JP2009510186A5 - - Google Patents

Info

Publication number

JP2009510186A5

JP2009510186A5 JP2008531534A JP2008531534A JP2009510186A5 JP 2009510186 A5 JP2009510186 A5 JP 2009510186A5 JP 2008531534 A JP2008531534 A JP 2008531534A JP 2008531534 A JP2008531534 A JP 2008531534A JP 2009510186 A5 JP2009510186 A5 JP 2009510186A5

Authority

JP

Japan

Prior art keywords

hyaluronic acid

acid derivative

derivative according

aryl

alkyl

Prior art date

2006-09-26

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical class CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 43
• -1 2-octenyl Chemical group 0.000 claims 30
• 125000003118 aryl group Chemical group 0.000 claims 16
• 125000000217 alkyl group Chemical group 0.000 claims 13
• 238000000034 method Methods 0.000 claims 11
• 229920002674 hyaluronan Polymers 0.000 claims 8
• 229960003160 hyaluronic acid Drugs 0.000 claims 8
• 239000000203 mixture Substances 0.000 claims 6
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 6
• 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 6
• 150000002148 esters Chemical class 0.000 claims 4
• 125000003837 (C1-C20) alkyl group Chemical group 0.000 claims 3
• 241000193830 Bacillus <bacterium> Species 0.000 claims 3
• 150000008064 anhydrides Chemical class 0.000 claims 3
• 238000006467 substitution reaction Methods 0.000 claims 3
• 239000004480 active ingredient Substances 0.000 claims 2
• 239000013543 active substance Substances 0.000 claims 2
• 239000002537 cosmetic Substances 0.000 claims 2
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 2
• 239000000546 pharmaceutical excipient Substances 0.000 claims 2
• GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 1
• 206010052428 Wound Diseases 0.000 claims 1
• 208000027418 Wounds and injury Diseases 0.000 claims 1
• 239000002253 acid Substances 0.000 claims 1
• 229920002877 acrylic styrene acrylonitrile Polymers 0.000 claims 1
• 239000007864 aqueous solution Substances 0.000 claims 1
• 239000002775 capsule Substances 0.000 claims 1
• 238000006243 chemical reaction Methods 0.000 claims 1
• 239000013078 crystal Substances 0.000 claims 1
• 239000003085 diluting agent Substances 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
• 239000008101 lactose Substances 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 239000000463 material Substances 0.000 claims 1
• 239000003094 microcapsule Substances 0.000 claims 1
• 239000013081 microcrystal Substances 0.000 claims 1
• 239000002088 nanocapsule Substances 0.000 claims 1
• 239000001384 succinic acid Substances 0.000 claims 1
• 239000003981 vehicle Substances 0.000 claims 1
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
• 230000029663 wound healing Effects 0.000 claims 1
• 0 C*(C)OC(C(*)C1*)[C@](C(O)=O)OC1OC(C(*)C(C*)OC1C(C)(C)C)C1NC(C)=O Chemical compound C*(C)OC(C(*)C1*)[C@](C(O)=O)OC1OC(C(*)C(C*)OC1C(C)(C)C)C1NC(C)=O 0.000 description 2

Cited By (1)