JP2008503203A5 - - Google Patents

Download PDF

Info

Publication number
JP2008503203A5
JP2008503203A5 JP2007510879A JP2007510879A JP2008503203A5 JP 2008503203 A5 JP2008503203 A5 JP 2008503203A5 JP 2007510879 A JP2007510879 A JP 2007510879A JP 2007510879 A JP2007510879 A JP 2007510879A JP 2008503203 A5 JP2008503203 A5 JP 2008503203A5
Authority
JP
Japan
Prior art keywords
pdx1
growth factor
cell culture
retinoid
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2007510879A
Other languages
English (en)
Japanese (ja)
Other versions
JP4926946B2 (ja
JP2008503203A (ja
Filing date
Publication date
Priority claimed from US11/021,618 external-priority patent/US7510876B2/en
Application filed filed Critical
Priority claimed from PCT/US2005/014239 external-priority patent/WO2005116073A2/en
Publication of JP2008503203A publication Critical patent/JP2008503203A/ja
Publication of JP2008503203A5 publication Critical patent/JP2008503203A5/ja
Application granted granted Critical
Publication of JP4926946B2 publication Critical patent/JP4926946B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

JP2007510879A 2004-04-27 2005-04-26 Ｐｄｘ１発現性内胚葉 Expired - Lifetime JP4926946B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US56629304P 2004-04-27 2004-04-27
US60/566,293 2004-04-27
US58656604P 2004-07-09 2004-07-09
US60/586,566 2004-07-09
US58794204P 2004-07-14 2004-07-14
US60/587,942 2004-07-14
US11/021,618 2004-12-23
US11/021,618 US7510876B2 (en) 2003-12-23 2004-12-23 Definitive endoderm
PCT/US2005/014239 WO2005116073A2 (en) 2004-04-27 2005-04-26 Pdx1 expressing endoderm

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2011147598A Division JP5669681B2 (ja) 2004-04-27 2011-07-01 Ｐｄｘ１発現性内胚葉

Publications (3)

Publication Number Publication Date
JP2008503203A JP2008503203A (ja) 2008-02-07
JP2008503203A5 true JP2008503203A5 (https=) 2008-06-19
JP4926946B2 JP4926946B2 (ja) 2012-05-09

Family

ID=45319532

Family Applications (6)

Application Number Title Priority Date Filing Date
JP2007510879A Expired - Lifetime JP4926946B2 (ja) 2004-04-27 2005-04-26 Ｐｄｘ１発現性内胚葉
JP2011147598A Expired - Lifetime JP5669681B2 (ja) 2004-04-27 2011-07-01 Ｐｄｘ１発現性内胚葉
JP2014168939A Expired - Lifetime JP6158152B2 (ja) 2004-04-27 2014-08-22 Ｐｄｘ１発現性内胚葉
JP2015111656A Expired - Lifetime JP6265942B2 (ja) 2004-04-27 2015-06-01 Ｐｄｘ１発現性内胚葉
JP2017026645A Expired - Lifetime JP6605520B2 (ja) 2004-04-27 2017-02-16 Ｐｄｘ１発現性内胚葉
JP2018167312A Expired - Lifetime JP6709262B2 (ja) 2004-04-27 2018-09-06 Ｐｄｘ１発現性内胚葉

Family Applications After (5)

Application Number Title Priority Date Filing Date
JP2011147598A Expired - Lifetime JP5669681B2 (ja) 2004-04-27 2011-07-01 Ｐｄｘ１発現性内胚葉
JP2014168939A Expired - Lifetime JP6158152B2 (ja) 2004-04-27 2014-08-22 Ｐｄｘ１発現性内胚葉
JP2015111656A Expired - Lifetime JP6265942B2 (ja) 2004-04-27 2015-06-01 Ｐｄｘ１発現性内胚葉
JP2017026645A Expired - Lifetime JP6605520B2 (ja) 2004-04-27 2017-02-16 Ｐｄｘ１発現性内胚葉
JP2018167312A Expired - Lifetime JP6709262B2 (ja) 2004-04-27 2018-09-06 Ｐｄｘ１発現性内胚葉

Country Status (14)

Country Link
EP (1) EP1740612B1 (https=)
JP (6) JP4926946B2 (https=)
KR (2) KR101278421B1 (https=)
CN (1) CN103103158B (https=)
AU (1) AU2005247869B2 (https=)
CA (1) CA2564114C (https=)
DK (2) DK1740612T3 (https=)
EA (1) EA011953B1 (https=)
ES (2) ES2751095T3 (https=)
IL (1) IL178847A (https=)
MX (1) MXPA06012445A (https=)
NZ (1) NZ550605A (https=)
SG (1) SG152273A1 (https=)
WO (1) WO2005116073A2 (https=)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7541185B2 (en) 2003-12-23 2009-06-02 Cythera, Inc. Methods for identifying factors for differentiating definitive endoderm
US7985585B2 (en) 2004-07-09 2011-07-26 Viacyte, Inc. Preprimitive streak and mesendoderm cells
CN103898047B (zh) 2003-12-23 2020-03-03 维亚希特公司 定形内胚层
US20050266554A1 (en) 2004-04-27 2005-12-01 D Amour Kevin A PDX1 expressing endoderm
US7625753B2 (en) 2003-12-23 2009-12-01 Cythera, Inc. Expansion of definitive endoderm cells
US8647873B2 (en) 2004-04-27 2014-02-11 Viacyte, Inc. PDX1 expressing endoderm
US8586357B2 (en) 2003-12-23 2013-11-19 Viacyte, Inc. Markers of definitive endoderm
AU2005272078B2 (en) * 2004-07-09 2011-04-14 Viacyte, Inc. Methods for identifying factors for differentiating definitive endoderm
US8187878B2 (en) 2004-08-13 2012-05-29 University Of Georgia Research Foundation, Inc. Methods for increasing definitive endoderm differentiation of pluripotent human embryonic stem cells with PI-3 kinase inhibitors
US8017395B2 (en) 2004-12-17 2011-09-13 Lifescan, Inc. Seeding cells on porous supports
AU2005322007B2 (en) * 2004-12-23 2011-06-30 Viacyte, Inc. Expansion of definitive endoderm cells
WO2006083782A2 (en) * 2005-01-31 2006-08-10 Es Cell International Pte Ltd. Directed differentiation of embryonic stem cells and uses thereof
CA2610646C (en) * 2005-06-02 2012-09-04 Arizona Board Of Regents On Behalf Of The University Of Arizona Prevascularized devices and related methods
JP2009500297A (ja) 2005-06-08 2009-01-08 セントカー・インコーポレーテツド 眼の変性についての細胞療法
AU2012202481B2 (en) * 2005-10-27 2015-07-02 Viacyte, Inc. PDX1-expressing dorsal and ventral foregut endoderm
WO2007051038A2 (en) * 2005-10-27 2007-05-03 Cythera, Inc. Pdx1-expressing dorsal and ventral foregut endoderm
SG170021A1 (en) 2006-02-23 2011-04-29 Novocell Inc Compositions and methods useful for culturing differentiable cells
JP6110048B2 (ja) 2006-03-02 2017-04-05 ヴィアサイト，インコーポレイテッド 内分泌前駆細胞、膵臓ホルモン発現細胞及びそれらの製造方法
US11254916B2 (en) 2006-03-02 2022-02-22 Viacyte, Inc. Methods of making and using PDX1-positive pancreatic endoderm cells
US7695965B2 (en) 2006-03-02 2010-04-13 Cythera, Inc. Methods of producing pancreatic hormones
US7989204B2 (en) 2006-04-28 2011-08-02 Viacyte, Inc. Hepatocyte lineage cells
AU2007244675A1 (en) * 2006-04-28 2007-11-08 Lifescan, Inc. Differentiation of human embryonic stem cells
US8741643B2 (en) 2006-04-28 2014-06-03 Lifescan, Inc. Differentiation of pluripotent stem cells to definitive endoderm lineage
US9080145B2 (en) 2007-07-01 2015-07-14 Lifescan Corporation Single pluripotent stem cell culture
DK2185693T3 (da) 2007-07-31 2019-09-23 Lifescan Inc Differentiering af humane embryoniske stamceller
US7695963B2 (en) 2007-09-24 2010-04-13 Cythera, Inc. Methods for increasing definitive endoderm production
CA2954431C (en) 2007-11-27 2021-08-24 Lifescan, Inc. Differentiation of human embryonic stem cells to pancreatic cells
EP2227487A1 (en) 2007-12-28 2010-09-15 Novo Nordisk A/S Ddr1-mediated cell purification of pancreatic endocrine cells through their progenitors
JP5733986B2 (ja) 2008-02-21 2015-06-10 ヤンセン バイオテツク，インコーポレーテツド 細胞の付着、培養、及び剥離のための方法、表面改質されたプレート、並びに組成物
CN101983336A (zh) 2008-04-03 2011-03-02 诺沃-诺迪斯克有限公司 Dner介导的胰腺内分泌前祖细胞及其子代的细胞纯化
US7939322B2 (en) 2008-04-24 2011-05-10 Centocor Ortho Biotech Inc. Cells expressing pluripotency markers and expressing markers characteristic of the definitive endoderm
US8623648B2 (en) 2008-04-24 2014-01-07 Janssen Biotech, Inc. Treatment of pluripotent cells
AU2009267167A1 (en) * 2008-06-30 2010-01-07 Centocor Ortho Biotech Inc. Differentiation of pluripotent stem cells
EP2942392B1 (en) 2008-06-30 2018-10-03 Janssen Biotech, Inc. Differentiation of pluripotent stem cells
US9234178B2 (en) 2008-10-31 2016-01-12 Janssen Biotech, Inc. Differentiation of human pluripotent stem cells
EP2350265B1 (en) 2008-10-31 2019-04-17 Janssen Biotech, Inc. Differentiation of human embryonic stem cells to the pancreatic endocrine lineage
US8008075B2 (en) 2008-11-04 2011-08-30 Viacyte, Inc. Stem cell aggregate suspension compositions and methods of differentiation thereof
US8895300B2 (en) 2008-11-04 2014-11-25 Viacyte, Inc. Scalable primate pluripotent stem cell aggregate suspension culture and differentiation thereof
JP2012508584A (ja) 2008-11-14 2012-04-12 ヴィアサイト，インコーポレイテッド ヒト多能性幹細胞由来膵臓細胞のカプセル化
KR101774546B1 (ko) 2008-11-20 2017-09-04 얀센 바이오테크 인코포레이티드 마이크로-캐리어 상의 만능 줄기 세포 배양
KR101687344B1 (ko) 2008-11-20 2016-12-16 얀센 바이오테크 인코포레이티드 평면 기재상의 세포 부착 및 배양을 위한 방법 및 조성물
US8785184B2 (en) 2009-07-20 2014-07-22 Janssen Biotech, Inc. Differentiation of human embryonic stem cells
CN103952372B (zh) 2009-07-20 2016-10-05 詹森生物科技公司 人胚胎干细胞的分化
CN102482643B (zh) 2009-07-20 2016-06-29 詹森生物科技公司 人胚胎干细胞的分化
US12441985B2 (en) 2009-12-23 2025-10-14 Janssen Biotech, Inc. Methods for making insulin in vivo
SG10201408552YA (en) 2009-12-23 2015-02-27 Janssen Biotech Inc Differentiation of human embryonic stem cells
CN102712902B (zh) 2009-12-23 2019-01-08 詹森生物科技公司 人胚胎干细胞的分化
PH12012501686A1 (en) 2010-03-01 2020-10-19 Janssen Biotech Inc Methods for purifying cells derived from pluripotent stem cells
US9719068B2 (en) 2010-05-06 2017-08-01 Children's Hospital Medical Center Methods and systems for converting precursor cells into intestinal tissues through directed differentiation
RU2587634C2 (ru) 2010-05-12 2016-06-20 Янссен Байотек, Инк. Дифференцирование эмбриональных стволовых клеток человека
EP3372672A1 (en) 2010-08-31 2018-09-12 Janssen Biotech, Inc. Differentiation of human embryonic stem cells
PL2853589T3 (pl) 2010-08-31 2018-05-30 Janssen Biotech, Inc Różnicowanie ludzkich zarodkowych komórek macierzystych
CN103154237B (zh) 2010-08-31 2016-03-16 詹森生物科技公司 多能干细胞的分化
JP5888852B2 (ja) * 2010-12-08 2016-03-22 学校法人近畿大学 免疫不全動物を用いた細胞の製法
JP2012143229A (ja) * 2010-12-24 2012-08-02 Chiba Univ 多能性幹細胞培養用組成物およびその用途
EP2723852B1 (en) 2011-06-21 2021-11-17 Novo Nordisk A/S Efficient induction of definitive endoderm from pluripotent stem cells
FI2794857T3 (fi) 2011-12-22 2026-03-25 Janssen Biotech Inc Ihmisen alkion kantasolujen erilaistaminen yksittäisiksi hormonaalisiksi insuliinipositiivisiksi soluiksi
CA2866590A1 (en) 2012-03-07 2013-09-12 Janssen Biotech, Inc. Defined media for expansion and maintenance of pluripotent stem cells
EP3450544A1 (en) 2012-06-08 2019-03-06 Janssen Biotech, Inc. Differentiation of human embryonic stem cells into pancreatic endodrine cells
US10370644B2 (en) 2012-12-31 2019-08-06 Janssen Biotech, Inc. Method for making human pluripotent suspension cultures and cells derived therefrom
ES2837763T3 (es) 2012-12-31 2021-07-01 Janssen Biotech Inc Cultivo de células madre embrionarias humanas en la interconexión aire-líquido para la diferenciación en células endocrinas pancreáticas
DK2938723T3 (da) 2012-12-31 2023-02-20 Janssen Biotech Inc Differentiering af humane embryonale stamceller til pancreatiske endokrine celler under anvendelse af hb9-regulatorer
BR112015015714A2 (pt) 2012-12-31 2017-07-11 Janssen Biotech Inc suspensão e aglomeração de células pluripotentes humanas para diferenciação em célu-las endócrinas pancreáticas
WO2015175307A1 (en) 2014-05-16 2015-11-19 Janssen Biotech, Inc. Use of small molecules to enhance mafa expression in pancreatic endocrine cells
SG10201801654RA (en) 2014-05-28 2018-04-27 Childrens Hospital Med Ct Methods and systems for converting precursor cells into gastric tissues through directed differentiation
AU2015331848B2 (en) 2014-10-17 2022-03-03 Children's Hospital Medical Center, D/B/A Cincinnati Children's Hospital Medical Center In vivo model of human small intestine using pluripotent stem cells and methods of making and using same
EP3819372A3 (en) 2015-04-24 2021-10-06 University of Copenhagen Isolation of bona fide pancreatic progenitor cells
US10420803B2 (en) 2016-04-14 2019-09-24 Janssen Biotech, Inc. Differentiation of pluripotent stem cells to intestinal midgut endoderm cells
CN109415685B (zh) 2016-05-05 2023-07-04 儿童医院医疗中心 用于体外制造胃底组织的方法和与其相关的组合物
EP4553082A3 (en) 2016-11-04 2025-08-20 Children's Hospital Medical Center Liver organoid compositions and methods of making and using same
EP3548507A4 (en) 2016-12-05 2020-07-15 Children's Hospital Medical Center COLON ORGANOIDS AND PROCESSES FOR THE PREPARATION AND USE THEREOF
JP7248586B2 (ja) 2017-04-14 2023-03-29 チルドレンズ ホスピタル メディカル センター 複数ドナー幹細胞組成物およびそれを作製する方法
EP3694603B1 (en) 2017-10-10 2026-04-08 Children's Hospital Medical Center Esophageal tissue and/or organoid compositions and methods of making same
CA2983845C (en) 2017-10-26 2024-01-30 University Of Copenhagen Generation of glucose-responsive beta cells
EP3727394A4 (en) 2017-12-21 2021-09-08 Children's Hospital Medical Center DIGITALIZED HUMAN ORGANOIDS AND METHOD OF USING THEREOF
EP4678727A3 (en) 2018-07-26 2026-03-11 Children's Hospital Medical Center Hepato-biliary-pancreatic tissues and methods of making same
CA3112026A1 (en) 2018-09-12 2020-03-19 Children's Hospital Medical Center Organoid compositions for the production of hematopoietic stem cells and derivatives thereof
US12600943B2 (en) 2019-02-01 2026-04-14 The University Of Hong Kong Innervated organoid compositions and methods of making same
EP3975926A1 (en) 2019-05-31 2022-04-06 W.L. Gore & Associates, Inc. A biocompatible membrane composite
EP3976236A1 (en) 2019-05-31 2022-04-06 W.L. Gore & Associates Inc. A biocompatible membrane composite
CN114173837A (zh) 2019-05-31 2022-03-11 W.L.戈尔及同仁股份有限公司 生物相容性膜复合材料
CA3139292C (en) 2019-05-31 2025-06-10 Viacyte, Inc. CELL ENCAPSULATION DEVICES WITH REGULATED OXYGEN DIFFUSION DISTANCES
US12497597B2 (en) 2019-05-31 2025-12-16 Children's Hospital Medical Center Methods of generating and expanding hematopoietic stem cells
AU2020283048A1 (en) 2019-05-31 2021-12-23 Children's Hospital Medical Center Shaped organoid compositions and methods of making same
CN116057185A (zh) 2020-08-15 2023-05-02 雷杰纳荣制药公司 治疗具有编码降钙素受体(calcr)的变体核酸分子的受试者的肥胖症

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3945846B2 (ja) * 1995-11-09 2007-07-18 武田薬品工業株式会社 膵臓機能改善剤
US6331406B1 (en) * 1997-03-31 2001-12-18 The John Hopkins University School Of Medicine Human enbryonic germ cell and methods of use
WO2000047720A2 (en) * 1999-02-10 2000-08-17 Curis, Inc. Pancreatic progenitor cells, methods and uses related thereto
JP4426064B2 (ja) * 2000-05-31 2010-03-03 独立行政法人科学技術振興機構 脊椎動物の膵臓のインビトロ形成方法
CA2415108A1 (en) * 2000-06-30 2002-01-10 Amcyte, Inc. Culturing pancreatic stem cells having a specified, intermediate stage of development
JP2004504834A (ja) * 2000-08-01 2004-02-19 イスム　リサーチ　ディベロップメント　カンパニー 胚性細胞の定方向分化
AU2001297880B2 (en) * 2000-11-30 2007-05-31 Stemron Inc. Isolated homozygous stem cells differentiated cells derived therefrom and materials and methods for making and using same
EP1366148A2 (en) * 2001-01-24 2003-12-03 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, represented by THE DEPARTMENT OF HEALTH & HUMAN SERVICES Differentiation of stem cells to pancreatic endocrine cells
EP1393066A4 (en) * 2001-05-15 2006-01-25 Rappaport Family Inst For Res INSULIN-PRODUCING CELLS DERIVED FROM HUMAN EMBRYONIC STEM CELLS
CA2451838A1 (en) * 2001-05-25 2002-12-05 Cythera, Inc. Stem cell differentiation
AU2002312514A1 (en) * 2001-06-14 2003-01-02 Regents Of The University Of California Hoxd3 compositions ad methods for improved wound healing
EP1298201A1 (en) * 2001-09-27 2003-04-02 Cardion AG Process for the production of cells exhibiting an islet-beta-cell-like state
MXPA04005010A (es) * 2001-11-26 2005-04-08 Advanced Cell Tech Inc METODO PARA HACER Y USAR NUCLEOS CELULARES SOMáTICOS METODOS PARA HACER Y USAR NUCLEOS CELULARES SOMáTICOS HUMANOS REPROGRAMADOS Y CELULAS DEL TALLO HUMANAS AUTOLOGAS E ISOGENICAS.
IL162131A0 (en) * 2001-12-07 2005-11-20 Geron Corp Islet cells from human embryonic stem cells
US20030138949A1 (en) * 2001-12-12 2003-07-24 Anil Bhushan Methods for the regeneration of pancreatic islets and expansion of pancreatic endocrine cells
US20030162290A1 (en) * 2002-01-25 2003-08-28 Kazutomo Inoue Method for inducing differentiation of embryonic stem cells into functioning cells
CA2483010A1 (en) * 2002-04-19 2003-10-30 University Of Pittsburgh Of The Commonwealth System Of Higher Education Placental derived stem cells and uses thereof
EP1516925A1 (en) * 2003-09-18 2005-03-23 Fundacion IVI para el Estudio de la reproduccion Humana (FIVIER) Generation of human embryonic stem cells from triploid zygotes
AU2005230832B2 (en) * 2004-04-01 2010-11-11 Wisconsin Alumni Research Foundation Differentiation of stem cells to endoderm and pancreatic lineage

Similar Documents

Publication Publication Date Title
JP2008503203A5 (https=)
JP2009513143A5 (https=)
Io et al. Capturing human trophoblast development with naive pluripotent stem cells in vitro
AU2025279827A1 (en) Method for reproducible differentiation of clinical-grade retinal pigment epithelium cells
JP2020103321A (ja) 前原始線条及び中内胚葉細胞
Golan-Mashiach et al. Design principle of gene expression used by human stem cells; implication for pluripotency
CA2549605A1 (en) Definitive endoderm
KR20190018709A (ko) 혈액을 유도 만능 줄기세포로 리프로그래밍하기 위한 신규하고 효율적인 방법
Pera et al. Gene expression profiles of human inner cell mass cells and embryonic stem cells
JP2008543338A5 (https=)
Pal et al. Comparative analysis of cardiomyocyte differentiation from human embryonic stem cells under 3-D and 2-D culture conditions
JP2012532585A5 (https=)
EP3121276A1 (en) Cardiomyocyte sorting method
Sudheer et al. Different concentrations of FGF ligands, FGF2 or FGF8 determine distinct states of WNT-induced presomitic mesoderm
Zhi et al. Elucidation of the pluripotent potential of bovine embryonic lineages facilitates the establishment of formative stem cell lines
Xie et al. Modeling early gastrulation in human blastoids with DNA methylation patterns of natural blastocysts
EP3571291A1 (en) Maintenance and expansion of pancreatic progenitor cells
Zhong et al. Barhl1 is required for the differentiation of inner ear hair cell-like cells from mouse embryonic stem cells
Ding et al. ETV2 overexpression promotes efficient differentiation of pluripotent stem cells to endothelial cells
Wang et al. Wnt inhibition safeguards porcine embryonic stem cells from the acquisition of extraembryonic endoderm cell fates
WO2018037091A1 (en) Methods for the identification and isolation of hematopoietic stem and progenitor cells
Nelson et al. Lineage specification of Flk-1+ progenitors is associated with divergent Sox7 expression in cardiopoiesis
Han et al. Isolation and in vitro culture of pig spermatogonial stem cell
Tobias et al. Targeted expression profiling reveals distinct stages of early canine fibroblast reprogramming are regulated by 2-oxoglutarate hydroxylases
CN119432720B (zh) 猪胚胎干细胞诱导形成猪类囊胚的方法及培养基