JP2009528406A5 - - Google Patents

Info

Publication number

JP2009528406A5

JP2009528406A5 JP2008556657A JP2008556657A JP2009528406A5 JP 2009528406 A5 JP2009528406 A5 JP 2009528406A5 JP 2008556657 A JP2008556657 A JP 2008556657A JP 2008556657 A JP2008556657 A JP 2008556657A JP 2009528406 A5 JP2009528406 A5 JP 2009528406A5

Authority

JP

Japan

Prior art keywords

hyaluronic acid

alkyl

acid derivative

aryl

group

Prior art date

2007-03-02

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical class CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 25
• -1 aryl / alkyl sulfones Chemical class 0.000 claims 23
• 125000003118 aryl group Chemical group 0.000 claims 17
• 125000000217 alkyl group Chemical group 0.000 claims 15
• RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 11
• 230000002209 hydrophobic effect Effects 0.000 claims 8
• 238000000034 method Methods 0.000 claims 7
• 125000002877 alkyl aryl group Chemical group 0.000 claims 6
• 239000000203 mixture Substances 0.000 claims 5
• 125000003837 (C1-C20) alkyl group Chemical group 0.000 claims 4
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 4
• 229920002674 hyaluronan Polymers 0.000 claims 4
• 229960003160 hyaluronic acid Drugs 0.000 claims 4
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
• 125000005440 p-toluyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C(*)=O)C([H])([H])[H] 0.000 claims 4
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
• 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 4
• 238000004519 manufacturing process Methods 0.000 claims 3
• 238000006467 substitution reaction Methods 0.000 claims 3
• 206010052428 Wound Diseases 0.000 claims 2
• 208000027418 Wounds and injury Diseases 0.000 claims 2
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
• 201000004384 Alopecia Diseases 0.000 claims 1
• 239000004909 Moisturizer Substances 0.000 claims 1
• 206010028980 Neoplasm Diseases 0.000 claims 1
• 239000002253 acid Substances 0.000 claims 1
• 239000004480 active ingredient Substances 0.000 claims 1
• 239000013543 active substance Substances 0.000 claims 1
• 238000007259 addition reaction Methods 0.000 claims 1
• 230000033115 angiogenesis Effects 0.000 claims 1
• 239000007864 aqueous solution Substances 0.000 claims 1
• 230000036621 balding Effects 0.000 claims 1
• 201000011510 cancer Diseases 0.000 claims 1
• 239000002537 cosmetic Substances 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 208000024963 hair loss Diseases 0.000 claims 1
• 230000003676 hair loss Effects 0.000 claims 1
• 239000000463 material Substances 0.000 claims 1
• 230000001333 moisturizer Effects 0.000 claims 1
• 125000004365 octenyl group Chemical group C(=CCCCCCC)* 0.000 claims 1
• 201000008482 osteoarthritis Diseases 0.000 claims 1
• 230000029663 wound healing Effects 0.000 claims 1