JP2010500876A - Ｉｌ−６媒介性シグナル伝達に関連する疾患及び障害の治療のための、ｉｌ−６ｒに指向性を有するアミノ酸配列及びこれを含むポリペプチド - Google Patents

Ｉｌ−６媒介性シグナル伝達に関連する疾患及び障害の治療のための、ｉｌ−６ｒに指向性を有するアミノ酸配列及びこれを含むポリペプチド Download PDF

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JP2010500876A
JP2010500876A JP2009524203A JP2009524203A JP2010500876A JP 2010500876 A JP2010500876 A JP 2010500876A JP 2009524203 A JP2009524203 A JP 2009524203A JP 2009524203 A JP2009524203 A JP 2009524203A JP 2010500876 A JP2010500876 A JP 2010500876A
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amino acid
acid sequence
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sequence
nanobody
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アレクサンドル コルクマン，ヨースト
バイラーナエール，イーエルエス
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アブリンクス エン．ヴェー．
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JP2009524203A 2006-08-18 2007-08-17 Ｉｌ−６媒介性シグナル伝達に関連する疾患及び障害の治療のための、ｉｌ−６ｒに指向性を有するアミノ酸配列及びこれを含むポリペプチド Pending JP2010500876A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US83890406P 2006-08-18 2006-08-18
US87301206P 2006-12-05 2006-12-05
US93832507P 2007-05-16 2007-05-16
PCT/EP2007/058587 WO2008020079A1 (en) 2006-08-18 2007-08-17 Amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of deseases and disorders associated with il-6-mediated signalling

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JP2010500876A true JP2010500876A (ja) 2010-01-14
JP2010500876A5 JP2010500876A5 (enExample) 2011-09-15

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JP2009524203A Pending JP2010500876A (ja) 2006-08-18 2007-08-17 Ｉｌ−６媒介性シグナル伝達に関連する疾患及び障害の治療のための、ｉｌ−６ｒに指向性を有するアミノ酸配列及びこれを含むポリペプチド

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US (5) US8629244B2 (enExample)
EP (1) EP2057191A1 (enExample)
JP (1) JP2010500876A (enExample)
AU (1) AU2007285695B2 (enExample)
CA (1) CA2666599A1 (enExample)
WO (1) WO2008020079A1 (enExample)

Cited By (5)

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JP2014511680A (ja) * 2011-03-28 2014-05-19 アブリンクス エン．ヴェー． 二特異性抗ｃｘｃｒ７免疫グロブリン単一可変ドメイン
US9512236B2 (en) 2006-12-19 2016-12-06 Ablynx N.V. Amino acid sequences directed against GPCRS and polypeptides comprising the same for the treatment of GPCR-related diseases and disorders
JP2016538280A (ja) * 2013-11-13 2016-12-08 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ オリゴペプチド及びその接合体を製造する方法
US9758584B2 (en) 2010-03-26 2017-09-12 Ablynx N.V. Biological materials related to CXCR7
JP2019178132A (ja) * 2013-07-31 2019-10-17 アムジエン・インコーポレーテツド 増殖分化因子１５（ｇｄｆ−１５）の構築物

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US8945558B2 (en) 2005-10-21 2015-02-03 Chugai Seiyaku Kabushiki Kaisha Methods for treating myocardial infarction comprising administering an IL-6 inhibitor
EP2025346B1 (en) 2006-04-07 2016-08-10 Osaka University Muscle regeneration promoter
NZ587107A (en) 2006-06-02 2012-05-25 Regeneron Pharma High affinity antibodies to human il-6 receptor
US8080248B2 (en) 2006-06-02 2011-12-20 Regeneron Pharmaceuticals, Inc. Method of treating rheumatoid arthritis with an IL-6R antibody
CA2666599A1 (en) 2006-08-18 2008-02-21 Ablynx N.V. Amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of diseases and disorders associated with il-6-mediated signalling
JP2010512734A (ja) * 2006-12-13 2010-04-30 アブリンクス エン．ヴェー． Ｉｌ−６／ｉｌ−６受容体複合体等受容体介在性シグナル伝達に関与する複合体に特異的なポリペプチド
KR101508019B1 (ko) 2007-01-23 2015-04-06 고쿠리츠 다이가쿠 호우징 신슈 다이가쿠 만성 거부반응 억제제
DK2158315T3 (en) 2007-06-25 2016-06-06 Esbatech Alcon Biomed Res Unit Methods of modifying antibodies and modified antibodies with improved functional properties
WO2009010539A2 (en) * 2007-07-19 2009-01-22 Ablynx. N.V. Receptor for interleukin-6 (il-6) from macaca fascicularis
WO2009095489A2 (en) * 2008-02-01 2009-08-06 Ablynx N.V. Improved amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of diseases and disorders associated with il-6-mediated signalling
CA2717015A1 (en) * 2008-03-05 2009-09-11 Ablynx Nv Novel antigen binding dimer-complexes, methods of making and uses thereof
CN102089325A (zh) 2008-04-17 2011-06-08 埃博灵克斯股份有限公司 能够结合血清白蛋白的肽，以及包含其的化合物、构建体和多肽
HUE042053T2 (hu) 2008-06-05 2019-06-28 Ablynx Nv Vírus burokfehérjéi elleni aminosav-szekvenciák és az azokat tartalmazó polipeptidek virális betegségek kezelésére
TWI528973B (zh) 2008-06-05 2016-04-11 Chugai Pharmaceutical Co Ltd Nerve infiltration inhibitor
US8444976B2 (en) 2008-07-02 2013-05-21 Argen-X B.V. Antigen binding polypeptides
WO2010010119A1 (en) 2008-07-22 2010-01-28 Ablynx Nv Amino acid sequences directed against multitarget scavenger receptors and polypeptides
TWI440469B (zh) 2008-09-26 2014-06-11 Chugai Pharmaceutical Co Ltd Improved antibody molecules
CA2740561C (en) * 2008-10-14 2021-01-19 National Research Council Of Canada Bsa-specific antibodies
EP2364328A2 (en) * 2008-12-10 2011-09-14 Ablynx NV Amino acid sequences directed against the angiopoietin/tie system and polypeptides comprising the same for the treatment of diseases and disorders related to angiogenesis
AU2009329501B2 (en) 2008-12-19 2015-11-26 Ablynx N.V. Genetic immunization for producing immunoglobulins against cell-associated antigens such as P2X7, CXCR7 or CXCR4
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