JP2009541327A5 - - Google Patents
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- JP2009541327A5 JP2009541327A5 JP2009516564A JP2009516564A JP2009541327A5 JP 2009541327 A5 JP2009541327 A5 JP 2009541327A5 JP 2009516564 A JP2009516564 A JP 2009516564A JP 2009516564 A JP2009516564 A JP 2009516564A JP 2009541327 A5 JP2009541327 A5 JP 2009541327A5
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- Prior art keywords
- alkyl
- compound according
- hydrogen
- aralkyl
- zaz
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81521806P | 2006-06-19 | 2006-06-19 | |
| US60/815,218 | 2006-06-19 | ||
| PCT/US2007/014427 WO2007149512A2 (en) | 2006-06-19 | 2007-06-19 | Peptide epoxyketones for pr0teas0me inhibition |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012241236A Division JP5740383B2 (ja) | 2006-06-19 | 2012-10-31 | 酵素阻害のための化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009541327A JP2009541327A (ja) | 2009-11-26 |
| JP2009541327A5 true JP2009541327A5 (https=) | 2010-07-22 |
| JP5226679B2 JP5226679B2 (ja) | 2013-07-03 |
Family
ID=38690245
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009516564A Expired - Fee Related JP5226679B2 (ja) | 2006-06-19 | 2007-06-19 | 酵素阻害のための化合物 |
| JP2012241236A Expired - Fee Related JP5740383B2 (ja) | 2006-06-19 | 2012-10-31 | 酵素阻害のための化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012241236A Expired - Fee Related JP5740383B2 (ja) | 2006-06-19 | 2012-10-31 | 酵素阻害のための化合物 |
Country Status (24)
| Country | Link |
|---|---|
| US (11) | US7691852B2 (https=) |
| EP (2) | EP2041158B1 (https=) |
| JP (2) | JP5226679B2 (https=) |
| KR (1) | KR101441703B1 (https=) |
| CN (1) | CN101506224B (https=) |
| AU (1) | AU2007261345B2 (https=) |
| BR (1) | BRPI0713309A2 (https=) |
| CA (1) | CA2657213C (https=) |
| CO (1) | CO6241190A2 (https=) |
| CY (1) | CY1114518T1 (https=) |
| DK (1) | DK2041158T3 (https=) |
| ES (1) | ES2415632T3 (https=) |
| IL (2) | IL196064A (https=) |
| MX (1) | MX2008016512A (https=) |
| MY (2) | MY183014A (https=) |
| NZ (4) | NZ603303A (https=) |
| PH (1) | PH12012501747A1 (https=) |
| PL (1) | PL2041158T3 (https=) |
| PT (1) | PT2041158E (https=) |
| RU (2) | RU2450016C2 (https=) |
| SI (1) | SI2041158T1 (https=) |
| UA (1) | UA101303C2 (https=) |
| WO (1) | WO2007149512A2 (https=) |
| ZA (2) | ZA200810765B (https=) |
Families Citing this family (41)
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|---|---|---|---|---|
| WO2005105827A2 (en) | 2004-04-15 | 2005-11-10 | Proteolix, Inc. | Compounds for proteasome enzyme inhibition |
| US8198270B2 (en) | 2004-04-15 | 2012-06-12 | Onyx Therapeutics, Inc. | Compounds for proteasome enzyme inhibition |
| US8088741B2 (en) | 2004-05-10 | 2012-01-03 | Onyx Therapeutics, Inc. | Compounds for enzyme inhibition |
| RU2453556C2 (ru) | 2005-11-09 | 2012-06-20 | Протеоликс, Инк. | Соединения для ингибирования фермента |
| RU2450016C2 (ru) | 2006-06-19 | 2012-05-10 | Протеоликс, Инк. | Пептидные эпоксикетоны для ингибирования протеасомы |
| KR20170040374A (ko) | 2007-10-04 | 2017-04-12 | 오닉스 세라퓨틱스, 인크. | 결정형 펩티드 에폭시 케톤 프로테아제 저해제 및 아미노산 케토-에폭시드의 합성 |
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| CA2791651C (en) | 2010-03-01 | 2019-08-20 | Onyx Therapeutics, Inc. | Compounds for immunoproteasome inhibition |
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| JP2015524394A (ja) | 2012-07-09 | 2015-08-24 | オニキス セラピューティクス, インク.Onyx Therapeutics, Inc. | ペプチドエポキシケトンプロテアーゼ阻害剤のプロドラッグ |
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| KR20150068464A (ko) * | 2012-10-12 | 2015-06-19 | 에프. 호프만-라 로슈 아게 | 매크로사이클릭 케토아미드 면역프로테아좀 억제제 |
| AR095426A1 (es) * | 2013-03-14 | 2015-10-14 | Onyx Therapeutics Inc | Inhibidores tripeptídicos de la epoxicetona proteasa |
| ES2687368T3 (es) * | 2013-03-14 | 2018-10-24 | Onyx Therapeutics, Inc. | Inhibidores de proteasa de epoxi cetona dipeptídica y tripeptídica |
| CN104174021A (zh) * | 2013-05-22 | 2014-12-03 | 复旦大学附属华山医院 | 蛋白酶体抑制剂在制备治疗慢性低度炎症性疾病药物中的用途 |
| CN105518019A (zh) * | 2013-09-06 | 2016-04-20 | 桑多斯股份公司 | 肽环氧基酮的合成 |
| ES2748434T3 (es) | 2014-01-10 | 2020-03-16 | Univ Cornell | Dipéptidos como inhibidores de inmunoproteasomas humanos |
| JP6551825B2 (ja) * | 2014-02-10 | 2019-07-31 | 公立大学法人首都大学東京 | クロマチン構造制御剤 |
| DE102014010220A1 (de) | 2014-07-10 | 2016-01-14 | Immunologik Gmbh | Mittel zur Behandlung retroviraler Infektionen |
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| EP3193904B1 (en) | 2014-08-18 | 2025-10-01 | Cornell University | Dipeptidomimetics as inhibitors of human immunoproteasomes |
| CN105017181B (zh) * | 2015-07-02 | 2017-10-10 | 南京师范大学 | 卡非佐米关键中间体及其衍生物的制备方法 |
| WO2017032487A1 (en) | 2015-08-27 | 2017-03-02 | Technische Universität München | Proteasome inhibitor comprising a signal-emitting moiety |
| KR102764027B1 (ko) | 2015-10-15 | 2025-02-07 | 코넬 유니버시티 | 프로테아좀 억제제 및 이의 용도 |
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| CA3029032C (en) | 2016-06-29 | 2024-10-29 | Kezar Life Sciences | CRYSTAL SALTS OF AN IMMUNOPROTEASOME PEPTIDE INHIBITOR EPOXYCETONE |
| EP3330260A1 (en) | 2016-12-01 | 2018-06-06 | Enantia, S.L. | Process for the preparation of an intermediate for the synthesis of i.a. carfilzomib |
| EP3589659B1 (en) | 2017-02-28 | 2025-04-09 | Mayo Foundation for Medical Education and Research | Combinations for use in the treatment of cancer |
| US11357817B2 (en) | 2017-05-15 | 2022-06-14 | The Regents Of The University Of California | Immunoproteasome inhibitor |
| CN117338932A (zh) | 2017-08-23 | 2024-01-05 | 科智生命科学公司 | 自身免疫性病症的治疗中的免疫蛋白酶体抑制剂和免疫抑制剂 |
| EP3694605A4 (en) | 2017-10-11 | 2021-10-27 | Cornell University | PEPTIDOMIMETIC PROTEASOME INHIBITORS |
| US11243207B2 (en) | 2018-03-29 | 2022-02-08 | Mayo Foundation For Medical Education And Research | Assessing and treating cancer |
| EP3778869A4 (en) | 2018-03-30 | 2021-12-08 | Kyoto University | CARDIOMYOCYTE MATURATION PROMOTOR |
| US20240216325A1 (en) * | 2019-11-25 | 2024-07-04 | Cornell University | Nuclear factor kappa b pathway inhibition to arrest calcific aortic stenosis |
| CN116528877A (zh) * | 2020-10-05 | 2023-08-01 | 默克专利股份公司 | 用于治疗血液障碍和实体瘤的lmp7选择性抑制剂 |
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2007
- 2007-06-19 RU RU2009101319/04A patent/RU2450016C2/ru not_active IP Right Cessation
- 2007-06-19 BR BRPI0713309-0A patent/BRPI0713309A2/pt not_active IP Right Cessation
- 2007-06-19 NZ NZ603303A patent/NZ603303A/en not_active IP Right Cessation
- 2007-06-19 UA UAA200814605A patent/UA101303C2/uk unknown
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- 2007-06-19 KR KR1020097000551A patent/KR101441703B1/ko not_active Expired - Fee Related
- 2007-06-19 CA CA2657213A patent/CA2657213C/en active Active
- 2007-06-19 DK DK07809745.8T patent/DK2041158T3/da active
- 2007-06-19 WO PCT/US2007/014427 patent/WO2007149512A2/en not_active Ceased
- 2007-06-19 JP JP2009516564A patent/JP5226679B2/ja not_active Expired - Fee Related
- 2007-06-19 PL PL07809745T patent/PL2041158T3/pl unknown
- 2007-06-19 PT PT78097458T patent/PT2041158E/pt unknown
- 2007-06-19 SI SI200731257T patent/SI2041158T1/sl unknown
- 2007-06-19 MY MYPI2013001328A patent/MY183014A/en unknown
- 2007-06-19 EP EP07809745.8A patent/EP2041158B1/en not_active Not-in-force
- 2007-06-19 ES ES07809745T patent/ES2415632T3/es active Active
- 2007-06-19 MX MX2008016512A patent/MX2008016512A/es active IP Right Grant
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- 2007-06-19 MY MYPI20085187A patent/MY147832A/en unknown
- 2007-06-19 EP EP11191554.2A patent/EP2484688B1/en not_active Not-in-force
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- 2007-06-19 NZ NZ597545A patent/NZ597545A/xx not_active IP Right Cessation
- 2007-06-19 AU AU2007261345A patent/AU2007261345B2/en not_active Ceased
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2008
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2010
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2011
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2012
- 2012-02-02 RU RU2012103671/04A patent/RU2012103671A/ru not_active Application Discontinuation
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2013
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- 2013-11-12 US US14/078,339 patent/US20140100169A1/en not_active Abandoned
- 2013-11-12 US US14/078,378 patent/US20140080753A1/en not_active Abandoned
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2015
- 2015-01-07 US US14/591,351 patent/US9657058B2/en not_active Expired - Fee Related
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