JP2009513143A5 - - Google Patents
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- Publication number
- JP2009513143A5 JP2009513143A5 JP2008538095A JP2008538095A JP2009513143A5 JP 2009513143 A5 JP2009513143 A5 JP 2009513143A5 JP 2008538095 A JP2008538095 A JP 2008538095A JP 2008538095 A JP2008538095 A JP 2008538095A JP 2009513143 A5 JP2009513143 A5 JP 2009513143A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- cell culture
- pdx1
- endoderm cells
- express
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 238000004113 cell culture Methods 0.000 claims 19
- 210000004039 endoderm cell Anatomy 0.000 claims 17
- 210000004027 cell Anatomy 0.000 claims 10
- 238000000034 method Methods 0.000 claims 10
- 108700011804 pancreatic and duodenal homeobox 1 Proteins 0.000 claims 10
- 210000005260 human cell Anatomy 0.000 claims 9
- 239000003102 growth factor Substances 0.000 claims 7
- 210000002438 upper gastrointestinal tract Anatomy 0.000 claims 7
- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 claims 6
- 229930002330 retinoic acid Natural products 0.000 claims 6
- 229960001727 tretinoin Drugs 0.000 claims 6
- 239000003550 marker Substances 0.000 claims 5
- 150000004492 retinoid derivatives Chemical class 0.000 claims 4
- 102100022123 Hepatocyte nuclear factor 1-beta Human genes 0.000 claims 3
- 102100029283 Hepatocyte nuclear factor 3-alpha Human genes 0.000 claims 3
- 102100029087 Hepatocyte nuclear factor 6 Human genes 0.000 claims 3
- 101001045758 Homo sapiens Hepatocyte nuclear factor 1-beta Proteins 0.000 claims 3
- 101001062353 Homo sapiens Hepatocyte nuclear factor 3-alpha Proteins 0.000 claims 3
- 101000988619 Homo sapiens Hepatocyte nuclear factor 6 Proteins 0.000 claims 3
- 101001069749 Homo sapiens Prospero homeobox protein 1 Proteins 0.000 claims 3
- 101000652324 Homo sapiens Transcription factor SOX-17 Proteins 0.000 claims 3
- 101000711846 Homo sapiens Transcription factor SOX-9 Proteins 0.000 claims 3
- 102100033880 Prospero homeobox protein 1 Human genes 0.000 claims 3
- 102100030243 Transcription factor SOX-17 Human genes 0.000 claims 3
- 102100034204 Transcription factor SOX-9 Human genes 0.000 claims 3
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 3
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 3
- 238000012258 culturing Methods 0.000 claims 3
- 102100028071 Fibroblast growth factor 7 Human genes 0.000 claims 2
- 108090000385 Fibroblast growth factor 7 Proteins 0.000 claims 2
- 102000013529 alpha-Fetoproteins Human genes 0.000 claims 2
- 108010026331 alpha-Fetoproteins Proteins 0.000 claims 2
- 238000012606 in vitro cell culture Methods 0.000 claims 2
- 210000002569 neuron Anatomy 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 230000009278 visceral effect Effects 0.000 claims 2
- 102100028096 Homeobox protein Nkx-6.2 Human genes 0.000 claims 1
- 101000578254 Homo sapiens Homeobox protein Nkx-6.1 Proteins 0.000 claims 1
- 101000578258 Homo sapiens Homeobox protein Nkx-6.2 Proteins 0.000 claims 1
- 101000979321 Homo sapiens Neurofilament medium polypeptide Proteins 0.000 claims 1
- 101000652332 Homo sapiens Transcription factor SOX-1 Proteins 0.000 claims 1
- 101000642523 Homo sapiens Transcription factor SOX-7 Proteins 0.000 claims 1
- 101000976653 Homo sapiens Zinc finger protein ZIC 1 Proteins 0.000 claims 1
- 102100023055 Neurofilament medium polypeptide Human genes 0.000 claims 1
- 102100030248 Transcription factor SOX-1 Human genes 0.000 claims 1
- 102100036730 Transcription factor SOX-7 Human genes 0.000 claims 1
- 102100023497 Zinc finger protein ZIC 1 Human genes 0.000 claims 1
- 108010023082 activin A Proteins 0.000 claims 1
- 238000003365 immunocytochemistry Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000003753 real-time PCR Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73091705P | 2005-10-27 | 2005-10-27 | |
| US60/730,917 | 2005-10-27 | ||
| PCT/US2006/042413 WO2007051038A2 (en) | 2005-10-27 | 2006-10-27 | Pdx1-expressing dorsal and ventral foregut endoderm |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013141267A Division JP5968270B2 (ja) | 2005-10-27 | 2013-07-05 | Ｐｄｘ１発現背側及び腹側前腸内胚葉 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009513143A JP2009513143A (ja) | 2009-04-02 |
| JP2009513143A5 true JP2009513143A5 (https=) | 2009-08-13 |
| JP5404047B2 JP5404047B2 (ja) | 2014-01-29 |
Family
ID=37769419
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008538095A Active JP5404047B2 (ja) | 2005-10-27 | 2006-10-27 | Ｐｄｘ１発現背側及び腹側前腸内胚葉 |
| JP2013141267A Active JP5968270B2 (ja) | 2005-10-27 | 2013-07-05 | Ｐｄｘ１発現背側及び腹側前腸内胚葉 |
| JP2015091898A Active JP6077046B2 (ja) | 2005-10-27 | 2015-04-28 | Ｐｄｘ１発現背側及び腹側前腸内胚葉 |
| JP2016229718A Active JP6366115B2 (ja) | 2005-10-27 | 2016-11-28 | Ｐｄｘ１発現背側及び腹側前腸内胚葉 |
| JP2018097236A Active JP6595041B2 (ja) | 2005-10-27 | 2018-05-21 | Ｐｄｘ１発現背側及び腹側前腸内胚葉 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013141267A Active JP5968270B2 (ja) | 2005-10-27 | 2013-07-05 | Ｐｄｘ１発現背側及び腹側前腸内胚葉 |
| JP2015091898A Active JP6077046B2 (ja) | 2005-10-27 | 2015-04-28 | Ｐｄｘ１発現背側及び腹側前腸内胚葉 |
| JP2016229718A Active JP6366115B2 (ja) | 2005-10-27 | 2016-11-28 | Ｐｄｘ１発現背側及び腹側前腸内胚葉 |
| JP2018097236A Active JP6595041B2 (ja) | 2005-10-27 | 2018-05-21 | Ｐｄｘ１発現背側及び腹側前腸内胚葉 |
Country Status (10)
| Country | Link |
|---|---|
| US (6) | US20070122905A1 (https=) |
| EP (3) | EP2674485B1 (https=) |
| JP (5) | JP5404047B2 (https=) |
| CN (1) | CN101351547A (https=) |
| AU (1) | AU2006305879B2 (https=) |
| CA (2) | CA2627645C (https=) |
| DK (2) | DK1957636T3 (https=) |
| ES (2) | ES2687233T3 (https=) |
| PL (1) | PL1957636T3 (https=) |
| WO (1) | WO2007051038A2 (https=) |
Families Citing this family (101)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003014313A2 (en) * | 2001-08-06 | 2003-02-20 | Bresagen, Ltd. | Alternative compositions and methods for the culture of stem cells |
| US20050266554A1 (en) * | 2004-04-27 | 2005-12-01 | D Amour Kevin A | PDX1 expressing endoderm |
| US7541185B2 (en) * | 2003-12-23 | 2009-06-02 | Cythera, Inc. | Methods for identifying factors for differentiating definitive endoderm |
| CN103898047B (zh) | 2003-12-23 | 2020-03-03 | 维亚希特公司 | 定形内胚层 |
| US8647873B2 (en) | 2004-04-27 | 2014-02-11 | Viacyte, Inc. | PDX1 expressing endoderm |
| WO2006025937A2 (en) * | 2004-07-07 | 2006-03-09 | The University Of North Carolina At Chapel Hill | Embryonic stem cell derivatives, and methods of making and using the same |
| EP1791952A4 (en) * | 2004-08-13 | 2008-06-11 | Univ Georgia Res Found | COMPOSITIONS AND METHODS OF SELF-RENEWAL AND DIFFERENTIATION IN HUMAN EMBRYONAL STEM CELLS |
| US8017395B2 (en) | 2004-12-17 | 2011-09-13 | Lifescan, Inc. | Seeding cells on porous supports |
| CA2613889A1 (en) | 2005-06-08 | 2006-12-14 | Centocor, Inc. | A cellular therapy for ocular degeneration |
| AU2006305879B2 (en) | 2005-10-27 | 2012-05-10 | Viacyte, Inc. | PDX1-expressing dorsal and ventral foregut endoderm |
| KR20080109775A (ko) | 2006-02-23 | 2008-12-17 | 노보셀, 인크 | 분화가능한 세포를 배양하는데 유용한 조성물 및 방법 |
| EP1999253B1 (en) * | 2006-03-02 | 2019-05-22 | Viacyte, Inc. | Endocrine precursor cells, pancreatic hormone-expressing cells and methods of production |
| US7695965B2 (en) | 2006-03-02 | 2010-04-13 | Cythera, Inc. | Methods of producing pancreatic hormones |
| US11254916B2 (en) | 2006-03-02 | 2022-02-22 | Viacyte, Inc. | Methods of making and using PDX1-positive pancreatic endoderm cells |
| US8741643B2 (en) | 2006-04-28 | 2014-06-03 | Lifescan, Inc. | Differentiation of pluripotent stem cells to definitive endoderm lineage |
| AU2007277364B2 (en) | 2006-07-26 | 2010-08-12 | Viacyte, Inc. | Methods of producing pancreatic hormones |
| US9080145B2 (en) | 2007-07-01 | 2015-07-14 | Lifescan Corporation | Single pluripotent stem cell culture |
| WO2009012428A2 (en) * | 2007-07-18 | 2009-01-22 | Lifescan, Inc. | Differentiation of human embryonic stem cells |
| CA3114827C (en) | 2007-07-31 | 2023-09-05 | Lifescan, Inc. | Differentiation of human embryonic stem cells to pancreatic endocrine |
| EP2195417A1 (en) * | 2007-08-24 | 2010-06-16 | University Court of the University of Edinburgh | Regionalised endoderm cells and uses thereof |
| EP2229434B1 (en) | 2007-11-27 | 2011-09-07 | Lifescan, Inc. | Differentiation of human embryonic stem cells |
| KR101731474B1 (ko) | 2008-02-21 | 2017-05-11 | 얀센 바이오테크 인코포레이티드 | 세포 부착, 배양 및 탈리를 위한 방법, 표면 개질 플레이트 및 조성물 |
| US8338170B2 (en) * | 2008-04-21 | 2012-12-25 | Viacyte, Inc. | Methods for purifying endoderm and pancreatic endoderm cells derived from human embryonic stem cells |
| US8623648B2 (en) | 2008-04-24 | 2014-01-07 | Janssen Biotech, Inc. | Treatment of pluripotent cells |
| US20090298178A1 (en) * | 2008-06-03 | 2009-12-03 | D Amour Kevin Allen | Growth factors for production of definitive endoderm |
| PL2310492T3 (pl) | 2008-06-30 | 2015-12-31 | Janssen Biotech Inc | Różnocowanie pluripotencjalnych komórek macierzystych |
| MX349178B (es) | 2008-10-31 | 2017-07-17 | Centocor Ortho Biotech Inc | Diferenciación de células madre embrionarias humanas al linaje endocrino pancreático. |
| PL2346988T3 (pl) | 2008-10-31 | 2017-10-31 | Janssen Biotech Inc | Różnicowanie ludzkich zarodkowych komórek macierzystych do linii endokrynnej trzustki |
| US8895300B2 (en) | 2008-11-04 | 2014-11-25 | Viacyte, Inc. | Scalable primate pluripotent stem cell aggregate suspension culture and differentiation thereof |
| US8008075B2 (en) | 2008-11-04 | 2011-08-30 | Viacyte, Inc. | Stem cell aggregate suspension compositions and methods of differentiation thereof |
| EP2356213B1 (en) | 2008-11-04 | 2019-05-29 | Viacyte, Inc. | Stem cell aggregate suspension compositions and methods for differentiation thereof |
| AU2009313870B2 (en) | 2008-11-14 | 2013-07-11 | Viacyte, Inc. | Encapsulation of pancreatic cells derived from human pluripotent stem cells |
| ES2584053T3 (es) | 2008-11-20 | 2016-09-23 | Janssen Biotech, Inc. | Métodos y composiciones para la unión de células y cultivo en sustratos planos |
| ES2642070T3 (es) | 2008-11-20 | 2017-11-15 | Janssen Biotech, Inc. | Cultivo de células madre pluripotentes en microportadores |
| US20100272695A1 (en) * | 2009-04-22 | 2010-10-28 | Alan Agulnick | Cell compositions derived from dedifferentiated reprogrammed cells |
| US9109245B2 (en) | 2009-04-22 | 2015-08-18 | Viacyte, Inc. | Cell compositions derived from dedifferentiated reprogrammed cells |
| US20120135519A1 (en) * | 2009-05-29 | 2012-05-31 | Cellartis Ab | INDUCED DERIVATION OF SPECIFIC ENDODERM FROM hPS CELL-DERIVED DEFINITIVE ENDODERM |
| SG177483A1 (en) * | 2009-07-20 | 2012-02-28 | Janssen Biotech Inc | Differentiation of human embryonic stem cells |
| KR102058901B1 (ko) | 2009-07-20 | 2019-12-24 | 얀센 바이오테크 인코포레이티드 | 인간 배아 줄기 세포의 분화 |
| EP2456859A4 (en) * | 2009-07-20 | 2015-03-18 | Janssen Biotech Inc | DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS |
| CA2784425A1 (en) | 2009-12-23 | 2011-06-30 | Centocor Ortho Biotech Inc. | Differentiation of human embryonic stem cells |
| SG181687A1 (en) | 2009-12-23 | 2012-07-30 | Centocor Ortho Biotech Inc | Differentiation of human embryonic stem cells |
| EP2542667A4 (en) | 2010-03-01 | 2013-07-31 | Janssen Biotech Inc | PROCESS FOR CLEANING CELLS OBTAINED FROM PLURIPOTENTIAL STEM CELLS |
| US9719068B2 (en) | 2010-05-06 | 2017-08-01 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into intestinal tissues through directed differentiation |
| RU2663339C1 (ru) | 2010-05-12 | 2018-08-03 | Янссен Байотек, Инк. | Дифференцирование эмбриональных стволовых клеток человека |
| CN103221536B (zh) | 2010-08-31 | 2016-08-31 | 詹森生物科技公司 | 人胚胎干细胞的分化 |
| EP2611907B1 (en) | 2010-08-31 | 2016-05-04 | Janssen Biotech, Inc. | Differentiation of pluripotent stem cells |
| ES2658146T3 (es) | 2010-08-31 | 2018-03-08 | Janssen Biotech, Inc. | Diferenciación de células madre embrionarias humanas |
| US9433557B2 (en) | 2011-02-21 | 2016-09-06 | Viacyte, Inc. | Loading system for an encapsulation device |
| KR102203056B1 (ko) | 2011-12-22 | 2021-01-14 | 얀센 바이오테크 인코포레이티드 | 인간 배아 줄기 세포의 단일 인슐린 호르몬 양성 세포로의 분화 |
| HK1206058A1 (en) | 2012-03-07 | 2015-12-31 | Janssen Biotech, Inc. | Defined media for expansion and maintenance of pluripotent stem cells |
| EP2857500B1 (en) | 2012-05-25 | 2018-01-31 | Saitama Medical University | Method for producing pancreatic hormone-producing cell, pancreatic hormone-producing cell, and differentiation/induction promoter |
| AU2013271581B2 (en) | 2012-06-08 | 2018-08-09 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells into pancreatic endocrine cells |
| AU2013248265B2 (en) | 2012-11-08 | 2018-11-01 | Viacyte, Inc. | Scalable primate pluripotent stem cell aggregate suspension culture and differentiation thereof |
| BR112015015770A2 (pt) | 2012-12-31 | 2017-07-11 | Janssen Biotech Inc | cultivo de células-tronco embrionárias humanas na interface ar-líquido para diferenciação em células pancreáticas endócrinas |
| US10370644B2 (en) | 2012-12-31 | 2019-08-06 | Janssen Biotech, Inc. | Method for making human pluripotent suspension cultures and cells derived therefrom |
| JP6557147B2 (ja) | 2012-12-31 | 2019-08-07 | ヤンセン バイオテツク，インコーポレーテツド | Ｈｂ９調節物を用いたヒト胚性幹細胞の膵臓内分泌細胞への分化 |
| RU2687379C2 (ru) | 2012-12-31 | 2019-05-13 | Янссен Байотек, Инк. | Суспендирование и кластеризация плюрипотентных клеток человека с целью их дифференцировки в панкреатические эндокринные клетки |
| US8859286B2 (en) | 2013-03-14 | 2014-10-14 | Viacyte, Inc. | In vitro differentiation of pluripotent stem cells to pancreatic endoderm cells (PEC) and endocrine cells |
| US10266807B2 (en) | 2013-04-03 | 2019-04-23 | FUJIFILM Cellular Dynamics, Inc. | Methods and compositions for culturing endoderm progenitor cells in suspension |
| WO2014189127A1 (ja) | 2013-05-24 | 2014-11-27 | 学校法人埼玉医科大学 | 新規ペプチド及びその用途 |
| SG11201510177WA (en) | 2013-06-11 | 2016-01-28 | Harvard College | SC-β CELLS AND COMPOSITIONS AND METHODS FOR GENERATING THE SAME |
| EP2896688A1 (en) * | 2014-01-20 | 2015-07-22 | Centre National de la Recherche Scientifique (CNRS) | A method of producing beta pancreatic cells from progenitor cells through the use of hydrogen peroxide |
| US11051900B2 (en) | 2014-04-16 | 2021-07-06 | Viacyte, Inc. | Tools and instruments for use with implantable encapsulation devices |
| US10006006B2 (en) | 2014-05-16 | 2018-06-26 | Janssen Biotech, Inc. | Use of small molecules to enhance MAFA expression in pancreatic endocrine cells |
| CN106661548B (zh) | 2014-05-28 | 2020-12-11 | 儿童医院医疗中心 | 用于经由定向分化将前体细胞转化为胃组织的方法和系统 |
| CN107075471A (zh) * | 2014-10-08 | 2017-08-18 | 新加坡科技研究局 | 将干细胞分化为肝细胞谱系的方法 |
| JP6804438B2 (ja) | 2014-10-17 | 2020-12-23 | チルドレンズ ホスピタル メディカル センター | 多能性幹細胞を使用するヒト小腸のｉｎ ｖｉｖｏモデル、並びにそれを作製、及び使用する方法 |
| WO2016100898A1 (en) | 2014-12-18 | 2016-06-23 | President And Fellows Of Harvard College | Serum-free in vitro directed differentiation protocol for generating stem cell-derived b cells and uses thereof |
| CN107614678B (zh) | 2014-12-18 | 2021-04-30 | 哈佛学院校长同事会 | 干细胞来源的β细胞的产生方法及其使用方法 |
| WO2016100909A1 (en) | 2014-12-18 | 2016-06-23 | President And Fellows Of Harvard College | METHODS FOR GENERATING STEM CELL-DERIVED β CELLS AND USES THEREOF |
| AU2015363008B2 (en) * | 2014-12-19 | 2021-12-09 | Janssen Biotech, Inc. | Suspension culturing of pluripotent stem cells |
| DK3443073T3 (da) | 2016-04-14 | 2024-09-02 | Janssen Biotech Inc | Differentiering af pluripotente stamceller til intestinale mellemtarmendodermceller |
| ES2929758T3 (es) | 2016-05-05 | 2022-12-01 | Childrens Hospital Med Ct | Métodos para la fabricación in vitro de tejido del fondo gástrico y composiciones relacionadas con el mismo |
| KR102729404B1 (ko) | 2016-11-04 | 2024-11-14 | 칠드런즈 호스피탈 메디칼 센터 | 간 유사 장기 조성물 및 이를 제조 및 사용하는 방법 |
| JP7068305B2 (ja) | 2016-12-05 | 2022-05-16 | チルドレンズ ホスピタル メディカル センター | 結腸オルガノイドならびにその作製方法および使用方法 |
| EP3587560A4 (en) * | 2017-01-27 | 2020-12-16 | Kaneka Corporation | Endodermal cell mass, and method for producing any one of three primary germ layer cell mass from pluripotent cells |
| US12281334B2 (en) | 2017-04-14 | 2025-04-22 | Children's Hospital Medical Center | Multi donor stem cell compositions and methods of making same |
| CN111565707A (zh) | 2017-06-14 | 2020-08-21 | 森玛治疗公司 | 用于递送治疗物的装置和方法 |
| US10391156B2 (en) | 2017-07-12 | 2019-08-27 | Viacyte, Inc. | University donor cells and related methods |
| EP3694603B1 (en) | 2017-10-10 | 2026-04-08 | Children's Hospital Medical Center | Esophageal tissue and/or organoid compositions and methods of making same |
| KR20250048146A (ko) | 2017-11-15 | 2025-04-07 | 셈마 테라퓨틱스, 인크. | 섬세포 제조 조성물 및 사용 방법 |
| US12379372B2 (en) | 2017-12-21 | 2025-08-05 | Children's Hospital Medical Center | Digitalized human organoids and methods of using same |
| KR102887406B1 (ko) | 2018-07-26 | 2025-11-19 | 칠드런즈 호스피탈 메디칼 센터 | 간-담도-췌장 조직 및 이를 제조하는 방법 |
| WO2020033879A1 (en) | 2018-08-10 | 2020-02-13 | Semma Therapeutics, Inc. | Stem cell derived islet differentiation |
| US12378572B2 (en) | 2018-09-07 | 2025-08-05 | Crispr Therapeutics Ag | Universal donor cells |
| AU2019339410A1 (en) | 2018-09-12 | 2021-04-15 | Children's Hospital Medical Center | Organoid compositions for the production of hematopoietic stem cells and derivatives thereof |
| WO2020160371A1 (en) | 2019-02-01 | 2020-08-06 | The University Of Hong Kong | Innervated organoid compositions and methods of making same |
| JP7617033B2 (ja) * | 2019-05-22 | 2025-01-17 | ザ クリーブランド クリニック ファウンデーション | 背側前腸及び前方ドメイン内胚葉細胞の生成 |
| WO2020243633A1 (en) | 2019-05-31 | 2020-12-03 | Children's Hospital Medical Center | Shaped organoid compositions and methods of making same |
| WO2020243613A1 (en) | 2019-05-31 | 2020-12-03 | Children's Hospital Medical Center | Methods of generating and expanding hematopoietic stem cells |
| AU2020282355B2 (en) | 2019-05-31 | 2023-11-02 | Viacyte, Inc. | A biocompatible membrane composite |
| WO2020243666A1 (en) | 2019-05-31 | 2020-12-03 | W. L. Gore & Associates, Inc. | A biocompatible membrane composite |
| CN114401752B (zh) | 2019-05-31 | 2023-04-04 | W.L.戈尔及同仁股份有限公司 | 具有受控氧扩散距离的细胞封装装置 |
| WO2020243665A1 (en) | 2019-05-31 | 2020-12-03 | W. L. Gore & Associates, Inc. | A biocompatible membrane composite |
| KR20220058579A (ko) | 2019-09-05 | 2022-05-09 | 크리스퍼 테라퓨틱스 아게 | 보편적 공여자 세포 |
| US11104918B2 (en) | 2019-09-05 | 2021-08-31 | Crispr Therapeutics Ag | Universal donor cells |
| US11850303B2 (en) | 2020-10-27 | 2023-12-26 | Uqora, Inc. | Gel and a suppository and methods to provide the gel and suppository |
| KR20230146007A (ko) | 2020-12-31 | 2023-10-18 | 크리스퍼 테라퓨틱스 아게 | 범용 공여자 세포 |
| WO2024151541A1 (en) | 2023-01-09 | 2024-07-18 | Sana Biotechnology, Inc. | Type-1 diabetes autoimmune mouse |
| CN121604968A (zh) | 2023-05-22 | 2026-03-03 | 萨那生物科技公司 | 递送胰岛细胞的方法及相关方法 |
Family Cites Families (80)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2161804A (en) | 1935-11-09 | 1939-06-13 | Baldwin Southwark Corp | Hydraulic press |
| US4873702A (en) | 1988-10-20 | 1989-10-10 | Chiu Ran Fun | Method and apparatus for DC restoration in digital receivers |
| US6165993A (en) | 1992-03-23 | 2000-12-26 | University Of Massachusetts Medical Center | DNA vaccines against rotavirus infections |
| US7153684B1 (en) * | 1992-10-08 | 2006-12-26 | Vanderbilt University | Pluripotential embryonic stem cells and methods of making same |
| US5690926A (en) | 1992-10-08 | 1997-11-25 | Vanderbilt University | Pluripotential embryonic cells and methods of making same |
| US5453357A (en) | 1992-10-08 | 1995-09-26 | Vanderbilt University | Pluripotential embryonic stem cells and methods of making same |
| US5593972A (en) | 1993-01-26 | 1997-01-14 | The Wistar Institute | Genetic immunization |
| US6015671A (en) * | 1995-06-07 | 2000-01-18 | Indiana University Foundation | Myocardial grafts and cellular compositions |
| US5874301A (en) * | 1994-11-21 | 1999-02-23 | National Jewish Center For Immunology And Respiratory Medicine | Embryonic cell populations and methods to isolate such populations |
| US5843780A (en) * | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
| US5748681A (en) | 1995-10-27 | 1998-05-05 | Lucent Technologies Inc | Offset correction for a homodyne radio |
| AU2192997A (en) | 1996-02-28 | 1997-09-16 | Vanderbilt University | Compositions and methods of making embryonic stem cells |
| US5877207A (en) * | 1996-03-11 | 1999-03-02 | Allergan Sales, Inc. | Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities |
| US5964261A (en) * | 1996-05-29 | 1999-10-12 | Baxter International Inc. | Implantation assembly |
| CA2277278A1 (en) | 1997-01-10 | 1998-07-16 | Life Technologies, Inc. | Embryonic stem cell serum replacement |
| US5798644A (en) | 1997-02-20 | 1998-08-25 | At&T Corp | Method and apparatus for locating buried conveyances using locating & confirmation signals with an array of sensors |
| US5793230A (en) | 1997-02-26 | 1998-08-11 | Sandia Corporation | Sensor readout detector circuit |
| US6090622A (en) | 1997-03-31 | 2000-07-18 | The Johns Hopkins School Of Medicine | Human embryonic pluripotent germ cells |
| US6331406B1 (en) * | 1997-03-31 | 2001-12-18 | The John Hopkins University School Of Medicine | Human enbryonic germ cell and methods of use |
| US6261281B1 (en) | 1997-04-03 | 2001-07-17 | Electrofect As | Method for genetic immunization and introduction of molecules into skeletal muscle and immune cells |
| JP2001516729A (ja) | 1997-09-15 | 2001-10-02 | ジェネティック・イミューナティ・リミテッド・ライアビリティ・カンパニー | 皮膚の抗原提示細胞に遺伝子を運搬する方法 |
| AU729377B2 (en) | 1997-10-23 | 2001-02-01 | Asterias Biotherapeutics, Inc. | Methods and materials for the growth of primate-derived primordial stem cells in feeder-free culture |
| US20030008919A1 (en) * | 1999-06-03 | 2003-01-09 | Jean-Baptiste Roullet | Use of retinoids to treat high blood pressure and other cardiovascular disease |
| US6921811B2 (en) * | 1998-09-22 | 2005-07-26 | Biosurface Engineering Technologies, Inc. | Bioactive coating composition and methods |
| US6667176B1 (en) * | 2000-01-11 | 2003-12-23 | Geron Corporation | cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells |
| DE19852800C1 (de) | 1998-11-16 | 2000-04-13 | Univ Albert Ludwigs Freiburg | Verfahren zur Herstellung von Antikörpern gegen ein Polypeptid, von dem die kodierende Nukleinsäure bekannt ist |
| JP2002538779A (ja) | 1999-02-10 | 2002-11-19 | キュリス インコーポレイテッド | 膵臓細胞前駆細胞、それらに関する方法及び利用 |
| US6872389B1 (en) * | 1999-07-08 | 2005-03-29 | Rhode Island Hospital | Liver stem cell |
| US7005252B1 (en) | 2000-03-09 | 2006-02-28 | Wisconsin Alumni Research Foundation | Serum free cultivation of primate embryonic stem cells |
| US6458589B1 (en) * | 2000-04-27 | 2002-10-01 | Geron Corporation | Hepatocyte lineage cells derived from pluripotent stem cells |
| US7256042B2 (en) * | 2000-04-27 | 2007-08-14 | Geron Corporation | Process for making hepatocytes from pluripotent stem cells |
| CA2417356A1 (en) | 2000-08-01 | 2002-02-07 | Yissum Research Development Company | Directed differentiation of embryonic cells |
| AU2002226075A1 (en) | 2000-10-23 | 2002-05-06 | University Of Kansas | Cadherin peptides for drug delivery and inhibition of tumor metastasis/invasion |
| CA2435826A1 (en) | 2001-01-24 | 2002-08-01 | The Government Of The United States Of America | Differentiation of stem cells to pancreatic endocrine cells |
| CA2450720A1 (en) * | 2001-06-13 | 2002-12-19 | Massachusetts Institute Of Technology | In vivo bioreactors |
| EP1298201A1 (en) | 2001-09-27 | 2003-04-02 | Cardion AG | Process for the production of cells exhibiting an islet-beta-cell-like state |
| CA2463914A1 (en) * | 2001-10-18 | 2003-04-24 | Ixion Biotechnology, Inc. | Conversion of liver stem and progenitor cells to pancreatic functional cells |
| US20030232430A1 (en) | 2001-11-26 | 2003-12-18 | Advanced Cell Technology | Methods for making and using reprogrammed human somatic cell nuclei and autologous and isogenic human stem cells |
| US7157278B2 (en) * | 2001-12-04 | 2007-01-02 | Organogenesis, Inc. | Cultured cells from pancreatic islets |
| CA2470539C (en) * | 2001-12-07 | 2011-10-04 | Geron Corporation | Islet cells from human embryonic stem cells |
| US20030138949A1 (en) * | 2001-12-12 | 2003-07-24 | Anil Bhushan | Methods for the regeneration of pancreatic islets and expansion of pancreatic endocrine cells |
| WO2004098490A2 (en) * | 2002-05-17 | 2004-11-18 | Mount Sinai School Of Medicine Of New York University | Mesoderm and definitive endoderm cell populations |
| US20060003446A1 (en) * | 2002-05-17 | 2006-01-05 | Gordon Keller | Mesoderm and definitive endoderm cell populations |
| CN1668324A (zh) | 2002-05-28 | 2005-09-14 | 诺沃塞尔公司 | 用于胰岛素产生细胞的方法、组合物及生长与分化因子 |
| WO2003102134A2 (en) * | 2002-05-28 | 2003-12-11 | Becton, Dickinson And Company | Pancreatic acinar cells into insulin producing cells |
| US20060040385A1 (en) * | 2002-12-05 | 2006-02-23 | Technion Research & Development Foundation Ltd. | Cultured human pancreatic islets, and uses thereof |
| FR2849043B1 (fr) * | 2002-12-24 | 2005-07-08 | Gemac | Procede de fabrication d'un vecteur de molecules actives applicable dans le domaine de la diffusion de principes actifs et vecteur obtenu |
| GB2414480B (en) * | 2003-02-07 | 2007-06-27 | Wisconsin Alumni Res Found | Directed genetic modifications of human stem cells |
| US20070154981A1 (en) | 2003-02-14 | 2007-07-05 | The Board Of Trustees Of The Leland Stanford Junior University | Insulin-producing cells derived from stem cells |
| US20030224411A1 (en) * | 2003-03-13 | 2003-12-04 | Stanton Lawrence W. | Genes that are up- or down-regulated during differentiation of human embryonic stem cells |
| US20040229350A1 (en) * | 2003-05-12 | 2004-11-18 | Nikolai Strelchenko | Morula derived embryonic stem cells |
| WO2004104184A1 (ja) | 2003-05-20 | 2004-12-02 | Riken | 内胚葉系幹細胞の調製 |
| WO2005017131A2 (en) | 2003-08-14 | 2005-02-24 | THE GOUVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF THE DEPARTMENT F HEALTH AND HUMAN SERVICES | Methods for the differentiation of human stem cells |
| WO2005033294A2 (en) | 2003-09-30 | 2005-04-14 | Regents Of The University Of California | Methods for maintaining hepatocytes in culture and for differentiating embryonic stem cells along a hepatocyte lineage |
| US7541185B2 (en) * | 2003-12-23 | 2009-06-02 | Cythera, Inc. | Methods for identifying factors for differentiating definitive endoderm |
| US20050266554A1 (en) * | 2004-04-27 | 2005-12-01 | D Amour Kevin A | PDX1 expressing endoderm |
| CN103898047B (zh) * | 2003-12-23 | 2020-03-03 | 维亚希特公司 | 定形内胚层 |
| US7625753B2 (en) * | 2003-12-23 | 2009-12-01 | Cythera, Inc. | Expansion of definitive endoderm cells |
| US7985585B2 (en) * | 2004-07-09 | 2011-07-26 | Viacyte, Inc. | Preprimitive streak and mesendoderm cells |
| WO2007059007A2 (en) * | 2005-11-14 | 2007-05-24 | Cythera, Inc. | Markers of definitive endoderm |
| CA2581424A1 (en) * | 2004-03-09 | 2005-09-22 | Gang Xu | Methods for generating insulin-producing cells |
| WO2005097980A2 (en) | 2004-03-26 | 2005-10-20 | Geron Corporation | New protocols for making hepatocytes from embryonic stem cells |
| CA2555571C (en) * | 2004-04-01 | 2012-10-16 | Wisconsin Alumni Research Foundation | Differentiation of stem cells to endoderm and pancreatic lineage |
| EP2377922B1 (en) * | 2004-04-27 | 2020-04-08 | Viacyte, Inc. | PDX1 expressing endoderm |
| CA2564114C (en) * | 2004-04-27 | 2018-10-09 | Cythera, Inc. | Pdx1 expressing endoderm |
| NZ582597A (en) | 2004-07-09 | 2011-08-26 | Viacyte Inc | Preprimitive streak and mesendoderm cells |
| CA2573283C (en) * | 2004-07-09 | 2023-03-14 | Cythera, Inc. | Methods for identifying factors for differentiating definitive endoderm |
| EP1791952A4 (en) * | 2004-08-13 | 2008-06-11 | Univ Georgia Res Found | COMPOSITIONS AND METHODS OF SELF-RENEWAL AND DIFFERENTIATION IN HUMAN EMBRYONAL STEM CELLS |
| EP1797171A1 (en) | 2004-09-29 | 2007-06-20 | Cellartis AB | Methods for the generation of hepatocyte-like cells from human blastocyst-derived stem (hbs) |
| JP2008528038A (ja) | 2005-01-31 | 2008-07-31 | エス セル インターナショナル ピーティーイー リミテッド | 胚性幹細胞の指示された分化及びその利用 |
| CN100425694C (zh) | 2005-04-15 | 2008-10-15 | 北京大学 | 诱导胚胎干细胞向胰腺细胞分化的方法 |
| WO2007002210A2 (en) | 2005-06-20 | 2007-01-04 | Bresagen, Inc. | Embryonic stem cell culture compositions and methods of use thereof |
| US7732202B2 (en) | 2005-10-21 | 2010-06-08 | International Stem Cell Corporation | Oxygen tension for the parthenogenic activation of human oocytes for the production of human embryonic stem cells |
| AU2006305879B2 (en) * | 2005-10-27 | 2012-05-10 | Viacyte, Inc. | PDX1-expressing dorsal and ventral foregut endoderm |
| GB0602063D0 (en) | 2006-02-02 | 2006-03-15 | Univ Manchester | Cell Culture |
| EP1999253B1 (en) * | 2006-03-02 | 2019-05-22 | Viacyte, Inc. | Endocrine precursor cells, pancreatic hormone-expressing cells and methods of production |
| US7695965B2 (en) * | 2006-03-02 | 2010-04-13 | Cythera, Inc. | Methods of producing pancreatic hormones |
| AU2007277364B2 (en) * | 2006-07-26 | 2010-08-12 | Viacyte, Inc. | Methods of producing pancreatic hormones |
| US20080241250A1 (en) * | 2006-11-08 | 2008-10-02 | Emans Pieter J | In vivo bioreactors and methods of making and using same |
| US7695963B2 (en) * | 2007-09-24 | 2010-04-13 | Cythera, Inc. | Methods for increasing definitive endoderm production |
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2006
- 2006-10-27 AU AU2006305879A patent/AU2006305879B2/en active Active
- 2006-10-27 JP JP2008538095A patent/JP5404047B2/ja active Active
- 2006-10-27 CA CA2627645A patent/CA2627645C/en active Active
- 2006-10-27 EP EP13171221.8A patent/EP2674485B1/en active Active
- 2006-10-27 DK DK06827129.5T patent/DK1957636T3/en active
- 2006-10-27 ES ES06827129.5T patent/ES2687233T3/es active Active
- 2006-10-27 DK DK13171221.8T patent/DK2674485T3/da active
- 2006-10-27 WO PCT/US2006/042413 patent/WO2007051038A2/en not_active Ceased
- 2006-10-27 EP EP06827129.5A patent/EP1957636B1/en active Active
- 2006-10-27 ES ES13171221T patent/ES2743202T3/es active Active
- 2006-10-27 US US11/588,693 patent/US20070122905A1/en not_active Abandoned
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- 2006-10-27 EP EP19179403.1A patent/EP3584311A1/en not_active Withdrawn
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- 2006-10-27 CN CNA2006800497075A patent/CN101351547A/zh active Pending
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