JP2009531276A5 - - Google Patents
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- JP2009531276A5 JP2009531276A5 JP2008548032A JP2008548032A JP2009531276A5 JP 2009531276 A5 JP2009531276 A5 JP 2009531276A5 JP 2008548032 A JP2008548032 A JP 2008548032A JP 2008548032 A JP2008548032 A JP 2008548032A JP 2009531276 A5 JP2009531276 A5 JP 2009531276A5
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- acid
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- cancer
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- 0 **N(*)c1c(*)[n]nc1C1=NC(*)=C(*)*1 Chemical compound **N(*)c1c(*)[n]nc1C1=NC(*)=C(*)*1 0.000 description 8
- UZXACZRAUVKJFI-UHFFFAOYSA-N Cc1nc(cc(c(OC)c2)OC)c2[nH]1 Chemical compound Cc1nc(cc(c(OC)c2)OC)c2[nH]1 UZXACZRAUVKJFI-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75533905P | 2005-12-30 | 2005-12-30 | |
| US60/755,339 | 2005-12-30 | ||
| GB0526607.7 | 2005-12-30 | ||
| GB0526607A GB0526607D0 (en) | 2005-12-30 | 2005-12-30 | Pharmaceutical compounds |
| US80621806P | 2006-06-29 | 2006-06-29 | |
| US60/806,218 | 2006-06-29 | ||
| PCT/GB2006/004954 WO2007077435A1 (en) | 2005-12-30 | 2006-12-29 | Pharmaceutical compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009531276A JP2009531276A (ja) | 2009-09-03 |
| JP2009531276A5 true JP2009531276A5 (https=) | 2010-02-18 |
| JP5474354B2 JP5474354B2 (ja) | 2014-04-16 |
Family
ID=38006842
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008548032A Expired - Fee Related JP5474354B2 (ja) | 2005-12-30 | 2006-12-29 | 医薬化合物 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US8399442B2 (https=) |
| EP (1) | EP1968579A1 (https=) |
| JP (1) | JP5474354B2 (https=) |
| WO (1) | WO2007077435A1 (https=) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
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| TWI372050B (en) * | 2003-07-03 | 2012-09-11 | Astex Therapeutics Ltd | (morpholin-4-ylmethyl-1h-benzimidazol-2-yl)-1h-pyrazoles |
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| WO2008001101A2 (en) * | 2006-06-29 | 2008-01-03 | Astex Therapeutics Limited | Pharmaceutical combinations |
| JP5528807B2 (ja) | 2006-10-12 | 2014-06-25 | アステックス、セラピューティックス、リミテッド | 複合薬剤 |
| GB0720113D0 (en) * | 2007-10-15 | 2007-11-28 | Cambridge Cancer Diagnostics L | Diagnostic, prognostic and predictive testing for cancer |
| JP2011522212A (ja) * | 2007-10-19 | 2011-07-28 | セル・シグナリング・テクノロジー・インコーポレイテツド | 癌の分類および使用法 |
| WO2009138799A1 (en) * | 2008-05-14 | 2009-11-19 | Astex Therapeutics Limited | Therapeutic uses of 1-cycl0pr0pyl-3 - [3- ( 5 -morpholin- 4 -ylmethyl- 1h-benz0imidaz0l- 2 -yl) -lh-pyrazol-4-yl] -urea |
| PT2350075E (pt) | 2008-09-22 | 2014-06-09 | Array Biopharma Inc | Compostos imidazo[1,2b]piridazina substituídos como inibidores da trk cinase |
| AR077468A1 (es) | 2009-07-09 | 2011-08-31 | Array Biopharma Inc | Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa |
| PH12012500252A1 (en) | 2009-08-07 | 2015-06-26 | Chugai Pharmaceutical Co Ltd | Aminopyrazole derivative |
| JP6161537B2 (ja) | 2010-04-07 | 2017-07-12 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | ピラゾール−4−イル−ヘテロシクリル−カルボキサミド化合物及び使用の方法 |
| EP2568980B1 (en) * | 2010-05-12 | 2015-11-11 | Merial, Inc. | Injectable parasiticidal formulations of levamisole and macrocyclic lactones |
| WO2012119091A1 (en) * | 2011-03-02 | 2012-09-07 | Beth Israel Deaconess Medical Center, Inc. | Mcl-1 as a therapeutic target in scffbw7 deficient neoplasm |
| AR088061A1 (es) | 2011-09-27 | 2014-05-07 | Hoffmann La Roche | Compuestos de pirazol-4-il-heterociclil-carboxamida y metodos de uso |
| US9241920B2 (en) | 2011-10-27 | 2016-01-26 | New York University | Inhibition of c-Myc ubiquitination to prevent cancer initiation and progression |
| JP6180425B2 (ja) | 2011-11-23 | 2017-08-23 | メディミューン,エルエルシー | Her3に特異的な結合分子及びそれらの使用 |
| EP2636752A1 (en) * | 2012-03-06 | 2013-09-11 | Universiteit Maastricht | In vitro method for determining disease outcome in pulmonary carcinoids. |
| PH12017500997A1 (en) | 2012-04-04 | 2018-02-19 | Samumed Llc | Indazole inhibitors of the wnt signal pathway and therapeutic uses thereof |
| US20150203589A1 (en) | 2012-07-24 | 2015-07-23 | The Trustees Of Columbia University In The City Of New York | Fusion proteins and methods thereof |
| RU2015117950A (ru) * | 2012-10-26 | 2016-12-20 | Ф. Хоффманн-Ля Рош Аг | 3,4-дизамещенный 1н-пиразол и 4,5-дизамещенный тиазол в качестве ингибиторов тирозинкиназы syk |
| PL403149A1 (pl) * | 2013-03-14 | 2014-09-15 | Celon Pharma Spółka Akcyjna | Nowe związki pochodne pirazolilobenzo[d]imidazolu |
| JP6799201B2 (ja) | 2013-07-31 | 2020-12-16 | アヴァリン ファーマ インク. | エアロゾルチロシンキナーゼ阻害剤の化合物、及びその使用 |
| US11305012B2 (en) | 2013-09-24 | 2022-04-19 | Medimmune, Llc | Binding molecules specific for HER3 and uses thereof |
| US10391081B2 (en) | 2013-12-27 | 2019-08-27 | Chugai Seiyaku Kabushiki Kaisha | FGFR gatekeeper mutant gene and drug targeting same |
| ES2913339T3 (es) * | 2014-01-31 | 2022-06-01 | Draka Elevator Products Inc | Dispositivo sensor de detección sísmica para equipo de transporte vertical |
| US10745490B2 (en) | 2014-04-11 | 2020-08-18 | Celldex Therapeutics, Inc. | Anti-ErbB antibodies and methods of use thereof |
| EA201692549A1 (ru) * | 2014-06-20 | 2017-08-31 | Эвайраджен Терепьютикс, Инк. | Безводная кристаллическая форма свободного основания 6-{2-[1-(6-метил-3-пиридазинил)-4-пиперидинил]этокси}-3-этокси-1,2-бензизоксазола |
| MA40596B1 (fr) | 2014-08-11 | 2021-12-31 | Acerta Pharma Bv | Combinaisons thérapeutiques d'un inhibiteur de btk et d'un inhibiteur de bcl-2 |
| TW201618773A (zh) | 2014-08-11 | 2016-06-01 | 艾森塔製藥公司 | Btk抑制劑、pi3k抑制劑、jak-2抑制劑、及/或cdk4/6抑制劑的治療組合物 |
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| HUE061448T2 (hu) | 2014-11-16 | 2023-07-28 | Array Biopharma Inc | (S)-N-(5-((R)-2-(2,5-difluorofenil)-pirrolidin-1-il)-pirazolo[1,5-A]pirimidin-3-il) -3-hidroxipirrolidin-1-karboxamid-hidrogénszulfát kristályos formája |
| EP3312172B1 (en) | 2015-06-17 | 2020-05-06 | Chugai Seiyaku Kabushiki Kaisha | Aminopyrazole derivatives useful as src kinase inhibitors |
| BR112018000808A2 (pt) | 2015-07-16 | 2018-09-04 | Array Biopharma Inc | compostos de pirazolo[1,5-a]piridina substituída como inibidores de ret cinase |
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| BR112018009252A2 (pt) | 2015-11-06 | 2018-11-06 | Samumed Llc | tratamento da osteoartrite |
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| ES2987474T3 (es) | 2016-04-04 | 2024-11-15 | Loxo Oncology Inc | Formulaciones líquidas de (S)-N-(5-((R)-2-(2,5-difluorofenil)-pirrolidin-1-IL)-pirazolo[1,5-A]pirimidin-3-IL)-3-hidroxipirrolidina-1-carboxamida |
| ES2836222T3 (es) | 2016-05-18 | 2021-06-24 | Loxo Oncology Inc | Preparación de (S)-N-(5-((R)-2-(2,5-difluorofenil)pirrolidin-1-il)pirazolo[1,5-a]pirimidin-3-il)-3-hidroxipirrolidina-1-carboxamida |
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| TWI752098B (zh) | 2016-10-10 | 2022-01-11 | 美商亞雷生物製藥股份有限公司 | 作為ret激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物 |
| TWI704148B (zh) | 2016-10-10 | 2020-09-11 | 美商亞雷生物製藥股份有限公司 | 作為ret激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物 |
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| US11168090B2 (en) | 2017-01-18 | 2021-11-09 | Array Biopharma Inc. | Substituted pyrazolo[1,5-a]pyrazines as RET kinase inhibitors |
| WO2018136663A1 (en) | 2017-01-18 | 2018-07-26 | Array Biopharma, Inc. | Ret inhibitors |
| CN110494434B (zh) * | 2017-03-14 | 2022-05-24 | 豪夫迈·罗氏有限公司 | 吡唑并氯苯基化合物、其组合物及其使用方法 |
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| TWI791053B (zh) | 2017-10-10 | 2023-02-01 | 美商亞雷生物製藥股份有限公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之結晶形式及其醫藥組合物 |
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| EP3752161A4 (en) * | 2018-02-15 | 2021-12-22 | Children's Hospital Medical Center | METHOD OF TREATMENT OF FIBROSE |
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| WO2006092430A1 (de) | 2005-03-03 | 2006-09-08 | Universität des Saarlandes | Selektive hemmstoffe humaner corticoidsynthasen |
| AU2006218403A1 (en) | 2005-03-03 | 2006-09-08 | Sirtris Pharmaceuticals, Inc. | Fused heterocyclic compounds and their use as sirtuin modulators |
| WO2006094209A2 (en) | 2005-03-03 | 2006-09-08 | Sirtris Pharmaceuticals, Inc. | N-benzimidazolylalkyl-substituted amide sirtuin modulators |
| WO2006124780A2 (en) | 2005-05-12 | 2006-11-23 | Kalypsys, Inc. | Ih-benzo [d] imidazole compounds as inhibitors of b-raf kinase |
| EP1899299B1 (en) | 2005-06-27 | 2010-10-20 | Bristol-Myers Squibb Company | C-linked cyclic antagonists of p2y1 receptor useful in the treatment of thrombotic conditions |
| EP1910385B1 (en) | 2005-08-04 | 2013-07-24 | Sirtris Pharmaceuticals, Inc. | Benzothiazoles and thiazolopyridines as sirtuin modulators |
| JP2007045752A (ja) | 2005-08-10 | 2007-02-22 | Takeda Chem Ind Ltd | 5員芳香族複素環誘導体、その製造法および用途 |
| DE102005057894A1 (de) | 2005-12-02 | 2007-06-06 | Basf Ag | Stabilisierte polymerisierbare Mischungen |
| EP2049119A2 (en) * | 2006-06-29 | 2009-04-22 | Astex Therapeutics Limited | Pharmaceutical combinations of 1-cyclopropyl-3-[3-(5-morphoolin-4-ylmethyl-1h-benzoimidazol-2-yl)-1h-1-pyrazol-4-yl]-urea |
| WO2008001101A2 (en) | 2006-06-29 | 2008-01-03 | Astex Therapeutics Limited | Pharmaceutical combinations |
| FR2903406B1 (fr) | 2006-07-04 | 2012-08-10 | Aventis Pharma Sa | Derives de pyrazolylbenzimidazole,compositions les contenant et utilisation |
| JP5528807B2 (ja) * | 2006-10-12 | 2014-06-25 | アステックス、セラピューティックス、リミテッド | 複合薬剤 |
-
2006
- 2006-12-29 EP EP06831505A patent/EP1968579A1/en not_active Withdrawn
- 2006-12-29 US US12/159,054 patent/US8399442B2/en not_active Expired - Fee Related
- 2006-12-29 JP JP2008548032A patent/JP5474354B2/ja not_active Expired - Fee Related
- 2006-12-29 WO PCT/GB2006/004954 patent/WO2007077435A1/en not_active Ceased
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