JP2010106029A5 - - Google Patents
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- Publication number
- JP2010106029A5 JP2010106029A5 JP2009274988A JP2009274988A JP2010106029A5 JP 2010106029 A5 JP2010106029 A5 JP 2010106029A5 JP 2009274988 A JP2009274988 A JP 2009274988A JP 2009274988 A JP2009274988 A JP 2009274988A JP 2010106029 A5 JP2010106029 A5 JP 2010106029A5
- Authority
- JP
- Japan
- Prior art keywords
- btcs
- tcro
- cation
- solution
- polar group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35871802P | 2002-02-25 | 2002-02-25 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003571422A Division JP2005518453A (ja) | 2002-02-25 | 2003-02-25 | 二極性トランスカロテノイド塩およびそれらの使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010106029A JP2010106029A (ja) | 2010-05-13 |
| JP2010106029A5 true JP2010106029A5 (https=) | 2010-12-02 |
Family
ID=27765977
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003571422A Withdrawn JP2005518453A (ja) | 2002-02-25 | 2003-02-25 | 二極性トランスカロテノイド塩およびそれらの使用 |
| JP2009274988A Pending JP2010106029A (ja) | 2002-02-25 | 2009-12-02 | 二極性トランスカロテノイド塩およびそれらの使用 |
| JP2010110185A Withdrawn JP2010229137A (ja) | 2002-02-25 | 2010-05-12 | 二極性トランスカロテノイド塩およびそれらの使用 |
| JP2013197629A Expired - Fee Related JP5774655B2 (ja) | 2002-02-25 | 2013-09-24 | 二極性トランスカロテノイド塩およびそれらの使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003571422A Withdrawn JP2005518453A (ja) | 2002-02-25 | 2003-02-25 | 二極性トランスカロテノイド塩およびそれらの使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010110185A Withdrawn JP2010229137A (ja) | 2002-02-25 | 2010-05-12 | 二極性トランスカロテノイド塩およびそれらの使用 |
| JP2013197629A Expired - Fee Related JP5774655B2 (ja) | 2002-02-25 | 2013-09-24 | 二極性トランスカロテノイド塩およびそれらの使用 |
Country Status (19)
| Country | Link |
|---|---|
| US (4) | US7351844B2 (https=) |
| EP (1) | EP1487774B1 (https=) |
| JP (4) | JP2005518453A (https=) |
| KR (1) | KR101020115B1 (https=) |
| CN (1) | CN1671643B (https=) |
| AU (1) | AU2003215396B2 (https=) |
| BR (1) | BR0307935A (https=) |
| CA (1) | CA2477245A1 (https=) |
| CZ (1) | CZ2004904A3 (https=) |
| EA (1) | EA200401111A1 (https=) |
| HU (1) | HUP0500134A3 (https=) |
| IL (1) | IL163685A0 (https=) |
| MX (1) | MXPA04008253A (https=) |
| NO (1) | NO20043661L (https=) |
| NZ (2) | NZ564486A (https=) |
| PL (1) | PL373780A1 (https=) |
| UA (1) | UA83341C2 (https=) |
| WO (1) | WO2003072734A2 (https=) |
| ZA (1) | ZA200406673B (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7759506B2 (en) | 2002-02-25 | 2010-07-20 | Diffusion Pharmaceuticals Llc | Bipolar trans carotenoid salts and their uses |
| CA2477245A1 (en) * | 2002-02-25 | 2003-09-04 | Diffusion Pharmaceuticals Llc | Bipolar trans carotenoid salts and their uses |
| AU2011265546B2 (en) * | 2003-08-25 | 2016-05-12 | Diffusion Pharmaceuticals Llc | Bipolar Trans Carotenoid Salts and Their Uses |
| CA2537210C (en) * | 2003-08-25 | 2013-06-04 | Diffusion Pharmaceuticals Llc | Bipolar trans carotenoid salts and their uses |
| EP2540696B1 (en) * | 2005-02-24 | 2020-01-01 | Diffusion Pharmaceuticals LLC | Trans carotenoids, formulation and uses |
| JPWO2006112283A1 (ja) * | 2005-04-13 | 2008-12-11 | 理研ビタミン株式会社 | 抗疲労剤 |
| EP1965807A4 (en) * | 2005-11-23 | 2010-10-27 | Epix Delaware Inc | S1P RECEPTOR MODULATING COMPOUNDS AND THEIR USE |
| US20070288322A1 (en) * | 2006-05-23 | 2007-12-13 | Toshiba Tec Kabushiki Kaisha | Portable terminal and its programs, settlement apparatus, and merchandising information providing apparatus |
| CN101687757A (zh) | 2007-04-13 | 2010-03-31 | 扩散药品有限公司 | 双极性反式类胡萝卜素作为预治疗及其在周围血管疾病的治疗中的应用 |
| CA2688837A1 (en) * | 2007-06-19 | 2008-12-24 | Novartis Ag | Organic compounds |
| KR20100083820A (ko) | 2007-10-31 | 2010-07-22 | 디퓨젼 파마슈티컬즈 엘엘씨 | 저분자 확산을 촉진시키는 신규한 치료요법 |
| CN101157645B (zh) * | 2007-11-27 | 2010-06-02 | 江南大学 | 一种藏红花酸的合成方法 |
| EP2445339B1 (en) | 2009-06-22 | 2019-08-07 | Diffusion Pharmaceuticals LLC | Diffusion enhancing compound and its use with a thrombolytic |
| JP2010090151A (ja) * | 2009-12-09 | 2010-04-22 | Diffusion Pharmaceuticals Llc | 双極性トランスカロテノイド塩及びそれらの使用 |
| AU2011262361A1 (en) | 2010-06-02 | 2013-01-10 | Diffusion Pharmaceuticals Llc | Oral formulations of bipolar trans carotenoids |
| CN101967087A (zh) * | 2010-09-21 | 2011-02-09 | 上海大学 | (e)- 4.4-二甲氧基-2-丁烯醛的制备方法 |
| CN103172504B (zh) * | 2011-12-26 | 2014-10-08 | 南京工业大学 | 2,7-二甲基-2,4,6-辛三烯-1,8-二醛的合成方法 |
| CA3018550A1 (en) | 2016-03-24 | 2017-09-28 | Diffusion Pharmaceuticals Llc | Use of bipolar trans carotenoids with chemotherapy and radiotherapy for treatment of cancer |
| JP7355394B2 (ja) | 2018-05-03 | 2023-10-03 | エル.イー.エー.エフ. ホールディングス グループ エルエルシー | カロテノイド組成物およびその使用 |
| WO2021207690A1 (en) * | 2020-04-09 | 2021-10-14 | L.E.A.F. Holdings Group Llc | Trans-crocetin compositions and treatment regimens |
| WO2021207650A1 (en) * | 2020-04-09 | 2021-10-14 | L.E.A.F. Holdings Group Llc | Trans-crocetin compositions and treatment regimens |
| US20240316000A1 (en) * | 2021-06-29 | 2024-09-26 | Diffusion Pharmaceuticals Llc | Methods of treatment |
| WO2023081779A1 (en) * | 2021-11-03 | 2023-05-11 | Diffusion Pharmaceuticals Llc | Crystalline forms of a diffusion enhancing compound |
| CN114534729B (zh) * | 2022-03-07 | 2024-05-03 | 万华化学集团股份有限公司 | 一种催化剂及其制备方法和其在电化学法制备β-胡萝卜素中的应用 |
Family Cites Families (71)
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| US2948748A (en) * | 1960-08-09 | Esters thereof | ||
| US2175843A (en) * | 1936-06-26 | 1939-10-10 | Winthrop Chem Co Inc | Polyene carboxylic acids and esters and manufacture thereof |
| CH468330A (de) | 1966-01-28 | 1969-02-15 | Hoffmann La Roche | Verfahren zur Herstellung von isoprenoiden Verbindungen |
| US3489806A (en) | 1967-01-19 | 1970-01-13 | Hoffmann La Roche | Isoprenoid compounds and a process for producing the same |
| CH522572A (de) | 1969-10-31 | 1972-06-30 | Hoffmann La Roche | Verfahren zur Herstellung von Polyenverbindungen |
| US3788468A (en) * | 1973-05-01 | 1974-01-29 | Univ Virginia | Process for increasing oxygen diffusivity |
| US3853993A (en) * | 1973-05-01 | 1974-12-10 | Univ Virginia | Process for increasing oxygen diffusivity and method for treating atherosclerosis |
| US3853933A (en) * | 1974-01-14 | 1974-12-10 | Gen Electric | Continuous process for producing polysiloxane oils utilizing a carbon black catalyst |
| DE2505869C3 (de) * | 1975-02-12 | 1978-05-18 | Basf Ag, 6700 Ludwigshafen | Verfahren zur Herstellung von symmetrischen Carotinoiden |
| US3965261A (en) * | 1975-04-29 | 1976-06-22 | University Of Virginia | Method for treating papillomas |
| US3975519A (en) * | 1975-06-09 | 1976-08-17 | University Of Virginia | Method for increasing the oxygen partial pressure in the bloodstream of mammals |
| US4070460A (en) * | 1975-11-10 | 1978-01-24 | University Of Virginia Patents Foundation | Method for treating cerebral edema |
| US4009270A (en) * | 1975-11-21 | 1977-02-22 | The University Of Virginia | Method for treating spinal cord injury |
| US4038144A (en) * | 1976-04-19 | 1977-07-26 | The University Of Virginia | Method of increasing fermentation yields |
| US4046880A (en) * | 1976-04-20 | 1977-09-06 | The University Of Virginia | Method of treating hypertension |
| US4068144A (en) * | 1976-09-20 | 1978-01-10 | Recognition Equipment Incorporated | Liquid jet modulator with piezoelectric hemispheral transducer |
| US4099270A (en) * | 1977-02-16 | 1978-07-11 | Jabour Richard J | Slip-on rubber gloves |
| US4216211A (en) * | 1977-10-31 | 1980-08-05 | The Procter & Gamble Company | Therapeutic composition |
| US4176179A (en) * | 1978-04-17 | 1979-11-27 | The University Of Virginia Alumni Patents Foundation | Method for treating arthritis |
| US4699664A (en) | 1985-05-01 | 1987-10-13 | Nestec S.A. | Stabilized natural pigment complexes |
| US5032613A (en) * | 1986-02-12 | 1991-07-16 | W. Keith R. Watson | Method and composition for treating arthritis |
| JPH0661211B2 (ja) * | 1986-08-29 | 1994-08-17 | 花王株式会社 | パン用改質剤、パン生地及びパンの製造方法 |
| US5811119A (en) | 1987-05-19 | 1998-09-22 | Board Of Regents, The University Of Texas | Formulation and use of carotenoids in treatment of cancer |
| US5472946A (en) | 1988-04-08 | 1995-12-05 | Peck; James V. | Transdermal penetration enhancers |
| FR2647343B1 (fr) | 1989-05-24 | 1994-05-06 | Rhone Poulenc Sante | Nouvelle forme pharmaceutique poreuse et sa preparation |
| IT1233303B (it) | 1989-06-07 | 1992-03-26 | Azionaria Costruzioni Acma Spa | Apparecchiatura per il convogliamento di prodotti |
| US5053240A (en) | 1989-10-24 | 1991-10-01 | Kalamazoo Holdings, Inc. | Norbixin adducts with water-soluble or water-dispersible proteins or branched-chain or cyclic polysaccharides |
| US5175843A (en) * | 1989-10-30 | 1992-12-29 | General Electric Company | Computer-aided design method for restructuring computational networks to minimize shimming delays |
| JPH04264020A (ja) | 1991-02-18 | 1992-09-18 | Yamanouchi Pharmaceut Co Ltd | 安定な凍結乾燥製剤 |
| US5107030A (en) * | 1991-03-04 | 1992-04-21 | Loyola University Of Chicago | Method of making 2,7-dimethyl-2,4,6-octatrienedial and derivatives thereof |
| JP3176716B2 (ja) | 1991-06-21 | 2001-06-18 | 武田薬品工業株式会社 | 溶解性が向上した難水溶性薬物組成物 |
| JP2977961B2 (ja) * | 1991-07-26 | 1999-11-15 | 株式会社資生堂 | 化粧料 |
| JPH06248193A (ja) | 1993-02-25 | 1994-09-06 | Ensuiko Sugar Refining Co Ltd | クロセチン含有着色料 |
| IL110139A0 (en) * | 1993-06-28 | 1994-10-07 | Howard Foundation | Pharmaceutically-active antioxidants |
| JPH0723736A (ja) | 1993-06-30 | 1995-01-27 | Taishiyoo Technos:Kk | カロチノイド色素の可溶化方法 |
| JP2704356B2 (ja) | 1994-02-08 | 1998-01-26 | 正和薬品株式会社 | 脳機能改善剤 |
| JPH07291854A (ja) | 1994-04-26 | 1995-11-07 | Tanabe Seiyaku Co Ltd | 溶解性の改善された医薬品製剤 |
| GB2290964A (en) | 1994-07-08 | 1996-01-17 | Arto Olavi Urtti | Transdermal drug delivery system |
| US6060511A (en) * | 1995-10-05 | 2000-05-09 | Gainer; John L. | Trans-sodium crocetinate, methods of making and methods of use thereof |
| US6090771A (en) * | 1996-10-24 | 2000-07-18 | Reckitt Benckiser Inc. | Low residue aqueous hard surface cleaning and disinfecting compositions |
| RU2107496C1 (ru) | 1997-02-10 | 1998-03-27 | Российская медицинская академия последипломного образования Министерства здравоохранения РФ | Способ лечения диабетической ангиопатии |
| US6391336B1 (en) | 1997-09-22 | 2002-05-21 | Royer Biomedical, Inc. | Inorganic-polymer complexes for the controlled release of compounds including medicinals |
| US6150561A (en) * | 1997-10-03 | 2000-11-21 | Roche Vitamins Inc. | Method of making carotenoids |
| JPH11209642A (ja) | 1998-01-27 | 1999-08-03 | Taito Kk | アナトー色素製剤及びその製造方法 |
| MA25590A1 (fr) | 1998-09-14 | 2002-12-31 | Inhale Therapeutic Syst | Agent actif de delivraison de poudre seche |
| BE1012495A3 (fr) * | 1999-03-02 | 2000-11-07 | Messadek Jallal | La glycine-betaine pour son usage antithrombotique. |
| CA2355814C (en) | 2000-09-14 | 2010-06-29 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Pharmaceutical composition for ophthalmic use |
| CA2477245A1 (en) | 2002-02-25 | 2003-09-04 | Diffusion Pharmaceuticals Llc | Bipolar trans carotenoid salts and their uses |
| US7759506B2 (en) | 2002-02-25 | 2010-07-20 | Diffusion Pharmaceuticals Llc | Bipolar trans carotenoid salts and their uses |
| US20030180282A1 (en) | 2002-03-25 | 2003-09-25 | Victor Serebruany | Method of treatment of thrombotic events |
| RU2226096C1 (ru) | 2002-07-01 | 2004-03-27 | Санкт-Петербургский государственный научно-исследовательский институт скорой помощи им. И.И.Джанелидзе | Способ лечения последствий тканевой гипоксии у пациентов в критическом состоянии |
| CN101845009B (zh) * | 2002-07-29 | 2012-10-03 | 卡达克斯药物公司 | 用于抑制和改善疾病的类胡萝卜素结构类似物 |
| DE10254809A1 (de) | 2002-11-22 | 2004-06-03 | Basf Ag | Verfahren zur Herstellung von Carotinoiden |
| EP1569692B1 (en) | 2002-11-25 | 2010-11-10 | Jallal Messadek | Betaine and salicylic acid compositions |
| US20040109920A1 (en) | 2002-12-04 | 2004-06-10 | Bioactives Llc | Coated carotenoid cyclodextrin complexes |
| CA2537210C (en) | 2003-08-25 | 2013-06-04 | Diffusion Pharmaceuticals Llc | Bipolar trans carotenoid salts and their uses |
| RU2265434C2 (ru) | 2003-09-30 | 2005-12-10 | Государственное учреждение Научно-исследовательский Институт Общей реаниматологии Российской Академии Медицинских Наук (ГУ НИИ ОР РАМН) | Способ лечения острого респираторного дистресс-синдрома |
| RU2256446C1 (ru) | 2003-10-22 | 2005-07-20 | Государственное учреждение Межотраслевой научно-технический комплекс "Микрохирургия глаза" им. акад. С.Н. Федорова | Способ профилактики метастазов после хирургического удаления внутриглазных новообразований |
| US7446101B1 (en) | 2003-12-12 | 2008-11-04 | Bioactives, Llc | Bioavailable carotenoid-cyclodextrin formulations for soft-gels and other encapsulation systems |
| WO2005120495A1 (en) | 2004-06-14 | 2005-12-22 | Salama Zoser B | Anti-cancer composition comprising proline or its derivatives and an anti-tumour antibody |
| JP4514114B2 (ja) | 2004-06-18 | 2010-07-28 | ヤマハ発動機株式会社 | コイル可動形リニアモータおよび単軸ロボット |
| EP1802287A2 (en) | 2004-09-27 | 2007-07-04 | Sigmoid Biotechnologies Limited | Minicapsule formulations |
| WO2006039685A2 (en) | 2004-10-01 | 2006-04-13 | Hawaii Biotech, Inc. | Methods for synthesis of chiral intermediates of carotenoids, carotenoid analogs, and carotenoid derivatives |
| EP2540696B1 (en) | 2005-02-24 | 2020-01-01 | Diffusion Pharmaceuticals LLC | Trans carotenoids, formulation and uses |
| US20090176287A1 (en) | 2005-02-24 | 2009-07-09 | Regents Of The University Of Minnesota | Producing carotenoids |
| WO2006099015A2 (en) | 2005-03-09 | 2006-09-21 | Cardax Pharmaceuticals, Inc. | Carotenoids, carotenoid analogs, or carotenoid derivatives for the treatment of proliferative disorders |
| EP2258441A3 (en) | 2005-09-02 | 2011-09-21 | Intercell USA, Inc. | Devices for transcutaneous delivery of vaccines and transdermal delivery of drugs |
| ITMI20052486A1 (it) | 2005-12-23 | 2007-06-24 | Italiana Sint Spa | Procedimento di sintesi di intermedi per la preparazione di astaxantina |
| CA2644423A1 (en) | 2006-03-24 | 2007-10-04 | Ian Simon Tracton | Stable packaged dosage form and process therefor |
| CN101687757A (zh) | 2007-04-13 | 2010-03-31 | 扩散药品有限公司 | 双极性反式类胡萝卜素作为预治疗及其在周围血管疾病的治疗中的应用 |
| KR20100083820A (ko) | 2007-10-31 | 2010-07-22 | 디퓨젼 파마슈티컬즈 엘엘씨 | 저분자 확산을 촉진시키는 신규한 치료요법 |
-
2003
- 2003-02-25 CA CA002477245A patent/CA2477245A1/en not_active Abandoned
- 2003-02-25 EA EA200401111A patent/EA200401111A1/ru unknown
- 2003-02-25 HU HU0500134A patent/HUP0500134A3/hu unknown
- 2003-02-25 BR BR0307935-0A patent/BR0307935A/pt not_active IP Right Cessation
- 2003-02-25 NZ NZ564486A patent/NZ564486A/en not_active IP Right Cessation
- 2003-02-25 KR KR1020047013118A patent/KR101020115B1/ko not_active Expired - Fee Related
- 2003-02-25 AU AU2003215396A patent/AU2003215396B2/en not_active Ceased
- 2003-02-25 NZ NZ535323A patent/NZ535323A/en not_active IP Right Cessation
- 2003-02-25 UA UA20040807055A patent/UA83341C2/uk unknown
- 2003-02-25 JP JP2003571422A patent/JP2005518453A/ja not_active Withdrawn
- 2003-02-25 PL PL03373780A patent/PL373780A1/xx not_active Application Discontinuation
- 2003-02-25 CN CN038045664A patent/CN1671643B/zh not_active Expired - Fee Related
- 2003-02-25 WO PCT/US2003/005521 patent/WO2003072734A2/en not_active Ceased
- 2003-02-25 EP EP03711221.6A patent/EP1487774B1/en not_active Expired - Lifetime
- 2003-02-25 CZ CZ2004904A patent/CZ2004904A3/cs unknown
- 2003-02-25 US US10/372,717 patent/US7351844B2/en not_active Expired - Lifetime
- 2003-02-25 MX MXPA04008253A patent/MXPA04008253A/es active IP Right Grant
- 2003-02-25 IL IL16368503A patent/IL163685A0/xx unknown
-
2004
- 2004-08-23 ZA ZA200406673A patent/ZA200406673B/en unknown
- 2004-09-01 NO NO20043661A patent/NO20043661L/no not_active Application Discontinuation
-
2007
- 2007-03-19 US US11/723,383 patent/US20070161610A1/en not_active Abandoned
- 2007-04-27 US US11/790,779 patent/US8269027B2/en not_active Expired - Fee Related
-
2009
- 2009-12-02 JP JP2009274988A patent/JP2010106029A/ja active Pending
-
2010
- 2010-05-12 JP JP2010110185A patent/JP2010229137A/ja not_active Withdrawn
-
2012
- 2012-09-17 US US13/621,650 patent/US20140051759A1/en not_active Abandoned
-
2013
- 2013-09-24 JP JP2013197629A patent/JP5774655B2/ja not_active Expired - Fee Related
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