JP2009540838A5 - - Google Patents
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- JP2009540838A5 JP2009540838A5 JP2009516818A JP2009516818A JP2009540838A5 JP 2009540838 A5 JP2009540838 A5 JP 2009540838A5 JP 2009516818 A JP2009516818 A JP 2009516818A JP 2009516818 A JP2009516818 A JP 2009516818A JP 2009540838 A5 JP2009540838 A5 JP 2009540838A5
- Authority
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- Prior art keywords
- amino acids
- cell receptor
- loop region
- modification
- modified
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims description 67
- 108091008874 T cell receptors Proteins 0.000 claims description 66
- 229920001184 polypeptide Polymers 0.000 claims description 50
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 50
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 50
- 238000000034 method Methods 0.000 claims description 46
- 238000012986 modification Methods 0.000 claims description 35
- 230000004048 modification Effects 0.000 claims description 35
- 108020004707 nucleic acids Proteins 0.000 claims description 10
- 102000039446 nucleic acids Human genes 0.000 claims description 10
- 150000007523 nucleic acids Chemical class 0.000 claims description 10
- 238000012216 screening Methods 0.000 claims description 6
- 239000000427 antigen Substances 0.000 claims description 5
- 108091007433 antigens Proteins 0.000 claims description 5
- 102000036639 antigens Human genes 0.000 claims description 5
- 125000003729 nucleotide group Chemical group 0.000 claims description 4
- 238000012360 testing method Methods 0.000 claims description 2
- 150000001413 amino acids Chemical class 0.000 claims 42
- 238000012217 deletion Methods 0.000 claims 18
- 230000037430 deletion Effects 0.000 claims 18
- 238000006467 substitution reaction Methods 0.000 claims 18
- 238000003780 insertion Methods 0.000 claims 14
- 230000037431 insertion Effects 0.000 claims 14
- 125000003275 alpha amino acid group Chemical group 0.000 claims 10
- 230000035772 mutation Effects 0.000 claims 4
- 210000001744 T-lymphocyte Anatomy 0.000 claims 2
- 239000002773 nucleotide Substances 0.000 claims 2
- 108091026890 Coding region Proteins 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 238000002708 random mutagenesis Methods 0.000 claims 1
- 210000004027 cell Anatomy 0.000 description 10
- 108090000623 proteins and genes Proteins 0.000 description 10
- 102000004169 proteins and genes Human genes 0.000 description 6
- 230000004927 fusion Effects 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- 241000238631 Hexapoda Species 0.000 description 3
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 3
- 238000000746 purification Methods 0.000 description 3
- 238000010187 selection method Methods 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 2
- 238000001042 affinity chromatography Methods 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 210000004102 animal cell Anatomy 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000004587 chromatography analysis Methods 0.000 description 2
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 210000004962 mammalian cell Anatomy 0.000 description 2
- 244000063299 Bacillus subtilis Species 0.000 description 1
- 235000014469 Bacillus subtilis Nutrition 0.000 description 1
- 101710132601 Capsid protein Proteins 0.000 description 1
- 101710094648 Coat protein Proteins 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 241000724791 Filamentous phage Species 0.000 description 1
- 108010024636 Glutathione Proteins 0.000 description 1
- 102100021181 Golgi phosphoprotein 3 Human genes 0.000 description 1
- 101710155188 Hexon-interlacing protein Proteins 0.000 description 1
- 101001082397 Human adenovirus B serotype 3 Hexon-associated protein Proteins 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 241000235058 Komagataella pastoris Species 0.000 description 1
- 101710125418 Major capsid protein Proteins 0.000 description 1
- 101710141454 Nucleoprotein Proteins 0.000 description 1
- 101710083689 Probable capsid protein Proteins 0.000 description 1
- 101000918244 Pseudoalteromonas phage PM2 Peptidoglycan hydrolase P7 Proteins 0.000 description 1
- 101000584831 Pseudoalteromonas phage PM2 Protein P6 Proteins 0.000 description 1
- 101001120093 Pseudoalteromonas phage PM2 Protein P8 Proteins 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 210000001557 animal structure Anatomy 0.000 description 1
- 238000011091 antibody purification Methods 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 230000009260 cross reactivity Effects 0.000 description 1
- 230000009089 cytolysis Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 239000013604 expression vector Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 108020001507 fusion proteins Proteins 0.000 description 1
- 102000037865 fusion proteins Human genes 0.000 description 1
- 229960003180 glutathione Drugs 0.000 description 1
- 238000013537 high throughput screening Methods 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 230000014726 immortalization of host cell Effects 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 229940072221 immunoglobulins Drugs 0.000 description 1
- 238000000099 in vitro assay Methods 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 210000002751 lymph Anatomy 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 238000004091 panning Methods 0.000 description 1
- 238000002823 phage display Methods 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000009258 tissue cross reactivity Effects 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 238000001890 transfection Methods 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 210000005253 yeast cell Anatomy 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ATA1146/2006 | 2006-07-05 | ||
| AT0114606A AT503861B1 (de) | 2006-07-05 | 2006-07-05 | Verfahren zur manipulation von t-zell-rezeptoren |
| PCT/AT2007/000342 WO2008003115A1 (en) | 2006-07-05 | 2007-07-05 | Method for engineering t-cell receptors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013246485A Division JP5864520B2 (ja) | 2006-07-05 | 2013-11-28 | Ｔ細胞受容体の製造方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009540838A JP2009540838A (ja) | 2009-11-26 |
| JP2009540838A5 true JP2009540838A5 (enExample) | 2013-11-21 |
| JP5426372B2 JP5426372B2 (ja) | 2014-02-26 |
Family
ID=38434794
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009516818A Expired - Fee Related JP5426372B2 (ja) | 2006-07-05 | 2007-07-05 | Ｔ細胞受容体の製造方法 |
| JP2013246485A Expired - Fee Related JP5864520B2 (ja) | 2006-07-05 | 2013-11-28 | Ｔ細胞受容体の製造方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013246485A Expired - Fee Related JP5864520B2 (ja) | 2006-07-05 | 2013-11-28 | Ｔ細胞受容体の製造方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US20100009863A1 (enExample) |
| EP (2) | EP2894164A1 (enExample) |
| JP (2) | JP5426372B2 (enExample) |
| AT (1) | AT503861B1 (enExample) |
| DK (1) | DK2051996T3 (enExample) |
| ES (1) | ES2531515T3 (enExample) |
| HU (1) | HUE024559T2 (enExample) |
| PL (1) | PL2051996T3 (enExample) |
| SI (1) | SI2051996T1 (enExample) |
| WO (1) | WO2008003115A1 (enExample) |
Families Citing this family (106)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7994298B2 (en) | 2004-09-24 | 2011-08-09 | Trustees Of Dartmouth College | Chimeric NK receptor and methods for treating cancer |
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| AU2008304555A1 (en) * | 2007-09-25 | 2009-04-02 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Modified T cell receptors and related materials and methods |
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| US9273283B2 (en) | 2009-10-29 | 2016-03-01 | The Trustees Of Dartmouth College | Method of producing T cell receptor-deficient T cells expressing a chimeric receptor |
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| US9833476B2 (en) | 2011-08-31 | 2017-12-05 | The Trustees Of Dartmouth College | NKP30 receptor targeted therapeutics |
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| LT2956175T (lt) | 2013-02-15 | 2017-12-11 | The Regents Of The University Of California | Chimerinis antigeno receptorius ir jo panaudojimo būdai |
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-
2006
- 2006-07-05 AT AT0114606A patent/AT503861B1/de not_active IP Right Cessation
-
2007
- 2007-07-05 EP EP14191631.2A patent/EP2894164A1/en not_active Ceased
- 2007-07-05 EP EP07763740.3A patent/EP2051996B1/en not_active Not-in-force
- 2007-07-05 WO PCT/AT2007/000342 patent/WO2008003115A1/en not_active Ceased
- 2007-07-05 ES ES07763740.3T patent/ES2531515T3/es active Active
- 2007-07-05 DK DK07763740.3T patent/DK2051996T3/en active
- 2007-07-05 US US12/307,582 patent/US20100009863A1/en not_active Abandoned
- 2007-07-05 PL PL07763740T patent/PL2051996T3/pl unknown
- 2007-07-05 HU HUE07763740A patent/HUE024559T2/hu unknown
- 2007-07-05 JP JP2009516818A patent/JP5426372B2/ja not_active Expired - Fee Related
- 2007-07-05 SI SI200731617T patent/SI2051996T1/sl unknown
-
2012
- 2012-05-29 US US13/482,926 patent/US20130040836A1/en not_active Abandoned
-
2013
- 2013-11-28 JP JP2013246485A patent/JP5864520B2/ja not_active Expired - Fee Related
-
2016
- 2016-10-03 US US15/284,471 patent/US20170015727A1/en not_active Abandoned
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