JP2009531276A5 - - Google Patents
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- JP2009531276A5 JP2009531276A5 JP2008548032A JP2008548032A JP2009531276A5 JP 2009531276 A5 JP2009531276 A5 JP 2009531276A5 JP 2008548032 A JP2008548032 A JP 2008548032A JP 2008548032 A JP2008548032 A JP 2008548032A JP 2009531276 A5 JP2009531276 A5 JP 2009531276A5
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- acid
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- cancer
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- 0 **N(*)c1c(*)[n]nc1C1=NC(*)=C(*)*1 Chemical compound **N(*)c1c(*)[n]nc1C1=NC(*)=C(*)*1 0.000 description 8
- UZXACZRAUVKJFI-UHFFFAOYSA-N Cc1nc(cc(c(OC)c2)OC)c2[nH]1 Chemical compound Cc1nc(cc(c(OC)c2)OC)c2[nH]1 UZXACZRAUVKJFI-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75533905P | 2005-12-30 | 2005-12-30 | |
| US60/755,339 | 2005-12-30 | ||
| GB0526607.7 | 2005-12-30 | ||
| GB0526607A GB0526607D0 (en) | 2005-12-30 | 2005-12-30 | Pharmaceutical compounds |
| US80621806P | 2006-06-29 | 2006-06-29 | |
| US60/806,218 | 2006-06-29 | ||
| PCT/GB2006/004954 WO2007077435A1 (en) | 2005-12-30 | 2006-12-29 | Pharmaceutical compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009531276A JP2009531276A (ja) | 2009-09-03 |
| JP2009531276A5 true JP2009531276A5 (https=) | 2010-02-18 |
| JP5474354B2 JP5474354B2 (ja) | 2014-04-16 |
Family
ID=38006842
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008548032A Expired - Fee Related JP5474354B2 (ja) | 2005-12-30 | 2006-12-29 | 医薬化合物 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US8399442B2 (https=) |
| EP (1) | EP1968579A1 (https=) |
| JP (1) | JP5474354B2 (https=) |
| WO (1) | WO2007077435A1 (https=) |
Families Citing this family (63)
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| AR077468A1 (es) | 2009-07-09 | 2011-08-31 | Array Biopharma Inc | Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa |
| HRP20151258T1 (hr) | 2009-08-07 | 2016-02-26 | Chugai Seiyaku Kabushiki Kaisha | Derivat aminopirazola |
| JP6161537B2 (ja) | 2010-04-07 | 2017-07-12 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | ピラゾール−4−イル−ヘテロシクリル−カルボキサミド化合物及び使用の方法 |
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| WO2013063560A2 (en) * | 2011-10-27 | 2013-05-02 | New York University | INHIBITION OF c-MYC UBIQUITINATION TO PREVENT CANCER INITIATION AND PROGRESSION |
| DK2797957T3 (da) | 2011-11-23 | 2019-09-23 | Medimmune Llc | Bindingsmolekyler specifikke for her3 og anvendelser deraf |
| EP2636752A1 (en) * | 2012-03-06 | 2013-09-11 | Universiteit Maastricht | In vitro method for determining disease outcome in pulmonary carcinoids. |
| PH12017500997A1 (en) | 2012-04-04 | 2018-02-19 | Samumed Llc | Indazole inhibitors of the wnt signal pathway and therapeutic uses thereof |
| US20150203589A1 (en) | 2012-07-24 | 2015-07-23 | The Trustees Of Columbia University In The City Of New York | Fusion proteins and methods thereof |
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| US11305012B2 (en) | 2013-09-24 | 2022-04-19 | Medimmune, Llc | Binding molecules specific for HER3 and uses thereof |
| JP6514645B2 (ja) | 2013-12-27 | 2019-05-15 | 中外製薬株式会社 | Fgfrゲートキーパー変異遺伝子およびそれを標的とする医薬 |
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| PL3179991T3 (pl) | 2014-08-11 | 2022-02-14 | Acerta Pharma B.V. | Kombinacje terapeutyczne inhibitora btk i inhibitora bcl-2 |
| TW201618775A (zh) | 2014-08-11 | 2016-06-01 | 艾森塔製藥公司 | Btk抑制劑、pi3k抑制劑、jak-2抑制劑、pd-1抑制劑及/或pd-l1抑制劑之治療組合物 |
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| JP6762300B2 (ja) | 2015-06-17 | 2020-09-30 | 中外製薬株式会社 | アミノピラゾール誘導体 |
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| MX380092B (es) | 2015-11-06 | 2025-03-11 | Samumed Llc | Tratamiento de la osteoartritis. |
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| MX390577B (es) | 2016-06-01 | 2025-03-20 | Samumed Llc | Proceso de preparación de n-(5-(3-(7-(3-fluorofenil)-3h-imidazo[4,5-c]piridin-2-il)-1h-indazol-5-il)piridin-3-il)-3-metilbutanamida. |
| TWI704148B (zh) | 2016-10-10 | 2020-09-11 | 美商亞雷生物製藥股份有限公司 | 作為ret激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物 |
| TWI752098B (zh) | 2016-10-10 | 2022-01-11 | 美商亞雷生物製藥股份有限公司 | 作為ret激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物 |
| JOP20190092A1 (ar) | 2016-10-26 | 2019-04-25 | Array Biopharma Inc | عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها |
| WO2018136663A1 (en) | 2017-01-18 | 2018-07-26 | Array Biopharma, Inc. | Ret inhibitors |
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| JP2020510061A (ja) * | 2017-03-14 | 2020-04-02 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | ピラゾロクロロフェニル化合物、組成物及びその使用方法 |
| JOP20190213A1 (ar) | 2017-03-16 | 2019-09-16 | Array Biopharma Inc | مركبات حلقية ضخمة كمثبطات لكيناز ros1 |
| TWI876442B (zh) | 2017-10-10 | 2025-03-11 | 美商絡速藥業公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之調配物 |
| TWI791053B (zh) | 2017-10-10 | 2023-02-01 | 美商亞雷生物製藥股份有限公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之結晶形式及其醫藥組合物 |
| JP7060694B2 (ja) | 2018-01-18 | 2022-04-26 | アレイ バイオファーマ インコーポレイテッド | Retキナーゼ阻害剤としての置換ピロロ[2,3-d]ピリミジン化合物 |
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| US20210213037A1 (en) * | 2018-02-15 | 2021-07-15 | Children's Hospital Medical Center | Methods for treating fibrosis |
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| WO2019178239A1 (en) * | 2018-03-13 | 2019-09-19 | Board Of Regents, The University Of Texas System | Methods for treatment of cancers with egfr activating mutations |
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| US20230000842A1 (en) * | 2019-01-17 | 2023-01-05 | Samumed, Llc | Methods of treating cartilage disorders through inhibition of clk and dyrk |
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| WO2006124780A2 (en) | 2005-05-12 | 2006-11-23 | Kalypsys, Inc. | Ih-benzo [d] imidazole compounds as inhibitors of b-raf kinase |
| DE602006017694D1 (de) | 2005-06-27 | 2010-12-02 | Bristol Myers Squibb Co | C-verknüpfte zyklische antagonisten des p2y1-rezeptors mit eignung bei der behandlung thrombotischer leiden |
| DK1910384T3 (da) | 2005-08-04 | 2012-12-17 | Sirtris Pharmaceuticals Inc | Imidazo [2,1-b] thiazol-derivater som sirtuinmodulerende forbindelser |
| JP2007045752A (ja) | 2005-08-10 | 2007-02-22 | Takeda Chem Ind Ltd | 5員芳香族複素環誘導体、その製造法および用途 |
| DE102005057894A1 (de) | 2005-12-02 | 2007-06-06 | Basf Ag | Stabilisierte polymerisierbare Mischungen |
| EP2043635A2 (en) | 2006-06-29 | 2009-04-08 | Astex Therapeutics Limited | Pharmaceutical combinations |
| JP5523829B2 (ja) | 2006-06-29 | 2014-06-18 | アステックス、セラピューティックス、リミテッド | 複合薬剤 |
| FR2903406B1 (fr) | 2006-07-04 | 2012-08-10 | Aventis Pharma Sa | Derives de pyrazolylbenzimidazole,compositions les contenant et utilisation |
| EP2073807A1 (en) | 2006-10-12 | 2009-07-01 | Astex Therapeutics Limited | Pharmaceutical combinations |
-
2006
- 2006-12-29 US US12/159,054 patent/US8399442B2/en not_active Expired - Fee Related
- 2006-12-29 WO PCT/GB2006/004954 patent/WO2007077435A1/en not_active Ceased
- 2006-12-29 EP EP06831505A patent/EP1968579A1/en not_active Withdrawn
- 2006-12-29 JP JP2008548032A patent/JP5474354B2/ja not_active Expired - Fee Related
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