JP2011206064A5 - - Google Patents
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- JP2011206064A5 JP2011206064A5 JP2011165510A JP2011165510A JP2011206064A5 JP 2011206064 A5 JP2011206064 A5 JP 2011206064A5 JP 2011165510 A JP2011165510 A JP 2011165510A JP 2011165510 A JP2011165510 A JP 2011165510A JP 2011206064 A5 JP2011206064 A5 JP 2011206064A5
- Authority
- JP
- Japan
- Prior art keywords
- medium
- stem cells
- culture
- embryonic stem
- human
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000002609 medium Substances 0.000 claims 20
- 210000001671 embryonic stem cell Anatomy 0.000 claims 17
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 claims 12
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 12
- 102000018233 Fibroblast Growth Factor Human genes 0.000 claims 9
- 108050007372 Fibroblast Growth Factor Proteins 0.000 claims 9
- 229940126864 fibroblast growth factor Drugs 0.000 claims 9
- 210000004027 cell Anatomy 0.000 claims 7
- OGNSCSPNOLGXSM-UHFFFAOYSA-N (+/-)-DABA Natural products NCCC(N)C(O)=O OGNSCSPNOLGXSM-UHFFFAOYSA-N 0.000 claims 6
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 6
- 102000004877 Insulin Human genes 0.000 claims 6
- 108090001061 Insulin Proteins 0.000 claims 6
- HXEACLLIILLPRG-YFKPBYRVSA-N L-pipecolic acid Chemical compound [O-]C(=O)[C@@H]1CCCC[NH2+]1 HXEACLLIILLPRG-YFKPBYRVSA-N 0.000 claims 6
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 claims 6
- 102000004338 Transferrin Human genes 0.000 claims 6
- 108090000901 Transferrin Proteins 0.000 claims 6
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 6
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 6
- 150000001413 amino acids Chemical class 0.000 claims 6
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims 6
- 238000012258 culturing Methods 0.000 claims 6
- 229960003692 gamma aminobutyric acid Drugs 0.000 claims 6
- 239000008103 glucose Substances 0.000 claims 6
- 229940125396 insulin Drugs 0.000 claims 6
- HXEACLLIILLPRG-RXMQYKEDSA-N l-pipecolic acid Natural products OC(=O)[C@H]1CCCCN1 HXEACLLIILLPRG-RXMQYKEDSA-N 0.000 claims 6
- 229910052744 lithium Inorganic materials 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- 239000000758 substrate Substances 0.000 claims 6
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims 6
- 239000012581 transferrin Substances 0.000 claims 6
- 229940088594 vitamin Drugs 0.000 claims 6
- 229930003231 vitamin Natural products 0.000 claims 6
- 235000013343 vitamin Nutrition 0.000 claims 6
- 239000011782 vitamin Substances 0.000 claims 6
- 229940024606 amino acid Drugs 0.000 claims 5
- 229960001031 glucose Drugs 0.000 claims 5
- 210000000130 stem cell Anatomy 0.000 claims 5
- 238000004113 cell culture Methods 0.000 claims 4
- 239000003636 conditioned culture medium Substances 0.000 claims 4
- 102000002584 Octamer Transcription Factor-3 Human genes 0.000 claims 3
- 108010068425 Octamer Transcription Factor-3 Proteins 0.000 claims 3
- 239000001963 growth medium Substances 0.000 claims 3
- 102000009027 Albumins Human genes 0.000 claims 2
- 108010088751 Albumins Proteins 0.000 claims 2
- 108010035532 Collagen Proteins 0.000 claims 2
- 102000008186 Collagen Human genes 0.000 claims 2
- 108010067306 Fibronectins Proteins 0.000 claims 2
- 102000016359 Fibronectins Human genes 0.000 claims 2
- 108060003393 Granulin Proteins 0.000 claims 2
- 108010085895 Laminin Proteins 0.000 claims 2
- 102000007547 Laminin Human genes 0.000 claims 2
- 108010031318 Vitronectin Proteins 0.000 claims 2
- 102100035140 Vitronectin Human genes 0.000 claims 2
- 229920001436 collagen Polymers 0.000 claims 2
- FDJKUWYYUZCUJX-AJKRCSPLSA-N N-glycoloyl-beta-neuraminic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@@H]1O[C@](O)(C(O)=O)C[C@H](O)[C@H]1NC(=O)CO FDJKUWYYUZCUJX-AJKRCSPLSA-N 0.000 claims 1
- FDJKUWYYUZCUJX-UHFFFAOYSA-N N-glycolyl-beta-neuraminic acid Natural products OCC(O)C(O)C1OC(O)(C(O)=O)CC(O)C1NC(=O)CO FDJKUWYYUZCUJX-UHFFFAOYSA-N 0.000 claims 1
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 claims 1
- 206010039491 Sarcoma Diseases 0.000 claims 1
- 102000040945 Transcription factor Human genes 0.000 claims 1
- 108091023040 Transcription factor Proteins 0.000 claims 1
- 210000002469 basement membrane Anatomy 0.000 claims 1
- 239000006143 cell culture medium Substances 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000012606 in vitro cell culture Methods 0.000 claims 1
- 210000001778 pluripotent stem cell Anatomy 0.000 claims 1
- 230000002035 prolonged effect Effects 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000000717 retained effect Effects 0.000 claims 1
- 125000005629 sialic acid group Chemical group 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60804004P | 2004-09-08 | 2004-09-08 | |
| US60/608,040 | 2004-09-08 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007531300A Division JP5420837B2 (ja) | 2004-09-08 | 2005-09-08 | 胚幹細胞の培地及び培養 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011206064A JP2011206064A (ja) | 2011-10-20 |
| JP2011206064A5 true JP2011206064A5 (https=) | 2011-12-01 |
Family
ID=35351611
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007531300A Expired - Lifetime JP5420837B2 (ja) | 2004-09-08 | 2005-09-08 | 胚幹細胞の培地及び培養 |
| JP2011165510A Pending JP2011206064A (ja) | 2004-09-08 | 2011-07-28 | 胚幹細胞の培地及び培養 |
| JP2013202449A Pending JP2014014373A (ja) | 2004-09-08 | 2013-09-27 | 胚幹細胞の培地及び培養 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007531300A Expired - Lifetime JP5420837B2 (ja) | 2004-09-08 | 2005-09-08 | 胚幹細胞の培地及び培養 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013202449A Pending JP2014014373A (ja) | 2004-09-08 | 2013-09-27 | 胚幹細胞の培地及び培養 |
Country Status (17)
| Country | Link |
|---|---|
| US (5) | US7449334B2 (https=) |
| EP (1) | EP1791948B1 (https=) |
| JP (3) | JP5420837B2 (https=) |
| KR (1) | KR101264940B1 (https=) |
| CN (2) | CN101052712A (https=) |
| AT (1) | ATE549395T1 (https=) |
| AU (1) | AU2005282510B2 (https=) |
| BR (1) | BRPI0514778B1 (https=) |
| CA (1) | CA2579643C (https=) |
| ES (1) | ES2383813T3 (https=) |
| GB (1) | GB2432846B (https=) |
| IL (1) | IL181437A (https=) |
| IS (1) | IS8618A (https=) |
| MX (1) | MX2007002390A (https=) |
| NO (1) | NO344695B1 (https=) |
| NZ (1) | NZ553241A (https=) |
| WO (1) | WO2006029197A1 (https=) |
Families Citing this family (90)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE549395T1 (de) * | 2004-09-08 | 2012-03-15 | Wisconsin Alumni Res Found | Medium und kultur von embryonalen stammzellen |
| AU2005282414C1 (en) * | 2004-09-08 | 2011-04-07 | Wisconsin Alumni Research Foundation | Culturing human embryonic stem cells |
| US8017395B2 (en) | 2004-12-17 | 2011-09-13 | Lifescan, Inc. | Seeding cells on porous supports |
| JP2009500297A (ja) | 2005-06-08 | 2009-01-08 | セントカー・インコーポレーテツド | 眼の変性についての細胞療法 |
| WO2007016245A2 (en) * | 2005-07-29 | 2007-02-08 | Vivicells International, Llc | Reprogramming of adult or neonic stem cells and methods of use |
| GB2445338A (en) * | 2005-10-07 | 2008-07-02 | Cellartis Ab | A method for obtaining a xeno-free HBS cell line |
| US8741643B2 (en) | 2006-04-28 | 2014-06-03 | Lifescan, Inc. | Differentiation of pluripotent stem cells to definitive endoderm lineage |
| GB0613756D0 (en) * | 2006-07-12 | 2006-08-23 | Univ Sheffield | Cell culture medium |
| WO2008089351A1 (en) * | 2007-01-17 | 2008-07-24 | Wisconsin Alumni Research Foundation | Improved culture of stem cells |
| US8153427B2 (en) * | 2007-03-15 | 2012-04-10 | California Stem Cell, Inc. | Cardiomyocytes and methods of producing and purifying cardiomyocytes |
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| CA2954431C (en) | 2007-11-27 | 2021-08-24 | Lifescan, Inc. | Differentiation of human embryonic stem cells to pancreatic cells |
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| CA2307807C (en) * | 1997-10-23 | 2008-09-02 | Andrea G. Bodnar | Methods and materials for the growth of primate-derived primordial stem cells in feeder-free culture |
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| JP5128946B2 (ja) * | 2004-05-21 | 2013-01-23 | ウィセル リサーチ インスティテュート インコーポレイテッド | 胚性幹細胞のフィーダー非依存性長期培養 |
| ATE549395T1 (de) * | 2004-09-08 | 2012-03-15 | Wisconsin Alumni Res Found | Medium und kultur von embryonalen stammzellen |
| AU2005282414C1 (en) * | 2004-09-08 | 2011-04-07 | Wisconsin Alumni Research Foundation | Culturing human embryonic stem cells |
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