JP2009502969A - 非晶質エファビレンツ及びその製造 - Google Patents

非晶質エファビレンツ及びその製造 Download PDF

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Publication number
JP2009502969A
JP2009502969A JP2008524271A JP2008524271A JP2009502969A JP 2009502969 A JP2009502969 A JP 2009502969A JP 2008524271 A JP2008524271 A JP 2008524271A JP 2008524271 A JP2008524271 A JP 2008524271A JP 2009502969 A JP2009502969 A JP 2009502969A
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JP
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Prior art keywords
efavirenz
composition
solvent
polymer
amorphous
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Pending
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JP2008524271A
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English (en)
Japanese (ja)
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JP2009502969A5 (https=
Inventor
アルフレッド ドーニー ジョン
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ISP Investments LLC
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ISP Investments LLC
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Publication of JP2009502969A publication Critical patent/JP2009502969A/ja
Publication of JP2009502969A5 publication Critical patent/JP2009502969A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/536—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Cardiology (AREA)
  • AIDS & HIV (AREA)
  • Medicinal Preparation (AREA)
  • Glanulating (AREA)
  • Vaporization, Distillation, Condensation, Sublimation, And Cold Traps (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2008524271A 2005-07-28 2006-07-28 非晶質エファビレンツ及びその製造 Pending JP2009502969A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70337405P 2005-07-28 2005-07-28
PCT/US2006/029822 WO2007014393A2 (en) 2005-07-28 2006-07-28 Amorphous efavirenz and the production thereof

Publications (2)

Publication Number Publication Date
JP2009502969A true JP2009502969A (ja) 2009-01-29
JP2009502969A5 JP2009502969A5 (https=) 2009-09-10

Family

ID=37450928

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2008524271A Pending JP2009502969A (ja) 2005-07-28 2006-07-28 非晶質エファビレンツ及びその製造
JP2008524228A Active JP5243247B2 (ja) 2005-07-28 2006-07-28 スプレー乾燥された粉体及び粒状化された材料の特性の改良方法、並びにそれによって製造した製品

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2008524228A Active JP5243247B2 (ja) 2005-07-28 2006-07-28 スプレー乾燥された粉体及び粒状化された材料の特性の改良方法、並びにそれによって製造した製品

Country Status (6)

Country Link
US (2) US20070026073A1 (https=)
EP (2) EP1909762A2 (https=)
JP (2) JP2009502969A (https=)
CN (3) CN101277682B (https=)
BR (1) BRPI0614455A2 (https=)
WO (2) WO2007016435A2 (https=)

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EP1912730A2 (en) 2008-04-23
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US20070026073A1 (en) 2007-02-01
WO2007014393A3 (en) 2007-05-31
CN101277682A (zh) 2008-10-01
US10532028B2 (en) 2020-01-14
US20070026083A1 (en) 2007-02-01
JP2009502487A (ja) 2009-01-29
WO2007016435A2 (en) 2007-02-08
CN101277682B (zh) 2015-07-29
JP5243247B2 (ja) 2013-07-24
WO2007014393A2 (en) 2007-02-01
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