JP2009525283A5 - - Google Patents
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- JP2009525283A5 JP2009525283A5 JP2008552504A JP2008552504A JP2009525283A5 JP 2009525283 A5 JP2009525283 A5 JP 2009525283A5 JP 2008552504 A JP2008552504 A JP 2008552504A JP 2008552504 A JP2008552504 A JP 2008552504A JP 2009525283 A5 JP2009525283 A5 JP 2009525283A5
- Authority
- JP
- Japan
- Prior art keywords
- formulation
- collagenase
- mixture
- measured
- high performance
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 claims description 79
- 108060005980 Collagenase Proteins 0.000 claims description 24
- 102000029816 Collagenase Human genes 0.000 claims description 24
- 229960002424 collagenase Drugs 0.000 claims description 24
- 238000000034 method Methods 0.000 claims description 17
- 201000010099 disease Diseases 0.000 claims description 12
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 12
- 231100000241 scar Toxicity 0.000 claims description 8
- 102000008186 Collagen Human genes 0.000 claims description 7
- 108010035532 Collagen Proteins 0.000 claims description 7
- 229920001436 collagen Polymers 0.000 claims description 7
- 230000001404 mediated effect Effects 0.000 claims description 7
- 238000002360 preparation method Methods 0.000 claims description 6
- 208000002874 Acne Vulgaris Diseases 0.000 claims description 5
- 206010000496 acne Diseases 0.000 claims description 5
- 208000035484 Cellulite Diseases 0.000 claims description 4
- 208000001708 Dupuytren contracture Diseases 0.000 claims description 4
- 206010016654 Fibrosis Diseases 0.000 claims description 4
- 208000002260 Keloid Diseases 0.000 claims description 4
- 206010024612 Lipoma Diseases 0.000 claims description 4
- 206010049752 Peau d'orange Diseases 0.000 claims description 4
- 206010034464 Periarthritis Diseases 0.000 claims description 4
- 208000031737 Tissue Adhesions Diseases 0.000 claims description 4
- 230000015572 biosynthetic process Effects 0.000 claims description 4
- 230000036232 cellulite Effects 0.000 claims description 4
- 230000000994 depressogenic effect Effects 0.000 claims description 4
- 230000004761 fibrosis Effects 0.000 claims description 4
- 206010020718 hyperplasia Diseases 0.000 claims description 4
- 210000001117 keloid Anatomy 0.000 claims description 4
- 230000001613 neoplastic effect Effects 0.000 claims description 4
- 230000037303 wrinkles Effects 0.000 claims description 4
- 206010023330 Keloid scar Diseases 0.000 claims description 3
- 230000002390 hyperplastic effect Effects 0.000 claims description 3
- 238000009472 formulation Methods 0.000 claims 62
- YRQNKMKHABXEJZ-UVQQGXFZSA-N chembl176323 Chemical compound C1C[C@]2(C)[C@@]3(C)CC(N=C4C[C@]5(C)CCC6[C@]7(C)CC[C@@H]([C@]7(CC[C@]6(C)[C@@]5(C)CC4=N4)C)CCCCCCCC)=C4C[C@]3(C)CCC2[C@]2(C)CC[C@H](CCCCCCCC)[C@]21C YRQNKMKHABXEJZ-UVQQGXFZSA-N 0.000 claims 21
- 238000001914 filtration Methods 0.000 claims 14
- 238000004007 reversed phase HPLC Methods 0.000 claims 11
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 10
- 229930006000 Sucrose Natural products 0.000 claims 10
- 239000007983 Tris buffer Substances 0.000 claims 10
- 239000005720 sucrose Substances 0.000 claims 10
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims 10
- 239000007972 injectable composition Substances 0.000 claims 9
- 238000003756 stirring Methods 0.000 claims 8
- 238000003556 assay Methods 0.000 claims 6
- 230000000694 effects Effects 0.000 claims 6
- 238000011084 recovery Methods 0.000 claims 6
- GDBQQVLCIARPGH-UHFFFAOYSA-N Leupeptin Natural products CC(C)CC(NC(C)=O)C(=O)NC(CC(C)C)C(=O)NC(C=O)CCCN=C(N)N GDBQQVLCIARPGH-UHFFFAOYSA-N 0.000 claims 5
- GDBQQVLCIARPGH-ULQDDVLXSA-N leupeptin Chemical compound CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C=O)CCCN=C(N)N GDBQQVLCIARPGH-ULQDDVLXSA-N 0.000 claims 5
- 108010052968 leupeptin Proteins 0.000 claims 5
- 239000001888 Peptone Substances 0.000 claims 4
- 108010080698 Peptones Proteins 0.000 claims 4
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 claims 4
- 229910052921 ammonium sulfate Inorganic materials 0.000 claims 4
- 235000011130 ammonium sulphate Nutrition 0.000 claims 4
- 238000000855 fermentation Methods 0.000 claims 4
- 230000004151 fermentation Effects 0.000 claims 4
- 239000000706 filtrate Substances 0.000 claims 4
- 235000019319 peptone Nutrition 0.000 claims 4
- 208000004362 Penile Induration Diseases 0.000 claims 3
- 208000020758 Peyronie disease Diseases 0.000 claims 3
- 206010040954 Skin wrinkling Diseases 0.000 claims 3
- 239000008176 lyophilized powder Substances 0.000 claims 3
- 239000000546 pharmaceutical excipient Substances 0.000 claims 3
- 241000894006 Bacteria Species 0.000 claims 2
- 241000193159 Hathewaya histolytica Species 0.000 claims 2
- 239000012614 Q-Sepharose Substances 0.000 claims 2
- 239000000853 adhesive Substances 0.000 claims 2
- 230000001070 adhesive effect Effects 0.000 claims 2
- 238000001042 affinity chromatography Methods 0.000 claims 2
- 238000005349 anion exchange Methods 0.000 claims 2
- 206010003246 arthritis Diseases 0.000 claims 2
- 239000000872 buffer Substances 0.000 claims 2
- 238000004440 column chromatography Methods 0.000 claims 2
- 239000012141 concentrate Substances 0.000 claims 2
- 239000002158 endotoxin Substances 0.000 claims 2
- WHWDWIHXSPCOKZ-UHFFFAOYSA-N hexahydrofarnesyl acetone Natural products CC(C)CCCC(C)CCCC(C)CCCC(C)=O WHWDWIHXSPCOKZ-UHFFFAOYSA-N 0.000 claims 2
- 230000000409 histolytic effect Effects 0.000 claims 2
- 239000003446 ligand Substances 0.000 claims 2
- 239000000047 product Substances 0.000 claims 2
- 238000000746 purification Methods 0.000 claims 2
- 230000001105 regulatory effect Effects 0.000 claims 2
- 238000000926 separation method Methods 0.000 claims 2
- 235000013311 vegetables Nutrition 0.000 claims 2
- 102000013382 Gelatinases Human genes 0.000 claims 1
- 108010026132 Gelatinases Proteins 0.000 claims 1
- 108010013295 Microbial collagenase Proteins 0.000 claims 1
- 238000005571 anion exchange chromatography Methods 0.000 claims 1
- 108090001092 clostripain Proteins 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000001568 sexual effect Effects 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 208000032544 Cicatrix Diseases 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 230000037387 scars Effects 0.000 description 2
- 201000010603 frozen shoulder Diseases 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 238000001361 intraarterial administration Methods 0.000 description 1
- 238000007917 intracranial administration Methods 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000007919 intrasynovial administration Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US76347006P | 2006-01-30 | 2006-01-30 | |
| US60/763,470 | 2006-01-30 | ||
| US78413506P | 2006-03-20 | 2006-03-20 | |
| US60/784,135 | 2006-03-20 | ||
| US11/699,302 | 2007-01-29 | ||
| US11/699,302 US7811560B2 (en) | 2006-01-30 | 2007-01-29 | Compositions and methods for treating collagen-mediated diseases |
| PCT/US2007/002654 WO2007089851A2 (en) | 2006-01-30 | 2007-01-30 | Compositions and methods for treating collagen-mediated diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011285435A Division JP2012070758A (ja) | 2006-01-30 | 2011-12-27 | コラーゲン媒介疾患を処置するための組成物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009525283A JP2009525283A (ja) | 2009-07-09 |
| JP2009525283A5 true JP2009525283A5 (https=) | 2012-02-23 |
| JP5309289B2 JP5309289B2 (ja) | 2013-10-09 |
Family
ID=38328033
Family Applications (8)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008552504A Active JP5309289B2 (ja) | 2006-01-30 | 2007-01-30 | コラーゲン媒介疾患を処置するための組成物および方法 |
| JP2011285435A Withdrawn JP2012070758A (ja) | 2006-01-30 | 2011-12-27 | コラーゲン媒介疾患を処置するための組成物および方法 |
| JP2015072261A Active JP6230200B2 (ja) | 2006-01-30 | 2015-03-31 | コラーゲン媒介疾患を処置するための組成物および方法 |
| JP2016196519A Active JP6389493B2 (ja) | 2006-01-30 | 2016-10-04 | コラーゲン媒介疾患を処置するための組成物および方法 |
| JP2017173236A Active JP6851943B2 (ja) | 2006-01-30 | 2017-09-08 | コラーゲン媒介疾患を処置するための組成物および方法 |
| JP2018126943A Active JP6792596B2 (ja) | 2006-01-30 | 2018-07-03 | コラーゲン媒介疾患を処置するための組成物および方法 |
| JP2019229674A Active JP6944989B2 (ja) | 2006-01-30 | 2019-12-19 | コラーゲン媒介疾患を処置するための組成物および方法 |
| JP2021070232A Active JP7191152B2 (ja) | 2006-01-30 | 2021-04-19 | コラーゲン媒介疾患を処置するための組成物および方法 |
Family Applications After (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011285435A Withdrawn JP2012070758A (ja) | 2006-01-30 | 2011-12-27 | コラーゲン媒介疾患を処置するための組成物および方法 |
| JP2015072261A Active JP6230200B2 (ja) | 2006-01-30 | 2015-03-31 | コラーゲン媒介疾患を処置するための組成物および方法 |
| JP2016196519A Active JP6389493B2 (ja) | 2006-01-30 | 2016-10-04 | コラーゲン媒介疾患を処置するための組成物および方法 |
| JP2017173236A Active JP6851943B2 (ja) | 2006-01-30 | 2017-09-08 | コラーゲン媒介疾患を処置するための組成物および方法 |
| JP2018126943A Active JP6792596B2 (ja) | 2006-01-30 | 2018-07-03 | コラーゲン媒介疾患を処置するための組成物および方法 |
| JP2019229674A Active JP6944989B2 (ja) | 2006-01-30 | 2019-12-19 | コラーゲン媒介疾患を処置するための組成物および方法 |
| JP2021070232A Active JP7191152B2 (ja) | 2006-01-30 | 2021-04-19 | コラーゲン媒介疾患を処置するための組成物および方法 |
Country Status (17)
| Country | Link |
|---|---|
| US (16) | US7811560B2 (https=) |
| EP (6) | EP3508571B1 (https=) |
| JP (8) | JP5309289B2 (https=) |
| KR (2) | KR20080093142A (https=) |
| CN (2) | CN105999244B (https=) |
| AU (2) | AU2007211313C1 (https=) |
| BR (1) | BRPI0708017A2 (https=) |
| CA (1) | CA2637262C (https=) |
| DK (2) | DK2474321T3 (https=) |
| ES (3) | ES2992881T3 (https=) |
| HU (2) | HUE041764T2 (https=) |
| IL (6) | IL291175B2 (https=) |
| MX (1) | MX2008009756A (https=) |
| NZ (2) | NZ593907A (https=) |
| PT (2) | PT1987141T (https=) |
| TR (1) | TR201903008T4 (https=) |
| WO (1) | WO2007089851A2 (https=) |
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| US6958150B2 (en) * | 1994-12-15 | 2005-10-25 | Advance Biofactures Of Curacao, N.V. | Reduction of adipose tissue |
| US20070224184A1 (en) * | 2006-02-22 | 2007-09-27 | The Research Foundation Of The State University Of New York | Method for treating cellulite |
| US7811560B2 (en) * | 2006-01-30 | 2010-10-12 | Auxilium Us Holdings, Llc | Compositions and methods for treating collagen-mediated diseases |
| US10071143B1 (en) | 2007-05-03 | 2018-09-11 | The Research Foundation For The State University Of New York | Methods for non-surgical treatment of carpal tunnel syndrome |
| EP2725035A1 (en) | 2007-10-02 | 2014-04-30 | Avaxia Biologics, Inc. | Antibody therapy for use in the digestive tract |
| US20100159564A1 (en) * | 2007-11-30 | 2010-06-24 | Dwulet Francis E | Protease resistant recombinant bacterial collagenases |
| TWI395593B (zh) | 2008-03-06 | 2013-05-11 | Halozyme Inc | 可活化的基質降解酵素之活體內暫時性控制 |
| ES2388219T3 (es) * | 2008-06-02 | 2012-10-10 | F. Hoffmann-La Roche Ag | Purificación mejorada de colagenasas a partir de un cultivo líquido de Clostridium histolyticum |
| US8236356B2 (en) * | 2008-06-11 | 2012-08-07 | Roche Diagnostics Operations, Inc. | Growth medium for Clostridium histolyticum |
| EP2403523A1 (en) * | 2009-03-06 | 2012-01-11 | Halozyme, Inc. | Temperature sensitive mutants of matrix metalloprotease 1 und uses thereof |
| ES2385239B1 (es) | 2010-09-30 | 2013-06-19 | Proteos Biotech S.L.U. | Uso de colagenasa g recombinante, colagenasa h recombinante y pz-peptidasa recombinante para el tratamiento de enfermedades que cursan con alteraciones del colágeno. |
| WO2012125948A1 (en) | 2011-03-16 | 2012-09-20 | Biospecifics Technologies Corp. | Compositions and methods for producing clostridial collagenases |
| WO2013011514A1 (en) | 2011-07-20 | 2013-01-24 | Mediwound Ltd. | Proteolytic extract from bromelain for the treatment of connective tissue disorders |
| JP2014530873A (ja) * | 2011-10-21 | 2014-11-20 | オーキシリウム インターナショナル ホールディングス，インコーポレイテッド | Ｅｆｐの治療または低減方法 |
| PT2802652T (pt) | 2012-01-12 | 2019-09-10 | Endo Global Ventures | Enzimas de clostridium histolyticum |
| ITPD20120118A1 (it) * | 2012-04-18 | 2013-10-19 | Fidia Farmaceutici | "nuovo processo di produzione e purificazione dell'enzima collagenasi da vibrio alginolyticus" |
| BR112014027347A2 (pt) | 2012-05-01 | 2017-06-27 | Proteolease Ltd | método para extrair um dente em um sujeito com essa necessidade, método para substituir um dente com um implante dentário e kit para extrair um dente |
| BR102012013110A2 (pt) | 2012-05-31 | 2014-05-27 | Cristalia Prod Quimicos Farm | Meio de cultura para bactérias do gênero clostridium livre de componentes de origem animal e processo para produção de sobrenadante contendo uma ou mais proteases com atividade colagenolítica e gelatinolítica |
| US9636385B2 (en) | 2012-10-24 | 2017-05-02 | The Research Foundation For The State University Of New York | Use of collagenase to treat glaucoma |
| US20150196625A9 (en) | 2013-01-07 | 2015-07-16 | Rudolph D. Paladini | Metal Sensitive Mutants of Matrix Metalloproteases and uses thereof |
| US20160000890A1 (en) | 2013-03-15 | 2016-01-07 | Biospecifics Technologies Corp. | Thermosensitive hydrogel collagenase formulations |
| EP3834840B8 (en) * | 2013-03-15 | 2025-09-17 | Endo Biologics Limited | Treatment method and product for uterine fibroids using purified collagenase |
| CA2915814A1 (en) * | 2013-06-18 | 2014-12-24 | Harrow Ip, Llc | Local use of pentoxifylline to treat peyronie's disease |
| US10383875B2 (en) | 2013-06-18 | 2019-08-20 | Harrow Ip, Llc | Pharmaceutical formulations of xanthine or xanthine derivatives, and their use |
| US10117892B2 (en) * | 2013-08-29 | 2018-11-06 | Allergan, Inc. | Devices and methods for reducing the appearance of cellulite |
| CN103751102A (zh) | 2014-01-15 | 2014-04-30 | 上海交通大学 | 一种胶原酶温敏水凝胶及其制备方法和应用 |
| CN105477628B (zh) * | 2014-09-19 | 2021-04-30 | 山东蓝金生物工程有限公司 | 抗癌组合物及其用途 |
| CN105412916B (zh) * | 2014-09-19 | 2021-04-30 | 达森生物药业有限公司 | 治疗乳腺癌的组合物及其用途 |
| CN105477627B (zh) * | 2014-09-19 | 2021-04-30 | 山东蓝金生物工程有限公司 | 治疗前列腺癌的组合物及其用途 |
| CN105412917B (zh) * | 2014-09-19 | 2021-04-30 | 达森生物药业有限公司 | 治疗实体瘤的抗癌组合物及其用途 |
| DE202014105440U1 (de) * | 2014-11-12 | 2016-02-15 | Bilz Werkzeugfabrik Gmbh & Co. Kg | Werkzeugaufnahme |
| KR101723168B1 (ko) * | 2015-04-28 | 2017-04-05 | 주식회사 대웅 | 보툴리눔 독소의 제조를 위한 배지 조성물 |
| US10303245B2 (en) * | 2015-05-04 | 2019-05-28 | Adobe Inc. | Methods and devices for detecting and responding to changes in eye conditions during presentation of video on electronic devices |
| EP4591945A3 (en) | 2017-03-01 | 2026-04-15 | Endo Operations Limited | Apparatus and method for assessing and treating cellulite |
| JP7227918B2 (ja) | 2017-03-28 | 2023-02-22 | エンド ベンチャーズ リミテッド | コラゲナーゼ産生の改良された方法 |
| WO2020021332A2 (en) | 2018-07-12 | 2020-01-30 | Endo Global Aesthetics Limited | Injection techniques for the treatment of cellulite |
| WO2020021330A2 (en) | 2018-07-12 | 2020-01-30 | Endo Global Aesthetics Limited | Injection techniques for the treatment of cellulite |
| US20240277595A1 (en) | 2018-09-18 | 2024-08-22 | Endo Global Aesthetics Limited | Compositions and methods for treating cellulite |
| US20220305094A1 (en) | 2019-01-06 | 2022-09-29 | Endo Global Aesthetics Limited | Collagenase formulations and methods of producing the same |
| US11872267B2 (en) | 2019-10-15 | 2024-01-16 | The Johns Hopkins University | Treatment of uterine fibroids using purified collagenase |
| WO2023131588A1 (en) | 2022-01-05 | 2023-07-13 | Nordmark Pharma Gmbh | Culture medium for cultivating hathewaya histolytica (or clostridium histolyticum) and the production of one or more proteases |
| CN116102638B (zh) * | 2023-01-09 | 2025-05-16 | 中国农业科学院农产品加工研究所 | 基于亲和吸附富集骨胶原蛋白成骨活性肽的方法 |
| WO2026028155A1 (en) | 2024-08-01 | 2026-02-05 | Endo Biologics Limited | Methods of treating plantar fasciitis |
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| CN101107006B (zh) * | 2005-01-21 | 2013-09-11 | 纽约州立大学研究基金会 | 治疗黏连性关节囊炎的方法 |
| US7811560B2 (en) * | 2006-01-30 | 2010-10-12 | Auxilium Us Holdings, Llc | Compositions and methods for treating collagen-mediated diseases |
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