JP2013532492A5 - - Google Patents
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- JP2013532492A5 JP2013532492A5 JP2013523366A JP2013523366A JP2013532492A5 JP 2013532492 A5 JP2013532492 A5 JP 2013532492A5 JP 2013523366 A JP2013523366 A JP 2013523366A JP 2013523366 A JP2013523366 A JP 2013523366A JP 2013532492 A5 JP2013532492 A5 JP 2013532492A5
- Authority
- JP
- Japan
- Prior art keywords
- albumin
- pluripotent stem
- free medium
- cells
- human
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 238000000034 method Methods 0.000 claims 26
- 239000002609 medium Substances 0.000 claims 24
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 18
- 210000001778 pluripotent stem cell Anatomy 0.000 claims 15
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 10
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 10
- 210000004027 cell Anatomy 0.000 claims 10
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims 10
- 102000004877 Insulin Human genes 0.000 claims 9
- 108090001061 Insulin Proteins 0.000 claims 9
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 claims 9
- 102000004338 Transferrin Human genes 0.000 claims 9
- 108090000901 Transferrin Proteins 0.000 claims 9
- 150000001413 amino acids Chemical class 0.000 claims 9
- 229940125396 insulin Drugs 0.000 claims 9
- 150000003839 salts Chemical class 0.000 claims 9
- 229910052711 selenium Inorganic materials 0.000 claims 9
- 239000011669 selenium Substances 0.000 claims 9
- 239000012581 transferrin Substances 0.000 claims 9
- 229940088594 vitamin Drugs 0.000 claims 9
- 229930003231 vitamin Natural products 0.000 claims 9
- 235000013343 vitamin Nutrition 0.000 claims 9
- 239000011782 vitamin Substances 0.000 claims 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 9
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 8
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims 8
- 239000008103 glucose Substances 0.000 claims 8
- 230000008672 reprogramming Effects 0.000 claims 7
- 229960001031 glucose Drugs 0.000 claims 6
- 229940024606 amino acid Drugs 0.000 claims 5
- 239000003112 inhibitor Substances 0.000 claims 5
- 239000011435 rock Substances 0.000 claims 5
- 238000010367 cloning Methods 0.000 claims 4
- 210000001082 somatic cell Anatomy 0.000 claims 4
- 230000010261 cell growth Effects 0.000 claims 3
- 239000011159 matrix material Substances 0.000 claims 3
- LZAXPYOBKSJSEX-UHFFFAOYSA-N blebbistatin Chemical compound C1CC2(O)C(=O)C3=CC(C)=CC=C3N=C2N1C1=CC=CC=C1 LZAXPYOBKSJSEX-UHFFFAOYSA-N 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 239000001963 growth medium Substances 0.000 claims 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 claims 2
- FERIUCNNQQJTOY-UHFFFAOYSA-M Butyrate Chemical compound CCCC([O-])=O FERIUCNNQQJTOY-UHFFFAOYSA-M 0.000 claims 1
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Natural products CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 206010021143 Hypoxia Diseases 0.000 claims 1
- 102100035140 Vitronectin Human genes 0.000 claims 1
- 108010031318 Vitronectin Proteins 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 210000001671 embryonic stem cell Anatomy 0.000 claims 1
- 230000008014 freezing Effects 0.000 claims 1
- 238000007710 freezing Methods 0.000 claims 1
- 229960000890 hydrocortisone Drugs 0.000 claims 1
- 230000001146 hypoxic effect Effects 0.000 claims 1
- 210000004263 induced pluripotent stem cell Anatomy 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 230000007774 longterm Effects 0.000 claims 1
- 238000007747 plating Methods 0.000 claims 1
- 239000013598 vector Substances 0.000 claims 1
- 239000013603 viral vector Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37112810P | 2010-08-05 | 2010-08-05 | |
| US61/371,128 | 2010-08-05 | ||
| PCT/US2011/046796 WO2012019122A2 (en) | 2010-08-05 | 2011-08-05 | Simplified basic media for human pluripotent cell culture |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016186896A Division JP2017018137A (ja) | 2010-08-05 | 2016-09-26 | ヒト多能性細胞培養のための簡易基本培地 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013532492A JP2013532492A (ja) | 2013-08-19 |
| JP2013532492A5 true JP2013532492A5 (https=) | 2014-09-25 |
| JP6043999B2 JP6043999B2 (ja) | 2016-12-14 |
Family
ID=44543813
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013523366A Active JP6043999B2 (ja) | 2010-08-05 | 2011-08-05 | ヒト多能性細胞培養のための簡易基本培地 |
| JP2016186896A Pending JP2017018137A (ja) | 2010-08-05 | 2016-09-26 | ヒト多能性細胞培養のための簡易基本培地 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016186896A Pending JP2017018137A (ja) | 2010-08-05 | 2016-09-26 | ヒト多能性細胞培養のための簡易基本培地 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US9279103B2 (https=) |
| EP (1) | EP2601288B1 (https=) |
| JP (2) | JP6043999B2 (https=) |
| KR (1) | KR101829488B1 (https=) |
| CN (2) | CN108531444A (https=) |
| AU (1) | AU2011285531B2 (https=) |
| BR (2) | BR112013002811A8 (https=) |
| CA (1) | CA2807418C (https=) |
| DK (1) | DK2601288T3 (https=) |
| IL (1) | IL224431A (https=) |
| SG (1) | SG187699A1 (https=) |
| WO (1) | WO2012019122A2 (https=) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8017395B2 (en) | 2004-12-17 | 2011-09-13 | Lifescan, Inc. | Seeding cells on porous supports |
| US9080145B2 (en) | 2007-07-01 | 2015-07-14 | Lifescan Corporation | Single pluripotent stem cell culture |
| DK2185693T3 (da) | 2007-07-31 | 2019-09-23 | Lifescan Inc | Differentiering af humane embryoniske stamceller |
| CA2954431C (en) | 2007-11-27 | 2021-08-24 | Lifescan, Inc. | Differentiation of human embryonic stem cells to pancreatic cells |
| JP5733986B2 (ja) | 2008-02-21 | 2015-06-10 | ヤンセン バイオテツク，インコーポレーテツド | 細胞の付着、培養、及び剥離のための方法、表面改質されたプレート、並びに組成物 |
| EP2942392B1 (en) | 2008-06-30 | 2018-10-03 | Janssen Biotech, Inc. | Differentiation of pluripotent stem cells |
| US9234178B2 (en) | 2008-10-31 | 2016-01-12 | Janssen Biotech, Inc. | Differentiation of human pluripotent stem cells |
| EP2350265B1 (en) | 2008-10-31 | 2019-04-17 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells to the pancreatic endocrine lineage |
| KR101687344B1 (ko) | 2008-11-20 | 2016-12-16 | 얀센 바이오테크 인코포레이티드 | 평면 기재상의 세포 부착 및 배양을 위한 방법 및 조성물 |
| KR101774546B1 (ko) | 2008-11-20 | 2017-09-04 | 얀센 바이오테크 인코포레이티드 | 마이크로-캐리어 상의 만능 줄기 세포 배양 |
| CN102482643B (zh) | 2009-07-20 | 2016-06-29 | 詹森生物科技公司 | 人胚胎干细胞的分化 |
| SG10201408552YA (en) | 2009-12-23 | 2015-02-27 | Janssen Biotech Inc | Differentiation of human embryonic stem cells |
| PH12012501686A1 (en) | 2010-03-01 | 2020-10-19 | Janssen Biotech Inc | Methods for purifying cells derived from pluripotent stem cells |
| RU2587634C2 (ru) | 2010-05-12 | 2016-06-20 | Янссен Байотек, Инк. | Дифференцирование эмбриональных стволовых клеток человека |
| US9279107B2 (en) | 2010-08-05 | 2016-03-08 | Wisconsin Alumni Research Foundation | Simplified basic media for human pluripotent cell culture |
| PL2853589T3 (pl) | 2010-08-31 | 2018-05-30 | Janssen Biotech, Inc | Różnicowanie ludzkich zarodkowych komórek macierzystych |
| CN103154237B (zh) | 2010-08-31 | 2016-03-16 | 詹森生物科技公司 | 多能干细胞的分化 |
| EP3372672A1 (en) | 2010-08-31 | 2018-09-12 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells |
| AU2012347919B2 (en) | 2011-12-05 | 2017-02-02 | Factor Bioscience Inc. | Methods and products for transfecting cells |
| US8497124B2 (en) | 2011-12-05 | 2013-07-30 | Factor Bioscience Inc. | Methods and products for reprogramming cells to a less differentiated state |
| WO2013090919A1 (en) | 2011-12-16 | 2013-06-20 | Wisconsin Alumni Research Foundation | Fgf-2 having enhanced stability |
| FI2794857T3 (fi) | 2011-12-22 | 2026-03-25 | Janssen Biotech Inc | Ihmisen alkion kantasolujen erilaistaminen yksittäisiksi hormonaalisiksi insuliinipositiivisiksi soluiksi |
| CA2866590A1 (en) | 2012-03-07 | 2013-09-12 | Janssen Biotech, Inc. | Defined media for expansion and maintenance of pluripotent stem cells |
| EP3450544A1 (en) | 2012-06-08 | 2019-03-06 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells into pancreatic endodrine cells |
| KR102121086B1 (ko) | 2012-11-01 | 2020-06-09 | 팩터 바이오사이언스 인크. | 세포에서 단백질을 발현시키는 방법들과 생성물들 |
| US10370644B2 (en) | 2012-12-31 | 2019-08-06 | Janssen Biotech, Inc. | Method for making human pluripotent suspension cultures and cells derived therefrom |
| DK2938723T3 (da) | 2012-12-31 | 2023-02-20 | Janssen Biotech Inc | Differentiering af humane embryonale stamceller til pancreatiske endokrine celler under anvendelse af hb9-regulatorer |
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| BR112015015714A2 (pt) | 2012-12-31 | 2017-07-11 | Janssen Biotech Inc | suspensão e aglomeração de células pluripotentes humanas para diferenciação em célu-las endócrinas pancreáticas |
| SG11201505965TA (en) | 2013-01-31 | 2015-09-29 | Ajinomoto Kk | Culture method for stable undifferentiated proliferation of pluripotent stem cells |
| EP3015551B1 (en) * | 2013-06-28 | 2019-03-06 | Kaneka Corporation | Method for screening for pluripotent stem cell growth-promoting factor |
| WO2015006762A1 (en) * | 2013-07-12 | 2015-01-15 | The Board Of Trustees Of The University Of Arkansas | Methods and compositions for expanding long-term hematopoietic stem cell populations |
| KR101655383B1 (ko) | 2013-07-27 | 2016-09-08 | 고려대학교 산학협력단 | 소분자 화합물을 포함하는 만능성 줄기세포의 염색체 안정성 유지용 조성물 |
| WO2015042356A1 (en) | 2013-09-19 | 2015-03-26 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Chemically defined culture medium for stem cell maintenance and differentiation |
| EP3099801B1 (en) | 2014-01-31 | 2020-03-18 | Factor Bioscience Inc. | Synthetic rna for use in the treatment of dystrophic epidermolysis bullosa |
| JP6422221B2 (ja) * | 2014-03-04 | 2018-11-14 | 旭化成株式会社 | 多能性幹細胞からなる細胞塊製造方法 |
| US11015169B2 (en) | 2014-03-26 | 2021-05-25 | Kyoto University | Culture medium for pluripotent stem cells |
| WO2015175307A1 (en) | 2014-05-16 | 2015-11-19 | Janssen Biotech, Inc. | Use of small molecules to enhance mafa expression in pancreatic endocrine cells |
| WO2016022992A1 (en) * | 2014-08-07 | 2016-02-11 | Duke University | Compositions and methods for the reprogramming of cells into cardiomyocytes |
| AU2015305515B2 (en) | 2014-08-19 | 2020-12-03 | FUJIFILM Cellular Dynamics, Inc. | Neural networks formed from cells derived from pluripotent stem cells |
| WO2016123100A1 (en) | 2015-01-26 | 2016-08-04 | Fate Therapeutics, Inc. | Methods and compositions for inducing hematopoietic cell differentiation |
| CA2976376A1 (en) | 2015-02-13 | 2016-08-18 | Factor Bioscience Inc. | Nucleic acid products and methods of administration thereof |
| SG11201803145RA (en) | 2015-11-04 | 2018-05-30 | Fate Therapeutics Inc | Methods and compositions for inducing hematopoietic cell differentiation |
| KR20250141836A (ko) | 2015-11-04 | 2025-09-29 | 페이트 세러퓨틱스, 인코포레이티드 | 만능 세포의 유전자 조작 |
| US10420803B2 (en) | 2016-04-14 | 2019-09-24 | Janssen Biotech, Inc. | Differentiation of pluripotent stem cells to intestinal midgut endoderm cells |
| IL308824A (en) | 2016-08-17 | 2024-01-01 | Factor Bioscience Inc | Nucleic acid products and methods of administration thereof |
| KR101953573B1 (ko) * | 2017-03-31 | 2019-03-05 | 한양대학교 에리카산학협력단 | 난황줄기세포 배양을 위한 우태아혈청 조성물 및 이의 제조방법 |
| SG11201909331UA (en) * | 2017-04-18 | 2019-11-28 | Fujifilm Cellular Dynamics Inc | Antigen-specific immune effector cells |
| TWI814738B (zh) | 2017-09-08 | 2023-09-11 | 日商日產化學股份有限公司 | 細胞保存材料 |
| KR102121602B1 (ko) * | 2018-06-27 | 2020-06-10 | 주식회사 티아라줄기세포연구소 | 지방줄기세포배양용 배지 조성물 제조방법, 지방줄기세포배양용 배지 조성물 제조방법과 줄기세포 유효성분 3저 추출법을 이용한 줄기세포파쇄추출물(쉘드줄기세포) 제조방법, 이를 이용한 항관절염 치료용 조성물, 이를 이용한 염증억제 효과를 갖는 조성물 및 세포재생 효과를 갖는 조성물 |
| JP7474520B2 (ja) * | 2019-04-05 | 2024-04-25 | ザ・ユニバーシティ・オブ・ホンコン | 哺乳類の拡大ポテンシャル幹細胞のための培地、その組成物および方法 |
| CA3145425A1 (en) | 2019-07-03 | 2021-01-07 | Factor Bioscience Inc. | Cationic lipids and uses thereof |
| US10501404B1 (en) | 2019-07-30 | 2019-12-10 | Factor Bioscience Inc. | Cationic lipids and transfection methods |
| JP2022548776A (ja) * | 2019-09-19 | 2022-11-21 | ノースウェスタン ユニバーシティ | ヒト人工多能性幹細胞のための費用効果の高い培地およびプロトコル |
| CN110564673A (zh) * | 2019-09-26 | 2019-12-13 | 广东工业大学 | 一种干细胞培养液及其应用 |
| CN110564678B (zh) * | 2019-10-12 | 2023-04-07 | 广东唯泰生物科技有限公司 | 脐带华通氏胶间充质干细胞成骨定向分化的方法 |
| GB202003618D0 (en) | 2020-03-12 | 2020-04-29 | Univ Bristol | Gene Therapy |
| EP4342977A1 (en) * | 2022-09-26 | 2024-03-27 | Ares Trading S.A. | Serum free medium |
| WO2024091801A2 (en) * | 2022-10-13 | 2024-05-02 | President And Fellows Of Harvard College | Methods and compositions for inducing cell differentiation |
| CN119020297A (zh) * | 2024-10-22 | 2024-11-26 | 江苏凯基生物技术股份有限公司 | 一种用于人诱导多能干细胞的化学成分限定培养基 |
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| US7439064B2 (en) | 2000-03-09 | 2008-10-21 | Wicell Research Institute, Inc. | Cultivation of human embryonic stem cells in the absence of feeder cells or without conditioned medium |
| ATE549395T1 (de) | 2004-09-08 | 2012-03-15 | Wisconsin Alumni Res Found | Medium und kultur von embryonalen stammzellen |
| EP1962719A4 (en) * | 2005-08-29 | 2011-05-04 | Technion Res And Dev Of Foundation Ltd | MEDIA FOR BREEDING STEM CELLS |
| GB0606671D0 (en) | 2006-04-03 | 2006-05-10 | Plasso Technology Ltd | Cell Culture |
| US8513012B2 (en) * | 2008-05-02 | 2013-08-20 | Cellular Dynamics International, Inc. | Method for production of mast cells from stem cells |
| DK2356221T3 (en) * | 2008-10-24 | 2019-02-18 | Wisconsin Alumni Res Found | Pluripotent stem cells obtained by non-viral reprogramming |
| US9018010B2 (en) * | 2009-11-12 | 2015-04-28 | Technion Research & Development Foundation Limited | Culture media, cell cultures and methods of culturing pluripotent stem cells in an undifferentiated state |
-
2011
- 2011-08-05 US US13/204,354 patent/US9279103B2/en active Active
- 2011-08-05 CN CN201810229027.6A patent/CN108531444A/zh active Pending
- 2011-08-05 CA CA2807418A patent/CA2807418C/en active Active
- 2011-08-05 AU AU2011285531A patent/AU2011285531B2/en active Active
- 2011-08-05 BR BR112013002811A patent/BR112013002811A8/pt not_active Application Discontinuation
- 2011-08-05 KR KR1020137005512A patent/KR101829488B1/ko active Active
- 2011-08-05 CN CN2011800385969A patent/CN103180434A/zh active Pending
- 2011-08-05 BR BR122020000909-8A patent/BR122020000909B1/pt active IP Right Grant
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