JP2009517468A - 経皮吸収治療システム - Google Patents
経皮吸収治療システム Download PDFInfo
- Publication number
- JP2009517468A JP2009517468A JP2008543278A JP2008543278A JP2009517468A JP 2009517468 A JP2009517468 A JP 2009517468A JP 2008543278 A JP2008543278 A JP 2008543278A JP 2008543278 A JP2008543278 A JP 2008543278A JP 2009517468 A JP2009517468 A JP 2009517468A
- Authority
- JP
- Japan
- Prior art keywords
- tts
- active ingredient
- rivastigmine
- treatment
- layer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Dermatology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Emergency Medicine (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74151105P | 2005-12-01 | 2005-12-01 | |
| PCT/US2006/039557 WO2007064407A1 (en) | 2005-12-01 | 2006-10-10 | Transdermal therapeutic system |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013107198A Division JP5938612B2 (ja) | 2005-12-01 | 2013-05-21 | 経皮吸収治療システム |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009517468A true JP2009517468A (ja) | 2009-04-30 |
| JP2009517468A5 JP2009517468A5 (enExample) | 2009-11-26 |
Family
ID=37716856
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008543278A Withdrawn JP2009517468A (ja) | 2005-12-01 | 2006-10-10 | 経皮吸収治療システム |
| JP2013107198A Active JP5938612B2 (ja) | 2005-12-01 | 2013-05-21 | 経皮吸収治療システム |
| JP2015233544A Active JP6298034B2 (ja) | 2005-12-01 | 2015-11-30 | 経皮吸収治療システム |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013107198A Active JP5938612B2 (ja) | 2005-12-01 | 2013-05-21 | 経皮吸収治療システム |
| JP2015233544A Active JP6298034B2 (ja) | 2005-12-01 | 2015-11-30 | 経皮吸収治療システム |
Country Status (31)
| Country | Link |
|---|---|
| US (3) | US20070128263A1 (enExample) |
| EP (5) | EP1959937A1 (enExample) |
| JP (3) | JP2009517468A (enExample) |
| KR (7) | KR20180050441A (enExample) |
| CN (2) | CN102048713A (enExample) |
| AR (2) | AR057152A1 (enExample) |
| AT (1) | AT11185U1 (enExample) |
| AU (1) | AU2006320919B2 (enExample) |
| BR (2) | BR122013013162A2 (enExample) |
| CA (1) | CA2563110A1 (enExample) |
| DE (2) | DE202006021172U1 (enExample) |
| DK (5) | DK2292219T3 (enExample) |
| EC (1) | ECSP088469A (enExample) |
| ES (1) | ES2414455T3 (enExample) |
| FI (1) | FI10268U1 (enExample) |
| GT (1) | GT200800075A (enExample) |
| IL (4) | IL191311A (enExample) |
| MA (1) | MA30022B1 (enExample) |
| MY (2) | MY151020A (enExample) |
| NO (1) | NO20082753L (enExample) |
| NZ (1) | NZ568273A (enExample) |
| PH (2) | PH12013500772B1 (enExample) |
| PL (1) | PL2292219T4 (enExample) |
| PT (1) | PT2292219E (enExample) |
| RU (1) | RU2450805C2 (enExample) |
| SG (1) | SG2014014989A (enExample) |
| SI (1) | SI2292219T1 (enExample) |
| TN (1) | TNSN08238A1 (enExample) |
| TW (1) | TWI389709B (enExample) |
| WO (1) | WO2007064407A1 (enExample) |
| ZA (1) | ZA200803882B (enExample) |
Cited By (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5093545B1 (ja) * | 2012-02-28 | 2012-12-12 | ニチバン株式会社 | 貼付剤 |
| JP2013515025A (ja) * | 2009-12-22 | 2013-05-02 | アシノ アーゲー | リバスチグミンまたはその誘導体を投与するための経皮治療システム |
| JP2013177419A (ja) * | 2005-12-01 | 2013-09-09 | Novartis Ag | 経皮吸収治療システム |
| WO2013187451A1 (ja) * | 2012-06-12 | 2013-12-19 | 株式会社 ケイ・エム トランスダーム | 貼付剤 |
| JP2014503523A (ja) * | 2010-12-14 | 2014-02-13 | アシノ アーゲー | 有効成分を投与するための経皮治療システム |
| WO2014034939A1 (ja) | 2012-09-03 | 2014-03-06 | ニプロパッチ株式会社 | 貼付剤 |
| WO2014051128A1 (ja) * | 2012-09-28 | 2014-04-03 | 株式会社 ケイ・エム トランスダーム | 貼付剤 |
| JP2014508728A (ja) * | 2010-12-24 | 2014-04-10 | サムヤン バイオファーマシューティカルズ コーポレイション | リバスティグミンを含有する経皮吸収製剤 |
| JP2014513719A (ja) * | 2011-05-20 | 2014-06-05 | エスケー ケミカルズ カンパニー,リミテッド | リバスティグミン含有パッチ |
| WO2015087927A1 (ja) | 2013-12-12 | 2015-06-18 | 久光製薬株式会社 | カバー材付き貼付剤及びカバー材付き貼付剤キット |
| JP2015535827A (ja) * | 2012-09-21 | 2015-12-17 | マイラン・インコーポレーテッド | 経皮ドラッグデリバリーデバイス |
| JP2016522792A (ja) * | 2013-03-15 | 2016-08-04 | エヌエーエル ファーマスーティカル グループ リミテッド | リバスチグミンを含む、経皮薬物送達システム |
| US10076502B2 (en) | 2009-12-22 | 2018-09-18 | Luye Pharma Ag | Transdermal therapeutic system for administering rivastigmine or derivatives thereof |
| KR20190039950A (ko) | 2016-08-22 | 2019-04-16 | 규큐 야쿠힝 고교 가부시키가이샤 | 첩부제 |
| US10308408B2 (en) | 2014-05-15 | 2019-06-04 | Nichiban Co., Ltd. | Packaging for adhesive patch containing rivastigmine |
| JP2020523405A (ja) * | 2017-05-19 | 2020-08-06 | ボヒュン ファーマーシューティカル カンパニー リミテッド | ドネペジルを含有するマイクロニードル経皮パッチ |
| JP2021527695A (ja) * | 2018-06-19 | 2021-10-14 | エルテーエス ローマン テラピー−ジステーメ アーゲー | リバスチグミンを含有する経皮治療システム |
| US11975097B2 (en) | 2009-10-30 | 2024-05-07 | Ix Biopharma Ltd. | Fast dissolving solid dosage form |
| US12186426B2 (en) | 2009-10-30 | 2025-01-07 | Ix Biopharma Ltd. | Solid dosage form |
Families Citing this family (85)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9248104B2 (en) * | 2006-08-17 | 2016-02-02 | Core Tech Solutions, Inc. | Transdermal methods and systems for treating Alzheimer's disease |
| TWI630208B (zh) | 2008-12-08 | 2018-07-21 | 歐陸斯迪公司 | 二氫羥戊甲嗎啡 |
| GB0823554D0 (en) | 2008-12-24 | 2009-01-28 | Novartis Ag | Process for the preparation of optically active compounds using transfer hydrogenation |
| EP2419485B1 (en) * | 2009-04-17 | 2018-05-23 | 3M Innovative Properties Company | Silicone gel adhesive construction |
| WO2010129689A1 (en) * | 2009-05-05 | 2010-11-11 | Forest Laboratories Holdings Limited | Milnacipran formulations |
| WO2011073362A1 (en) | 2009-12-18 | 2011-06-23 | Novartis Ag | Process for the preparation of optically active compounds using pressure hydrogenation |
| US20100178307A1 (en) * | 2010-01-13 | 2010-07-15 | Jianye Wen | Transdermal anti-dementia active agent formulations and methods for using the same |
| DE102010024105A1 (de) * | 2010-06-17 | 2011-12-22 | Grünenthal GmbH | Transdermale Verabreichung von Memantin |
| RU2578971C2 (ru) * | 2010-06-17 | 2016-03-27 | Лтс Ломанн Терапи-Системе Аг | Трансдермальное введение мемантина |
| DE102010026903A1 (de) | 2010-07-12 | 2012-01-12 | Amw Gmbh | Transdermales therapeutisches System mit Avocadoöl oder Palmöl als Hilfsstoff |
| EP3517105B8 (en) | 2010-07-21 | 2021-06-23 | Kindeva Drug Delivery L.P. | Transdermal adhesive compositions, devices, and methods |
| CA2807552A1 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| US20120046383A1 (en) * | 2010-08-19 | 2012-02-23 | Terumo Kabushiki Kaisha | Silicone rubber composition |
| EP3431485B2 (en) | 2010-10-01 | 2024-09-04 | ModernaTX, Inc. | Engineered nucleic acids and methods of use thereof |
| KR101054317B1 (ko) * | 2011-01-28 | 2011-08-08 | 신신제약 주식회사 | 리바스티그민을 함유하는 경피흡수제제 |
| KR101317158B1 (ko) | 2011-02-18 | 2013-10-15 | 조선대학교산학협력단 | 갈란타민 또는 그의 염을 함유하는 경피흡수제제 |
| WO2012135805A2 (en) | 2011-03-31 | 2012-10-04 | modeRNA Therapeutics | Delivery and formulation of engineered nucleic acids |
| KR20120130073A (ko) * | 2011-05-20 | 2012-11-28 | 에스케이케미칼주식회사 | 리바스티그민 함유 패취 |
| CN103796645B (zh) | 2011-08-31 | 2017-06-20 | 东洋油墨Sc控股株式会社 | 贴剂 |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| EP2763701B1 (en) | 2011-10-03 | 2018-12-19 | Moderna Therapeutics, Inc. | Modified nucleosides, nucleotides, and nucleic acids, and uses thereof |
| RS62297B1 (sr) | 2011-11-23 | 2021-09-30 | Therapeuticsmd Inc | Prirodne kombinovane hormonske supstitucione formulacije i terapije |
| US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| KR20140102759A (ko) | 2011-12-16 | 2014-08-22 | 모더나 세라퓨틱스, 인코포레이티드 | 변형된 뉴클레오사이드, 뉴클레오타이드 및 핵산 조성물 |
| KR101399035B1 (ko) * | 2011-12-22 | 2014-05-28 | 주식회사 트랜스덤 | 리바스티그민을 함유하는 경피흡수제제 |
| DE102012000369A1 (de) | 2012-01-11 | 2013-07-11 | Alfred E. Tiefenbacher (Gmbh & Co. Kg) | Transdermales therapeutisches System mit Cholinesterase-Hemmer |
| WO2013142339A1 (en) | 2012-03-23 | 2013-09-26 | Novartis Ag | Transdermal therapeutic system and method |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| US9878056B2 (en) | 2012-04-02 | 2018-01-30 | Modernatx, Inc. | Modified polynucleotides for the production of cosmetic proteins and peptides |
| DE18200782T1 (de) | 2012-04-02 | 2021-10-21 | Modernatx, Inc. | Modifizierte polynukleotide zur herstellung von proteinen im zusammenhang mit erkrankungen beim menschen |
| US20150051559A1 (en) * | 2012-04-05 | 2015-02-19 | Sparsha Pharma International Private Limited | Transdermal patch for treatment of dementia or alzheimer type dementia |
| US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
| US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
| US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| WO2014028049A1 (en) * | 2012-08-15 | 2014-02-20 | Dow Corning Corporation | Multi - layer transdermal drug delivery system |
| KR20140038237A (ko) * | 2012-09-20 | 2014-03-28 | 에스케이케미칼주식회사 | 리바스티그민의 안정성이 개선된 의약품 |
| TW201431570A (zh) | 2012-11-22 | 2014-08-16 | Ucb Pharma Gmbh | 用於經皮投服羅替戈汀(Rotigotine)之多天式貼片 |
| CA2892529C (en) | 2012-11-26 | 2023-04-25 | Moderna Therapeutics, Inc. | Terminally modified rna |
| US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
| US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| WO2014111790A2 (en) | 2013-01-15 | 2014-07-24 | Zydus Technologies Limited | Stable transdermal pharmaceutical drug delivery system comprising rivastigmine |
| RU2560668C2 (ru) * | 2013-03-04 | 2015-08-20 | Общество с ограниченной ответственностью Научно-производственное объединение "Клеточные технологии" | Трансдермальный седативный фармацевтический гель для лечения психоэмоциальных расстройств |
| AR095259A1 (es) * | 2013-03-15 | 2015-09-30 | Noven Pharma | Composiciones y métodos para la administración transdérmica de fármacos de amina terciaria |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| GB201309654D0 (en) | 2013-05-30 | 2013-07-17 | Euro Celtique Sa | Method |
| TWI745577B (zh) * | 2013-06-12 | 2021-11-11 | 日商Km特蘭斯達股份有限公司 | 經皮吸收製劑 |
| PL3040068T3 (pl) | 2013-06-12 | 2022-01-10 | KM Transderm Ltd. | Arkusz samoprzylepny do zastosowania na skórę i kompozycja o absorpcji przezskórnej zastosowana w nim |
| CA2916183C (en) | 2013-07-03 | 2022-03-29 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system with electronic component |
| EA201690675A1 (ru) | 2013-10-03 | 2016-08-31 | Модерна Терапьютикс, Инк. | Полинуклеотиды, кодирующие рецептор липопротеинов низкой плотности |
| TWI704933B (zh) | 2013-10-07 | 2020-09-21 | 美商帝國製藥美國股份有限公司 | 右美托咪啶經皮輸送裝置及使用其之方法 |
| CN105764496B (zh) | 2013-10-07 | 2020-09-25 | 帝国制药美国公司 | 用于经皮递送非镇静量的右旋美托咪啶的方法和组合物 |
| TWI709417B (zh) | 2013-10-07 | 2020-11-11 | 美商帝國製藥美國股份有限公司 | 使用右美托咪啶經皮組成物用於治療注意力不足過動症、焦慮及失眠的方法及組成物 |
| CN103877063A (zh) * | 2014-03-24 | 2014-06-25 | 张绪伟 | 一种重酒石酸卡巴拉汀胶囊及其制备方法 |
| CN106413695B (zh) | 2014-04-08 | 2019-12-10 | 帝国制药美国公司 | 利伐斯的明透皮组合物及其使用方法 |
| CA2948219C (en) | 2014-05-20 | 2023-04-04 | Lts Lohmann Therapie-Systeme Ag | Method for adjusting the release of active agent in a transdermal delivery system |
| JP6573913B2 (ja) | 2014-05-20 | 2019-09-11 | エルテーエス ローマン テラピー−ジステーメ アーゲー | ロチゴチンを含む経皮送達システム |
| US11752110B2 (en) | 2014-05-20 | 2023-09-12 | Lts Lohmann Therapie-Systeme Ag | Transdermal delivery system including an interface mediator |
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