CA2643714C - Aryl/alkyl vinyl sulfone hyaluronic acid derivatives - Google Patents
Aryl/alkyl vinyl sulfone hyaluronic acid derivatives Download PDFInfo
- Publication number
- CA2643714C CA2643714C CA2643714A CA2643714A CA2643714C CA 2643714 C CA2643714 C CA 2643714C CA 2643714 A CA2643714 A CA 2643714A CA 2643714 A CA2643714 A CA 2643714A CA 2643714 C CA2643714 C CA 2643714C
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- CA
- Canada
- Prior art keywords
- hyaluronic acid
- acid derivative
- composition
- alkyl
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- -1 Aryl/alkyl vinyl sulfone hyaluronic acid derivatives Chemical class 0.000 title claims abstract description 52
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical class CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims abstract description 189
- 238000000034 method Methods 0.000 claims abstract description 60
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 27
- 125000003118 aryl group Chemical group 0.000 claims abstract description 25
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 9
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- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 5
- GUBGYTABKSRVRQ-QKKXKWKRSA-N lactose group Chemical group OC1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)[C@H](O2)CO)[C@H](O1)CO GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 5
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- AFOSIXZFDONLBT-UHFFFAOYSA-N divinyl sulfone Chemical compound C=CS(=O)(=O)C=C AFOSIXZFDONLBT-UHFFFAOYSA-N 0.000 description 6
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- Polysaccharides And Polysaccharide Derivatives (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
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| DKPA200600305 | 2006-03-02 | ||
| DKPA200600305 | 2006-03-02 | ||
| DKPA200600312 | 2006-03-03 | ||
| DKPA200600312 | 2006-03-03 | ||
| PCT/DK2007/000108 WO2007098770A1 (en) | 2006-03-02 | 2007-03-02 | Aryl/alkyl vinyl sulfone hyaluronic acid derivatives |
Publications (2)
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| CA2643714A1 CA2643714A1 (en) | 2007-09-07 |
| CA2643714C true CA2643714C (en) | 2014-04-29 |
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| CA2643714A Expired - Fee Related CA2643714C (en) | 2006-03-02 | 2007-03-02 | Aryl/alkyl vinyl sulfone hyaluronic acid derivatives |
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| US (1) | US8071757B2 (enExample) |
| EP (1) | EP1994062B1 (enExample) |
| JP (1) | JP5399716B2 (enExample) |
| CN (1) | CN101415732B (enExample) |
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| BR (1) | BRPI0708128A2 (enExample) |
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| DK (1) | DK1994062T3 (enExample) |
| ES (1) | ES2329731T3 (enExample) |
| WO (1) | WO2007098770A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP5758797B2 (ja) | 2008-04-04 | 2015-08-05 | ユニバーシティ・オブ・ユタ・リサーチ・ファウンデイション | アルキル化半合成グリコサミノグリカンエーテルならびにその製造および使用方法 |
| CN101870739B (zh) * | 2009-04-23 | 2015-07-22 | 华东理工大学 | 多粘类芽孢杆菌胞外多糖及其应用 |
| KR101551681B1 (ko) | 2009-07-30 | 2015-09-09 | 카르빌란 테라퓨틱스, 인코포레이티드 | 변형된 히알루론산 폴리머 조성물 및 관련방법 |
| JP6062917B2 (ja) | 2011-03-23 | 2017-01-18 | ザ ユニバーシティ オブ ユタ リサーチ ファウンデイション | 泌尿器科の炎症の治療及び予防の方法 |
| ITMI20110644A1 (it) * | 2011-04-14 | 2012-10-15 | Giuliani Spa | Sistema per il rilascio prolungato di agenti cosmetici |
| JP5998201B2 (ja) * | 2011-04-20 | 2016-09-28 | カービラン セラピューティクス， インコーポレイテッド | Ｉｎ−ｓｉｔｕゲル形成組成物 |
| CZ2012842A3 (cs) * | 2012-11-27 | 2014-08-20 | Contipro Biotech S.R.O. | Nanomicelární kompozice na bázi C6-C18-acylovaného hyaluronanu, způsob přípravy C6-C18-acylovaného hyaluronanu, způsob přípravy nanomicelární kompozice a stabilizované nanomicelární kompozice a použití |
| JP6800984B2 (ja) * | 2015-10-05 | 2020-12-16 | ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム | 軟骨傷害の検出及び処置のためのマイクロ並びにナノデバイス |
| WO2018053111A1 (en) | 2016-09-15 | 2018-03-22 | University Of Utah Research Foundation | In situ gelling compositions for the treatment or prevention of inflammation and tissue damage |
| JP2020532643A (ja) * | 2017-09-01 | 2020-11-12 | ピーエムアイディージー・エルエルシーＰｍｉｄｇ，Ｌｌｃ | 官能基化および架橋ポリマー |
| CN111228653A (zh) | 2018-11-13 | 2020-06-05 | 格莱科米拉治疗公司 | 用电离辐射加强癌症治疗的方法 |
| KR102441798B1 (ko) * | 2021-07-15 | 2022-09-08 | 아주대학교산학협력단 | 히알루론산 복합체를 포함하는 피부 질환 예방 또는 치료용 약학 조성물 |
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| US5128326A (en) * | 1984-12-06 | 1992-07-07 | Biomatrix, Inc. | Drug delivery systems based on hyaluronans derivatives thereof and their salts and methods of producing same |
| JP2002516306A (ja) * | 1998-05-29 | 2002-06-04 | ボーン ケア インターナショナル インコーポレイテッド | ヒドロキシ−２５−エン−ビタミンｄ化合物の製造方法 |
| CA2550718C (en) * | 2003-12-30 | 2013-11-05 | Genzyme Corporation | Cohesive gels from cross-linked hyaluronan and/or hylan, their preparation and use |
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2007
- 2007-03-02 DE DE602007001593T patent/DE602007001593D1/de active Active
- 2007-03-02 AU AU2007219545A patent/AU2007219545B2/en not_active Ceased
- 2007-03-02 EP EP07702514A patent/EP1994062B1/en not_active Not-in-force
- 2007-03-02 WO PCT/DK2007/000108 patent/WO2007098770A1/en not_active Ceased
- 2007-03-02 ES ES07702514T patent/ES2329731T3/es active Active
- 2007-03-02 JP JP2008556657A patent/JP5399716B2/ja not_active Expired - Fee Related
- 2007-03-02 CN CN2007800076102A patent/CN101415732B/zh not_active Expired - Fee Related
- 2007-03-02 CA CA2643714A patent/CA2643714C/en not_active Expired - Fee Related
- 2007-03-02 BR BRPI0708128-6A patent/BRPI0708128A2/pt not_active IP Right Cessation
- 2007-03-02 DK DK07702514T patent/DK1994062T3/da active
- 2007-03-02 US US12/161,717 patent/US8071757B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN101415732A (zh) | 2009-04-22 |
| AU2007219545B2 (en) | 2011-11-24 |
| JP2009528406A (ja) | 2009-08-06 |
| CA2643714A1 (en) | 2007-09-07 |
| JP5399716B2 (ja) | 2014-01-29 |
| ES2329731T3 (es) | 2009-11-30 |
| EP1994062B1 (en) | 2009-07-15 |
| US20110257123A1 (en) | 2011-10-20 |
| US8071757B2 (en) | 2011-12-06 |
| DE602007001593D1 (de) | 2009-08-27 |
| DK1994062T3 (da) | 2009-11-16 |
| EP1994062A1 (en) | 2008-11-26 |
| CN101415732B (zh) | 2011-10-12 |
| AU2007219545A1 (en) | 2007-09-07 |
| WO2007098770A1 (en) | 2007-09-07 |
| BRPI0708128A2 (pt) | 2011-05-17 |
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