JP2010529200A5 - - Google Patents
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- Publication number
- JP2010529200A5 JP2010529200A5 JP2010512241A JP2010512241A JP2010529200A5 JP 2010529200 A5 JP2010529200 A5 JP 2010529200A5 JP 2010512241 A JP2010512241 A JP 2010512241A JP 2010512241 A JP2010512241 A JP 2010512241A JP 2010529200 A5 JP2010529200 A5 JP 2010529200A5
- Authority
- JP
- Japan
- Prior art keywords
- isopropylpiperazin
- ylmethyl
- phenyl
- bipyridinyl
- hexahydro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 150000001875 compounds Chemical class 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 3
- PNOOMSVMGWAEBT-UHFFFAOYSA-N n,n-dimethyl-4-[6-[(4-propan-2-ylpiperazin-1-yl)methyl]pyridin-3-yl]benzamide Chemical compound C1CN(C(C)C)CCN1CC1=CC=C(C=2C=CC(=CC=2)C(=O)N(C)C)C=N1 PNOOMSVMGWAEBT-UHFFFAOYSA-N 0.000 claims 2
- DAVZGTOMALWXCJ-UHFFFAOYSA-N (4-methylpiperazin-1-yl)-[4-[5-[(4-propan-2-ylpiperazin-1-yl)methyl]pyridin-2-yl]phenyl]methanone Chemical compound C1CN(C(C)C)CCN1CC1=CC=C(C=2C=CC(=CC=2)C(=O)N2CCN(C)CC2)N=C1 DAVZGTOMALWXCJ-UHFFFAOYSA-N 0.000 claims 1
- NHTOQWBSOYPAMS-UHFFFAOYSA-N (4-methylpiperazin-1-yl)-[4-[6-(1-propan-2-ylpiperidin-4-yl)pyridin-3-yl]phenyl]methanone Chemical compound C1CN(C(C)C)CCC1C1=CC=C(C=2C=CC(=CC=2)C(=O)N2CCN(C)CC2)C=N1 NHTOQWBSOYPAMS-UHFFFAOYSA-N 0.000 claims 1
- YBHCACLGNQGJLP-UHFFFAOYSA-N (4-methylpiperazin-1-yl)-[4-[6-[(4-propan-2-ylpiperazin-1-yl)methyl]pyridazin-3-yl]phenyl]methanone Chemical compound C1CN(C(C)C)CCN1CC1=CC=C(C=2C=CC(=CC=2)C(=O)N2CCN(C)CC2)N=N1 YBHCACLGNQGJLP-UHFFFAOYSA-N 0.000 claims 1
- XQSHJCISSDLGEV-UHFFFAOYSA-N (4-methylpiperazin-1-yl)-[4-[6-[(4-propan-2-ylpiperazin-1-yl)methyl]pyridin-3-yl]phenyl]methanone Chemical compound C1CN(C(C)C)CCN1CC1=CC=C(C=2C=CC(=CC=2)C(=O)N2CCN(C)CC2)C=N1 XQSHJCISSDLGEV-UHFFFAOYSA-N 0.000 claims 1
- KMIVAGCIHIXFIP-UHFFFAOYSA-N [2-fluoro-4-[6-(1-propan-2-ylpiperidin-4-yl)pyridin-3-yl]phenyl]-pyrrolidin-1-ylmethanone Chemical compound C1CN(C(C)C)CCC1C1=CC=C(C=2C=C(F)C(C(=O)N3CCCC3)=CC=2)C=N1 KMIVAGCIHIXFIP-UHFFFAOYSA-N 0.000 claims 1
- XVLBUNVMXRTBHP-UHFFFAOYSA-N [4-[6-(1-propan-2-ylpiperidin-4-yl)pyridin-3-yl]phenyl]-pyrrolidin-1-ylmethanone Chemical compound C1CN(C(C)C)CCC1C1=CC=C(C=2C=CC(=CC=2)C(=O)N2CCCC2)C=N1 XVLBUNVMXRTBHP-UHFFFAOYSA-N 0.000 claims 1
- QNBXHIFHBCHDGL-UHFFFAOYSA-N morpholin-4-yl-[4-[6-[(4-propan-2-ylpiperazin-1-yl)methyl]pyridazin-3-yl]phenyl]methanone Chemical compound C1CN(C(C)C)CCN1CC1=CC=C(C=2C=CC(=CC=2)C(=O)N2CCOCC2)N=N1 QNBXHIFHBCHDGL-UHFFFAOYSA-N 0.000 claims 1
- YDSYVOPWZSMHER-UHFFFAOYSA-N n,n-dimethyl-4-[5-[(4-propan-2-ylpiperazin-1-yl)methyl]pyridin-2-yl]benzamide Chemical compound C1CN(C(C)C)CCN1CC1=CC=C(C=2C=CC(=CC=2)C(=O)N(C)C)N=C1 YDSYVOPWZSMHER-UHFFFAOYSA-N 0.000 claims 1
- AVRKXXJCLSNMEN-UHFFFAOYSA-N n,n-dimethyl-4-[6-[(4-propan-2-ylpiperazin-1-yl)methyl]pyridazin-3-yl]benzamide Chemical compound C1CN(C(C)C)CCN1CC1=CC=C(C=2C=CC(=CC=2)C(=O)N(C)C)N=N1 AVRKXXJCLSNMEN-UHFFFAOYSA-N 0.000 claims 1
- MMEYJWQPBRFMNG-UHFFFAOYSA-N n-[4-[5-[(4-propan-2-ylpiperazin-1-yl)methyl]pyridin-2-yl]phenyl]acetamide Chemical compound C1CN(C(C)C)CCN1CC1=CC=C(C=2C=CC(NC(C)=O)=CC=2)N=C1 MMEYJWQPBRFMNG-UHFFFAOYSA-N 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- PWJLBMVKVLMYOA-UHFFFAOYSA-N piperidin-1-yl-[4-[6-[(4-propan-2-ylpiperazin-1-yl)methyl]pyridazin-3-yl]phenyl]methanone Chemical compound C1CN(C(C)C)CCN1CC1=CC=C(C=2C=CC(=CC=2)C(=O)N2CCCCC2)N=N1 PWJLBMVKVLMYOA-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07109949A EP2014656A3 (en) | 2007-06-11 | 2007-06-11 | New heteocyclic h3 antagonists |
| US93451407P | 2007-06-13 | 2007-06-13 | |
| PCT/US2008/064106 WO2008154126A1 (en) | 2007-06-11 | 2008-05-19 | New heteocyclic h3 antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010529200A JP2010529200A (ja) | 2010-08-26 |
| JP2010529200A5 true JP2010529200A5 (https=) | 2011-06-02 |
Family
ID=39337237
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010512241A Withdrawn JP2010529200A (ja) | 2007-06-11 | 2008-05-19 | 新規の複素環ｈ３アンタゴニスト |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8344001B2 (https=) |
| EP (2) | EP2014656A3 (https=) |
| JP (1) | JP2010529200A (https=) |
| CN (1) | CN101795567A (https=) |
| AR (1) | AR066946A1 (https=) |
| CA (1) | CA2690486A1 (https=) |
| CL (1) | CL2008001705A1 (https=) |
| TW (1) | TW200918054A (https=) |
| WO (1) | WO2008154126A1 (https=) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030236259A1 (en) * | 2002-02-05 | 2003-12-25 | Rolf Hohlweg | Novel aryl- and heteroarylpiperazines |
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| EP2402324A1 (en) * | 2006-05-29 | 2012-01-04 | High Point Pharmaceuticals, LLC | Benzodioxolylcyclopropylpiperazinylpyridazines |
| US7638541B2 (en) | 2006-12-28 | 2009-12-29 | Metabolex Inc. | 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine |
| AU2008279447A1 (en) | 2007-07-19 | 2009-01-29 | Metabolex, Inc. | N-azacyclic substituted pyrrole, pyrazole, imidazole, triazole and tetrazole derivatives as agonists of the RUP3 or GPR119 receptor for the treatment of diabetes and metabolic disorders |
| AU2009231906A1 (en) * | 2008-03-31 | 2009-10-08 | Metabolex, Inc. | Oxymethylene aryl compounds and uses thereof |
| CA2727174A1 (en) * | 2008-06-20 | 2010-01-21 | Jiangao Song | Aryl gpr119 agonists and uses thereof |
| EP2311822A4 (en) * | 2008-08-01 | 2011-08-31 | Nippon Chemiphar Co | GPR119 AGONIST |
| JPWO2011025006A1 (ja) * | 2009-08-31 | 2013-01-31 | 日本ケミファ株式会社 | Ｇｐｒ１１９作動薬 |
| JP5909185B2 (ja) | 2009-10-01 | 2016-04-26 | シマベイ セラピューティクス， インコーポレーテッド | 置換テトラゾール−１−イルフェノキシメチルチアゾール−２−イルピペリジニルピリミジン塩 |
| JP5847813B2 (ja) | 2010-06-23 | 2016-01-27 | シマベイ セラピューティクス， インコーポレーテッド | ５−エチル−２−｛４−［４−（４−テトラゾル−１−イル−フェノキシメチル）−チアゾール−２−イル］−ピペリジン−１−イル｝−ピリミジンの組成物 |
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| KR20210130843A (ko) | 2013-07-31 | 2021-11-01 | 노파르티스 아게 | 1,4-이치환된 피리다진 유사체 및 smn-결핍-관련 상태를 치료하기 위한 그의 용도 |
| WO2016128343A1 (en) * | 2015-02-09 | 2016-08-18 | F. Hoffmann-La Roche Ag | Compounds for the treatment of cancer |
| EP3053577A1 (en) * | 2015-02-09 | 2016-08-10 | F. Hoffmann-La Roche AG | Compounds for the treatment of cancer |
| IL294124B2 (en) * | 2015-12-10 | 2024-02-01 | Ptc Therapeutics Inc | Methods for treating huntington's disease |
| AU2017305392A1 (en) | 2016-08-03 | 2019-02-21 | Cymabay Therapeutics, Inc. | Oxymethylene aryl compounds for treating inflammatory gastrointestinal diseases or gastrointestinal conditions |
| JOP20190219A1 (ar) * | 2017-05-09 | 2019-09-22 | Cardix Therapeutics LLC | تركيبات صيدلانية وطرق لعلاج أمراض القلب والأوعية الدموية |
| US11407753B2 (en) | 2017-06-05 | 2022-08-09 | Ptc Therapeutics, Inc. | Compounds for treating Huntington's disease |
| US11382918B2 (en) | 2017-06-28 | 2022-07-12 | Ptc Therapeutics, Inc. | Methods for treating Huntington's Disease |
| WO2019005993A1 (en) | 2017-06-28 | 2019-01-03 | Ptc Therapeutics, Inc. | METHODS OF TREATING HUNTINGTON'S DISEASE |
| MX2020009957A (es) | 2018-03-27 | 2021-01-15 | Ptc Therapeutics Inc | Compuestos para el tratamiento de enfermedad de hungtinton. |
| TWI657825B (zh) * | 2018-04-04 | 2019-05-01 | 美進醫藥公司 | 治療心血管疾病的組合藥物及其製備和使用方法 |
| CN108440401A (zh) * | 2018-04-13 | 2018-08-24 | 华东理工大学 | 5-[(4-乙基哌嗪-1-基)甲基]吡啶-2-胺的制备方法 |
| EP3814360B8 (en) | 2018-06-27 | 2024-11-06 | PTC Therapeutics, Inc. | Heteroaryl compounds for treating huntington's disease |
| PL3814357T3 (pl) | 2018-06-27 | 2024-09-16 | Ptc Therapeutics, Inc. | Związki heterocykliczne i heteroarylowe do leczenia choroby huntingtona |
| EP3814345B8 (en) | 2018-06-27 | 2024-10-30 | PTC Therapeutics, Inc. | Heteroaryl compounds for treating huntington's disease |
| WO2020231977A1 (en) | 2019-05-13 | 2020-11-19 | Ptc Therapeutics, Inc. | Compounds for treating huntington's disease |
| US20250051277A1 (en) | 2021-10-29 | 2025-02-13 | Sensorium Therapeutics, Inc. | Delivery of therapeutic alkaloid compounds |
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| FR2885615B1 (fr) * | 2005-05-12 | 2007-06-22 | Servier Lab | Nouveaux derives de phenylpyridinylpiperazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| MX2007015675A (es) * | 2005-07-04 | 2008-02-20 | Novo Nordisk As | Antagonistas del receptor de histamina h3. |
| KR101594898B1 (ko) | 2005-07-15 | 2016-02-18 | 알바니 몰레큘라 리써치, 인크. | 아릴- 및 헤테로아릴-치환된 테트라히드로벤자제핀, 및 노르에피네프린, 도파민 및 세로토닌의 재흡수를 차단하기 위한 용도 |
| US7851474B2 (en) | 2005-08-02 | 2010-12-14 | Neurogen Corporation | Dipiperazinyl ketones and related analogues |
| CN101410385B (zh) * | 2006-03-28 | 2011-08-24 | 高点制药有限责任公司 | 具有组胺h3受体活性的苯并噻唑类 |
| EP2038256A1 (en) * | 2006-05-23 | 2009-03-25 | TransTech Pharma, Inc | 6- (4-cyclopropylpiperazin-1-yl) -2 ' -methyl- [3, 4 ']-bipyridine and its use as a medicament |
| EP2402324A1 (en) * | 2006-05-29 | 2012-01-04 | High Point Pharmaceuticals, LLC | Benzodioxolylcyclopropylpiperazinylpyridazines |
-
2007
- 2007-06-11 EP EP07109949A patent/EP2014656A3/en not_active Withdrawn
-
2008
- 2008-05-19 CN CN200880100442A patent/CN101795567A/zh active Pending
- 2008-05-19 WO PCT/US2008/064106 patent/WO2008154126A1/en not_active Ceased
- 2008-05-19 JP JP2010512241A patent/JP2010529200A/ja not_active Withdrawn
- 2008-05-19 EP EP08755859A patent/EP2166850A4/en not_active Withdrawn
- 2008-05-19 CA CA2690486A patent/CA2690486A1/en not_active Abandoned
- 2008-05-19 US US12/663,103 patent/US8344001B2/en not_active Expired - Fee Related
- 2008-05-30 TW TW097120318A patent/TW200918054A/zh unknown
- 2008-06-10 CL CL2008001705A patent/CL2008001705A1/es unknown
- 2008-06-10 AR ARP080102468A patent/AR066946A1/es unknown
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