AT503861B1 - Verfahren zur manipulation von t-zell-rezeptoren - Google Patents
Verfahren zur manipulation von t-zell-rezeptoren Download PDFInfo
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- AT503861B1 AT503861B1 AT0114606A AT11462006A AT503861B1 AT 503861 B1 AT503861 B1 AT 503861B1 AT 0114606 A AT0114606 A AT 0114606A AT 11462006 A AT11462006 A AT 11462006A AT 503861 B1 AT503861 B1 AT 503861B1
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- C07K—PEPTIDES
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
Landscapes
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| DK07763740.3T DK2051996T3 (en) | 2006-07-05 | 2007-07-05 | Process for Preparing T-Cell Receptors |
| SI200731617T SI2051996T1 (sl) | 2006-07-05 | 2007-07-05 | Postopek za inženiring T-celičnih receptorjev |
| US12/307,582 US20100009863A1 (en) | 2006-07-05 | 2007-07-05 | Method for engineering t-cell receptors |
| EP14191631.2A EP2894164A1 (en) | 2006-07-05 | 2007-07-05 | Method for engineering T-cell receptors |
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| ES07763740.3T ES2531515T3 (es) | 2006-07-05 | 2007-07-05 | Método para modificar receptores de células T |
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| US13/482,926 US20130040836A1 (en) | 2006-07-05 | 2012-05-29 | Methods for engineering t-cell receptors |
| JP2013246485A JP5864520B2 (ja) | 2006-07-05 | 2013-11-28 | Ｔ細胞受容体の製造方法 |
| US15/284,471 US20170015727A1 (en) | 2006-07-05 | 2016-10-03 | Methods for engineering t-cell receptors |
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| WO2016105450A2 (en) | 2014-12-22 | 2016-06-30 | Xencor, Inc. | Trispecific antibodies |
| CA2975852A1 (en) | 2015-02-04 | 2016-08-11 | Twist Bioscience Corporation | Methods and devices for de novo oligonucleic acid assembly |
| US10227411B2 (en) | 2015-03-05 | 2019-03-12 | Xencor, Inc. | Modulation of T cells with bispecific antibodies and FC fusions |
| WO2016172377A1 (en) | 2015-04-21 | 2016-10-27 | Twist Bioscience Corporation | Devices and methods for oligonucleic acid library synthesis |
| KR20180029201A (ko) | 2015-05-18 | 2018-03-20 | 티씨알2 테라퓨틱스 인크. | 융합 단백질을 이용하는 tcr 리프로그래밍을 위한 조성물 및 방법 |
| AU2016324296A1 (en) | 2015-09-18 | 2018-04-12 | Twist Bioscience Corporation | Oligonucleic acid variant libraries and synthesis thereof |
| CN108698012A (zh) | 2015-09-22 | 2018-10-23 | 特韦斯特生物科学公司 | 用于核酸合成的柔性基底 |
| WO2017087723A1 (en) * | 2015-11-19 | 2017-05-26 | The Regents Of The University Of California | Conditionally repressible immune cell receptors and methods of use thereof |
| CN108603307A (zh) | 2015-12-01 | 2018-09-28 | 特韦斯特生物科学公司 | 功能化表面及其制备 |
| KR20180085800A (ko) | 2015-12-07 | 2018-07-27 | 젠코어 인코포레이티드 | Cd3 및 psma에 결합하는 이종이합체성 항체 |
| EA201891589A1 (ru) | 2016-01-08 | 2019-01-31 | Те Риджентс Оф Те Юниверсити Оф Калифорния | Условно активные гетеродимерные полипептиды и способы их применения |
| AU2017233035B2 (en) * | 2016-03-16 | 2021-08-05 | Neximmune, Inc. | Production of antigen-specific T-cells |
| IL263542B2 (en) | 2016-06-14 | 2024-10-01 | Xencor Inc | Bispecific antibodies inhibit immunological checkpoint |
| KR20190020341A (ko) | 2016-06-28 | 2019-02-28 | 젠코어 인코포레이티드 | 소마토스타틴 수용체 2에 결합하는 이종이량체 항체 |
| WO2018026953A1 (en) | 2016-08-02 | 2018-02-08 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using fusion proteins |
| CA3034769A1 (en) | 2016-08-22 | 2018-03-01 | Twist Bioscience Corporation | De novo synthesized nucleic acid libraries |
| US10793632B2 (en) | 2016-08-30 | 2020-10-06 | Xencor, Inc. | Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors |
| CN110248724B (zh) | 2016-09-21 | 2022-11-18 | 特韦斯特生物科学公司 | 基于核酸的数据存储 |
| IL302917A (en) | 2016-10-07 | 2023-07-01 | Tcr2 Therapeutics Inc | Compositions and methods for t-cell receptors reprogramming using fusion proteins |
| CN110214148A (zh) | 2016-10-14 | 2019-09-06 | Xencor股份有限公司 | 含有IL-15/IL-15Rα Fc融合蛋白和PD-1抗体片段的双特异性异源二聚体融合蛋白 |
| JP7291396B2 (ja) | 2016-11-22 | 2023-06-15 | ティーシーアール２ セラピューティクス インク． | 融合タンパク質を用いたｔｃｒの再プログラミングのための組成物及び方法 |
| CN110366613A (zh) * | 2016-12-16 | 2019-10-22 | 特韦斯特生物科学公司 | 免疫突触的变体文库及其合成 |
| PT3583120T (pt) | 2017-02-17 | 2022-12-15 | Denali Therapeutics Inc | Polipeptídeos de ligação ao recetor de transferrina manipulados |
| WO2018156792A1 (en) | 2017-02-22 | 2018-08-30 | Twist Bioscience Corporation | Nucleic acid based data storage |
| CN110913865A (zh) | 2017-03-15 | 2020-03-24 | 特韦斯特生物科学公司 | 免疫突触的变体文库及其合成 |
| WO2018231864A1 (en) | 2017-06-12 | 2018-12-20 | Twist Bioscience Corporation | Methods for seamless nucleic acid assembly |
| IL271205B2 (en) | 2017-06-12 | 2025-02-01 | Twist Bioscience Corp | Methods for assembling continuous nucleic acids |
| AU2018291497A1 (en) | 2017-06-30 | 2020-01-16 | Xencor, Inc. | Targeted heterodimeric Fc fusion proteins containing IL-15/IL-15Ra and antigen binding domains |
| ES2871146T3 (es) | 2017-07-14 | 2021-10-28 | Immatics Biotechnologies Gmbh | Molécula de polipéptido con especificidad dual mejorada |
| US11407837B2 (en) | 2017-09-11 | 2022-08-09 | Twist Bioscience Corporation | GPCR binding proteins and synthesis thereof |
| KR102637566B1 (ko) | 2017-10-20 | 2024-02-16 | 트위스트 바이오사이언스 코포레이션 | 폴리뉴클레오타이드 합성을 위한 가열된 나노웰 |
| US10981992B2 (en) | 2017-11-08 | 2021-04-20 | Xencor, Inc. | Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors |
| AU2018366199A1 (en) | 2017-11-08 | 2020-05-28 | Xencor, Inc. | Bispecific and monospecific antibodies using novel anti-PD-1 sequences |
| MX2020006322A (es) | 2017-12-19 | 2020-09-18 | Xencor Inc | Proteinas de fusion il-2 fc modificadas. |
| CN112041438B (zh) | 2018-01-04 | 2025-05-23 | 特韦斯特生物科学公司 | 基于dna的数字信息存储 |
| CN112469477A (zh) | 2018-04-04 | 2021-03-09 | Xencor股份有限公司 | 与成纤维细胞活化蛋白结合的异源二聚体抗体 |
| AU2019256539A1 (en) | 2018-04-18 | 2020-11-26 | Xencor, Inc. | PD-1 targeted heterodimeric fusion proteins containing IL-15/IL-15Ra Fc-fusion proteins and PD-1 antigen binding domains and uses thereof |
| EP3781598A1 (en) | 2018-04-18 | 2021-02-24 | Xencor, Inc. | Tim-3 targeted heterodimeric fusion proteins containing il-15/il-15ra fc-fusion proteins and tim-3 antigen binding domains |
| CA3100739A1 (en) | 2018-05-18 | 2019-11-21 | Twist Bioscience Corporation | Polynucleotides, reagents, and methods for nucleic acid hybridization |
| IL321690A (en) | 2018-07-26 | 2025-08-01 | Curevac Netherlands B V | Cancer vaccines for uterine cancer |
| CA3106574A1 (en) | 2018-07-26 | 2020-01-30 | Frame Pharmaceuticals B.V. | Arid1a, cdkn2a, kmt2b, kmt2d, tp53 and pten vaccines for cancer |
| EP3827265A1 (en) | 2018-07-26 | 2021-06-02 | Frame Pharmaceuticals B.V. | Cancer vaccines for kidney cancer |
| EP3827263A1 (en) | 2018-07-26 | 2021-06-02 | Frame Pharmaceuticals B.V. | Cancer vaccines for colorectal cancer |
| CA3106564A1 (en) | 2018-07-26 | 2020-01-30 | Frame Pharmaceuticals B.V. | Cancer vaccines for breast cancer |
| SG11202103192RA (en) | 2018-10-03 | 2021-04-29 | Xencor Inc | Il-12 heterodimeric fc-fusion proteins |
| CA3124980A1 (en) | 2018-12-26 | 2020-07-02 | Twist Bioscience Corporation | Highly accurate de novo polynucleotide synthesis |
| KR20210143766A (ko) | 2019-02-26 | 2021-11-29 | 트위스트 바이오사이언스 코포레이션 | Glp1 수용체에 대한 변이체 핵산 라이브러리 |
| CN113785057A (zh) | 2019-02-26 | 2021-12-10 | 特韦斯特生物科学公司 | 用于抗体优化的变异核酸文库 |
| AU2020232605A1 (en) | 2019-03-01 | 2021-10-21 | Xencor, Inc. | Heterodimeric antibodies that bind ENPP3 and CD3 |
| JP2022550497A (ja) | 2019-06-21 | 2022-12-02 | ツイスト バイオサイエンス コーポレーション | バーコードに基づいた核酸配列アセンブリ |
| AU2020355027A1 (en) | 2019-09-23 | 2022-04-21 | Twist Bioscience Corporation | Antibodies that bind CD3 Epsilon |
| CA3155629A1 (en) | 2019-09-23 | 2021-04-01 | Twist Bioscience Corporation | Variant nucleic acid libraries for crth2 |
| WO2021231976A1 (en) | 2020-05-14 | 2021-11-18 | Xencor, Inc. | Heterodimeric antibodies that bind prostate specific membrane antigen (psma) and cd3 |
| KR102607909B1 (ko) | 2020-08-19 | 2023-12-01 | 젠코어 인코포레이티드 | 항-cd28 조성물 |
| JP2024511319A (ja) | 2021-03-09 | 2024-03-13 | ゼンコア インコーポレイテッド | Ｃｄ３及びｃｌｄｎ６に結合するヘテロ二量体抗体 |
| JP2024509274A (ja) | 2021-03-10 | 2024-02-29 | ゼンコア インコーポレイテッド | Ｃｄ３及びｇｐｃ３に結合するヘテロ二量体抗体 |
| BR112023022765A2 (pt) | 2021-05-05 | 2024-01-02 | Immatics Biotechnologies Gmbh | Proteínas de ligação ao antígeno que ligam especificamente o prame |
| GB202113673D0 (en) * | 2021-09-24 | 2021-11-10 | Reflection Therapeutics Ltd | Targeted cell therapies |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993023537A1 (en) * | 1992-05-08 | 1993-11-25 | Creative Biomolecules | Chimeric multivalent protein analogues and methods of use thereof |
| US20040266993A1 (en) * | 2003-06-30 | 2004-12-30 | Evans Glen A. | Non-immunoglobulin binding polypeptides |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3588219T2 (de) * | 1984-03-01 | 2000-05-18 | The Board Of Trustees Of The Leland S. Stanford Junior University, Stanford | T-Zellenrezeptor, spezifisch für Antigenpolypeptide und verwandte Polynukleotide |
| WO1986005803A1 (fr) * | 1985-03-30 | 1986-10-09 | Marc Ballivet | Procede d'obtention d'adn, arn, peptides, polypeptides ou proteines, par une technique de recombinaison d'adn |
| US6492107B1 (en) * | 1986-11-20 | 2002-12-10 | Stuart Kauffman | Process for obtaining DNA, RNA, peptides, polypeptides, or protein, by recombinant DNA technique |
| US5270170A (en) | 1991-10-16 | 1993-12-14 | Affymax Technologies N.V. | Peptide library and screening method |
| WO1996018105A1 (en) | 1994-12-06 | 1996-06-13 | The President And Fellows Of Harvard College | Single chain t-cell receptor |
| US6358709B1 (en) * | 1995-12-07 | 2002-03-19 | Diversa Corporation | End selection in directed evolution |
| US6361974B1 (en) * | 1995-12-07 | 2002-03-26 | Diversa Corporation | Exonuclease-mediated nucleic acid reassembly in directed evolution |
| US6352842B1 (en) * | 1995-12-07 | 2002-03-05 | Diversa Corporation | Exonucease-mediated gene assembly in directed evolution |
| WO1997034631A1 (en) | 1996-03-18 | 1997-09-25 | Board Of Regents, The University Of Texas System | Immunoglobin-like domains with increased half lives |
| AU6685698A (en) | 1997-03-07 | 1998-09-22 | Sunol Molecular Corporation | Fusion proteins comprising bacteriophage coat protein and a single-chain t cell receptor |
| JP2002534966A (ja) | 1999-01-19 | 2002-10-22 | マキシジェン， インコーポレイテッド | オリゴヌクレオチド媒介核酸組換え |
| JP4972264B2 (ja) | 1999-12-06 | 2012-07-11 | ボード オブ トラスティーズ オブ ザ ユニバーシティ オブ イリノイ | 高親和性ｔｃｒタンパク質および方法 |
| EP1118661A1 (en) | 2000-01-13 | 2001-07-25 | Het Nederlands Kanker Instituut | T cell receptor libraries |
| JP2003274960A (ja) | 2000-02-03 | 2003-09-30 | Japan Science & Technology Corp | 可溶性ｔ細胞受容体タンパク質およびその作成方法 |
| WO2001062908A2 (en) * | 2000-02-22 | 2001-08-30 | Ahuva Nissim | Chimeric and tcr phage display libraries, chimeric and tcr reagents and methods of use thereof |
| WO2001070947A2 (en) | 2000-03-20 | 2001-09-27 | Maxygen, Inc. | Method for generating recombinant dna molecules in complex mixtures |
| JP2002058479A (ja) * | 2000-08-14 | 2002-02-26 | Canon Inc | 構造認識アミノ酸配列の取得方法 |
| PT1355919E (pt) | 2000-12-12 | 2011-03-02 | Medimmune Llc | Moléculas com semivida longa, composições que as contêm e suas utilizações |
| WO2002059263A2 (en) | 2000-12-19 | 2002-08-01 | Sunol Molecular Corporation | Transgenic animals comprising a humanized immune system |
| IL141539A0 (en) | 2001-02-20 | 2002-03-10 | Yeda Res & Dev | Dna molecules and cells transfected therewith |
| EP1281757A1 (en) | 2001-07-31 | 2003-02-05 | Direvo Biotech AG | Method for the production of nucleic acids consisting of stochastically combined parts of source nucleic acids |
| JP4317940B2 (ja) * | 2001-08-31 | 2009-08-19 | イミュノコア・リミテッド | 物質 |
| EP1394251A1 (en) | 2002-08-23 | 2004-03-03 | Direvo Biotech AG | Method for the selective randomization of polynucleotides |
| US7569664B2 (en) | 2002-10-09 | 2009-08-04 | Immunocore Limited | Single chain recombinant T cell receptors |
| PT1558643E (pt) | 2002-11-09 | 2009-08-24 | Immunocore Ltd | Apresentação de um receptor das células t |
| EP1567553A2 (en) | 2002-12-03 | 2005-08-31 | Avidex Ltd. | Complexes of receptors |
| GB0304068D0 (en) * | 2003-02-22 | 2003-03-26 | Avidex Ltd | Substances |
| DE602005011617D1 (de) | 2004-05-19 | 2009-01-22 | Medigene Ltd | Hochaffiner ny-eso-t-zellen-rezeptor |
| WO2005114215A2 (en) | 2004-05-19 | 2005-12-01 | Avidex Ltd | Method of improving t cell receptors |
| GB0411773D0 (en) | 2004-05-26 | 2004-06-30 | Avidex Ltd | Method for the identification of polypeptides which bind to a given peptide mhc complex or cd 1-antigen complex |
| CA2580412A1 (en) * | 2004-09-13 | 2006-03-23 | Government Of The United States Of America, Represented By The Secretary , Department Of Health And Human Services | Compositions comprising t cell receptors and methods of use thereof |
| JP2008514685A (ja) | 2004-10-01 | 2008-05-08 | メディジーン リミテッド | 治療剤に連結した、非天然型ジスルフィド鎖間結合を含有するｔ細胞レセプター |
| US20080274133A1 (en) | 2004-11-18 | 2008-11-06 | Avidex Ltd. | Soluble Bifunctional Proteins |
| GB0425732D0 (en) | 2004-11-23 | 2004-12-22 | Avidex Ltd | Gamma-delta t cell receptors |
| AU2006204459B2 (en) * | 2005-01-05 | 2012-11-01 | F-Star Therapeutics Limited | Synthetic immunoglobulin domains with binding properties engineered in regions of the molecule different from the complementarity determining regions |
-
2006
- 2006-07-05 AT AT0114606A patent/AT503861B1/de not_active IP Right Cessation
-
2007
- 2007-07-05 EP EP14191631.2A patent/EP2894164A1/en not_active Ceased
- 2007-07-05 EP EP07763740.3A patent/EP2051996B1/en not_active Not-in-force
- 2007-07-05 WO PCT/AT2007/000342 patent/WO2008003115A1/en not_active Ceased
- 2007-07-05 ES ES07763740.3T patent/ES2531515T3/es active Active
- 2007-07-05 DK DK07763740.3T patent/DK2051996T3/en active
- 2007-07-05 US US12/307,582 patent/US20100009863A1/en not_active Abandoned
- 2007-07-05 PL PL07763740T patent/PL2051996T3/pl unknown
- 2007-07-05 HU HUE07763740A patent/HUE024559T2/hu unknown
- 2007-07-05 JP JP2009516818A patent/JP5426372B2/ja not_active Expired - Fee Related
- 2007-07-05 SI SI200731617T patent/SI2051996T1/sl unknown
-
2012
- 2012-05-29 US US13/482,926 patent/US20130040836A1/en not_active Abandoned
-
2013
- 2013-11-28 JP JP2013246485A patent/JP5864520B2/ja not_active Expired - Fee Related
-
2016
- 2016-10-03 US US15/284,471 patent/US20170015727A1/en not_active Abandoned
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993023537A1 (en) * | 1992-05-08 | 1993-11-25 | Creative Biomolecules | Chimeric multivalent protein analogues and methods of use thereof |
| US20040266993A1 (en) * | 2003-06-30 | 2004-12-30 | Evans Glen A. | Non-immunoglobulin binding polypeptides |
Non-Patent Citations (1)
| Title |
|---|
| DIGIUSTO, DL, PALMER, E, MOL. IMMUNOL. 1994, JUN; 31(9): 693-9 * |
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Also Published As
| Publication number | Publication date |
|---|---|
| HUE024559T2 (hu) | 2016-02-29 |
| JP2009540838A (ja) | 2009-11-26 |
| US20170015727A1 (en) | 2017-01-19 |
| EP2051996A1 (en) | 2009-04-29 |
| PL2051996T3 (pl) | 2015-05-29 |
| US20100009863A1 (en) | 2010-01-14 |
| WO2008003115A1 (en) | 2008-01-10 |
| SI2051996T1 (sl) | 2015-04-30 |
| EP2051996B1 (en) | 2014-12-10 |
| JP5864520B2 (ja) | 2016-02-17 |
| JP5426372B2 (ja) | 2014-02-26 |
| DK2051996T3 (en) | 2015-03-02 |
| AT503861A1 (de) | 2008-01-15 |
| US20130040836A1 (en) | 2013-02-14 |
| ES2531515T3 (es) | 2015-03-16 |
| JP2014042532A (ja) | 2014-03-13 |
| EP2894164A1 (en) | 2015-07-15 |
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