PL2479165T3 - Związek glicynowy - Google Patents

Związek glicynowy

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Publication number
PL2479165T3
PL2479165T3 PL10817191T PL10817191T PL2479165T3 PL 2479165 T3 PL2479165 T3 PL 2479165T3 PL 10817191 T PL10817191 T PL 10817191T PL 10817191 T PL10817191 T PL 10817191T PL 2479165 T3 PL2479165 T3 PL 2479165T3
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PL
Poland
Prior art keywords
glycine compound
glycine
compound
Prior art date
Application number
PL10817191T
Other languages
English (en)
Inventor
Kousei Yoshihara
Daisuke Suzuki
Susumu Yamaki
Yuji Koga
Norio Seki
Jiro Fujiyasu
Masahiro Neya
Original Assignee
Astellas Pharma Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc. filed Critical Astellas Pharma Inc.
Publication of PL2479165T3 publication Critical patent/PL2479165T3/pl

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    • C07C237/28Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/40Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to a carbon atom of a six-membered aromatic ring
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    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20130576A1 (es) 2010-05-13 2013-05-19 Amgen Inc Compuestos heterociclicos de nitrogeno utiles como inhibidores de pde10
CN103459369B (zh) 2011-03-15 2015-05-27 安斯泰来制药株式会社 胍化合物
CN103626722B (zh) * 2012-08-27 2016-06-01 天津药物研究院 一氧化氮供体型降血糖化合物、其制备方法和用途
JP6367204B2 (ja) * 2012-10-12 2018-08-01 メドイミューン・リミテッドMedImmune Limited 結合用のピロロベンゾジアゼピン誘導体の合成および中間体
CA2915163A1 (en) 2013-06-12 2014-12-18 Proximagen Limited New therapeutic uses of enzyme inhibitors
WO2015189534A1 (en) 2014-06-12 2015-12-17 Proximagen Limited Vap-1 inhibitors for treating muscular dystrophy
AU2016301745B2 (en) 2015-08-06 2020-07-16 Ube Industries, Ltd. Substituted guanidine derivative
EP3386494A1 (en) 2015-12-07 2018-10-17 Benevolentai Cambridge Limited Vap-1 inhibitors for treating pain
SI3455216T1 (sl) * 2016-05-12 2021-02-26 Boehringer Ingelheim International Gmbh Piridinilni derivati, farmacevtski sestavki in njihove uporabe kot AOC3 inhibitorji
CN106008362B (zh) * 2016-05-24 2018-08-10 杰达维(上海)医药科技发展有限公司 一种嘧啶衍生物的制备方法
US11396514B2 (en) 2016-12-28 2022-07-26 Ube Corporation Substituted guanidine compounds
WO2018148856A1 (en) * 2017-02-14 2018-08-23 Eli Lilly And Company Diazaspirodecanyl-pyrimidine compounds useful as ssao inhibitors
CN107082828B (zh) * 2017-05-19 2019-09-17 暨南大学 一种活性氧响应性高分子载体及其制备方法
EP3873599B1 (en) 2018-10-29 2023-09-27 Boehringer Ingelheim International GmbH Pyridinyl sulfonamide derivatives, pharmaceutical compositions and uses thereof

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1181871B (it) 1985-04-01 1987-09-30 Consiglio Nazionale Ricerche Inibitori selettivi delle benzilamminossidasi rispetto ad altre amminossidasi
AU4055593A (en) 1992-05-15 1993-12-13 University Of Saskatchewan Method for preventing endothelium damage in mammals and for alleviating pain associated with gout and arthritis
AU7473398A (en) 1997-05-07 1998-11-27 University Of Pittsburgh Inhibitors of protein isoprenyl transferases
CA2319824A1 (en) 1998-01-30 1999-08-05 Shuichi Gomi Phenylpiperazine derivatives as integrin .alpha.v.beta.3 antagonists
JP2000178243A (ja) 1998-12-14 2000-06-27 Teijin Ltd ビフェニルアミジン誘導体
WO2002000606A1 (fr) 2000-06-28 2002-01-03 Takeda Chemical Industries, Ltd. Compose biphenyle
JP2002080439A (ja) * 2000-06-28 2002-03-19 Takeda Chem Ind Ltd ビフェニル化合物
NZ523463A (en) 2000-07-05 2004-06-25 Biotie Therapies Corp Inhibitors of copper-containing amine oxidases
ES2168084B1 (es) 2000-11-07 2003-11-16 Univ Barcelona Combinacion de aminas y compuestos de vanadio (iv) (v) para el tratatamiento y/o la prevencion de la diabetes mellitus.
WO2002038153A1 (en) 2000-11-09 2002-05-16 Biovitrum Ab New use of 4, 5, 6, 7-tetrahydroimidazo-[4,5-c]pyridine derivatives
WO2003057671A1 (fr) 2001-12-28 2003-07-17 Takeda Chemical Industries, Ltd. Compose biaryle et son utilisation
WO2004067521A1 (en) 2003-01-27 2004-08-12 Astellas Pharma Inc. Thiazole derivatives and their use as vap-1 inhibitors
TWI378092B (en) 2003-06-03 2012-12-01 Rib X Pharmaceuticals Inc Biaryl heterocyclic compounds and methods of making and using the same
US20070197541A1 (en) * 2003-07-29 2007-08-23 Oyelere Adegboyega K Biaryl heterocyclic amines,amides, and sulfur-containing compounds and methods of making and using the same
DK1708711T3 (da) 2004-01-30 2010-06-14 Biotie Therapies Oyj Sammensætninger, der især er anvendelige til behandling eller forebyggelse af metabolisk syndrom
CN1921841A (zh) 2004-02-25 2007-02-28 拉卓拉药物公司 用于治疗疾病的胺和酰胺类化合物
JP2007523955A (ja) * 2004-02-25 2007-08-23 ラ ホヤ ファーマシューティカル カンパニー 疾患の治療のためのアミンおよびアミド
JP2007217282A (ja) * 2004-03-04 2007-08-30 Astellas Pharma Inc 置換ピリミジン誘導体
EP1725236A4 (en) 2004-03-11 2009-05-13 Glaxo Group Ltd NEW M3 MUSCARIN ACETYLCHOLINE RECEPTOR ANTAGONISTS
CN101087601A (zh) 2004-08-02 2007-12-12 根梅迪卡治疗公司 用于抑制含铜胺氧化酶的化合物及其应用
ATE536344T1 (de) * 2005-07-04 2011-12-15 High Point Pharmaceuticals Llc Histamine h3 receptor antagonisten
US20070066646A1 (en) 2005-08-02 2007-03-22 Genmedica Therapeutics Sl Compounds for Inhibiting Copper-Containing Amine Oxidases and Uses Thereof
WO2007018319A1 (ja) * 2005-08-11 2007-02-15 Takeda Pharmaceutical Company Limited ピリジルフェノール化合物およびその用途
TW200813015A (en) 2006-03-15 2008-03-16 Mitsubishi Pharma Corp 2-(cyclic amino)-pyrimidone derivatives
US8338437B2 (en) 2007-02-28 2012-12-25 Methylgene Inc. Amines as small molecule inhibitors
WO2009055002A1 (en) * 2007-10-24 2009-04-30 La Jolla Pharmaceutical Company Combined inhibitors of cyclooxygenase and semicarbazide-sensitive amine oxidase (ssao) (vascular adhesion protein, vap-1)

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