DK1483371T3 - Isolerings- og kulturdyrkningsmetoder til mesenkymstamceller fra navlestrengsblod og differentieringsmetode til fra-navlestrengsblod-opnåede mesenkymstamceller til forskellige mesenkymvæv - Google Patents
Isolerings- og kulturdyrkningsmetoder til mesenkymstamceller fra navlestrengsblod og differentieringsmetode til fra-navlestrengsblod-opnåede mesenkymstamceller til forskellige mesenkymvævInfo
- Publication number
- DK1483371T3 DK1483371T3 DK03705473T DK03705473T DK1483371T3 DK 1483371 T3 DK1483371 T3 DK 1483371T3 DK 03705473 T DK03705473 T DK 03705473T DK 03705473 T DK03705473 T DK 03705473T DK 1483371 T3 DK1483371 T3 DK 1483371T3
- Authority
- DK
- Denmark
- Prior art keywords
- umbilical cord
- cord blood
- mesenchymal stem
- stem cells
- cells
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
- C12N5/0665—Blood-borne mesenchymal stem cells, e.g. from umbilical cord blood
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/20—Transition metals
- C12N2500/24—Iron; Fe chelators; Transferrin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/32—Amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/42—Organic phosphate, e.g. beta glycerophosphate
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/15—Transforming growth factor beta (TGF-β)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Developmental Biology & Embryology (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Materials For Medical Uses (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR20020008639 | 2002-02-19 | ||
PCT/KR2003/000339 WO2003070922A1 (en) | 2002-02-19 | 2003-02-19 | Isolation and culture-expansion methods of mesenchymal stem/progenitor cells from umbilical cord blood, and differentiation method of umbilical cord blood-derived mesenchymal stem/progenitor cells into various mesenchymal tissues |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1483371T3 true DK1483371T3 (da) | 2007-10-29 |
Family
ID=27751895
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK03705473T DK1483371T3 (da) | 2002-02-19 | 2003-02-19 | Isolerings- og kulturdyrkningsmetoder til mesenkymstamceller fra navlestrengsblod og differentieringsmetode til fra-navlestrengsblod-opnåede mesenkymstamceller til forskellige mesenkymvæv |
Country Status (11)
Country | Link |
---|---|
US (2) | US20050118714A1 (da) |
EP (1) | EP1483371B1 (da) |
JP (1) | JP2005517441A (da) |
KR (1) | KR100489248B1 (da) |
CN (1) | CN1281739C (da) |
AT (1) | ATE365793T1 (da) |
AU (1) | AU2003207399A1 (da) |
DE (1) | DE60314602T2 (da) |
DK (1) | DK1483371T3 (da) |
ES (1) | ES2287447T3 (da) |
WO (1) | WO2003070922A1 (da) |
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US7560280B2 (en) * | 2000-11-03 | 2009-07-14 | Kourion Therapeutics Gmbh | Human cord blood derived unrestricted somatic stem cells (USSC) |
US20040115804A1 (en) * | 2002-12-13 | 2004-06-17 | Yu-Show Fu | Cell system for generating somatic cells |
JP4950660B2 (ja) | 2003-06-27 | 2012-06-13 | エチコン、インコーポレイテッド | 分娩後由来細胞を使用する眼組織の修復および再生 |
US7875272B2 (en) | 2003-06-27 | 2011-01-25 | Ethicon, Incorporated | Treatment of stroke and other acute neuraldegenerative disorders using postpartum derived cells |
US8790637B2 (en) | 2003-06-27 | 2014-07-29 | DePuy Synthes Products, LLC | Repair and regeneration of ocular tissue using postpartum-derived cells |
US9592258B2 (en) | 2003-06-27 | 2017-03-14 | DePuy Synthes Products, Inc. | Treatment of neurological injury by administration of human umbilical cord tissue-derived cells |
US9572840B2 (en) | 2003-06-27 | 2017-02-21 | DePuy Synthes Products, Inc. | Regeneration and repair of neural tissue using postpartum-derived cells |
JP2007508023A (ja) * | 2003-10-14 | 2007-04-05 | ウニヴァズィテーツクリニークム ハンブルク−エッペンドルフ | 間葉幹細胞由来の血液生成物 |
US20090181087A1 (en) * | 2003-12-19 | 2009-07-16 | Viacell, Inc. | Use of human cord blood-derived pluripotent cells for the treatment of disease |
EP1544290A1 (en) * | 2003-12-19 | 2005-06-22 | Yu-Show Fu | A cell system for generating somatic cells |
US7816137B2 (en) | 2004-01-30 | 2010-10-19 | Lifecord Inc. | Method for isolating and culturing multipotent progenitor cells from umbilical cord blood |
WO2006015214A2 (en) * | 2004-07-29 | 2006-02-09 | Steenblock Research Institute, Inc. | Umbilical cord stem cell composition & method of treating neurological diseases |
PL1789534T3 (pl) | 2004-08-16 | 2015-03-31 | Cellresearch Corp Pte Ltd | Wyodrębnienie komórek macierzystych/progenitorowych z błony owodniowej pępowiny |
US20060045872A1 (en) * | 2004-08-25 | 2006-03-02 | Universidad Autonoma De Madrid Ciudad Universitaria de Cantoblanco | Use of adipose tissue-derived stromal stem cells in treating fistula |
AU2005322068B2 (en) | 2004-12-23 | 2011-09-01 | Ethicon Incorporated | Treatment of stroke and other acute neural degenerative disorders using postpartum derived cells |
AU2006249302A1 (en) * | 2005-05-27 | 2006-11-30 | Emory University | Chondrogenic compositions and methods of use |
GB0511723D0 (en) * | 2005-06-09 | 2005-07-13 | Smith & Nephew | Placental stem cells |
WO2007011088A1 (en) * | 2005-07-20 | 2007-01-25 | Seoul National University Industry Foundation | Method for culturingand proliferating hematopoietic stem cells and progenitor cells using human endometrial cells |
DE602005017812D1 (de) * | 2005-08-26 | 2009-12-31 | Seoul Nat Univ Ind Foundation | Multipotente blutstammzellen aus der nabelschnur und zellbehandlungsmittel damit zur behandlung der ischämischen krankheit |
EP1767617A1 (en) * | 2005-09-26 | 2007-03-28 | Letizia Mazzini | Mesenchymal stem cells isolation and expansion method and uses thereof |
US8287854B2 (en) | 2005-10-21 | 2012-10-16 | Cellresearch Corporation Pte Ltd | Skin equivalents derived from umbilical cord mesenchymal stem/progenitor cells and umbilical cord epithelial stem/progenitor cells |
KR100697326B1 (ko) * | 2005-12-02 | 2007-03-20 | 재단법인서울대학교산학협력재단 | Oct4 발현능을 가지는 제대혈 유래 다분화능 성체줄기세포 및 그의 제조방법 |
PL1971681T3 (pl) | 2005-12-16 | 2018-01-31 | Depuy Synthes Products Inc | Kompozycje oraz sposoby do hamowania niepożądanej odpowiedzi immunologicznej w przypadku transplantacji z brakiem zgodności tkankowej |
US9125906B2 (en) | 2005-12-28 | 2015-09-08 | DePuy Synthes Products, Inc. | Treatment of peripheral vascular disease using umbilical cord tissue-derived cells |
EP1976977B1 (en) * | 2005-12-29 | 2015-07-08 | Anthrogenesis Corporation | Placental stem cell populations |
WO2007089102A1 (en) * | 2006-02-01 | 2007-08-09 | Samsungn Life Public Welfare Foundation | Composition for treating developmental and/or chronic lung diseases comprising cells separated or proliferated from umbilical cord blood |
US20070178073A1 (en) | 2006-02-01 | 2007-08-02 | Samsung Life Public Welfare Foundation | Composition Comprising Separated or Proliferated Cells from Umbilical Cord Blood for Treating Developmental and/or Chronic Lung Disease |
WO2007114740A2 (fr) * | 2006-04-04 | 2007-10-11 | Trans-Technologies Ltd | Transplant biologique destiné à la thérapie cellulaire à base de cellules souches mésenchymateuses, obtenues à partir de la moelle osseuse |
ITTO20060282A1 (it) * | 2006-04-14 | 2007-10-15 | Univ Degli Studi Torino | Mezzo di coltura e composizione farmaceutica per la rigenerazione del tessuto cartilagineo relativo procedimento relativi usi e prodotti |
CN100453640C (zh) * | 2006-04-29 | 2009-01-21 | 中国医学科学院血液学研究所 | 一种从脐带血中分离多能成体祖细胞的方法 |
JPWO2007129428A1 (ja) * | 2006-05-02 | 2009-12-24 | 株式会社ステリック再生医科学研究所 | 幹細胞の単離方法 |
US9598673B2 (en) * | 2006-05-19 | 2017-03-21 | Creative Medical Health | Treatment of disc degenerative disease |
KR100791487B1 (ko) | 2006-05-29 | 2008-01-03 | 연세대학교 산학협력단 | 제대혈로부터 간엽줄기세포의 분리 및 배양 방법 |
JP5550902B2 (ja) * | 2006-06-26 | 2014-07-16 | テルモ ビーシーティー、インコーポレーテッド | 間葉系幹細胞の培養方法 |
KR100812544B1 (ko) * | 2006-10-19 | 2008-03-13 | 재단법인서울대학교산학협력재단 | 제대혈 유래 다분화능 줄기세포 및 이를 함유하는 허혈성괴사질환 치료용 세포치료제 |
JP5670053B2 (ja) | 2006-11-13 | 2015-02-18 | エシコン・インコーポレイテッドEthicon, Incorporated | マイクロキャリアを使用した、産褥由来の細胞の生体外での拡大 |
KR100902569B1 (ko) | 2007-01-19 | 2009-06-11 | 재단법인서울대학교산학협력재단 | 인간 탯줄 유래 중간엽 줄기세포 및 이의 확립방법 |
AU2007326171B2 (en) | 2006-11-30 | 2012-11-15 | Medipost Co., Ltd. | Use of a composition contaning human umbilical cord blood-derived mesenchymal stem cell for inducing differentiation and proliferation of neural precursor cells or neural stem cells to neural cells |
JP2010530214A (ja) * | 2007-03-01 | 2010-09-09 | クライオ−セル インターナショナル インコーポレイテッド | 子宮内膜細胞/月経血細胞の獲得、単離および凍結保存 |
KR101039235B1 (ko) | 2007-08-29 | 2011-06-07 | 메디포스트(주) | 제대혈 유래 간엽줄기세포를 포함하는 인터루킨-8 또는지알오-알파 발현 세포가 관련된 질병의 진단, 예방 또는치료용 조성물 |
SI2200622T2 (sl) * | 2007-09-19 | 2015-09-30 | Pluristem Ltd. | Adherentne celice iz adipoznih ali placentnih tkiv in njihova uporaba pri terapiji |
CN101543644B (zh) * | 2008-03-27 | 2012-07-25 | 中国人民解放军总医院 | 无支架工程软骨组织的构建方法及其产品 |
CN105030828B (zh) * | 2008-06-25 | 2020-10-02 | 麦瑟布莱斯特公司 | 椎间盘的修复和/或重建 |
KR20100054711A (ko) | 2008-11-14 | 2010-05-25 | 메디포스트(주) | 간엽 줄기세포 또는 이의 배양액을 포함하는 신경질환의 예방 또는 치료용 조성물 |
US10179900B2 (en) | 2008-12-19 | 2019-01-15 | DePuy Synthes Products, Inc. | Conditioned media and methods of making a conditioned media |
ES2665883T3 (es) | 2008-12-19 | 2018-04-30 | DePuy Synthes Products, Inc. | Tratamiento de enfermedades y trastornos pulmonares y pulmonares |
DE102009053519B4 (de) * | 2009-02-27 | 2013-05-16 | Ulrike Haas | Verfahren zur Gewinnung von Myofibroblasten zur Herstellung von zur Transplantation geeignetem Gewebe |
KR101764437B1 (ko) * | 2009-03-20 | 2017-08-02 | 메소블라스트, 아이엔씨. | 재프로그램된 다분화능 세포의 생성 방법 |
BRPI1013409A2 (pt) | 2009-03-26 | 2018-01-16 | Advanced Tech And Regenerative Medicine Llc | células de tecido de cordão umbilical humano como terapia para doença de alzheimer |
EP2431460B1 (en) * | 2009-05-13 | 2015-10-14 | Medipost, Co., Ltd. | Tsp-1, tsp-2 and il-17br associated with stem cell differentiation |
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CN102198156A (zh) * | 2010-03-26 | 2011-09-28 | 傅毓秀 | 用于治疗皮肤创伤之医药组合物 |
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CN102250837B (zh) * | 2011-06-28 | 2013-03-06 | 江苏省北科生物科技有限公司 | 脐带间充质干细胞数字化自动生产方法 |
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CN106377547B (zh) * | 2016-09-30 | 2019-05-31 | 孔五一 | 脐带血再生粒子的提取方法及其用途 |
CN106635968A (zh) * | 2016-10-14 | 2017-05-10 | 中卫华医(北京)生物科技有限公司 | 人脐带源间充质干细胞诱导分化成软骨细胞的方法 |
TWI656215B (zh) * | 2017-11-28 | 2019-04-11 | 宏齊科技股份有限公司 | 自周邊血液製備間質幹細胞群的方法及其用途 |
US11285177B2 (en) | 2018-01-03 | 2022-03-29 | Globus Medical, Inc. | Allografts containing viable cells and methods thereof |
KR102315584B1 (ko) | 2020-05-29 | 2021-10-21 | 단국대학교 천안캠퍼스 산학협력단 | 청각 내이 내 lgr5+ 청각 전구세포 분리방법 |
CN113249315A (zh) * | 2021-05-31 | 2021-08-13 | 上海南滨江细胞生物科技有限公司 | 一种脐血含有间充质干细胞的培养方法 |
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US5837539A (en) * | 1990-11-16 | 1998-11-17 | Osiris Therapeutics, Inc. | Monoclonal antibodies for human mesenchymal stem cells |
WO1997039104A1 (en) * | 1996-04-17 | 1997-10-23 | Osiris Therapeutics, Inc. | Cryopreservation and extensive subculturing of human mesenchymal stem cells |
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EP1082410B1 (en) * | 1998-05-29 | 2007-08-01 | Osiris Therapeutics, Inc. | Human cd45+ and/or fibroblast + mesenchymal stem cells |
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JP4621410B2 (ja) * | 2000-06-26 | 2011-01-26 | Ncメディカルリサーチ株式会社 | 神経細胞へ分化しうる細胞分画の調製方法及び神経変性疾患治療薬の製造方法 |
US7560280B2 (en) * | 2000-11-03 | 2009-07-14 | Kourion Therapeutics Gmbh | Human cord blood derived unrestricted somatic stem cells (USSC) |
CN1272022C (zh) * | 2001-08-14 | 2006-08-30 | 美迪宝斯特有限公司 | 用于治疗关节软骨损伤的组合物 |
-
2003
- 2003-02-19 CN CNB038036061A patent/CN1281739C/zh not_active Expired - Lifetime
- 2003-02-19 ES ES03705473T patent/ES2287447T3/es not_active Expired - Lifetime
- 2003-02-19 AU AU2003207399A patent/AU2003207399A1/en not_active Abandoned
- 2003-02-19 JP JP2003569815A patent/JP2005517441A/ja active Pending
- 2003-02-19 EP EP03705473A patent/EP1483371B1/en not_active Expired - Lifetime
- 2003-02-19 US US10/503,134 patent/US20050118714A1/en not_active Abandoned
- 2003-02-19 DE DE60314602T patent/DE60314602T2/de not_active Expired - Lifetime
- 2003-02-19 AT AT03705473T patent/ATE365793T1/de not_active IP Right Cessation
- 2003-02-19 KR KR10-2003-0010269A patent/KR100489248B1/ko active IP Right Grant
- 2003-02-19 DK DK03705473T patent/DK1483371T3/da active
- 2003-02-19 WO PCT/KR2003/000339 patent/WO2003070922A1/en active IP Right Grant
-
2009
- 2009-10-14 US US12/579,140 patent/US20100184218A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CN1630717A (zh) | 2005-06-22 |
JP2005517441A (ja) | 2005-06-16 |
WO2003070922A1 (en) | 2003-08-28 |
CN1281739C (zh) | 2006-10-25 |
US20050118714A1 (en) | 2005-06-02 |
DE60314602T2 (de) | 2008-02-28 |
AU2003207399A1 (en) | 2003-09-09 |
KR100489248B1 (ko) | 2005-05-11 |
US20100184218A1 (en) | 2010-07-22 |
ATE365793T1 (de) | 2007-07-15 |
EP1483371A1 (en) | 2004-12-08 |
ES2287447T3 (es) | 2007-12-16 |
KR20030069115A (ko) | 2003-08-25 |
DE60314602D1 (de) | 2007-08-09 |
EP1483371A4 (en) | 2005-07-27 |
EP1483371B1 (en) | 2007-06-27 |
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