JP2009500372A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2009500372A5 JP2009500372A5 JP2008519917A JP2008519917A JP2009500372A5 JP 2009500372 A5 JP2009500372 A5 JP 2009500372A5 JP 2008519917 A JP2008519917 A JP 2008519917A JP 2008519917 A JP2008519917 A JP 2008519917A JP 2009500372 A5 JP2009500372 A5 JP 2009500372A5
- Authority
- JP
- Japan
- Prior art keywords
- isopropylpiperazin
- phenyl
- compound
- isopropyl
- acetamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 25
- -1 acetamidomethyl Chemical group 0.000 claims 21
- 150000003839 salts Chemical class 0.000 claims 14
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 9
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims 6
- 125000002206 pyridazin-3-yl group Chemical group [H]C1=C([H])C([H])=C(*)N=N1 0.000 claims 5
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims 4
- NZNMSOFKMUBTKW-UHFFFAOYSA-N cyclohexanecarboxylic acid Chemical compound OC(=O)C1CCCCC1 NZNMSOFKMUBTKW-UHFFFAOYSA-N 0.000 claims 4
- MNDTWEIIGFBPGU-UHFFFAOYSA-N 2-methyl-n-[[4-[2-(4-propan-2-ylpiperazin-1-yl)pyrimidin-5-yl]phenyl]methyl]propanamide Chemical compound C1CN(C(C)C)CCN1C1=NC=C(C=2C=CC(CNC(=O)C(C)C)=CC=2)C=N1 MNDTWEIIGFBPGU-UHFFFAOYSA-N 0.000 claims 2
- UYGLHTXMKBIRNS-UHFFFAOYSA-N 4-[[4-[6-(4-propan-2-ylpiperazin-1-yl)pyridazin-3-yl]phenyl]methyl]morpholine Chemical compound C1CN(C(C)C)CCN1C1=CC=C(C=2C=CC(CN3CCOCC3)=CC=2)N=N1 UYGLHTXMKBIRNS-UHFFFAOYSA-N 0.000 claims 2
- WYLFMJBCGLMYKH-UHFFFAOYSA-N 4-[[4-[6-(4-propan-2-ylpiperazin-1-yl)pyridin-3-yl]phenyl]methyl]morpholine Chemical compound C1CN(C(C)C)CCN1C1=CC=C(C=2C=CC(CN3CCOCC3)=CC=2)C=N1 WYLFMJBCGLMYKH-UHFFFAOYSA-N 0.000 claims 2
- GQBXZHORMJLNOA-UHFFFAOYSA-N 4-methoxy-n-[4-[5-(4-propan-2-ylpiperazin-1-yl)pyrazin-2-yl]phenyl]cyclohexane-1-carboxamide Chemical compound C1CC(OC)CCC1C(=O)NC1=CC=C(C=2N=CC(=NC=2)N2CCN(CC2)C(C)C)C=C1 GQBXZHORMJLNOA-UHFFFAOYSA-N 0.000 claims 2
- 150000001408 amides Chemical class 0.000 claims 2
- VZFUCHSFHOYXIS-UHFFFAOYSA-N cycloheptane carboxylic acid Natural products OC(=O)C1CCCCCC1 VZFUCHSFHOYXIS-UHFFFAOYSA-N 0.000 claims 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 2
- MAYRNHMWKAUVGG-UHFFFAOYSA-N n-[4-[6-(4-propan-2-ylpiperazin-1-yl)pyridin-3-yl]phenyl]acetamide Chemical compound C1CN(C(C)C)CCN1C1=CC=C(C=2C=CC(NC(C)=O)=CC=2)C=N1 MAYRNHMWKAUVGG-UHFFFAOYSA-N 0.000 claims 2
- YIJRIDBOLBKRBO-UHFFFAOYSA-N n-[[4-[2-(4-cyclopropylpiperazin-1-yl)pyrimidin-5-yl]phenyl]methyl]acetamide Chemical compound C1=CC(CNC(=O)C)=CC=C1C1=CN=C(N2CCN(CC2)C2CC2)N=C1 YIJRIDBOLBKRBO-UHFFFAOYSA-N 0.000 claims 2
- GYYYLVXIECBOHI-UHFFFAOYSA-N n-[[4-[5-(4-propan-2-ylpiperazin-1-yl)pyrazin-2-yl]phenyl]methyl]acetamide Chemical compound C1CN(C(C)C)CCN1C1=CN=C(C=2C=CC(CNC(C)=O)=CC=2)C=N1 GYYYLVXIECBOHI-UHFFFAOYSA-N 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- DRMDQUOERVUHPA-UHFFFAOYSA-N 1-[5-[4-(piperidin-1-ylmethyl)phenyl]pyridin-2-yl]-4-propan-2-ylpiperazine Chemical compound C1CN(C(C)C)CCN1C1=CC=C(C=2C=CC(CN3CCCCC3)=CC=2)C=N1 DRMDQUOERVUHPA-UHFFFAOYSA-N 0.000 claims 1
- BEKFTRKEUNDTCU-UHFFFAOYSA-N 1-cyclopropyl-4-[5-[4-(piperidin-1-ylmethyl)phenyl]pyridin-2-yl]piperazine Chemical compound C=1C=C(C=2C=NC(=CC=2)N2CCN(CC2)C2CC2)C=CC=1CN1CCCCC1 BEKFTRKEUNDTCU-UHFFFAOYSA-N 0.000 claims 1
- HNZJIWIXRPBFAN-UHFFFAOYSA-N 1-cyclopropylpiperazine Chemical compound C1CC1N1CCNCC1 HNZJIWIXRPBFAN-UHFFFAOYSA-N 0.000 claims 1
- ZEFCEARMOCDCPB-UHFFFAOYSA-N 1-methyl-4-[[4-[6-(4-propan-2-ylpiperazin-1-yl)pyridin-3-yl]phenyl]methyl]piperazine Chemical compound C1CN(C(C)C)CCN1C1=CC=C(C=2C=CC(CN3CCN(C)CC3)=CC=2)C=N1 ZEFCEARMOCDCPB-UHFFFAOYSA-N 0.000 claims 1
- WHKWMTXTYKVFLK-UHFFFAOYSA-N 1-propan-2-ylpiperazine Chemical compound CC(C)N1CCNCC1 WHKWMTXTYKVFLK-UHFFFAOYSA-N 0.000 claims 1
- JBSLANHIBKBQGE-UHFFFAOYSA-N 2-cyclopropylacetamide Chemical compound NC(=O)CC1CC1 JBSLANHIBKBQGE-UHFFFAOYSA-N 0.000 claims 1
- IXDAZAZEKJNKGN-UHFFFAOYSA-N 3-(4-cyclopropylpiperazin-1-yl)-6-[4-(piperidin-1-ylmethyl)phenyl]pyridazine Chemical compound C=1C=C(C=2N=NC(=CC=2)N2CCN(CC2)C2CC2)C=CC=1CN1CCCCC1 IXDAZAZEKJNKGN-UHFFFAOYSA-N 0.000 claims 1
- ASCWYUGHPLOWDH-UHFFFAOYSA-N 4-[6-(4-cyclopropylpiperazin-1-yl)piperidin-3-yl]-n,n-dimethylbenzamide Chemical compound C1=CC(C(=O)N(C)C)=CC=C1C1CNC(N2CCN(CC2)C2CC2)CC1 ASCWYUGHPLOWDH-UHFFFAOYSA-N 0.000 claims 1
- RPOPBUGAPRBFNC-UHFFFAOYSA-N CC(C)N(CC1)CCN1C1=NC=C(C(C=C2)=CC=C2NC)N=C1.OC(C1CC1)=O Chemical compound CC(C)N(CC1)CCN1C1=NC=C(C(C=C2)=CC=C2NC)N=C1.OC(C1CC1)=O RPOPBUGAPRBFNC-UHFFFAOYSA-N 0.000 claims 1
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 claims 1
- FKILWTAZBZNLQA-UHFFFAOYSA-N [1-[[4-[6-(4-propan-2-ylpiperazin-1-yl)pyridazin-3-yl]phenyl]methyl]piperidin-4-yl]methanol Chemical compound C1CN(C(C)C)CCN1C1=CC=C(C=2C=CC(CN3CCC(CO)CC3)=CC=2)N=N1 FKILWTAZBZNLQA-UHFFFAOYSA-N 0.000 claims 1
- WUQXZHQQDRLESG-UHFFFAOYSA-N [1-[[4-[6-(4-propan-2-ylpiperazin-1-yl)pyridin-3-yl]phenyl]methyl]piperidin-4-yl]methanol Chemical compound C1CN(C(C)C)CCN1C1=CC=C(C=2C=CC(CN3CCC(CO)CC3)=CC=2)C=N1 WUQXZHQQDRLESG-UHFFFAOYSA-N 0.000 claims 1
- NLUXOIAQIFEKMZ-UHFFFAOYSA-N [4-(hydroxymethyl)piperidin-1-yl]-[4-[6-(4-propan-2-ylpiperazin-1-yl)pyridazin-3-yl]phenyl]methanone Chemical compound C1CN(C(C)C)CCN1C1=CC=C(C=2C=CC(=CC=2)C(=O)N2CCC(CO)CC2)N=N1 NLUXOIAQIFEKMZ-UHFFFAOYSA-N 0.000 claims 1
- QKFZTZONNQVHPU-UHFFFAOYSA-N [4-(hydroxymethyl)piperidin-1-yl]-[4-[6-(4-propan-2-ylpiperazin-1-yl)pyridin-3-yl]phenyl]methanone Chemical compound C1CN(C(C)C)CCN1C1=CC=C(C=2C=CC(=CC=2)C(=O)N2CCC(CO)CC2)C=N1 QKFZTZONNQVHPU-UHFFFAOYSA-N 0.000 claims 1
- YFJDURDXIYRGSU-UHFFFAOYSA-N [4-(methoxymethyl)piperidin-1-yl]-[4-[6-(4-propan-2-ylpiperazin-1-yl)pyridin-3-yl]phenyl]methanone Chemical compound C1CC(COC)CCN1C(=O)C1=CC=C(C=2C=NC(=CC=2)N2CCN(CC2)C(C)C)C=C1 YFJDURDXIYRGSU-UHFFFAOYSA-N 0.000 claims 1
- LGQXUTVSTGUQAC-UHFFFAOYSA-N [4-[6-(4-cyclopropylpiperazin-1-yl)pyridin-3-yl]phenyl]-(4-methylpiperazin-1-yl)methanone Chemical compound C1CN(C)CCN1C(=O)C1=CC=C(C=2C=NC(=CC=2)N2CCN(CC2)C2CC2)C=C1 LGQXUTVSTGUQAC-UHFFFAOYSA-N 0.000 claims 1
- VFOJBFMVKVZNCI-UHFFFAOYSA-N [4-[6-(4-cyclopropylpiperazin-1-yl)pyridin-3-yl]phenyl]-piperidin-1-ylmethanone Chemical compound C=1C=C(C=2C=NC(=CC=2)N2CCN(CC2)C2CC2)C=CC=1C(=O)N1CCCCC1 VFOJBFMVKVZNCI-UHFFFAOYSA-N 0.000 claims 1
- METKIMKYRPQLGS-UHFFFAOYSA-N atenolol Chemical compound CC(C)NCC(O)COC1=CC=C(CC(N)=O)C=C1 METKIMKYRPQLGS-UHFFFAOYSA-N 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- AIMMVWOEOZMVMS-UHFFFAOYSA-N cyclopropanecarboxamide Chemical compound NC(=O)C1CC1 AIMMVWOEOZMVMS-UHFFFAOYSA-N 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 125000006222 dimethylaminomethyl group Chemical group [H]C([H])([H])N(C([H])([H])[H])C([H])([H])* 0.000 claims 1
- WSFSSNUMVMOOMR-BJUDXGSMSA-N methanone Chemical compound O=[11CH2] WSFSSNUMVMOOMR-BJUDXGSMSA-N 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 1
- BBRXHRDNHPYYBH-UHFFFAOYSA-N morpholin-4-yl-[4-[6-(4-propan-2-ylpiperazin-1-yl)pyridazin-3-yl]phenyl]methanone Chemical compound C1CN(C(C)C)CCN1C1=CC=C(C=2C=CC(=CC=2)C(=O)N2CCOCC2)N=N1 BBRXHRDNHPYYBH-UHFFFAOYSA-N 0.000 claims 1
- ZSUUCLLIOSUIFH-UHFFFAOYSA-N n,n-di(propan-2-yl)acetamide Chemical compound CC(C)N(C(C)C)C(C)=O ZSUUCLLIOSUIFH-UHFFFAOYSA-N 0.000 claims 1
- NMJPJZWVPWRPFO-UHFFFAOYSA-N n,n-dimethyl-1-[4-[6-(4-propan-2-ylpiperazin-1-yl)pyridazin-3-yl]phenyl]methanamine Chemical compound C1CN(C(C)C)CCN1C1=CC=C(C=2C=CC(CN(C)C)=CC=2)N=N1 NMJPJZWVPWRPFO-UHFFFAOYSA-N 0.000 claims 1
- AYFUAUFOSCUTET-UHFFFAOYSA-N n,n-dimethyl-1-[4-[6-(4-propan-2-ylpiperazin-1-yl)pyridin-3-yl]phenyl]methanamine Chemical compound C1CN(C(C)C)CCN1C1=CC=C(C=2C=CC(CN(C)C)=CC=2)C=N1 AYFUAUFOSCUTET-UHFFFAOYSA-N 0.000 claims 1
- TUAHSNWHUAKVCR-UHFFFAOYSA-N n-[4-[5-(4-cyclopropylpiperazin-1-yl)pyrazin-2-yl]phenyl]acetamide Chemical compound C1=CC(NC(=O)C)=CC=C1C1=CN=C(N2CCN(CC2)C2CC2)C=N1 TUAHSNWHUAKVCR-UHFFFAOYSA-N 0.000 claims 1
- NGTLTQLSPDZYPW-UHFFFAOYSA-N n-[4-[5-(4-propan-2-ylpiperazin-1-yl)pyrazin-2-yl]phenyl]acetamide Chemical compound C1CN(C(C)C)CCN1C1=CN=C(C=2C=CC(NC(C)=O)=CC=2)C=N1 NGTLTQLSPDZYPW-UHFFFAOYSA-N 0.000 claims 1
- GPXYLVXVRKANSK-UHFFFAOYSA-N n-[4-[5-(4-propan-2-ylpiperazin-1-yl)pyrazin-2-yl]phenyl]cyclopropanecarboxamide Chemical compound C1CN(C(C)C)CCN1C1=CN=C(C=2C=CC(NC(=O)C3CC3)=CC=2)C=N1 GPXYLVXVRKANSK-UHFFFAOYSA-N 0.000 claims 1
- LBYGIPJOYIERIC-UHFFFAOYSA-N n-[4-[6-(4-cyclopropylpiperazin-1-yl)pyridazin-3-yl]-2-methoxyphenyl]acetamide Chemical compound C1=C(NC(C)=O)C(OC)=CC(C=2N=NC(=CC=2)N2CCN(CC2)C2CC2)=C1 LBYGIPJOYIERIC-UHFFFAOYSA-N 0.000 claims 1
- FMNUHNONGPWMAA-UHFFFAOYSA-N n-[4-[6-(4-cyclopropylpiperazin-1-yl)pyridazin-3-yl]phenyl]acetamide Chemical compound C1=CC(NC(=O)C)=CC=C1C1=CC=C(N2CCN(CC2)C2CC2)N=N1 FMNUHNONGPWMAA-UHFFFAOYSA-N 0.000 claims 1
- CYAYFSOHSRHVAN-UHFFFAOYSA-N n-[4-[6-(4-cyclopropylpiperazin-1-yl)pyridazin-3-yl]phenyl]cyclopropanecarboxamide Chemical compound C1CC1C(=O)NC(C=C1)=CC=C1C(N=N1)=CC=C1N(CC1)CCN1C1CC1 CYAYFSOHSRHVAN-UHFFFAOYSA-N 0.000 claims 1
- DXPPODZAPXVITK-UHFFFAOYSA-N n-[4-[6-(4-propan-2-ylpiperazin-1-yl)pyridazin-3-yl]phenyl]acetamide Chemical compound C1CN(C(C)C)CCN1C1=CC=C(C=2C=CC(NC(C)=O)=CC=2)N=N1 DXPPODZAPXVITK-UHFFFAOYSA-N 0.000 claims 1
- ZDKOYMJLEZWCHR-UHFFFAOYSA-N n-[[4-[6-(4-propan-2-ylpiperazin-1-yl)pyridin-3-yl]phenyl]methyl]acetamide Chemical compound C1CN(C(C)C)CCN1C1=CC=C(C=2C=CC(CNC(C)=O)=CC=2)C=N1 ZDKOYMJLEZWCHR-UHFFFAOYSA-N 0.000 claims 1
- MDZLFSAWUYNYHO-UHFFFAOYSA-N n-methyl-n-[4-[5-(4-propan-2-ylpiperazin-1-yl)pyrazin-2-yl]phenyl]acetamide Chemical compound C1CN(C(C)C)CCN1C1=CN=C(C=2C=CC(=CC=2)N(C)C(C)=O)C=N1 MDZLFSAWUYNYHO-UHFFFAOYSA-N 0.000 claims 1
- QJQAMHYHNCADNR-UHFFFAOYSA-N n-methylpropanamide Chemical compound CCC(=O)NC QJQAMHYHNCADNR-UHFFFAOYSA-N 0.000 claims 1
- AVPKHOTUOHDTLW-UHFFFAOYSA-N oxane-4-carboxylic acid Chemical compound OC(=O)C1CCOCC1 AVPKHOTUOHDTLW-UHFFFAOYSA-N 0.000 claims 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05106038.2 | 2005-07-04 | ||
| EP05106038 | 2005-07-04 | ||
| EP05106037.4 | 2005-07-04 | ||
| EP05106037 | 2005-07-04 | ||
| EP05109674 | 2005-10-18 | ||
| EP05109674.1 | 2005-10-18 | ||
| EP06114615 | 2006-05-29 | ||
| EP06114615.5 | 2006-05-29 | ||
| PCT/EP2006/063753 WO2007003604A2 (en) | 2005-07-04 | 2006-06-30 | Hists1mine h3 receptor antagonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009500372A JP2009500372A (ja) | 2009-01-08 |
| JP2009500372A5 true JP2009500372A5 (https=) | 2011-12-15 |
| JP5121707B2 JP5121707B2 (ja) | 2013-01-16 |
Family
ID=37198852
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008519917A Expired - Fee Related JP5121707B2 (ja) | 2005-07-04 | 2006-06-30 | 新規医薬 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US8501739B2 (https=) |
| EP (3) | EP1902028A2 (https=) |
| JP (1) | JP5121707B2 (https=) |
| KR (1) | KR101286569B1 (https=) |
| CN (1) | CN103110635A (https=) |
| AT (1) | ATE536344T1 (https=) |
| AU (1) | AU2006264966B2 (https=) |
| BR (1) | BRPI0613564A2 (https=) |
| CA (1) | CA2614116A1 (https=) |
| ES (1) | ES2375929T3 (https=) |
| MX (1) | MX2007015675A (https=) |
| RU (1) | RU2499795C2 (https=) |
| WO (1) | WO2007003604A2 (https=) |
Families Citing this family (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030236259A1 (en) * | 2002-02-05 | 2003-12-25 | Rolf Hohlweg | Novel aryl- and heteroarylpiperazines |
| RU2499795C2 (ru) | 2005-07-04 | 2013-11-27 | Хай Пойнт Фармасьютикалс, ЛЛС | Антагонисты гистаминовых н3-рецепторов |
| GB0525957D0 (en) * | 2005-12-21 | 2006-02-01 | Astrazeneca Ab | Methods |
| WO2007117399A2 (en) | 2006-03-31 | 2007-10-18 | Janssen Pharmaceutica N.V. | Benzoimidazol-2-yl pyrimidines and pyrazines as modulators of the histamine h4 receptor |
| US8318927B2 (en) * | 2006-05-23 | 2012-11-27 | High Point Pharmaceuticals, Llc | 6-(4-cyclopropylpiperazin-1-yl)-2′-methyl-[3, 4′]-bipyridine and its uses as a medicament |
| SG163547A1 (en) * | 2006-05-29 | 2010-08-30 | High Point Pharmaceuticals Llc | 3- (1, 3-benz0di0x0l-5-yl) -6- (4-cyclopropylpiperazin-1-yl) -pyridazine, its salts and solvates and its use as histamine h3 receptor antagonist |
| CN103382174A (zh) | 2006-06-23 | 2013-11-06 | 雅培制药有限公司 | 作为组胺h3受体调节物的环丙胺衍生物 |
| US9108948B2 (en) | 2006-06-23 | 2015-08-18 | Abbvie Inc. | Cyclopropyl amine derivatives |
| TW200901998A (en) * | 2007-03-06 | 2009-01-16 | Astrazeneca Ab | Novel 2-heteroaryl substituted benzothiophenes and benzofuranes |
| CA2687931C (en) * | 2007-05-31 | 2016-05-24 | Boehringer Ingelheim International Gmbh | Ccr2 receptor antagonists and uses thereof |
| EP2014656A3 (en) * | 2007-06-11 | 2011-08-24 | High Point Pharmaceuticals, LLC | New heteocyclic h3 antagonists |
| CA2712885A1 (en) * | 2008-01-30 | 2009-08-06 | Cephalon, Inc. | Substituted pyridazine derivatives which have histamine h3 antagonist activity |
| SI2291080T1 (sl) | 2008-05-14 | 2015-11-30 | The Scripps Research Institute | Novi modulatorji sfingosinskih fosfatnih receptorjev |
| US9371311B2 (en) | 2008-06-30 | 2016-06-21 | Janssen Pharmaceutica Nv | Benzoimidazol-2-yl pyrimidine derivatives |
| US8193363B2 (en) | 2008-08-29 | 2012-06-05 | Astrazeneca Ab | Compounds suitable as precursors to compounds that are useful for imaging amyloid deposits |
| HUE025547T2 (en) | 2008-12-19 | 2016-02-29 | Boehringer Ingelheim Int | Cyclic pyrimidine-4-carboxamides as CCR2 receptor antagonists for the treatment of inflammation, asthma and COPD |
| US20120022057A1 (en) * | 2009-03-18 | 2012-01-26 | Schering Corporation | Bicyclic compounds as inhibitors of diacyglycerol acyltransferase |
| US9186353B2 (en) | 2009-04-27 | 2015-11-17 | Abbvie Inc. | Treatment of osteoarthritis pain |
| JP5640983B2 (ja) * | 2009-09-16 | 2014-12-17 | アステラス製薬株式会社 | グリシン化合物 |
| ES2674275T3 (es) | 2009-12-17 | 2018-06-28 | Centrexion Therapeutics Corporation | Antagonistas del receptor CCR2 y usos de los mismos |
| AR081626A1 (es) | 2010-04-23 | 2012-10-10 | Cytokinetics Inc | Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos |
| AR081331A1 (es) | 2010-04-23 | 2012-08-08 | Cytokinetics Inc | Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos |
| US9133123B2 (en) | 2010-04-23 | 2015-09-15 | Cytokinetics, Inc. | Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use |
| WO2011143162A1 (en) * | 2010-05-11 | 2011-11-17 | Sanofi | Substituted n-heteroaryl bipyrrolidine carboxamides, preparation and therapeutic use thereof |
| EP2569298B1 (en) | 2010-05-12 | 2015-11-25 | Boehringer Ingelheim International GmbH | Novel ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments |
| WO2011141477A1 (en) | 2010-05-12 | 2011-11-17 | Boehringer Ingelheim International Gmbh | New ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments |
| WO2011144501A1 (en) | 2010-05-17 | 2011-11-24 | Boehringer Ingelheim International Gmbh | Ccr2 antagonists and uses thereof |
| EP2576542B1 (en) | 2010-05-25 | 2015-04-22 | Boehringer Ingelheim International GmbH | Cyclic amide derivatives of pyridazine-3-carboxylic acids and their use in the treatment of pulmonary, pain, immune related and cardiovascular diseases |
| EP2576538B1 (en) | 2010-06-01 | 2015-10-28 | Boehringer Ingelheim International GmbH | New CCR2 antagonists |
| US8853390B2 (en) | 2010-09-16 | 2014-10-07 | Abbvie Inc. | Processes for preparing 1,2-substituted cyclopropyl derivatives |
| EP2731941B1 (en) | 2011-07-15 | 2019-05-08 | Boehringer Ingelheim International GmbH | Novel and selective ccr2 antagonists |
| WO2013076590A1 (en) | 2011-11-23 | 2013-05-30 | Oxygen Healthcare Research Pvt. Ltd | Benzothiazine compounds as h3 receptor ligands |
| US8729263B2 (en) * | 2012-08-13 | 2014-05-20 | Novartis Ag | 1,4-disubstituted pyridazine analogs there of and methods for treating SMN-deficiency-related conditions |
| PT2964229T (pt) | 2013-03-06 | 2020-03-23 | Janssen Pharmaceutica Nv | Moduladores de piridina benzimidazol-2-ilo do recetor h4 de histamina |
| GB201311953D0 (en) * | 2013-07-03 | 2013-08-14 | Redx Pharma Ltd | Compounds |
| EP4105208A1 (en) | 2013-07-31 | 2022-12-21 | Novartis AG | 1,4-disubstituted pyridazine derivatives and their use for treating smn-deficiency-related conditions |
| EP3053577A1 (en) * | 2015-02-09 | 2016-08-10 | F. Hoffmann-La Roche AG | Compounds for the treatment of cancer |
| EP3256126B1 (en) * | 2015-02-09 | 2024-03-27 | F. Hoffmann-La Roche AG | Compounds for the treatment of cancer |
| MX383744B (es) | 2015-07-02 | 2025-03-14 | Centrexion Therapeutics Corp | Citrato de (4-((3r,4r)-3-metoxitetrahidro-piran-4-ilamino)piperidin-1-il) (5-metil-6-(((2r, 6s)-6-(p-tolil)tetrahidro-2h-piran-2-il) metilamino) pirimidin-4-il) metanona. |
| EP3373935B1 (en) * | 2015-11-12 | 2021-09-01 | Merck Sharp & Dohme Corp. | Cyanopyridine derivatives as liver x receptor beta agonists, compositions, and their use |
| EA201800367A1 (ru) * | 2015-12-10 | 2019-02-28 | ПиТиСи ТЕРАПЬЮТИКС, ИНК. | Способы лечения болезни хантингтона |
| WO2018165520A1 (en) | 2017-03-10 | 2018-09-13 | Vps-3, Inc. | Metalloenzyme inhibitor compounds |
| EP3634953B1 (en) | 2017-06-05 | 2024-01-03 | PTC Therapeutics, Inc. | Compounds for treating huntington's disease |
| CN111182898B (zh) | 2017-06-28 | 2024-04-16 | Ptc医疗公司 | 用于治疗亨廷顿氏病的方法 |
| MX2019015580A (es) | 2017-06-28 | 2020-07-28 | Ptc Therapeutics Inc | Metodos para tratar la enfermedad de huntington. |
| EA202092001A1 (ru) | 2018-03-27 | 2021-01-29 | ПиТиСи ТЕРАПЬЮТИКС, ИНК. | Соединения для лечения болезни гентингтона |
| WO2020005877A1 (en) | 2018-06-27 | 2020-01-02 | Ptc Therapeutics, Inc. | Heteroaryl compounds for treating huntington's disease |
| EP3814360B8 (en) | 2018-06-27 | 2024-11-06 | PTC Therapeutics, Inc. | Heteroaryl compounds for treating huntington's disease |
| HRP20240935T1 (hr) | 2018-06-27 | 2024-11-22 | Ptc Therapeutics, Inc. | Heterociklični i heteroaril spojevi za liječenje huntingtonove bolesti |
| JP7649257B2 (ja) | 2019-05-13 | 2025-03-19 | ピーティーシー セラピューティクス， インコーポレイテッド | ハンチントン病を処置するための化合物 |
| AU2020321955A1 (en) | 2019-07-30 | 2022-03-17 | Eikonizo Therapapeutics, Inc. | HDAC6 inhibitors and uses thereof |
| CN114600165B (zh) | 2019-09-17 | 2025-08-15 | 波士顿偏振测定公司 | 用于使用偏振提示表面建模的系统和方法 |
| EP4042366A4 (en) | 2019-10-07 | 2023-11-15 | Boston Polarimetrics, Inc. | SYSTEMS AND METHODS FOR AUGMENTING SENSOR SYSTEMS AND IMAGING SYSTEMS WITH POLARIZATION |
| WO2021108002A1 (en) | 2019-11-30 | 2021-06-03 | Boston Polarimetrics, Inc. | Systems and methods for transparent object segmentation using polarization cues |
| KR102942542B1 (ko) | 2020-01-29 | 2026-03-23 | 인트린식 이노베이션 엘엘씨 | 물체 포즈 검출 및 측정 시스템들을 특성화하기 위한 시스템들 및 방법들 |
| WO2021154459A1 (en) | 2020-01-30 | 2021-08-05 | Boston Polarimetrics, Inc. | Systems and methods for synthesizing data for training statistical models on different imaging modalities including polarized images |
| WO2021243088A1 (en) | 2020-05-27 | 2021-12-02 | Boston Polarimetrics, Inc. | Multi-aperture polarization optical systems using beam splitters |
| WO2022053541A1 (en) * | 2020-09-10 | 2022-03-17 | Eracal Therapeutics Ltd. | Compounds for use as appetite suppressant |
| US12020455B2 (en) | 2021-03-10 | 2024-06-25 | Intrinsic Innovation Llc | Systems and methods for high dynamic range image reconstruction |
| US12069227B2 (en) | 2021-03-10 | 2024-08-20 | Intrinsic Innovation Llc | Multi-modal and multi-spectral stereo camera arrays |
| US11954886B2 (en) | 2021-04-15 | 2024-04-09 | Intrinsic Innovation Llc | Systems and methods for six-degree of freedom pose estimation of deformable objects |
| US11290658B1 (en) | 2021-04-15 | 2022-03-29 | Boston Polarimetrics, Inc. | Systems and methods for camera exposure control |
| US12067746B2 (en) | 2021-05-07 | 2024-08-20 | Intrinsic Innovation Llc | Systems and methods for using computer vision to pick up small objects |
| US12175741B2 (en) | 2021-06-22 | 2024-12-24 | Intrinsic Innovation Llc | Systems and methods for a vision guided end effector |
| US12340538B2 (en) | 2021-06-25 | 2025-06-24 | Intrinsic Innovation Llc | Systems and methods for generating and using visual datasets for training computer vision models |
| US12172310B2 (en) | 2021-06-29 | 2024-12-24 | Intrinsic Innovation Llc | Systems and methods for picking objects using 3-D geometry and segmentation |
| US11689813B2 (en) | 2021-07-01 | 2023-06-27 | Intrinsic Innovation Llc | Systems and methods for high dynamic range imaging using crossed polarizers |
| US12293535B2 (en) | 2021-08-03 | 2025-05-06 | Intrinsic Innovation Llc | Systems and methods for training pose estimators in computer vision |
| US20250333397A1 (en) * | 2021-08-30 | 2025-10-30 | Remix Therapeutics Inc. | Compounds and methods for modulating splicing |
| CN114478478B (zh) * | 2022-02-18 | 2023-06-13 | 厦门大学 | N-(1-(6-(取代苯基)哒嗪-3-基)哌啶-3-基)胺/酰胺衍生物及制备方法 |
| IL316201A (en) | 2022-04-08 | 2024-12-01 | Eikonizo Therapeutics Inc | Oxadiazole HDAC6 inhibitors and their uses |
Family Cites Families (132)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB753166A (en) | 1953-05-22 | 1956-07-18 | Miles Lab | Improvements in or relating to substituted piperazines |
| US2724713A (en) * | 1954-03-24 | 1955-11-22 | American Cyanamid Co | 1-carbobenzoxypiperazines and process of preparing same |
| US2993899A (en) * | 1958-03-31 | 1961-07-25 | Miles Lab | Acetylenically unsaturated piperazine derivatives |
| US3164598A (en) * | 1963-02-01 | 1965-01-05 | American Home Prod | Substituted 1, 4-diazabicyclo[4.3.0]nonanes and methods for their preparation |
| US3309370A (en) * | 1964-07-16 | 1967-03-14 | Miles Lab | Bicycloalkyl piperazine derivatives and process |
| GB1293565A (en) * | 1969-05-03 | 1972-10-18 | Aspro Nicholas Ltd | Aminophthalazines and pharmaceutical compositions thereof |
| US3886161A (en) * | 1970-12-14 | 1975-05-27 | Sandoz Ag | 2-Piperazino-3-cyano-5-phenyl-pyridines |
| GB1345880A (en) * | 1971-06-18 | 1974-02-06 | Cepbepe | Pyridazine derivatives |
| DE2516040C2 (de) * | 1974-06-10 | 1984-12-20 | Dr. Karl Thomae Gmbh, 7950 Biberach | Benzimidazole, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel |
| FR2306694A1 (fr) | 1975-04-07 | 1976-11-05 | Parcor | Derives de la piperazine |
| GB1545094A (en) * | 1976-12-14 | 1979-05-02 | Gist Brocades Nv | Piperazine derivatives |
| US4144346A (en) | 1977-01-31 | 1979-03-13 | Janssen Pharmaceutica N.V. | Novel 1-(1,3-dioxolan-2-ylmethyl)-1H-imidazoles |
| HU175471B (hu) * | 1977-06-13 | 1980-08-28 | Gyogyszerkutato Intezet | Sposob poluchenija novykh proizvodnykh 3-skobka-1-pirazolil-skobka zakryta-piridazina |
| US4163849A (en) * | 1978-03-17 | 1979-08-07 | Merck & Co., Inc. | Piperazinylpyrazines |
| DE2824764A1 (de) * | 1978-06-06 | 1979-12-20 | Hoechst Ag | Neue pyridylpiperazinderivate und verfahren zu ihrer herstellung |
| DE3160397D1 (en) | 1980-02-22 | 1983-07-14 | Tanabe Seiyaku Co | Phenoxyalkane derivative and processes for preparing same |
| US4339579A (en) * | 1980-12-29 | 1982-07-13 | American Home Products Corporation | 2,6-Bis-(pyrrolopyrazinyl)pyrazines |
| US4616014A (en) * | 1981-10-22 | 1986-10-07 | Fujisawa Pharmaceutical Co., Ltd. | Triazine derivatives, and pharmaceutical compositions comprising the same |
| US5001125A (en) * | 1984-03-26 | 1991-03-19 | Janssen Pharmaceutica N.V. | Anti-virally active pyridazinamines |
| FR2573075B1 (fr) | 1984-09-14 | 1987-03-20 | Innothera Lab Sa | Nouvelles (pyridyl-2)-1 piperazines, leur procede de preparation et leur application en therapeutique |
| DE3526235A1 (de) | 1984-11-16 | 1986-05-22 | Bayer Ag, 5090 Leverkusen | Fluessigkristallzusammensetzungen |
| EP0204003A4 (en) * | 1984-11-27 | 1987-06-03 | Dainippon Pharmaceutical Co | 2-(1-piperazinyl)-4-substituted phenylquinoline derivatives, process for their preparation, and medicinal composition containing same. |
| EP0200024B1 (de) | 1985-04-30 | 1992-07-01 | ARZNEIMITTELWERK DRESDEN GmbH | 3-Cyan-pyridine, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung |
| US4670505A (en) * | 1985-08-23 | 1987-06-02 | Hercules Incorporated | Polyacrylate dispersions |
| PH25772A (en) | 1985-08-30 | 1991-10-18 | Novo Industri As | Insulin analogues, process for their preparation |
| DK111387A (da) | 1986-03-05 | 1987-09-06 | Otsuka Pharma Co Ltd | Carbostyrilderivater og salte deraf, laegemiddel indeholdende saadanne derivater samt fremgangsmaade til fremstilling af derivaterne |
| DE3609596A1 (de) * | 1986-03-21 | 1987-10-01 | Hoechst Ag | 2-azolylmethyl-2-aryl-1,3-dioxolane und deren salze, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung |
| MY104343A (en) | 1987-11-23 | 1994-03-31 | Janssen Pharmaceutica Nv | Novel pyridizinamine deravatives |
| DE3803860A1 (de) | 1988-02-09 | 1989-08-17 | Basf Ag | N,n'-disubstituierte piperazine |
| DE3837825A1 (de) | 1988-11-08 | 1990-05-10 | Hoechst Ag | Neue insulinderivate, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung |
| ES2058630T3 (es) | 1989-03-03 | 1994-11-01 | Dainippon Pharmaceutical Co | Derivados de 2-(1-piperazinil)-4-fenilcicloalcanopiridinas, procedimientos de preparacion y composiciones farmaceuticas que los contienen. |
| GB9012316D0 (en) | 1990-06-01 | 1990-07-18 | Wellcome Found | Pharmacologically active cns compounds |
| WO1994014780A1 (en) | 1992-12-18 | 1994-07-07 | The Wellcome Foundation Limited | Pyrimidine, pyridine, pteridinone and indazole derivatives as enzyme inhibitors |
| DE4308028B4 (de) * | 1993-03-13 | 2012-08-16 | Merck Patent Gmbh | 1,2,2,2-Tetrafluorethylether und flüssigkristallines Medium |
| WO1994022846A1 (en) | 1993-03-30 | 1994-10-13 | Pfizer Inc. | Compounds enhancing antitumor activity of other cytotoxic agents |
| JP3377826B2 (ja) | 1993-05-06 | 2003-02-17 | ヘキスト・アクチェンゲゼルシャフト | 液晶組成物に使用するための新規化合物 |
| WO1995000550A1 (en) | 1993-06-21 | 1995-01-05 | Novo Nordisk A/S | Aspb28 insulin crystals |
| CZ287945B6 (cs) | 1993-09-17 | 2001-03-14 | Novo Nordisk A/S | Inzulinový derivát a farmaceutický prostředek s jeho obsahem pro léčení diabetu |
| IL111730A (en) | 1993-11-29 | 1998-12-06 | Fujisawa Pharmaceutical Co | Piperazine derivatives processes for the preparation thereof and pharmaceutical compositions containing the same |
| US5504188A (en) | 1994-06-16 | 1996-04-02 | Eli Lilly And Company | Preparation of stable zinc insulin analog crystals |
| DE4423044A1 (de) | 1994-07-01 | 1996-01-04 | Hoechst Ag | 1-(3-Alkyloxiran-2-yl)alkylester mesogener Carbonsäuren und ihre Verwendung in flüssigkristallinen Mischungen |
| DE4425642A1 (de) | 1994-07-20 | 1996-01-25 | Merck Patent Gmbh | Partiell fluorierte Benzolderivate |
| WO1997002245A1 (en) | 1995-07-06 | 1997-01-23 | Japan Tobacco Inc. | Benzamidoxime derivatives and medicinal use thereof |
| US6130217A (en) * | 1995-09-20 | 2000-10-10 | Pfizer Inc | Compounds enhancing antitumor activity of other cytotoxic agents |
| AU707325B2 (en) * | 1995-11-09 | 1999-07-08 | Sanofi-Aventis | 5-phenyl-3-(piperidin-4-yl)-1,3,4-oxadiazol-2(3H)-one derivatives for use as 5-HT4 or H3 receptor ligands |
| AU727775B2 (en) | 1996-01-17 | 2000-12-21 | Novo Nordisk A/S | Fused 1,2,4-thiadiazine and fused 1,4-thiazine derivatives, their preparation and use |
| CN1221417A (zh) | 1996-07-26 | 1999-06-30 | 雷迪博士研究基金会 | 具有抗糖尿病、降低血脂、抗高血压性能的噻唑烷二酮化合物,其制备方法及其药物组合物 |
| IL128332A0 (en) | 1996-08-30 | 2000-01-31 | Novo Nordisk As | GLP-1 derivatives |
| DZ2376A1 (fr) | 1996-12-19 | 2002-12-28 | Smithkline Beecham Plc | Dérivés de sulfonamides nouveaux procédé pour leurpréparation et compositions pharmaceutiques les c ontenant. |
| IL127296A (en) | 1996-12-31 | 2003-01-12 | Reddy Research Foundation | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them |
| WO1997041119A1 (en) | 1997-05-02 | 1997-11-06 | Dr. Reddy's Research Foundation | Novel antidiabetic compounds having hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them |
| US6613942B1 (en) | 1997-07-01 | 2003-09-02 | Novo Nordisk A/S | Glucagon antagonists/inverse agonists |
| AU749271B2 (en) | 1997-07-01 | 2002-06-20 | Agouron Pharmaceuticals, Inc. | Glucagon antagonists/inverse agonists |
| PL338013A1 (en) | 1997-07-16 | 2000-09-25 | Novo Nordisk As | Derivatives of condensed 1,2,4-thiadiazine, their production and application |
| WO1999004390A1 (en) | 1997-07-17 | 1999-01-28 | Sony Corporation | Magnetic recording medium and magnetic recorder/reproducer comprising the same |
| ATE404539T1 (de) | 1997-10-02 | 2008-08-15 | Eisai R&D Man Co Ltd | Kondensierte pyridinderivate |
| US6440961B1 (en) | 1997-10-27 | 2002-08-27 | Dr. Reddy's Research Foundation | Tricyclic compounds and their use in medicine: process for their preparation and pharmaceutical compositions containing them |
| WO1999019313A1 (en) | 1997-10-27 | 1999-04-22 | Dr. Reddy's Research Foundation | Novel tricyclic compounds and their use in medicine; process for their preparation and pharmaceutical compositions containing them |
| NZ503788A (en) | 1997-10-27 | 2002-11-26 | Agouron Pharma | 4-aminothiazole derivatives and their use as inhibitors of cyclin-dependent kinases |
| AU6966498A (en) | 1997-12-02 | 1998-10-30 | Dr. Reddy's Research Foundation | Thiazolidinedione and oxazolidinedione derivatives having antidiabetic, hypol ipidaemic and antihypertensive properties |
| EP0978512A1 (en) | 1998-07-29 | 2000-02-09 | Societe Civile Bioprojet | Non-imidazole aryloxy (or arylthio) alkylamines as histamine H3-receptor antagonists and their therapeutic applications |
| EP1123279A1 (en) | 1998-10-21 | 2001-08-16 | Novo Nordisk A/S | New compounds, their preparation and use |
| AU6325599A (en) | 1998-10-21 | 2000-05-08 | Dr. Reddy's Research Foundation | New compounds, their preparation and use |
| WO2000023451A1 (en) | 1998-10-21 | 2000-04-27 | Novo Nordisk A/S | New compounds, their preparation and use |
| WO2000023416A1 (en) | 1998-10-21 | 2000-04-27 | Novo Nordisk A/S | New compounds, their preparation and use |
| US6353018B1 (en) | 1998-10-21 | 2002-03-05 | Novo Nordisk A/S | Compounds, their preparation and use |
| JP2002527503A (ja) | 1998-10-21 | 2002-08-27 | ノボ ノルディスク アクティーゼルスカブ | 新規化合物類、それらの調製及び使用 |
| PT1140945E (pt) | 1998-12-18 | 2003-10-31 | Novo Nordisk As | Derivados 1 2 4 tiadiazina fundidos a sua preparacao e a sua utilizacao |
| WO2000041121A1 (en) | 1999-01-07 | 2000-07-13 | Ccrewards.Com | Method and arrangement for issuance and management of digital coupons and sales offers |
| JP2002534512A (ja) | 1999-01-15 | 2002-10-15 | ノボ ノルディスク アクティーゼルスカブ | 非ペプチドｇｌｐ−１アゴニスト |
| CN1351597A (zh) | 1999-04-16 | 2002-05-29 | 雷迪研究基金会 | 抗糖尿病的新型多晶形物、其制备方法和含有它们的药物组合物 |
| WO2000063189A1 (en) | 1999-04-16 | 2000-10-26 | Novo Nordisk A/S | Crystalline r- guanidines, arginine or (l) -arginine (2s) -2- ethoxy -3-{4- [2-(10h -phenoxazin -10-yl)ethoxy]phenyl}propanoate |
| AU2953699A (en) | 1999-04-16 | 2000-11-02 | Dr. Reddy's Research Foundation | Novel polymorphic forms of an antidiabetic agent: process for their preparation and a pharmaceutical composition containing them |
| KR20020005703A (ko) | 1999-04-20 | 2002-01-17 | 한센 핀 베네드, 안네 제헤르, 웨이콥 마리안느 | 신규한 화합물, 그의 제법 및 용도 |
| WO2000063196A1 (en) | 1999-04-20 | 2000-10-26 | Novo Nordisk A/S | New compounds, their preparation and use |
| JP2002542246A (ja) | 1999-04-20 | 2002-12-10 | ノボ ノルディスク アクティーゼルスカブ | 新規な化合物、それらの製造及び使用 |
| WO2000063190A1 (en) | 1999-04-20 | 2000-10-26 | Novo Nordisk A/S | New compounds, their preparation and use |
| AU2935200A (en) | 1999-04-30 | 2000-11-17 | Pfizer Products Inc. | Compounds for the treatment of obesity |
| DE19922723A1 (de) | 1999-05-18 | 2000-11-23 | Clariant Gmbh | Aktivmatrix-Displays mit hohem Kontrast |
| DE19934799B4 (de) * | 1999-07-28 | 2008-01-24 | Az Electronic Materials (Germany) Gmbh | Chiral-smektische Flüssigkristallmischung und ihre Verwendung in Aktivmatrix-Displays mit hohen Kontrastwerten |
| GB9926302D0 (en) | 1999-11-05 | 2000-01-12 | Smithkline Beecham Plc | Novel compounds |
| GB9926303D0 (en) | 1999-11-05 | 2000-01-12 | Smithkline Beecham Plc | Novel compounds |
| US6602872B1 (en) | 1999-12-13 | 2003-08-05 | Merck & Co., Inc. | Substituted pyridazines having cytokine inhibitory activity |
| FR2802206B1 (fr) * | 1999-12-14 | 2005-04-22 | Sod Conseils Rech Applic | Derives de 4-aminopiperidine et leur utilisation en tant que medicament |
| DE60022386T2 (de) | 1999-12-16 | 2006-06-22 | Schering Corp. | Substituierte imidazole als neuropeptide y y5 rezeptor antagonisten |
| FI20000480A0 (fi) | 2000-03-01 | 2000-03-01 | Orion Yhtymae Oyj | Kinoliini- ja naftaleenijohdannaisia alfa-2 antagonisteina |
| WO2001066534A2 (en) | 2000-03-09 | 2001-09-13 | Abbott Laboratories | Cyclic and bicyclic diamino histamine-3 receptor antagonists |
| DK1268479T3 (da) | 2000-03-31 | 2004-04-19 | Ortho Mcneil Pharm Inc | Phenylsubstituerede indolizinderivater og deres anvendelse som histamin H3-ligander |
| WO2001074810A2 (en) | 2000-03-31 | 2001-10-11 | Ortho Mcneil Pharmaceutical, Inc. | Method for using 2-aryloxyalkylaminobenzoxazoles and 2-aryloxyalkylaminobenzothiazoles as h3 antagonists |
| WO2001074773A2 (en) | 2000-03-31 | 2001-10-11 | Ortho Mcneil Pharmaceutical, Inc. | Phenyl-substituted indoles as histamine h3-receptor antagonists |
| WO2001074813A2 (en) | 2000-03-31 | 2001-10-11 | Ortho Mcneil Pharmaceutical, Inc. | METHOD FOR USING 2- OR 3-ARYL SUBSTITUTED IMIDAZO[1,2-a] PYRIDINES AS H3 ANTAGONISTS |
| US6908929B2 (en) | 2000-03-31 | 2005-06-21 | Ortho-Mcneil Pharmaceutical, Inc. | Phenyl-substituted imidazopyridines |
| CZ2003686A3 (cs) | 2000-08-08 | 2003-08-13 | Ortho Mcneil Pharmaceutical, Inc. | Neimidazolové aryloxypiperidiny |
| US6316475B1 (en) | 2000-11-17 | 2001-11-13 | Abbott Laboratories | Aminoalkoxybiphenylcarboxamides as histamine-3 receptor ligands and their therapeutic applications |
| US20030078271A1 (en) | 2001-01-31 | 2003-04-24 | Blackburn Thomas P. | Use of GAL3 receptor antagonists for the treatment of depression and/or anxiety and compounds useful in such methods |
| FR2827288B1 (fr) * | 2001-07-12 | 2003-10-31 | Servier Lab | Nouveaux derives d'octahydro-2h-pyrido[1,2-a]pyrazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| US20030073672A1 (en) * | 2001-09-05 | 2003-04-17 | Breitenbucher J. Guy | Method for treating allergies using substituted pyrazoles |
| AU2003203148A1 (en) * | 2002-02-05 | 2003-09-02 | High Point Pharmaceuticals, Llc | Novel aryl- and heteroarylpiperazines |
| US20030236259A1 (en) * | 2002-02-05 | 2003-12-25 | Rolf Hohlweg | Novel aryl- and heteroarylpiperazines |
| JP2003277755A (ja) | 2002-03-26 | 2003-10-02 | Fuji Photo Film Co Ltd | 液晶組成物および液晶素子 |
| US6864261B2 (en) * | 2002-05-02 | 2005-03-08 | Euro-Celtique S.A. | Therapeutic agents useful for treating pain |
| SE0201544D0 (sv) * | 2002-05-17 | 2002-05-17 | Biovitrum Ab | Novel compounds and thier use |
| ES2283768T3 (es) | 2002-06-06 | 2007-11-01 | Novo Nordisk A/S | Hexahidropirrolo(1,2-a)piracinas, octahidropirido(1,2-a)piracinas y decahidropiracino(1,2-a)acepinas sustituidas. |
| US6906060B2 (en) * | 2002-06-06 | 2005-06-14 | Novo Nordisk A/S | Substituted hexahydropyrrolo[1,2-a]pyrazines, octahydropyrido[1,2-a]-pyrazines and decahydropyrazino[1,2-a]azepines |
| DE10246657A1 (de) * | 2002-10-07 | 2004-04-15 | Merck Patent Gmbh | Chirales Phenolderivat, dieses enthaltendes Flüssigkristallmedium, Verfahren zur Herstellung eines Flüssigkristallmediums und elektrooptische Flüssigkristallanzeige |
| US7332508B2 (en) | 2002-12-18 | 2008-02-19 | Novo Nordisk A/S | Substituted homopiperidine, piperidine or pyrrolidine derivatives |
| DK1651615T3 (da) * | 2003-07-29 | 2010-05-25 | High Point Pharmaceuticals Llc | Pyridazinyl-piperaziner og anvendelse deraf som histamin-H3-receptorligander |
| US20050028438A1 (en) * | 2003-08-05 | 2005-02-10 | Campana Kimberly A. | Plastic lawn edging fabricated by a continuous vacuum forming process |
| AU2004274309B2 (en) * | 2003-09-22 | 2010-04-08 | Msd K.K. | Novel piperidine derivative |
| US20070032477A1 (en) * | 2003-10-17 | 2007-02-08 | Waer Mark J A | Pteridine derivatives useful for making pharmaceutical compositions |
| AU2004289304A1 (en) | 2003-11-10 | 2005-05-26 | Synta Pharmaceuticals, Corp. | Pyridine compounds |
| FR2864080B1 (fr) * | 2003-12-23 | 2006-02-03 | Sanofi Synthelabo | Derives de 1-piperazine-et-1-homopiperazine-carboxylates, leur preparation et leur application en therapeutique |
| JP2007217282A (ja) | 2004-03-04 | 2007-08-30 | Astellas Pharma Inc | 置換ピリミジン誘導体 |
| AU2005233584B2 (en) | 2004-04-09 | 2010-12-09 | Merck Sharp & Dohme Corp. | Inhibitors of Akt activity |
| JP4926943B2 (ja) | 2004-04-13 | 2012-05-09 | シンタ ファーマシューティカルズ コーポレーション | Ｉｌ−１２産生を阻害する二塩 |
| EP1745039A4 (en) | 2004-05-08 | 2009-07-22 | Neurogen Corp | 3-ARYL-5,6-DISUBSTITUTED PYRIDAZINES |
| BRPI0510486A (pt) * | 2004-05-19 | 2007-11-20 | Basf Ag | composto, processo para preparar o mesmo, agente pesticida, e, processo para combater fungos nocivos fitopatogênicos |
| AU2005249494A1 (en) | 2004-05-28 | 2005-12-15 | Vertex Pharmaceuticals Incorporated | Modulators of muscarinic receptors |
| JP5337375B2 (ja) | 2004-11-02 | 2013-11-06 | ノースウェスタン ユニバーシティ | ピリダジン化合物、組成物および方法 |
| AU2005311534B2 (en) | 2004-12-03 | 2011-02-17 | F. Hoffmann-La Roche Ag | 3-substituted pyridine derivatives as H3 antagonists |
| WO2006090273A2 (en) | 2005-02-22 | 2006-08-31 | Warner-Lambert Company Llc | [1,8]naphthyridin-2-ones and related compounds with keto or hydroxyl linkers for the treatment of schizophrenia |
| CA2606288A1 (en) | 2005-04-18 | 2006-10-26 | Neurogen Corporation | Subtituted heteroaryl cb1 antagonists |
| FR2885615B1 (fr) | 2005-05-12 | 2007-06-22 | Servier Lab | Nouveaux derives de phenylpyridinylpiperazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR2885616B1 (fr) * | 2005-05-12 | 2007-06-22 | Servier Lab | Nouveaux derives de phenylpyridinylpiperazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| WO2006124874A2 (en) | 2005-05-12 | 2006-11-23 | Kalypsys, Inc. | Inhibitors of b-raf kinase |
| RU2499795C2 (ru) | 2005-07-04 | 2013-11-27 | Хай Пойнт Фармасьютикалс, ЛЛС | Антагонисты гистаминовых н3-рецепторов |
| UA95454C2 (uk) | 2005-07-15 | 2011-08-10 | Амр Текнолоджи, Інк. | Арил- і гетероарилзаміщені тетрагідробензазепіни і їх застосування для блокування зворотного захоплення норепінефрину, допаміну і серотоніну |
| US7851474B2 (en) | 2005-08-02 | 2010-12-14 | Neurogen Corporation | Dipiperazinyl ketones and related analogues |
| MX2008011123A (es) * | 2006-03-28 | 2008-09-30 | High Point Pharmaceuticals Llc | Benzotiazoles que tienen actividad de receptor h3 de histamina. |
| US8318927B2 (en) * | 2006-05-23 | 2012-11-27 | High Point Pharmaceuticals, Llc | 6-(4-cyclopropylpiperazin-1-yl)-2′-methyl-[3, 4′]-bipyridine and its uses as a medicament |
| SG163547A1 (en) * | 2006-05-29 | 2010-08-30 | High Point Pharmaceuticals Llc | 3- (1, 3-benz0di0x0l-5-yl) -6- (4-cyclopropylpiperazin-1-yl) -pyridazine, its salts and solvates and its use as histamine h3 receptor antagonist |
| EP2014656A3 (en) * | 2007-06-11 | 2011-08-24 | High Point Pharmaceuticals, LLC | New heteocyclic h3 antagonists |
-
2006
- 2006-06-30 RU RU2011142654/04A patent/RU2499795C2/ru not_active IP Right Cessation
- 2006-06-30 US US11/917,823 patent/US8501739B2/en not_active Expired - Fee Related
- 2006-06-30 BR BRPI0613564-1A patent/BRPI0613564A2/pt not_active IP Right Cessation
- 2006-06-30 WO PCT/EP2006/063753 patent/WO2007003604A2/en not_active Ceased
- 2006-06-30 EP EP06764002A patent/EP1902028A2/en not_active Withdrawn
- 2006-06-30 AU AU2006264966A patent/AU2006264966B2/en not_active Ceased
- 2006-06-30 EP EP11176842A patent/EP2386554A1/en not_active Withdrawn
- 2006-06-30 EP EP10166493A patent/EP2233470B1/en not_active Not-in-force
- 2006-06-30 MX MX2007015675A patent/MX2007015675A/es active IP Right Grant
- 2006-06-30 ES ES10166493T patent/ES2375929T3/es active Active
- 2006-06-30 KR KR1020087000240A patent/KR101286569B1/ko not_active Expired - Fee Related
- 2006-06-30 CA CA002614116A patent/CA2614116A1/en not_active Abandoned
- 2006-06-30 AT AT10166493T patent/ATE536344T1/de active
- 2006-06-30 CN CN2012104648404A patent/CN103110635A/zh active Pending
- 2006-06-30 JP JP2008519917A patent/JP5121707B2/ja not_active Expired - Fee Related
-
2012
- 2012-05-15 US US13/472,090 patent/US8846677B2/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2009500372A5 (https=) | ||
| RU2011142654A (ru) | Антагонисты гистаминовых н3-рецепторов | |
| JP2009541268A5 (https=) | ||
| JP2010529200A5 (https=) | ||
| JP2017505794A5 (https=) | ||
| RU2009101911A (ru) | Производные пиридина и пиразина в качестве ингибиторов mnk-киназы | |
| CA2551529A1 (en) | Amide derivative and medicine | |
| RU2015113746A (ru) | Замещенные сульфонамиды | |
| RU2012127760A (ru) | Bcl-2-селективные апоптоз-индуцирующие средства для лечения рака и иммунных заболеваний | |
| RU2013114352A (ru) | Азабензотиазолы, композиции и способы применения | |
| RU2010110640A (ru) | Соединения и композиции 5-(4-(галогеналкокси)фенил)пиримидин-2-амина в качестве ингибиторов киназ | |
| JP2009526072A5 (https=) | ||
| JP2004534010A5 (https=) | ||
| JP2010510319A5 (https=) | ||
| JP2013510876A5 (https=) | ||
| ME01507B (me) | Imidazotriazini i imidazopirimidini kao inhibitori kinaze | |
| JP2012502099A5 (https=) | ||
| SI2797918T1 (en) | Bromodomain inhibitors | |
| RU2003131693A (ru) | Новые ингибиторы тирозин киназ | |
| RU2012136643A (ru) | [5,6]- гетероциклическое соединение | |
| RU2018104702A (ru) | Новые соединения пирролопиримидина в качестве ингибиторов протеинкиназ | |
| RU2018110770A (ru) | Ингибиторы mdm2 и их комбинации | |
| JP2011520941A5 (https=) | ||
| RU2018138047A (ru) | Гетероциклические вещества - агонисты gpr119 | |
| JP2010540504A5 (https=) |