AR095259A1 - Composiciones y métodos para la administración transdérmica de fármacos de amina terciaria - Google Patents
Composiciones y métodos para la administración transdérmica de fármacos de amina terciariaInfo
- Publication number
- AR095259A1 AR095259A1 ARP140100871A ARP140100871A AR095259A1 AR 095259 A1 AR095259 A1 AR 095259A1 AR P140100871 A ARP140100871 A AR P140100871A AR P140100871 A ARP140100871 A AR P140100871A AR 095259 A1 AR095259 A1 AR 095259A1
- Authority
- AR
- Argentina
- Prior art keywords
- polymers
- delivery system
- drug delivery
- group
- transdermal drug
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 5
- 229940079593 drug Drugs 0.000 title abstract 4
- 239000003814 drug Substances 0.000 title abstract 4
- 150000003512 tertiary amines Chemical class 0.000 title abstract 3
- 229920000642 polymer Polymers 0.000 abstract 12
- 238000013271 transdermal drug delivery Methods 0.000 abstract 7
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 6
- 150000001875 compounds Chemical class 0.000 abstract 4
- 239000012458 free base Substances 0.000 abstract 4
- 239000011159 matrix material Substances 0.000 abstract 4
- 239000000853 adhesive Substances 0.000 abstract 2
- 230000001070 adhesive effect Effects 0.000 abstract 2
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 2
- 125000002843 carboxylic acid group Chemical group 0.000 abstract 2
- 239000012528 membrane Substances 0.000 abstract 2
- 229920000058 polyacrylate Polymers 0.000 abstract 2
- 229920005573 silicon-containing polymer Polymers 0.000 abstract 2
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 abstract 1
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 abstract 1
- 239000004698 Polyethylene Substances 0.000 abstract 1
- 229920002367 Polyisobutene Polymers 0.000 abstract 1
- XSVMFMHYUFZWBK-NSHDSACASA-N Rivastigmine Chemical compound CCN(C)C(=O)OC1=CC=CC([C@H](C)N(C)C)=C1 XSVMFMHYUFZWBK-NSHDSACASA-N 0.000 abstract 1
- 229920002472 Starch Polymers 0.000 abstract 1
- DQXBYHZEEUGOBF-UHFFFAOYSA-N but-3-enoic acid;ethene Chemical compound C=C.OC(=O)CC=C DQXBYHZEEUGOBF-UHFFFAOYSA-N 0.000 abstract 1
- 229920002678 cellulose Polymers 0.000 abstract 1
- 239000001913 cellulose Substances 0.000 abstract 1
- 229920001577 copolymer Polymers 0.000 abstract 1
- 239000005038 ethylene vinyl acetate Substances 0.000 abstract 1
- 229960002428 fentanyl Drugs 0.000 abstract 1
- IVLVTNPOHDFFCJ-UHFFFAOYSA-N fentanyl citrate Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O.C=1C=CC=CC=1N(C(=O)CC)C(CC1)CCN1CCC1=CC=CC=C1 IVLVTNPOHDFFCJ-UHFFFAOYSA-N 0.000 abstract 1
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 abstract 1
- -1 polyethylene Polymers 0.000 abstract 1
- 229920000573 polyethylene Polymers 0.000 abstract 1
- 229920000098 polyolefin Polymers 0.000 abstract 1
- 229920000346 polystyrene-polyisoprene block-polystyrene Polymers 0.000 abstract 1
- 229960004136 rivastigmine Drugs 0.000 abstract 1
- KFQYTPMOWPVWEJ-INIZCTEOSA-N rotigotine Chemical compound CCCN([C@@H]1CC2=CC=CC(O)=C2CC1)CCC1=CC=CS1 KFQYTPMOWPVWEJ-INIZCTEOSA-N 0.000 abstract 1
- 229960003179 rotigotine Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 235000019698 starch Nutrition 0.000 abstract 1
- 229920002554 vinyl polymer Polymers 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Medicinal Preparation (AREA)
- Inorganic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Sistema de administración transdérmica de fármacos para la administración transdérmica de fármacos de aminas terciarias, como por ejemplo rivastigmina, fentanilo o rotigotina, que comprenden una matriz de polímero que comprende una forma de base libre del fármaco y al menos y al menos un compuesto que contiene un grupo carboxilo. En algunas formas de realización, los sistemas incluyen una membrana de control de flujo y una cara adhesivas que entra en contacto con la piel separada de la matriz del polímero. Reivindicación 1: Un sistema de administración transdérmica de fármacos que comprende una matriz de polímero que comprende la forma de base libre de un fármaco de amina terciaria y al menos un compuesto que contiene un grupo carboxilo, en donde las cantidades relativas de base libre y de compuesto que contiene un grupo carboxilo son tales que más del 50% de la base libre se asocia con un grupo ácido carboxílico para formar una sal. Reivindicación 10: El sistema de administración transdérmica de fármacos de acuerdo con cualquiera de las reivindicaciones 1 - 7, en donde al menos un compuesto que contiene un grupo carboxilo es un ácido carboxílico polimérico. Reivindicación 11: El sistema de administración transdérmica de fármacos de acuerdo con la reivindicación 10, en donde el ácido carboxílico polimérico se selecciona entre grupo formado por copolímeros aniónicos basados en ácido metacrílico y metacrilato de metilo, polímeros cabómero polímeros carbopol, polímeros de vinilo que contienen grupos de ácido carboxílico, polímeros de celulosa que contienen un grupo carboxilo o y almidones que contienen un grupo carboxilo. Reivindicación 24: El sistema de administración transdérmica de fármacos de acuerdo con cualquiera de las reivindicaciones 1 - 7, en donde la matriz de polímero comprende un polímero que se selecciona entre el grupo formado por polímeros de acrílico, polímeros de silicona, polímeros de poliisobutileno, copolímeros de bloques de estireno-isopreno estireno, y mezclas de dos o más mezclas de los mismos. Reivindicación 25: El sistema de administración transdérmica de fármacos de acuerdo con la reivindicación 7, en donde la membrana que controla el flujo comprende un polímero que se selecciona entre el grupo formado por polietileno, poliolefina, y/o polímeros de acetato de etilen vinilo. Reivindicación 26: El sistema de administración transdérmica de fármacos de acuerdo con la reivindicación 7, en donde el adhesivo superficial comprende un polímero que se selecciona entre el grupo formado por polímeros de acrílico, polímeros de silicona, y mezclas de dos o más mezclas de los mismos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361793120P | 2013-03-15 | 2013-03-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR095259A1 true AR095259A1 (es) | 2015-09-30 |
Family
ID=50729773
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP140100871A AR095259A1 (es) | 2013-03-15 | 2014-03-12 | Composiciones y métodos para la administración transdérmica de fármacos de amina terciaria |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US10987316B2 (es) |
| AR (1) | AR095259A1 (es) |
| TW (1) | TW201521796A (es) |
| WO (1) | WO2014151492A1 (es) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015535253A (ja) | 2012-10-25 | 2015-12-10 | ノーヴェン ファーマシューティカルズ インコーポレイテッド | アンフェタミンの組成物及びアンフェタミンを経皮送達する方法 |
| JP2016505006A (ja) | 2012-12-28 | 2016-02-18 | ノーヴェン ファーマシューティカルズ インコーポレイテッド | レボノルゲストレル及びエチニルエストラジオール用の経皮薬物送達システム |
| AR095260A1 (es) | 2013-03-15 | 2015-09-30 | Noven Pharma | Composiciones de anfetaminas transdérmicas estables y métodos de fabricación |
| TWI682790B (zh) | 2014-07-31 | 2020-01-21 | 美商諾芬藥品公司 | 用於經皮藥物遞送組合物之含聚矽氧之丙烯酸聚合物 |
| WO2016065008A1 (en) | 2014-10-21 | 2016-04-28 | The Procter & Gamble Company | Method of improving skin appearance |
| TWI689321B (zh) | 2015-02-06 | 2020-04-01 | 美商諾芬藥品公司 | 用於經皮藥物傳送之壓力敏感性黏合劑 |
| US10406116B2 (en) | 2015-02-06 | 2019-09-10 | Noven Pharmaceuticals, Inc. | Pressure-sensitive adhesives for transdermal drug delivery |
| AU2016226458A1 (en) * | 2015-03-04 | 2017-09-21 | Noven Pharmaceuticals, Inc. | Oligomeric/polymeric silicone fluids for use in transdermal drug delivery systems |
| WO2016187426A1 (en) | 2015-05-19 | 2016-11-24 | Amorphex Therapeutics Llc | A device that delivers a sustained low-dose of a myopia-suppressing drug |
| US10537498B2 (en) * | 2015-10-22 | 2020-01-21 | The Procter & Gamble Company | Barrier patch of a foamed film and methods of improving skin appearance |
| WO2017070078A1 (en) * | 2015-10-22 | 2017-04-27 | The Procter & Gamble Company | Barrier patch of a foamed film and methods of improving skin appearance |
| KR102614709B1 (ko) | 2016-12-20 | 2023-12-18 | 에르테에스 로만 테라피-시스테메 아게 | 아세나핀 및 폴리실록산 또는 폴리이소부틸렌을 함유하는 경피흡수 치료 시스템 |
| PL3338768T3 (pl) * | 2016-12-20 | 2020-05-18 | Lts Lohmann Therapie-Systeme Ag | Transdermalny system terapeutyczny zawierający asenapinę |
| US10751265B2 (en) | 2017-01-09 | 2020-08-25 | The Procter & Gamble | Barrier patch with soluble film and methods of improving skin appearance |
| US10799431B2 (en) | 2017-01-09 | 2020-10-13 | The Procter & Gamble Company | Barrier patch with soluble film and methods of improving skin appearance |
| US10857076B2 (en) | 2017-01-09 | 2020-12-08 | The Procter & Gamble Company | Barrier patch with soluble film and methods of improving skin appearance |
| US11052054B2 (en) | 2017-04-19 | 2021-07-06 | Inep Europe Sarl | Method for manufacturing a transdermal device |
| WO2018194879A1 (en) * | 2017-04-19 | 2018-10-25 | Inep Europe Sarl | Method for making a transdermal fentanyl patch with even drug crystal distribution |
| US10391065B2 (en) | 2017-04-19 | 2019-08-27 | Inep Europe Sarl | Method for making a transdermal fentanyl patch with even drug crystal distribution |
| CN110769945B (zh) | 2017-06-22 | 2023-01-24 | 宝洁公司 | 包括水溶性层和气相沉积涂层的美容护理品膜 |
| CA3067938A1 (en) | 2017-06-26 | 2019-01-03 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system containing asenapine and silicone acrylic hybrid polymer |
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| US10751266B2 (en) | 2018-03-19 | 2020-08-25 | The Procter & Gamble Company | Method of making a barrier patch with soluble film |
| CA3101418A1 (en) * | 2018-06-19 | 2019-12-26 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system containing rivastigmine |
| PL3810100T3 (pl) | 2018-06-20 | 2025-05-12 | Lts Lohmann Therapie-Systeme Ag | Transdermalny system terapeutyczny zawierający asenapinę |
| CN118806732A (zh) | 2018-06-20 | 2024-10-22 | 罗曼治疗系统股份公司 | 含有阿塞那平的透皮治疗系统 |
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| JP2015535253A (ja) | 2012-10-25 | 2015-12-10 | ノーヴェン ファーマシューティカルズ インコーポレイテッド | アンフェタミンの組成物及びアンフェタミンを経皮送達する方法 |
| KR20150103077A (ko) | 2012-12-28 | 2015-09-09 | 노벤 파머수티컬즈, 인코퍼레이티드 | 비스테로이드성 항염증제의 경피 전달을 위한 조성물 및 방법 |
| US9295726B2 (en) | 2012-12-28 | 2016-03-29 | Noven Pharamceuticals, Inc. | Multi-polymer compositions for transdermal drug delivery |
| JP2016505006A (ja) | 2012-12-28 | 2016-02-18 | ノーヴェン ファーマシューティカルズ インコーポレイテッド | レボノルゲストレル及びエチニルエストラジオール用の経皮薬物送達システム |
| US11337936B2 (en) | 2013-03-14 | 2022-05-24 | Noven Pharmaceuticals, Inc. | Amphetamine transdermal compositions with acrylic block copolymer |
| US20140276483A1 (en) | 2013-03-14 | 2014-09-18 | Noven Pharmaceuticals, Inc. | Transdermal methylphenidate compositions with acrylic block copolymers |
| US20140276479A1 (en) | 2013-03-14 | 2014-09-18 | Noven Pharmaceuticals, Inc. | Transdermal drug delivery system with overlay |
| AR095258A1 (es) | 2013-03-14 | 2015-09-30 | Noven Pharma | Composiciones transdérmicas de metilfenidato con adhesivos a base de goma |
| TWI682790B (zh) * | 2014-07-31 | 2020-01-21 | 美商諾芬藥品公司 | 用於經皮藥物遞送組合物之含聚矽氧之丙烯酸聚合物 |
-
2014
- 2014-03-12 AR ARP140100871A patent/AR095259A1/es unknown
- 2014-03-13 TW TW103109202A patent/TW201521796A/zh unknown
- 2014-03-13 WO PCT/US2014/025845 patent/WO2014151492A1/en not_active Ceased
- 2014-03-13 US US14/208,348 patent/US10987316B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US10987316B2 (en) | 2021-04-27 |
| TW201521796A (zh) | 2015-06-16 |
| WO2014151492A1 (en) | 2014-09-25 |
| US20140276478A1 (en) | 2014-09-18 |
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