BR112016007410A8 - conjugados de sn-38 de liberação lenta, formulações farmacêuticas e usos dos conjugados - Google Patents
conjugados de sn-38 de liberação lenta, formulações farmacêuticas e usos dos conjugados Download PDFInfo
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- BR112016007410A8 BR112016007410A8 BR112016007410A BR112016007410A BR112016007410A8 BR 112016007410 A8 BR112016007410 A8 BR 112016007410A8 BR 112016007410 A BR112016007410 A BR 112016007410A BR 112016007410 A BR112016007410 A BR 112016007410A BR 112016007410 A8 BR112016007410 A8 BR 112016007410A8
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- conjugates
- slow release
- pharmaceutical formulations
- glucuronate
- abstract
- Prior art date
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- C08G65/333—Polymers modified by chemical after-treatment with organic compounds containing nitrogen
- C08G65/33396—Polymers modified by chemical after-treatment with organic compounds containing nitrogen having oxygen in addition to nitrogen
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/34—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives
- C08G65/48—Polymers modified by chemical after-treatment
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G83/00—Macromolecular compounds not provided for in groups C08G2/00 - C08G81/00
- C08G83/002—Dendritic macromolecules
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
resumo liberação lenta de conjugados de sn 38 os conjugados de sn 38 que proporcionam taxas de liberação de droga óptimas e minimizar a formação do glucuronato correspondente são descritos. os conjugados de sn 38 liberados a partir de um polietileno glicol através de um mecanismo de eliminação ß.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361887111P | 2013-10-04 | 2013-10-04 | |
US61/887,111 | 2013-10-04 | ||
PCT/US2014/059146 WO2015051307A1 (en) | 2013-10-04 | 2014-10-03 | Slow-release conjugates of sn-38 |
Publications (3)
Publication Number | Publication Date |
---|---|
BR112016007410A2 BR112016007410A2 (pt) | 2017-08-01 |
BR112016007410A8 true BR112016007410A8 (pt) | 2020-02-27 |
BR112016007410B1 BR112016007410B1 (pt) | 2022-07-19 |
Family
ID=51871275
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112016007410-6A BR112016007410B1 (pt) | 2013-10-04 | 2014-10-03 | Conjugados de sn-38 de liberação lenta, formulações farmacêuticas, métodos de preparo do referido conjugado e usos relacionados |
Country Status (14)
Country | Link |
---|---|
US (2) | US10016411B2 (pt) |
EP (1) | EP3052101B1 (pt) |
JP (2) | JP6473145B2 (pt) |
KR (1) | KR102320753B1 (pt) |
CN (1) | CN106061483B (pt) |
AU (2) | AU2014331591B2 (pt) |
BR (1) | BR112016007410B1 (pt) |
CA (1) | CA2925132C (pt) |
DK (1) | DK3052101T3 (pt) |
ES (1) | ES2759905T3 (pt) |
MX (1) | MX371201B (pt) |
SG (2) | SG10201811365RA (pt) |
TW (1) | TWI716342B (pt) |
WO (1) | WO2015051307A1 (pt) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SG10201811365RA (en) * | 2013-10-04 | 2019-02-27 | Prolynx Llc | Slow-release conjugates of sn-38 |
CN107375288B (zh) | 2016-05-16 | 2019-08-23 | 博瑞生物医药(苏州)股份有限公司 | 多臂的聚合靶向抗癌偶联物 |
WO2018192550A1 (zh) | 2017-04-21 | 2018-10-25 | 博瑞生物医药(苏州)股份有限公司 | 多臂靶向抗癌偶联物 |
US20200360545A1 (en) * | 2018-01-12 | 2020-11-19 | Prolynx Llc | Protocol for minimizing toxicity of combination dosages and imaging agent for verification |
KR20210072002A (ko) * | 2018-09-17 | 2021-06-16 | 더 칠드런스 호스피탈 오브 필라델피아 | 폴리머 기반 거대분자 프로드러그 |
EP3946460A4 (en) * | 2019-04-05 | 2023-03-29 | Prolynx LLC | IMPROVED CONJUGATION LINKERS |
KR20220054368A (ko) * | 2019-08-28 | 2022-05-02 | 프로린크스 엘엘시 | Dna 손상 반응의 컨쥬게이션된 억제제 |
WO2022064052A1 (en) | 2020-09-28 | 2022-03-31 | Fundació Institut De Recerca Biomèdica (Irb Barcelona) | Peptidic conjugates of sn38 useful in the treatment of cancer |
US11976196B2 (en) * | 2021-04-14 | 2024-05-07 | Cambridge Crops, Inc. | Silk packaging applications |
AU2023242296A1 (en) | 2022-03-28 | 2024-09-19 | Gate2Brain, S.L. | Peptidic water-soluble delivery system of anticancer drugs |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6011042A (en) * | 1997-10-10 | 2000-01-04 | Enzon, Inc. | Acyl polymeric derivatives of aromatic hydroxyl-containing compounds |
EP1534823A4 (en) * | 2002-07-12 | 2008-12-31 | Biomarin Pharm Inc | USE OF ISOCYANATE BINDING AGENTS FOR PRODUCING BIOPOLYMER-HYDRAULIC ACTIVE SUBSTANCE CONJUGATES |
US7495099B2 (en) | 2002-10-31 | 2009-02-24 | Nippon Kayaku Kabushiki Kaisha | High-molecular weight derivatives of camptothecins |
US20040247624A1 (en) * | 2003-06-05 | 2004-12-09 | Unger Evan Charles | Methods of making pharmaceutical formulations for the delivery of drugs having low aqueous solubility |
EP2626083A1 (en) * | 2003-09-17 | 2013-08-14 | Nektar Therapeutics | Multi-arm polymer prodrugs |
US7462627B2 (en) | 2006-02-09 | 2008-12-09 | Enzon Pharmaceuticals, Inc. | Multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin for treatment of breast, colorectal, pancreatic, ovarian and lung cancers |
RU2009114154A (ru) * | 2006-09-15 | 2010-10-20 | Энзон Фармасьютикалз, Инк. (Us) | Полимерные пролекарства с направленной доставкой, содержащие полифункциональные линкеры |
KR20110075029A (ko) * | 2008-10-21 | 2011-07-05 | 엔즌 파마슈티칼스, 인코포레이티드 | 7-에틸-10-하이드록시캄토테신의 다중-암 고분자 컨쥬게이트로 신경모세포종의 치료 |
CA2743907A1 (en) | 2008-11-18 | 2010-05-27 | Baxter International Inc. | Methods of determining polydispersity and/or molecular weight distribution of a polyethylene glycol sample |
CN102448469A (zh) | 2009-05-28 | 2012-05-09 | 摩萨纳医疗有限公司 | 包括具有可变的释放速率的连接物的聚缩醛(酮)-药物共轭物 |
DK2501413T3 (da) * | 2009-11-18 | 2019-06-11 | Nektar Therapeutics | Syre-saltformer af polymermedikamentkonjugater |
CN103025165B (zh) * | 2010-05-05 | 2016-06-08 | 普罗林科斯有限责任公司 | 自大分子共轭物的控释 |
WO2011140376A1 (en) * | 2010-05-05 | 2011-11-10 | Prolynx Llc | Controlled drug release from dendrimers |
JP2012000072A (ja) * | 2010-06-18 | 2012-01-05 | Japan Health Science Foundation | 新規な抗フィブリン抗体 |
WO2012029076A2 (en) | 2010-08-30 | 2012-03-08 | Sun Pharma Advanced Research Company Ltd. | Stable pharmaceutical composition |
JP5899241B2 (ja) * | 2010-12-21 | 2016-04-06 | ネクター セラピューティクス | ペメトレキセドベースの化合物のマルチアームポリマープロドラッグコンジュゲート |
WO2013036857A1 (en) * | 2011-09-07 | 2013-03-14 | Prolynx Llc | Sulfone linkers |
SG10201811365RA (en) * | 2013-10-04 | 2019-02-27 | Prolynx Llc | Slow-release conjugates of sn-38 |
-
2014
- 2014-10-03 SG SG10201811365RA patent/SG10201811365RA/en unknown
- 2014-10-03 BR BR112016007410-6A patent/BR112016007410B1/pt active IP Right Grant
- 2014-10-03 JP JP2016520004A patent/JP6473145B2/ja active Active
- 2014-10-03 EP EP14796322.7A patent/EP3052101B1/en active Active
- 2014-10-03 TW TW103134678A patent/TWI716342B/zh active
- 2014-10-03 CN CN201480062543.4A patent/CN106061483B/zh active Active
- 2014-10-03 SG SG11201602258WA patent/SG11201602258WA/en unknown
- 2014-10-03 US US15/026,579 patent/US10016411B2/en active Active
- 2014-10-03 DK DK14796322.7T patent/DK3052101T3/da active
- 2014-10-03 KR KR1020167011936A patent/KR102320753B1/ko active IP Right Grant
- 2014-10-03 MX MX2016004299A patent/MX371201B/es active IP Right Grant
- 2014-10-03 CA CA2925132A patent/CA2925132C/en active Active
- 2014-10-03 WO PCT/US2014/059146 patent/WO2015051307A1/en active Application Filing
- 2014-10-03 ES ES14796322T patent/ES2759905T3/es active Active
- 2014-10-03 AU AU2014331591A patent/AU2014331591B2/en active Active
-
2018
- 2018-06-14 US US16/009,078 patent/US10342792B2/en active Active
- 2018-11-01 AU AU2018256608A patent/AU2018256608A1/en not_active Abandoned
-
2019
- 2019-01-24 JP JP2019010029A patent/JP6842479B2/ja active Active
Also Published As
Publication number | Publication date |
---|---|
DK3052101T3 (da) | 2019-12-16 |
AU2014331591B2 (en) | 2018-08-16 |
US20180289695A1 (en) | 2018-10-11 |
CN106061483B (zh) | 2021-01-08 |
MX371201B (es) | 2020-01-22 |
AU2014331591A1 (en) | 2016-05-19 |
TWI716342B (zh) | 2021-01-21 |
US10342792B2 (en) | 2019-07-09 |
JP2016531895A (ja) | 2016-10-13 |
WO2015051307A1 (en) | 2015-04-09 |
ES2759905T3 (es) | 2020-05-12 |
EP3052101A1 (en) | 2016-08-10 |
JP6473145B2 (ja) | 2019-02-20 |
JP2019104739A (ja) | 2019-06-27 |
CN106061483A (zh) | 2016-10-26 |
CA2925132A1 (en) | 2015-04-09 |
KR20160065203A (ko) | 2016-06-08 |
SG10201811365RA (en) | 2019-02-27 |
JP6842479B2 (ja) | 2021-03-17 |
AU2018256608A1 (en) | 2018-11-22 |
BR112016007410A2 (pt) | 2017-08-01 |
KR102320753B1 (ko) | 2021-11-02 |
US10016411B2 (en) | 2018-07-10 |
TW201601759A (zh) | 2016-01-16 |
US20160243106A1 (en) | 2016-08-25 |
SG11201602258WA (en) | 2016-04-28 |
MX2016004299A (es) | 2016-10-04 |
BR112016007410B1 (pt) | 2022-07-19 |
CA2925132C (en) | 2021-11-30 |
EP3052101B1 (en) | 2019-11-20 |
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B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B15K | Others concerning applications: alteration of classification |
Ipc: A61K 31/4745 (2006.01), A61K 9/00 (2006.01), A61K |
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B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
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