07 | ノボザイムス アクティーゼルスカブ | 低いアレルゲン性のタンパク質変異型 |
| ATE365210T1 (de) | 1998-10-30 | 2007-07-15 | Novozymes As | Glykosylierte proteine mit reduzierter allergenität |
| US7312062B2 (en) * | 1998-11-27 | 2007-12-25 | Novozymes A/S | Lipolytic enzyme variants |
| EP1131416B1 (en) | 1998-11-27 | 2009-09-02 | Novozymes A/S | Lipolytic enzyme variants |
| EP1162995B1 (de) | 1999-03-17 | 2003-06-04 | Solvay Pharmaceuticals GmbH | Enzyme zur behandlung von diabetes mellitus typ i |
| KR20010108379A (ko) * | 1999-03-31 | 2001-12-07 | 피아 스타르 | 리파제 변이체 |
| EP2278000A1 (en) * | 1999-03-31 | 2011-01-26 | Novozymes A/S | Lipase variant |
| KR20020077421A (ko) | 2000-02-08 | 2002-10-11 | 에프. 호프만-라 로슈 아게 | 동물 사료에서 산-안정성 서브틸리신 프로테아제의 사용 |
| CA2406621A1 (en) * | 2000-04-28 | 2001-11-08 | Novozymes A/S | Protein variants having modified immunogenicity |
| CA2431972C (en) * | 2001-01-10 | 2012-10-23 | Novozymes A/S | Thermostable lipolytic enzyme variant |
| AR032392A1 (es) * | 2001-01-19 | 2003-11-05 | Solvay Pharm Gmbh | Mezcla de enzimas, preparado farmaceutico y utilizacion de dicho preparado. |
| JP4287149B2 (ja) | 2001-02-07 | 2009-07-01 | ノボザイムス アクティーゼルスカブ | リパーゼ変異体 |
| DK2295556T3 (en) | 2002-01-16 | 2015-01-26 | Novozymes As | Lipolytic Enzyme Variants and Method of Preparation thereof. |
| AU2004208860A1 (en) | 2003-02-06 | 2004-08-19 | Novozymes A/S | Human heavy chain antibody expression in filamentous fungi |
| EP2290057A3 (en) | 2003-05-09 | 2011-08-03 | Novozymes A/S | Variant lipolytic enzymes |
| US20060236414A1 (en) | 2003-06-19 | 2006-10-19 | Novozymes A/S | Proteases and methods for producing them |
| US20060251763A1 (en) | 2003-06-19 | 2006-11-09 | Patkar Shamkant A | Phospholipase variants |
| WO2005070962A1 (en) | 2004-01-21 | 2005-08-04 | Novozymes A/S | Production of a monoclonal antibody in a heterokaryon fungus or in a fungal host cell |
| ES2314646T3 (es) | 2004-03-22 | 2009-03-16 | Solvay Pharmaceuticals Gmbh | Composiciones farmaceuticas por via de productos que contienen lipasa , en particular de pancreatina, que contienen tensioactivos. |
| SI1809320T1 (sl) | 2004-10-14 | 2010-11-30 | Cystic Fibrosis Foundation Therapeutics Inc | Sestavki ki vsebujejo lipazo proteazo in amilazo za zdravljenje pankreasne insuficience |
| EP1851311A2 (en) | 2005-02-10 | 2007-11-07 | Novozymes A/S | Enzymatic enantioselective ester or amide hydrolysis or synthesis |
| AU2006261443A1 (en) | 2005-06-24 | 2006-12-28 | Novozymes A/S | Proteases for pharmaceutical use |
| EP1896057A2 (en) | 2005-06-24 | 2008-03-12 | Novozymes A/S | Amylases for pharmaceutical use |
| US20090047266A1 (en) * | 2005-06-24 | 2009-02-19 | Novozymes A/S | Lipases for Pharmaceutical Use |
| WO2007080197A2 (en) * | 2006-01-16 | 2007-07-19 | Novozymes A/S | Immobilised enzymes |
| ES2629332T3 (es) * | 2006-01-23 | 2017-08-08 | Novozymes A/S | Variantes de lipasa |
| JP2009523900A (ja) | 2006-01-23 | 2009-06-25 | ザ プロクター アンド ギャンブル カンパニー | リパーゼと漂白剤触媒を含む組成物 |
| US8273348B2 (en) * | 2006-12-21 | 2012-09-25 | Novozymes A/S | Lipase variants for pharmaceutical use |
-
2007
- 2007-12-12 US US12/519,868 patent/US8273348B2/en active Active
- 2007-12-12 EP EP10172609.9A patent/EP2261328B1/en active Active
- 2007-12-12 CA CA3081308A patent/CA3081308C/en active Active
- 2007-12-12 MX MX2009006597A patent/MX2009006597A/es not_active Application Discontinuation
- 2007-12-12 WO PCT/US2007/087168 patent/WO2008079685A2/en not_active Ceased
- 2007-12-12 CA CA2961041A patent/CA2961041C/en active Active
- 2007-12-12 CN CN201510504893.8A patent/CN105112386A/zh active Pending
- 2007-12-12 CN CN200780051638.6A patent/CN101743308B/zh active Active
- 2007-12-12 AU AU2007337150A patent/AU2007337150A1/en not_active Abandoned
- 2007-12-12 EP EP12155319.2A patent/EP2455462B1/en active Active
- 2007-12-12 RU RU2009128067/10A patent/RU2009128067A/ru not_active Application Discontinuation
- 2007-12-12 JP JP2009543078A patent/JP5406040B2/ja active Active
- 2007-12-12 EP EP12155317.6A patent/EP2455461B1/en active Active
- 2007-12-12 CA CA2670643A patent/CA2670643C/en active Active
- 2007-12-12 BR BRPI0721103-1A patent/BRPI0721103A2/pt not_active IP Right Cessation
- 2007-12-12 EP EP12155294.7A patent/EP2455459B1/en active Active
- 2007-12-12 KR KR1020097014850A patent/KR20090101930A/ko not_active Withdrawn
- 2007-12-12 EP EP07869130A patent/EP2099907A2/en not_active Withdrawn
- 2007-12-12 EP EP12155315A patent/EP2455460A3/en not_active Withdrawn
- 2007-12-18 TW TW096148377A patent/TW200829698A/zh unknown
- 2007-12-21 AR ARP070105859A patent/AR064494A1/es not_active Application Discontinuation
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2009
- 2009-05-21 IL IL198893A patent/IL198893A0/en unknown
- 2009-05-25 ZA ZA200903598A patent/ZA200903598B/xx unknown
- 2009-07-20 NO NO20092729A patent/NO20092729L/no not_active Application Discontinuation
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- 2012-08-16 US US13/587,043 patent/US9029115B2/en active Active
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI903491B (zh) * | 2024-05-09 | 2025-11-01 | 國立高雄科技大學 | 水體與沉積物通量培養系統 |
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