JP2008543338A5 - - Google Patents
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- Publication number
- JP2008543338A5 JP2008543338A5 JP2008518339A JP2008518339A JP2008543338A5 JP 2008543338 A5 JP2008543338 A5 JP 2008543338A5 JP 2008518339 A JP2008518339 A JP 2008518339A JP 2008518339 A JP2008518339 A JP 2008518339A JP 2008543338 A5 JP2008543338 A5 JP 2008543338A5
- Authority
- JP
- Japan
- Prior art keywords
- bmp
- cells
- culturing
- activin
- culture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 17
- 210000004027 cell Anatomy 0.000 claims 15
- 238000012258 culturing Methods 0.000 claims 10
- 108010023082 activin A Proteins 0.000 claims 5
- 210000004413 cardiac myocyte Anatomy 0.000 claims 4
- 108010049931 Bone Morphogenetic Protein 2 Proteins 0.000 claims 2
- 108010049955 Bone Morphogenetic Protein 4 Proteins 0.000 claims 2
- 108010049870 Bone Morphogenetic Protein 7 Proteins 0.000 claims 2
- 102100024506 Bone morphogenetic protein 2 Human genes 0.000 claims 2
- 102100024505 Bone morphogenetic protein 4 Human genes 0.000 claims 2
- 102100022544 Bone morphogenetic protein 7 Human genes 0.000 claims 2
- 102000004218 Insulin-Like Growth Factor I Human genes 0.000 claims 2
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 claims 2
- 239000002609 medium Substances 0.000 claims 2
- 239000012679 serum free medium Substances 0.000 claims 2
- 108010059616 Activins Proteins 0.000 claims 1
- 102100026818 Inhibin beta E chain Human genes 0.000 claims 1
- 102000048143 Insulin-Like Growth Factor II Human genes 0.000 claims 1
- 108090001117 Insulin-Like Growth Factor II Proteins 0.000 claims 1
- 239000000488 activin Substances 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 230000000747 cardiac effect Effects 0.000 claims 1
- 210000002242 embryoid body Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69314105P | 2005-06-22 | 2005-06-22 | |
| US60/693,141 | 2005-06-22 | ||
| PCT/US2006/024060 WO2007002136A2 (en) | 2005-06-22 | 2006-06-20 | Differentiation of primate pluripotent stem cells to cardiomyocyte-lineage cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013135917A Division JP2013215206A (ja) | 2005-06-22 | 2013-06-28 | 心筋細胞系列細胞への霊長類多能性幹細胞の分化 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008543338A JP2008543338A (ja) | 2008-12-04 |
| JP2008543338A5 true JP2008543338A5 (https=) | 2009-04-16 |
| JP5560393B2 JP5560393B2 (ja) | 2014-07-23 |
Family
ID=37595761
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008518339A Expired - Fee Related JP5560393B2 (ja) | 2005-06-22 | 2006-06-20 | 心筋細胞系列細胞への霊長類多能性幹細胞の分化 |
| JP2013135917A Pending JP2013215206A (ja) | 2005-06-22 | 2013-06-28 | 心筋細胞系列細胞への霊長類多能性幹細胞の分化 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013135917A Pending JP2013215206A (ja) | 2005-06-22 | 2013-06-28 | 心筋細胞系列細胞への霊長類多能性幹細胞の分化 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US9062289B2 (https=) |
| EP (1) | EP1910518B1 (https=) |
| JP (2) | JP5560393B2 (https=) |
| KR (2) | KR101529317B1 (https=) |
| CN (1) | CN101228264B (https=) |
| AU (1) | AU2006262329B2 (https=) |
| CA (1) | CA2611809C (https=) |
| GB (1) | GB2441718B (https=) |
| IL (1) | IL187611A (https=) |
| WO (1) | WO2007002136A2 (https=) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2658786A1 (en) * | 2006-07-28 | 2008-01-31 | Children's Memorial Hospital | Methods of inhibiting tumor cell aggressiveness using the microenvironment of human embryonic stem cells |
| US8106004B2 (en) * | 2006-07-28 | 2012-01-31 | Children's Memorial Hospital | Methods of inhibiting tumor cell aggressiveness using the microenvironment of human embryonic stem cells |
| CA2717962C (en) | 2008-03-27 | 2019-05-14 | Mount Sinai School Of Medicine Of New York University | Human cardiovascular progenitor cells |
| JP5902092B2 (ja) | 2009-10-19 | 2016-04-13 | セルラー ダイナミクス インターナショナル, インコーポレイテッド | 心筋細胞の生成 |
| US9181529B2 (en) | 2010-10-19 | 2015-11-10 | Cellular Dynamics International, Inc. | Titration of differentiation medium components |
| EP2640829A4 (en) | 2010-11-17 | 2014-06-11 | Univ Kyoto | CARDIOMYOCYTE AND / OR CARDIOVORA CELL PROLIFERATING AGENTS AND METHOD FOR PROLIFERATING CARDIOMYOCYTES AND / OR CARDIOVORA CELLS |
| WO2012135253A1 (en) | 2011-03-29 | 2012-10-04 | Geron Corporation | Enriched populations of cardiomyocyte lineage cells from pluripotent stem cells |
| JP5840855B2 (ja) | 2011-03-30 | 2016-01-06 | 学校法人東京女子医科大学 | 胚性幹細胞から心筋シートを製造する方法 |
| DK2694644T3 (en) | 2011-03-30 | 2018-04-16 | Cellular Dynamics Int Inc | Priming of pluripotent stem cells for neural differentiation |
| WO2012133954A1 (en) | 2011-03-31 | 2012-10-04 | Kyoto University | Novel cardiomyocyte marker |
| CN107529709B (zh) | 2011-06-16 | 2019-05-07 | Ge视频压缩有限责任公司 | 解码器、编码器、解码和编码视频的方法及存储介质 |
| CN111500665A (zh) | 2011-07-21 | 2020-08-07 | 小利兰·斯坦福大学托管委员会 | 来自患者的诱导性多能干细胞的心肌细胞及其使用方法 |
| GB201121101D0 (en) * | 2011-12-08 | 2012-01-18 | Nhs Blood & Transplant | A method of preparing isolated cells and uses |
| JP5920741B2 (ja) | 2012-03-15 | 2016-05-18 | iHeart Japan株式会社 | 人工多能性幹細胞から心筋および血管系混合細胞群を製造する方法 |
| US20150184129A1 (en) | 2012-07-17 | 2015-07-02 | Kyoto University | Novel cardiomyocyte marker |
| JP6429280B2 (ja) | 2013-05-14 | 2018-11-28 | 国立大学法人京都大学 | 効率的な心筋細胞の誘導方法 |
| EP3006559B1 (en) | 2013-05-31 | 2019-11-06 | iHeart Japan Corporation | Layered cell sheet incorporating hydrogel |
| WO2014192312A1 (ja) * | 2013-05-31 | 2014-12-04 | 国立大学法人 東京医科歯科大学 | 正常な内向きのカリウム電流特性を有するiPS細胞由来心筋モデル細胞 |
| CN120796168A (zh) | 2013-06-11 | 2025-10-17 | 哈佛学院校长同事会 | SC-β细胞以及用于产生其的组合物和方法 |
| US10538740B2 (en) | 2014-03-20 | 2020-01-21 | Kyoto University | Method for sorting cardiomyocytes |
| RU2016146567A (ru) * | 2014-05-06 | 2018-06-08 | Ф. Хоффманн-Ля Рош Аг | Способ дифференцировки плюрипотентных стволовых клеток в кардиомиоциты |
| JP6265515B2 (ja) * | 2014-09-16 | 2018-01-24 | 国立大学法人大阪大学 | 多能性幹細胞由来心筋細胞集団の製造方法 |
| EP3234110B1 (en) | 2014-12-18 | 2024-02-28 | President and Fellows of Harvard College | METHODS FOR GENERATING STEM CELL-DERIVED ß CELLS AND USES THEREOF |
| CN107614678B (zh) | 2014-12-18 | 2021-04-30 | 哈佛学院校长同事会 | 干细胞来源的β细胞的产生方法及其使用方法 |
| WO2016100898A1 (en) | 2014-12-18 | 2016-06-23 | President And Fellows Of Harvard College | Serum-free in vitro directed differentiation protocol for generating stem cell-derived b cells and uses thereof |
| US10556388B2 (en) * | 2015-04-22 | 2020-02-11 | Eastman Chemical Company | Polyester-based tape composites for wood reinforcement |
| CN107921148A (zh) | 2015-05-08 | 2018-04-17 | 哈佛学院校长同事会 | 通用供体干细胞和相关方法 |
| EP3710021A4 (en) | 2017-11-15 | 2021-08-11 | Semma Therapeutics, Inc. | ISLAND CELL MANUFACTURING COMPOSITIONS AND METHOD OF USE |
| EP3778902A4 (en) | 2018-03-30 | 2021-12-29 | Kyoto University | Cell production method |
| AU2019241702B2 (en) | 2018-03-30 | 2023-07-27 | Orizuru Therapeutics, Inc | Heterocyclic compound |
| JP7344486B2 (ja) | 2018-03-30 | 2023-09-14 | 国立大学法人京都大学 | 心筋細胞成熟促進剤 |
| WO2020033879A1 (en) | 2018-08-10 | 2020-02-13 | Semma Therapeutics, Inc. | Stem cell derived islet differentiation |
| EP3842538A4 (en) | 2018-08-10 | 2022-06-08 | Kyoto University | METHOD OF TRANSFECTION INTO CARDIOMYOCYTES USING CATIONIC LIPID |
| US12479791B2 (en) | 2018-08-10 | 2025-11-25 | Takeda Pharmaceutical Company Limited | Cationic lipid |
| JP7728747B2 (ja) | 2019-08-23 | 2025-08-25 | サナ バイオテクノロジー,インコーポレイテッド | Cd24発現細胞およびそれらの用途 |
| WO2022036150A1 (en) | 2020-08-13 | 2022-02-17 | Sana Biotechnology, Inc. | Methods of treating sensitized patients with hypoimmunogenic cells, and associated methods and compositions |
| US20240226164A1 (en) | 2021-05-27 | 2024-07-11 | Sana Biotechnology, Inc. | Hypoimmunogenic cells comprising engineered hla-e or hla-g |
| KR20240046319A (ko) | 2021-07-14 | 2024-04-08 | 사나 바이오테크놀로지, 인크. | 저면역원성 세포에서의 y 염색체-연결 항원의 변경된 발현 |
| AU2022327174A1 (en) | 2021-08-11 | 2024-02-15 | Sana Biotechnology, Inc. | Inducible systems for altering gene expression in hypoimmunogenic cells |
| JP2024535677A (ja) | 2021-08-11 | 2024-10-02 | サナ バイオテクノロジー,インコーポレイテッド | 即時血液媒介性炎症反応を減少させるための同種細胞療法を目的とした遺伝子改変細胞 |
| US20240358761A1 (en) | 2021-08-11 | 2024-10-31 | Sana Biotechnology, Inc. | Genetically modified cells for allogeneic cell therapy |
| EP4384598A1 (en) | 2021-08-11 | 2024-06-19 | Sana Biotechnology, Inc. | Genetically modified cells for allogeneic cell therapy to reduce complement-mediated inflammatory reactions |
| KR20230073749A (ko) | 2021-11-19 | 2023-05-26 | 주식회사 로킷헬스케어 | 박동형 심근 패치의 제조방법 및 이를 이용하여 제조된 박동형 심근 패치 |
| WO2023183313A1 (en) | 2022-03-22 | 2023-09-28 | Sana Biotechnology, Inc. | Engineering cells with a transgene in b2m or ciita locus and associated compositions and methods |
| AU2024232721A1 (en) | 2023-03-03 | 2025-10-09 | Kyoto University | Method for producing primed pluripotent stem cells |
| EP4716541A2 (en) | 2023-05-22 | 2026-04-01 | Sana Biotechnology, Inc. | Methods of delivery of islet cells and related methods |
| WO2025054202A1 (en) | 2023-09-05 | 2025-03-13 | Sana Biotechnology, Inc. | Method of screening a sample comprising a transgene with a unique barcode |
| WO2025151838A1 (en) | 2024-01-12 | 2025-07-17 | Sana Biotechnology, Inc. | Safety switches to control in vitro and in vivo proliferation of cell therapy products |
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|---|---|---|---|---|
| US4491632A (en) | 1979-10-22 | 1985-01-01 | The Massachusetts General Hospital | Process for producing antibodies to hepatitis virus and cell lines therefor |
| US4444887A (en) | 1979-12-10 | 1984-04-24 | Sloan-Kettering Institute | Process for making human antibody producing B-lymphocytes |
| EP0043718B1 (en) | 1980-07-07 | 1984-11-28 | National Research Development Corporation | Improvements in or relating to cell lines |
| GB2197915B (en) | 1986-11-19 | 1990-11-14 | Rolls Royce Plc | Improvements in or relating to fluid bearings |
| WO1992013066A1 (en) | 1991-01-24 | 1992-08-06 | Loyola University Of Chicago | Mammalian cardiac myocyte cell line |
| US5543318A (en) | 1991-06-12 | 1996-08-06 | Smith; David A. | Method of isolation, culture and proliferation of human atrial myocytes |
| US5523226A (en) | 1993-05-14 | 1996-06-04 | Biotechnology Research And Development Corp. | Transgenic swine compositions and methods |
| US6015671A (en) | 1995-06-07 | 2000-01-18 | Indiana University Foundation | Myocardial grafts and cellular compositions |
| US5602301A (en) | 1993-11-16 | 1997-02-11 | Indiana University Foundation | Non-human mammal having a graft and methods of delivering protein to myocardial tissue |
| DE4441327C1 (de) | 1994-11-22 | 1995-11-09 | Inst Pflanzengenetik & Kultur | Embryonale Herzmuskelzellen, ihre Herstellung und ihre Verwendung |
| US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
| DE69735622T2 (de) | 1996-08-16 | 2007-04-12 | MCW Research Foundation, Inc., Milwaukee | Knochen morphogenetisches protein und fibroblasten wachstumsfaktor enthaltende zusammensetzungen und methoden zur induzierung der kardiogenese |
| US20020061837A1 (en) | 1996-09-05 | 2002-05-23 | Lough John W. | Bone morphogenetic protein and fibroblast growth factor compositions and methods for the induction of cardiogenesis |
| US6261836B1 (en) | 1996-10-01 | 2001-07-17 | Geron Corporation | Telomerase |
| CA2277278A1 (en) | 1997-01-10 | 1998-07-16 | Life Technologies, Inc. | Embryonic stem cell serum replacement |
| US6331406B1 (en) | 1997-03-31 | 2001-12-18 | The John Hopkins University School Of Medicine | Human enbryonic germ cell and methods of use |
| US6099832A (en) | 1997-05-28 | 2000-08-08 | Genzyme Corporation | Transplants for myocardial scars |
| US6110459A (en) | 1997-05-28 | 2000-08-29 | Mickle; Donald A. G. | Transplants for myocardial scars and methods and cellular preparations |
| US6387369B1 (en) | 1997-07-14 | 2002-05-14 | Osiris Therapeutics, Inc. | Cardiac muscle regeneration using mesenchymal stem cells |
| CA2307807C (en) | 1997-10-23 | 2008-09-02 | Andrea G. Bodnar | Methods and materials for the growth of primate-derived primordial stem cells in feeder-free culture |
| DE19755800A1 (de) | 1997-12-16 | 1999-06-17 | Merck Patent Gmbh | Cyclopeptidderivate |
| AU3112499A (en) | 1998-03-23 | 1999-10-18 | Zymogenetics Inc. | Cardiac-derived stem cells |
| CA2324591A1 (en) | 1998-04-09 | 1999-10-21 | Bresagen Limited | Cell differentiation/proliferation and maintenance factor and uses thereof |
| DE69937888T2 (de) | 1998-07-31 | 2009-01-02 | Genzyme Corp., Cambridge | Verfahren zur Herstellung mesenchymaler Stammzellen |
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| US7410798B2 (en) | 2001-01-10 | 2008-08-12 | Geron Corporation | Culture system for rapid expansion of human embryonic stem cells |
| US20020168766A1 (en) | 2000-01-11 | 2002-11-14 | Gold Joseph D. | Genetically altered human pluripotent stem cells |
| IL129966A (en) | 1999-05-14 | 2009-12-24 | Technion Res & Dev Foundation | ISOLATED HUMAN EMBRYOID BODIES (hEB) DERIVED FROM HUMAN EMBRYONIC STEM CELLS |
| AU783935B2 (en) | 1999-06-18 | 2006-01-05 | Indiana University Research And Technology Corporation | Cardiomyocytes with enhanced proliferative potential, and methods for preparing and using same |
| EP1221956A2 (en) | 1999-09-30 | 2002-07-17 | McGILL UNIVERSITY | Autologous marrow stem cell (msc) transplantation for myocardial regeneration |
| US6280718B1 (en) | 1999-11-08 | 2001-08-28 | Wisconsin Alumni Reasearch Foundation | Hematopoietic differentiation of human pluripotent embryonic stem cells |
| EP1254952A4 (en) | 1999-12-28 | 2004-09-22 | Kyowa Hakko Kogyo Kk | CELLS THAT ARE ABLE TO DIFFERENTIZE IN THE HEART MUSCLE CELLS |
| US20020142457A1 (en) | 1999-12-28 | 2002-10-03 | Akihiro Umezawa | Cell having the potentiality of differentiation into cardiomyocytes |
| CA2397292A1 (en) | 2000-01-14 | 2001-07-19 | Bresagen Limited | Cell production |
| AU2001229731A1 (en) | 2000-01-21 | 2001-07-31 | The Johns Hopkins University School Of Medicine | Human embryoid body-derived cells |
| AU2001243551A1 (en) | 2000-03-10 | 2001-09-24 | Indiana University Research & Technology Corporation | Multipotent cell and cardiomyocyte cell populations, and routes to and uses of same |
| WO2002013760A2 (en) | 2000-07-31 | 2002-02-21 | New York Medical College | Methods and compositions for the repair and/or regeneration of damaged myocardium |
| US20020061587A1 (en) | 2000-07-31 | 2002-05-23 | Piero Anversa | Methods and compositions for the repair and/or regeneration of damaged myocardium |
| JP2004504834A (ja) * | 2000-08-01 | 2004-02-19 | イスム リサーチ ディベロップメント カンパニー | 胚性細胞の定方向分化 |
| US6607720B1 (en) | 2000-09-05 | 2003-08-19 | Yong-Fu Xiao | Genetically altered mammalian embryonic stem cells, their living progeny, and their therapeutic application for improving cardiac function after myocardial infarction |
| US6534052B1 (en) | 2000-09-05 | 2003-03-18 | Yong-Fu Xiao | Cardiac function comprising implantation of embryonic stem cell in which differentiation has been initiated |
| IL155728A0 (en) | 2000-11-22 | 2003-11-23 | Geron Corp | Tolerizing allografts of pluripotent stem cells |
| US20030031651A1 (en) | 2001-04-13 | 2003-02-13 | Lee Ike W. | Methods and reagents for cell transplantation |
| US7732199B2 (en) * | 2001-07-12 | 2010-06-08 | Geron Corporation | Process for making transplantable cardiomyocytes from human embryonic stem cells |
| WO2003006950A2 (en) | 2001-07-12 | 2003-01-23 | Geron Corporation | Cells of the cardiomyocyte lineage produced from human pluripotent stem cells |
| WO2003008535A2 (en) | 2001-07-20 | 2003-01-30 | Technion Research And Development Foundation Ltd. | Methods of generating human cardiac cells and tissues and uses thereof |
| EP1421182A4 (en) | 2001-07-24 | 2005-03-23 | Es Cell Int Pte Ltd | PROCESS FOR INDUCING DIFFERENTIATION OF STEM CELLS |
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| US8298606B2 (en) | 2002-03-08 | 2012-10-30 | The Regents Of The University Of California | Methods and compositions for stabilizing the myocardium |
| NZ535243A (en) * | 2002-03-15 | 2008-05-30 | Wicell Res Inst Inc | Method for generating primate trophoblasts |
| US7247477B2 (en) | 2002-04-16 | 2007-07-24 | Technion Research & Development Foundation Ltd. | Methods for the in-vitro identification, isolation and differentiation of vasculogenic progenitor cells |
| US6898272B2 (en) * | 2002-08-01 | 2005-05-24 | Spirent Communications | System and method for testing telecommunication devices |
| US7569222B2 (en) | 2002-11-18 | 2009-08-04 | Woerly Stephane | Hydrogel membrane composition and use thereof |
| US20050031598A1 (en) | 2002-12-10 | 2005-02-10 | Shulamit Levenberg | Engineering three-dimensional tissue structures using differentiating embryonic stem cells |
| AU2003901099A0 (en) | 2003-03-11 | 2003-03-27 | Es Cell International Pte Ltd. | Methods of inducing differentiation of stem cells |
| US20030224411A1 (en) | 2003-03-13 | 2003-12-04 | Stanton Lawrence W. | Genes that are up- or down-regulated during differentiation of human embryonic stem cells |
| US20050266554A1 (en) * | 2004-04-27 | 2005-12-01 | D Amour Kevin A | PDX1 expressing endoderm |
| US20050142121A1 (en) | 2003-12-24 | 2005-06-30 | Gold Joseph D. | System for improving acceptance of tissue grafts made from embryonic stem cells |
| JP4971131B2 (ja) * | 2004-03-19 | 2012-07-11 | ジェロン・コーポレーション | 再生医学に適した高純度心筋細胞調製物を作製するための方法 |
| US20050214938A1 (en) | 2004-03-26 | 2005-09-29 | Gold Joseph D | Cardiac bodies: clusters of spontaneously contracting cells for regenerating cardiac function |
| US7452718B2 (en) * | 2004-03-26 | 2008-11-18 | Geron Corporation | Direct differentiation method for making cardiomyocytes from human embryonic stem cells |
| WO2006138718A2 (en) | 2005-06-17 | 2006-12-28 | Drexel University | Three-dimensional scaffolds for tissue engineering made by processing complex extracts of natural extracellular matrices |
| MX2009007101A (es) | 2006-12-29 | 2009-12-01 | Univ Washington | Superficies y materiales antibioincrustación bifuncionales. |
| US8354274B2 (en) | 2008-01-30 | 2013-01-15 | Geron Corporation | Synthetic surfaces for culturing cells in chemically defined media |
| TW201042038A (en) | 2009-05-28 | 2010-12-01 | Corning Inc | Synthetic microcarriers for culturing cells |
-
2006
- 2006-06-20 JP JP2008518339A patent/JP5560393B2/ja not_active Expired - Fee Related
- 2006-06-20 KR KR1020087001452A patent/KR101529317B1/ko not_active Expired - Fee Related
- 2006-06-20 KR KR1020137021754A patent/KR20130099253A/ko not_active Ceased
- 2006-06-20 WO PCT/US2006/024060 patent/WO2007002136A2/en not_active Ceased
- 2006-06-20 CA CA2611809A patent/CA2611809C/en not_active Expired - Fee Related
- 2006-06-20 EP EP06785229.3A patent/EP1910518B1/en not_active Not-in-force
- 2006-06-20 US US11/471,916 patent/US9062289B2/en active Active
- 2006-06-20 GB GB0800264A patent/GB2441718B/en not_active Expired - Fee Related
- 2006-06-20 CN CN200680022866.6A patent/CN101228264B/zh not_active Expired - Fee Related
- 2006-06-20 AU AU2006262329A patent/AU2006262329B2/en not_active Ceased
-
2007
- 2007-11-25 IL IL187611A patent/IL187611A/en not_active IP Right Cessation
-
2013
- 2013-06-28 JP JP2013135917A patent/JP2013215206A/ja active Pending
-
2015
- 2015-06-22 US US14/746,599 patent/US20150284684A1/en not_active Abandoned
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