JP2009297025A - 撹拌タンクバイオリアクタ - Google Patents
撹拌タンクバイオリアクタ Download PDFInfo
- Publication number
- JP2009297025A JP2009297025A JP2009128573A JP2009128573A JP2009297025A JP 2009297025 A JP2009297025 A JP 2009297025A JP 2009128573 A JP2009128573 A JP 2009128573A JP 2009128573 A JP2009128573 A JP 2009128573A JP 2009297025 A JP2009297025 A JP 2009297025A
- Authority
- JP
- Japan
- Prior art keywords
- bioreactor
- port
- ports
- housing
- furthest
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000007788 liquid Substances 0.000 claims abstract description 28
- 239000000523 sample Substances 0.000 claims abstract description 24
- 238000005070 sampling Methods 0.000 claims abstract description 11
- 239000007789 gas Substances 0.000 claims description 27
- 229920003023 plastic Polymers 0.000 claims description 17
- 239000004033 plastic Substances 0.000 claims description 17
- 238000013019 agitation Methods 0.000 claims description 13
- 239000002184 metal Substances 0.000 claims description 9
- 239000000919 ceramic Substances 0.000 claims description 8
- 238000003756 stirring Methods 0.000 claims description 7
- 239000012530 fluid Substances 0.000 claims description 4
- 230000008878 coupling Effects 0.000 claims description 3
- 238000010168 coupling process Methods 0.000 claims description 3
- 238000005859 coupling reaction Methods 0.000 claims description 3
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 2
- 239000002028 Biomass Substances 0.000 claims description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 2
- 238000004891 communication Methods 0.000 claims description 2
- 238000012258 culturing Methods 0.000 claims description 2
- 239000008101 lactose Substances 0.000 claims description 2
- 239000001301 oxygen Substances 0.000 claims description 2
- 229910052760 oxygen Inorganic materials 0.000 claims description 2
- 230000000717 retained effect Effects 0.000 claims description 2
- 239000002991 molded plastic Substances 0.000 abstract description 8
- 239000011521 glass Substances 0.000 abstract description 6
- 239000000463 material Substances 0.000 abstract description 4
- 229910000831 Steel Inorganic materials 0.000 abstract description 3
- 239000010959 steel Substances 0.000 abstract description 3
- 238000005516 engineering process Methods 0.000 abstract description 2
- 230000006872 improvement Effects 0.000 abstract description 2
- 230000007547 defect Effects 0.000 abstract 1
- 230000007246 mechanism Effects 0.000 description 13
- 210000004027 cell Anatomy 0.000 description 12
- 238000000034 method Methods 0.000 description 7
- -1 sampling Substances 0.000 description 7
- 239000000853 adhesive Substances 0.000 description 6
- 230000001070 adhesive effect Effects 0.000 description 6
- 229920000642 polymer Polymers 0.000 description 6
- 238000000465 moulding Methods 0.000 description 5
- 229920001577 copolymer Polymers 0.000 description 4
- 238000010438 heat treatment Methods 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 239000004698 Polyethylene Substances 0.000 description 3
- 239000004793 Polystyrene Substances 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 239000002609 medium Substances 0.000 description 3
- 229920000573 polyethylene Polymers 0.000 description 3
- 229920000098 polyolefin Polymers 0.000 description 3
- 229920002223 polystyrene Polymers 0.000 description 3
- 230000005855 radiation Effects 0.000 description 3
- 230000001954 sterilising effect Effects 0.000 description 3
- 238000004659 sterilization and disinfection Methods 0.000 description 3
- 239000004575 stone Substances 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- 241000233866 Fungi Species 0.000 description 2
- 239000004677 Nylon Substances 0.000 description 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 2
- 210000004102 animal cell Anatomy 0.000 description 2
- 235000012000 cholesterol Nutrition 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 238000005553 drilling Methods 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 229920001778 nylon Polymers 0.000 description 2
- 239000004417 polycarbonate Substances 0.000 description 2
- 229920000515 polycarbonate Polymers 0.000 description 2
- 229920000728 polyester Polymers 0.000 description 2
- 229920000139 polyethylene terephthalate Polymers 0.000 description 2
- 239000005020 polyethylene terephthalate Substances 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 238000001175 rotational moulding Methods 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 239000004801 Chlorinated PVC Substances 0.000 description 1
- 241000699802 Cricetulus griseus Species 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- 241000721701 Lynx Species 0.000 description 1
- 239000004695 Polyether sulfone Substances 0.000 description 1
- 239000004697 Polyetherimide Substances 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 239000004699 Ultra-high molecular weight polyethylene Substances 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 229920000122 acrylonitrile butadiene styrene Polymers 0.000 description 1
- 239000004676 acrylonitrile butadiene styrene Substances 0.000 description 1
- 238000005273 aeration Methods 0.000 description 1
- 239000003570 air Substances 0.000 description 1
- 125000005362 aryl sulfone group Chemical group 0.000 description 1
- 230000000712 assembly Effects 0.000 description 1
- 238000000429 assembly Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 229920000457 chlorinated polyvinyl chloride Polymers 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000010304 firing Methods 0.000 description 1
- 229920002457 flexible plastic Polymers 0.000 description 1
- 239000004811 fluoropolymer Substances 0.000 description 1
- 229920002313 fluoropolymer Polymers 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 229920001903 high density polyethylene Polymers 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 229920000092 linear low density polyethylene Polymers 0.000 description 1
- 239000004707 linear low-density polyethylene Substances 0.000 description 1
- 229920001684 low density polyethylene Polymers 0.000 description 1
- 239000004702 low-density polyethylene Substances 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 125000005395 methacrylic acid group Chemical group 0.000 description 1
- 239000012982 microporous membrane Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229920005787 opaque polymer Polymers 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 210000001672 ovary Anatomy 0.000 description 1
- 230000010412 perfusion Effects 0.000 description 1
- 239000002985 plastic film Substances 0.000 description 1
- 229920006255 plastic film Polymers 0.000 description 1
- 229920002492 poly(sulfone) Polymers 0.000 description 1
- 229920006393 polyether sulfone Polymers 0.000 description 1
- 229920001601 polyetherimide Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 239000004810 polytetrafluoroethylene Substances 0.000 description 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 239000005060 rubber Substances 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 229920000785 ultra high molecular weight polyethylene Polymers 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M1/00—Apparatus for enzymology or microbiology
- C12M1/02—Apparatus for enzymology or microbiology with agitation means; with heat exchange means
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/46—Means for fastening
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M1/00—Apparatus for enzymology or microbiology
- C12M1/04—Apparatus for enzymology or microbiology with gas introduction means
- C12M1/06—Apparatus for enzymology or microbiology with gas introduction means with agitator, e.g. impeller
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/20—Material Coatings
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/28—Constructional details, e.g. recesses, hinges disposable or single use
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/38—Caps; Covers; Plugs; Pouring means
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/48—Holding appliances; Racks; Supports
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Sustainable Development (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Clinical Laboratory Science (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
【解決手段】本発明は、成形プラスチックから形成される使い捨て可能なバイオリアクタである。バイオリアクタは、予め滅菌されるとともに、互いにシールされる上端部と本体とを有する。上端部およびハウジングの側面には1つ以上のポートが形成される。少なくとも1つのポートは、ハウジングにおける液体/空気の高さよりも下側にあることが好ましい。液体/空気界面高さよりも下側にある1つ以上のポートは、サンプリングポート、または、プローブ或いはドレインのためのアクセスポート、または、液体或いは気体のための供給ポートとして使用されてもよい。バイオリアクタは、既存の支持構造および制御を利用する既存のガラスアセンブリまたはスチールアセンブリのための直接的な改良を提供する。
【選択図】図1
Description
本出願は、全体の内容が参照により本明細書に組み込まれる2008年6月11日に出願された米国仮特許出願第61/131,640号の利益を主張する。
4 スタンド
6 脚部
8 支持リム
10 支持片
12 駆動機構
16 上端部
20 シャフト
22 バイオリアクタ本体
24 クリップ
30、32 ポート
Claims (23)
- バイオマスを培養し、発酵させ、あるいは、処理するためのバイオリアクタであって、半硬質プラスチックおよび硬質プラスチックからなるグループから選択されるプラスチックから形成される予め滅菌された使い捨て可能なハウジングを備え、前記ハウジングが互いにシールされる上端部と本体とを有し、本体が内部空間を有し、ハウジングの上端部および本体のそれぞれにはハウジングの内部と流体連通する1つ以上のポートが形成され、本体の内部空間を環境から分離するために1つ以上のポートがキャップを有する、バイオリアクタ。
- 1つ以上のポートが上端部および本体に成形される、請求項1に記載のバイオリアクタ。
- 1つ以上のポートが上端部および本体に成形され、本体の少なくとも1つのポートがハウジングの液体/空気界面よりも下側の高さにある、請求項1に記載のバイオリアクタ。
- 2つ以上のポートが存在し、少なくとも1つのポートがハウジングの液体/空気界面よりも下側の高さで本体に成形される、請求項1に記載のバイオリアクタ。
- 上端部が一連の第1のポートを有し、本体が一連の第2のポートを有する、請求項1に記載のバイオリアクタ。
- 1つ以上のパドルを有してハウジングの本体内に装着される撹拌シャフトを更に備える、請求項1に記載のバイオリアクタ。
- 1つ以上のパドルを有してハウジングの本体内に装着され且つ磁気要素を含む撹拌シャフトを更に備え、磁気要素が、撹拌シャフトの磁気要素と略平行な位置で本体の外部であるが本体に隣接して位置する磁気ドライブと相互作用する、請求項1に記載のバイオリアクタ。
- 1つ以上のパドルを有してハウジングの本体内に装着される撹拌シャフトを更に備え、シャフトが、ポートを介してハウジングの上端部を貫通して延びるとともに、1つ以上のガスケットによってポートで液密シールされる、請求項1に記載のバイオリアクタ。
- 本体が、上端部から最も離れた本体の部分に隣接するポートを含み、上端部から最も離れたポートが散気装置を含む、請求項1に記載のバイオリアクタ。
- 本体が、上端部から最も離れた本体の部分に隣接するポートを含み、上端部から最も離れたポートが、プラスチック、セラミック、および、金属フリットからなるグループから選択されるフリットにより形成される散気装置を含む、請求項1に記載のバイオリアクタ。
- 本体が、上端部から最も離れた本体の部分に隣接するポートを含み、上端部から最も離れたポートが、本体の内部に散気装置を含み、散気装置が、プラスチック、セラミック、および、金属フリットからなるグループから選択されるフリットにより形成され、ポートが、本体の外部部分のガスラインに対して接続される、請求項1に記載のバイオリアクタ。
- 本体が、上端部から最も離れた本体の部分に隣接するポートを含み、上端部から最も離れたポートが、本体の内部に成形される散気装置を含み、散気装置が、プラスチック、セラミック、および、金属フリットからなるグループから選択されるフリットにより形成され、ポートが、本体の外部部分のガスラインに対して接続される、請求項1に記載のバイオリアクタ。
- 本体が、上端部から最も離れた本体の部分に隣接するポートを含み、上端部から最も離れたポートが、本体の内部に対して選択的に保持される散気装置を含み、散気装置が、プラスチック、セラミック、および、金属フリットからなるグループから選択されるフリットにより形成され、ポートが、本体の外部部分のガスラインに対して接続される、請求項1に記載のバイオリアクタ。
- 本体の1つ以上のポートがそれぞれ、ルアー管継手およびホースバーブからなるグループから選択される管継手に接続される、請求項1に記載のバイオリアクタ。
- 本体の1つ以上のポートがそれぞれ、管継手に接続されるとともに、逆止弁およびサンプリングデバイスからなるグループから選択されるデバイスを含む、請求項1に記載のバイオリアクタ。
- 本体の1つ以上のポートがそれぞれ、管継手に接続されるとともに、サンプリング用のセプタムと、セプタムを穿刺するためのニードルとを有し、ニードルが前穿刺部と後部とを有し、ニードルが前穿刺部から後部へと延びる中空ルーメンを有し、後部がチューブに接続され、チューブがサンプル容器に接続される、請求項1に記載のバイオリアクタ。
- 本体の1つ以上のポートがそれぞれ、管継手に接続されるとともに、サンプリング用のセプタムと、セプタムを穿刺するためのニードルとを有し、ニードルが前穿刺部と後部とを有し、ニードルが前穿刺部から後部へと延びる中空ルーメンを有し、後部がチューブに接続され、チューブがサンプル容器に接続され、容器がバッグおよびシリンジからなるグループから選択される、請求項1に記載のバイオリアクタ。
- 複数のポートが存在し、少なくとも1つのポートがパラメータプローブを含む、請求項1に記載のバイオリアクタ。
- 複数のポートが存在し、少なくとも1つのポートがパラメータプローブを含み、プローブが、pH、温度、溶存酸素、乳糖濃度、および、圧力からなるグループから選択される、請求項1に記載のバイオリアクタ。
- 1つ以上のパドルを有してハウジングの本体内に装着される撹拌シャフトと、撹拌シャフトの下端を保持するために本体の内部空間の底面に位置する保持ハブとを更に備える、請求項1に記載のバイオリアクタ。
- ハウジングの本体内に装着される磁気結合要素を有するインペラと、本体内でインペラを遠隔的に駆動させるためにインペラに隣接する本体の外面上に位置する磁気駆動要素とを更に備える、請求項1に記載のバイオリアクタ。
- 上端部が、バイオリアクタの上端部に取り付けられる1つ以上のチューブクリップを有する、請求項1に記載のバイオリアクタ。
- ハウジングの底部の外壁が2つ以上のロッキングタブを有し、2つ以上のロッキング特徴形態を有するスタンドを更に備え、ロッキング特徴形態が、スタンド内にハウジングを直立に安定した態様で保持するためにハウジングのロッキングタブと相互作用する、請求項1に記載のバイオリアクタ。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13164008P | 2008-06-11 | 2008-06-11 | |
US61/131,640 | 2008-06-11 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2009297025A true JP2009297025A (ja) | 2009-12-24 |
JP5281483B2 JP5281483B2 (ja) | 2013-09-04 |
Family
ID=41229479
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2009128573A Active JP5281483B2 (ja) | 2008-06-11 | 2009-05-28 | 撹拌タンクバイオリアクタ |
Country Status (9)
Country | Link |
---|---|
US (2) | US8999702B2 (ja) |
EP (1) | EP2141224B1 (ja) |
JP (1) | JP5281483B2 (ja) |
KR (1) | KR101386026B1 (ja) |
CN (1) | CN101724548B (ja) |
AU (1) | AU2009201890B2 (ja) |
ES (1) | ES2808600T3 (ja) |
SG (1) | SG158007A1 (ja) |
WO (1) | WO2009151514A1 (ja) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2016059355A (ja) * | 2014-09-19 | 2016-04-25 | 株式会社ジェイ・エム・エス | 細胞培養容器 |
JP2016534728A (ja) * | 2013-10-31 | 2016-11-10 | ハミルトン・ボナドゥウ・アーゲー | 細胞培養容器の蓋 |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2902799B1 (fr) | 2006-06-27 | 2012-10-26 | Millipore Corp | Procede et unite de preparation d'un echantillon pour l'analyse microbiologique d'un liquide |
US8569464B2 (en) | 2006-12-21 | 2013-10-29 | Emd Millipore Corporation | Purification of proteins |
WO2008079302A2 (en) | 2006-12-21 | 2008-07-03 | Millipore Corporation | Purification of proteins |
US8362217B2 (en) | 2006-12-21 | 2013-01-29 | Emd Millipore Corporation | Purification of proteins |
US8217099B2 (en) * | 2008-05-22 | 2012-07-10 | Iteq (Dongguan) Corporation | Thermosetting resin composition |
JP2012511929A (ja) | 2008-12-16 | 2012-05-31 | イー・エム・デイー・ミリポア・コーポレイシヨン | 攪拌タンク反応器及び方法 |
US20110223581A1 (en) * | 2008-12-19 | 2011-09-15 | Stobbe Tech A/S | Electronically controlled diaphragm pump |
EP2251407B1 (en) * | 2009-05-12 | 2016-06-29 | Eppendorf AG | Disposable bioreactor and method for its production |
US9719705B2 (en) * | 2009-09-30 | 2017-08-01 | Ge Healthcare Bio-Sciences Corp. | Disposable bioreactor condenser bag and filter heater |
EP2513287B1 (en) * | 2009-12-17 | 2016-10-12 | GE Healthcare Bio-Sciences AB | Sensor attachment arrangement for flexible bags |
KR101551295B1 (ko) | 2010-05-17 | 2015-09-08 | 이엠디 밀리포어 코포레이션 | 생체분자 정제용 자극 반응성 중합체 |
KR20120058293A (ko) * | 2010-11-29 | 2012-06-07 | 백원옥 | 마그네틱을 이용한 일회용 미생물 배양용기 및 배양장치 |
US10717960B2 (en) | 2011-10-10 | 2020-07-21 | Dasgip Information And Technology Gmbh | Biotechnological apparatus comprising a bioreactor, exhaust gas temperature control device for a bioreactor and a method for treating an exhaust gas stream in a biotechnological apparatus |
EP2674480B2 (de) | 2012-06-15 | 2023-04-05 | DASGIP Information and Process Technology GmbH | Anschlussvorrichtung für eine sterile Einweg-Fluidleitung eines Einwegbioreaktors und Verfahren zum Behandeln eines Fluidstroms |
GB2495934A (en) * | 2011-10-25 | 2013-05-01 | Tap Biosystems Phc Ltd | Bioreactor outlet air conditioning systems and associated methods |
ES2785973T3 (es) | 2011-11-07 | 2020-10-08 | Rapid Micro Biosystems Inc | Casete para ensayos de esterilidad |
MX2014012439A (es) | 2012-04-16 | 2015-01-16 | Rapid Micro Biosystems Inc | Dispositivo para cultivar celulas. |
DK2674479T3 (en) | 2012-06-15 | 2015-04-13 | Eppendorf Ag | One-way bioreactor and top plate and method of manufacture |
WO2014196915A1 (en) * | 2013-06-05 | 2014-12-11 | Ge Healthcare Bio-Sciences Ab | Disposable container and mixing system comprising the container |
US11549091B2 (en) | 2013-08-27 | 2023-01-10 | Cytiva Sweden Ab | Bioreactor with addition tube |
SG10201910334WA (en) * | 2013-09-16 | 2020-01-30 | Genentech Inc | Bioreactors with multiple or adjustable -position agitator designs |
JP6487917B2 (ja) | 2013-11-21 | 2019-03-20 | ディステック,インコーポレーテッド | 使い捨てバイオリアクター、並びに使い捨てバイオリアクターを構築する方法及び使用する方法 |
DE102014001615B3 (de) * | 2014-02-10 | 2015-05-28 | Yoen Ok Roth | Vorrichtung für die Kultivierung von adhärenten Zellen |
US10088398B2 (en) * | 2015-02-11 | 2018-10-02 | Emd Millipore Corporation | Stirred cell and method of using same |
CN104805013A (zh) * | 2015-05-25 | 2015-07-29 | 固元本草汉方生物科技股份有限公司 | 一次性气升式植物根部组织培养的反应器 |
USD804653S1 (en) | 2015-06-12 | 2017-12-05 | Emd Millipore Corporation | Pressure vessel |
KR102621101B1 (ko) | 2015-08-08 | 2024-01-05 | 스토베 게엠베하 | 생물학적 활동을 지원하는 일회용 생물 공정 시스템 |
US10323223B2 (en) * | 2016-01-22 | 2019-06-18 | Pbs Biotech, Inc. | Homogeneous cell dispensing mixer |
US11359172B2 (en) * | 2017-08-09 | 2022-06-14 | Sartorius Stedim Biotech Gmbh | Upstream and downstream processing within single-use containers |
JP7372912B2 (ja) | 2017-10-03 | 2023-11-01 | エイベック,インコーポレイテッド | 反応装置系 |
CA3029678A1 (en) * | 2018-01-26 | 2019-07-26 | Sentinel Biologics, Inc. | Apparatus for microorganism isolation, characterization, identification and methods of use thereof |
US10855064B2 (en) * | 2018-04-18 | 2020-12-01 | Tadpole Products, Llc | System for electronic doorframe |
NL2021470B1 (en) | 2018-08-15 | 2020-02-24 | Applikon Biotechnology B V | Lid configuration for a bioreactor |
EP3877504A2 (en) * | 2018-11-07 | 2021-09-15 | Bluebird Bio, Inc. | Cell therapy vessels |
DE102019115147B4 (de) * | 2019-06-05 | 2021-01-14 | Schott Ag | Biokompatibles Verbundelement und Verfahren zur Herstellung eines biokompatiblen Verbundelements |
US20220251492A1 (en) * | 2019-06-28 | 2022-08-11 | I Peace, Inc. | Cell culture vessel and cell culture device |
KR102383015B1 (ko) * | 2020-03-23 | 2022-04-05 | 프레스티지바이오로직스 주식회사 | 항체 의약품 제조 공정을 위한 하이브리드 무균 연결 시스템 및 무균 연결 방법 |
US20220017845A1 (en) * | 2020-07-15 | 2022-01-20 | Entegris, Inc. | Kit for installing impeller into process vessel |
CN112081576B (zh) * | 2020-09-14 | 2022-04-19 | 西南石油大学 | 一种基于plc控制的可视化连续加压反应装置 |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH02283274A (ja) * | 1989-04-24 | 1990-11-20 | Tetsuya Toge | 膜型細胞培養装置 |
JP2001522710A (ja) * | 1997-11-12 | 2001-11-20 | ダイアックス コーポレイション | クロマトグラフィカートリッジとのシール可能な連結をもたらすための装置および方法 |
JP2007522801A (ja) * | 2004-01-07 | 2007-08-16 | リーブテック,インコーポレイテッド | 一体のスパージャーとセンサー受け器を有する混合用袋 |
JP2007282629A (ja) * | 2006-03-23 | 2007-11-01 | Fujimori Kogyo Co Ltd | 培養袋及び培養器 |
JP2007534335A (ja) * | 2004-04-27 | 2007-11-29 | バクスター・インターナショナル・インコーポレイテッド | 攪拌タンク反応器システム |
JP2008501347A (ja) * | 2004-06-04 | 2008-01-24 | エクセラーエックス, インコーポレイテッド | 使い捨て可能なバイオリアクターシステムおよび方法 |
JP2008505650A (ja) * | 2004-07-12 | 2008-02-28 | ソリン・グループ・イタリア・ソシエタ・ア・レスポンサビリタ・リミタータ | ヒト細胞を増殖させるための装置及び方法 |
Family Cites Families (211)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3483089A (en) * | 1966-05-31 | 1969-12-09 | B D Lab Inc | Anaerobe jar closure assembly |
US3565973A (en) | 1967-11-14 | 1971-02-23 | Amicon Corp | Purifying cross-linked polyelectrolytes |
US3556302A (en) | 1969-01-06 | 1971-01-19 | Amicon Corp | Filtration apparatus having flow distributor |
US3632507A (en) | 1970-06-30 | 1972-01-04 | Standard Brands Chem Ind Inc | Flocculation of particles dispersed in aqueous media and flocculants used therein |
US3702806A (en) | 1970-09-03 | 1972-11-14 | William Emil Oliva | Disposable culture media container |
US3737377A (en) | 1971-01-27 | 1973-06-05 | Miles Lab | Purification of lactase |
GB1354349A (en) | 1971-10-12 | 1974-06-05 | Allied Colloids Mfg | Flocculating agents |
US3968037A (en) | 1972-09-01 | 1976-07-06 | Calgon Corporation | Emulsion polymerization of cationic monomers |
US4045377A (en) | 1975-10-20 | 1977-08-30 | Hercules Incorporated | Cationic polymer prepared from dicyandiamide, a polyamide, a dialkylamine, and an epoxide |
US4055469A (en) | 1976-12-10 | 1977-10-25 | Eastman Kodak Company | Purification of microbial enzyme extracts using synthetic polyelectrolytes |
FR2413974A1 (fr) | 1978-01-06 | 1979-08-03 | David Bernard | Sechoir pour feuilles imprimees par serigraphie |
US4188265A (en) | 1978-02-15 | 1980-02-12 | Almore International, Inc. | Portable incubator |
US4200695A (en) | 1978-09-19 | 1980-04-29 | Rohm And Haas Company | Flocs for filtration and deionization prepared from cationic and anionic emulsion ion exchange resins |
US4359537A (en) | 1978-09-19 | 1982-11-16 | Rohm And Haas Company | Emulsion copolymer anion exchange resins |
US4380590A (en) | 1978-09-19 | 1983-04-19 | Rohm And Haas Company | Emulsion copolymer cation exchange resins |
US4515893A (en) | 1979-04-26 | 1985-05-07 | Ortho Pharmaceutical Corporation | Hybrid cell line for producing complement-fixing monoclonal antibody to human T cells |
US4305829A (en) | 1979-06-29 | 1981-12-15 | Union Carbide Corporation | Process for flocculating an aqueous suspension of particles with quaternary ammonium graft copolymers |
DE2934854A1 (de) | 1979-08-29 | 1981-09-10 | Basf Ag, 6700 Ludwigshafen | Verfahren zur herstellung von stickstoffhaltigen kondensationsprodukten und deren verwendung |
CA1180827A (en) | 1982-03-23 | 1985-01-08 | Michael Heskins | Polymeric flocculants |
US4382028A (en) | 1982-07-19 | 1983-05-03 | Monsanto Company | Separation of plasma proteins from cell culture systems |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US4828701A (en) | 1983-08-25 | 1989-05-09 | Regents Of The University Of Minnesota | Temperature-sensitive method of size-selective extraction from solution |
US4634675A (en) | 1983-12-29 | 1987-01-06 | New Brunswick Scientific Co., Inc. | Agitator for a fermentation and tissue culturing vessel |
US4533496A (en) | 1984-05-08 | 1985-08-06 | Monsanto Company | Method of isolating monoclonal antibodies from hybridoma cultures |
US5672347A (en) | 1984-07-05 | 1997-09-30 | Genentech, Inc. | Tumor necrosis factor antagonists and their use |
US4649117A (en) | 1985-03-15 | 1987-03-10 | Hoffmann-La Roche Inc. | Air lift bioreactor |
US4780409A (en) | 1985-05-02 | 1988-10-25 | Genetic Systems Corporation | Thermally induced phase separation immunoassay |
US4904385A (en) | 1985-05-23 | 1990-02-27 | The Dow Chemical Company | Porous filter media and membrane support means |
US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
US4863613A (en) | 1985-10-25 | 1989-09-05 | Regents Of The University Of Minnesota | Soy protein isolation process using swellable poly(N-isopropylacrylamide) gels |
US5091178A (en) | 1986-02-21 | 1992-02-25 | Oncogen | Tumor therapy with biologically active anti-tumor antibodies |
US4925785A (en) | 1986-03-07 | 1990-05-15 | Biotechnica Diagnostics, Inc. | Nucleic acid hybridization assays |
US4912032A (en) | 1986-04-17 | 1990-03-27 | Genetec Systems Corporation | Methods for selectively reacting ligands immobilized within a temperature-sensitive polymer gel |
IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
US4839046A (en) | 1987-08-20 | 1989-06-13 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Bio-reactor chamber |
US5091313A (en) | 1988-08-05 | 1992-02-25 | Tanox Biosystems, Inc. | Antigenic epitopes of IgE present on B cell but not basophil surface |
US5720937A (en) | 1988-01-12 | 1998-02-24 | Genentech, Inc. | In vivo tumor detection assay |
US5429952A (en) | 1988-02-02 | 1995-07-04 | Biocode, Inc. | Marking of products to establish identity and source |
DE68919361T2 (de) | 1988-06-21 | 1995-05-24 | Genentech Inc | Therapeutische zusammensetzungen für die behandlung von myocard-infarkten. |
US4968435A (en) | 1988-12-19 | 1990-11-06 | American Cyanamid Company | Cross-linked cationic polymeric microparticles |
US5340865A (en) | 1988-12-19 | 1994-08-23 | Cytec Technology Corp. | Cross-linked cationic polyermic microparticles |
US6191242B1 (en) | 1988-12-19 | 2001-02-20 | Cytec Technology Corp. | Process for making high performance anionic polymeric flocculating agents |
US5152903A (en) | 1988-12-19 | 1992-10-06 | American Cyanamid Company | Cross-linked cationic polymeric microparticles |
MX18620A (es) | 1988-12-19 | 1993-10-01 | American Cyanamid Co | Floculante polimerico de alto desempeño, proceso para su preparacion, metodo para la liberacion de agua de un dispersion de solidos suspendidos y metodo de floculacion de una dispersion de solidos suspendidos |
US5354481A (en) | 1988-12-19 | 1994-10-11 | Cytec Technology Corp. | Water-soluble highly branched polymeric microparticles |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
US5003047A (en) | 1989-01-10 | 1991-03-26 | Massachusetts Institute Of Technology | Method for purifying biologically active ligate |
CA2062795A1 (en) | 1989-06-29 | 1990-12-30 | Michael W. Fanger | Bispecific reagents for aids therapy |
US5047511A (en) | 1989-08-28 | 1991-09-10 | Pitman-Moore, Inc. | Method for recovering recombinant proteins |
JPH03296657A (ja) | 1990-04-13 | 1991-12-27 | W R Grace & Co | 電気泳動用支持体およびそれを用いた電気泳動法 |
JPH046463A (ja) | 1990-04-16 | 1992-01-10 | W R Grace & Co | 液体クロマトグラフィー用担体およびそれを用いた液体クロマトグラフィー法 |
DE4103969A1 (de) | 1991-02-09 | 1992-08-13 | Basf Ag | Verfahren zur herstellung von feinteiligen, wasserloeslichen oder wasserquellbaren polymerisaten |
US5238545A (en) | 1991-02-27 | 1993-08-24 | W. R. Grace & Co.-Conn. | Electrophoretic gel for separation and recovery of substances and its use |
US5171450A (en) | 1991-03-20 | 1992-12-15 | Nalco Chemical Company | Monitoring and dosage control of tagged polymers in cooling water systems |
JPH06507398A (ja) | 1991-05-14 | 1994-08-25 | リプリジェン コーポレーション | Hiv感染治療のための異種複合抗体 |
WO1993004173A1 (en) | 1991-08-14 | 1993-03-04 | Genentech, Inc. | Immunoglobulin variants for specific fc epsilon receptors |
JPH06510448A (ja) | 1991-09-11 | 1994-11-24 | ザ ユニバーシティー オブ メルボルン | 静脈内薬剤注入方法 |
ES2097925T3 (es) | 1991-09-18 | 1997-04-16 | Affymax Tech Nv | Metodo para sintetizar diversas colecciones de oligomeros. |
WO1993008829A1 (en) | 1991-11-04 | 1993-05-13 | The Regents Of The University Of California | Compositions that mediate killing of hiv-infected cells |
US5525519A (en) | 1992-01-07 | 1996-06-11 | Middlesex Sciences, Inc. | Method for isolating biomolecules from a biological sample with linear polymers |
EP0625200B1 (en) | 1992-02-06 | 2005-05-11 | Chiron Corporation | Biosynthetic binding protein for cancer marker |
ATE140726T1 (de) | 1992-02-07 | 1996-08-15 | Monsanto Co | Biologische künstliche leber |
US5258122A (en) | 1992-04-16 | 1993-11-02 | Amicon, Inc. | Cross-flow filter device with pressure-balancing feature |
ATE159262T1 (de) | 1992-07-22 | 1997-11-15 | Hoechst Ag | Hydrophile zentren aufweisende polyvinylamin- derivate, verfahren zu ihrer herstellung sowie die verwendung der verbindungen als arzneimittel, wirkstoffträger und nahrungsmittelhilfsstoff |
AU687755B2 (en) | 1992-08-21 | 1998-03-05 | Genentech Inc. | Method for treating an LFA-1-mediated disorder |
US5736137A (en) | 1992-11-13 | 1998-04-07 | Idec Pharmaceuticals Corporation | Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma |
US5324787A (en) | 1992-11-18 | 1994-06-28 | Air Products And Chemicals, Inc. | Modification of poly (vinylamine) |
SE9300090D0 (sv) | 1993-01-14 | 1993-01-14 | Bo Gustav Mattiasson | Affinitetsrening med komplexbunden ligand |
US5374971A (en) * | 1993-03-12 | 1994-12-20 | Picturetel Corporation | Two-view video camera stand and support method |
US5840851A (en) | 1993-07-23 | 1998-11-24 | Plomer; J. Jeffrey | Purification of hemoglobin |
US5354801A (en) | 1993-08-12 | 1994-10-11 | Cytec Technology Corp. | Process for producing small polymer phase droplet microemulsions by multistep aqueous phase addition |
JP3507852B2 (ja) | 1993-12-10 | 2004-03-15 | ジェネンテク,インコーポレイテッド | アレルギー診断法および抗アレルギー性治療剤のスクリーニング法 |
WO1995019181A1 (en) | 1994-01-18 | 1995-07-20 | Genentech, Inc. | A METHOD OF TREATMENT OF PARASITIC INFECTION USING IgE ANTAGONISTS |
DE4406624A1 (de) | 1994-03-01 | 1995-09-07 | Roehm Gmbh | Vernetzte wasserlösliche Polymerdispersionen |
CA2181787A1 (en) | 1994-03-03 | 1995-09-08 | Claire M. Doerschuk | Anti-il-8 monoclonal antibodies for treatment of inflammatory disorders |
US5512480A (en) * | 1994-03-11 | 1996-04-30 | Baxter International Inc. | Flow-through bioreactor with grooves for cell retention |
TW474813B (en) | 1994-06-10 | 2002-02-01 | Geltex Pharma Inc | Alkylated composition for removing bile salts from a patient |
WO1996002577A1 (en) | 1994-07-18 | 1996-02-01 | Gel Sciences, Inc. | Responsive polymer gel beads |
US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
IL117645A (en) | 1995-03-30 | 2005-08-31 | Genentech Inc | Vascular endothelial cell growth factor antagonists for use as medicaments in the treatment of age-related macular degeneration |
US5573675A (en) | 1995-05-11 | 1996-11-12 | Nalco Chemical Company | Clarification of deinking process waters using polymers containing vinylamine |
WO1996040210A1 (en) | 1995-06-07 | 1996-12-19 | Imclone Systems Incorporated | Antibody and antibody fragments for inhibiting the growth of tumors |
US6267958B1 (en) | 1995-07-27 | 2001-07-31 | Genentech, Inc. | Protein formulation |
CA2230557A1 (en) | 1995-09-01 | 1997-03-13 | University Of Washington | Interactive molecular conjugates |
GB2305936B (en) | 1995-10-06 | 1997-09-03 | Jonathan William Lewis | Sterile, disposable culture vessels for the rapid growth of bacteria |
JPH09124697A (ja) | 1995-11-01 | 1997-05-13 | Toagosei Co Ltd | ペプチド及びモノクローナル抗体 |
US5879564A (en) | 1995-11-14 | 1999-03-09 | Cytec Technology Corp. | High performance polymer flocculating agents |
US5807489A (en) | 1995-11-14 | 1998-09-15 | Cytec Technology Corp. | High performance polymer flocculating agents |
ZA97248B (en) | 1996-01-18 | 1997-07-18 | Rohm & Haas | Method for identifying and quantifying polymers utilizing immunoassay techniques |
ES2183131T3 (es) | 1996-01-23 | 2003-03-16 | Genentech Inc | Anticuerpos anti-cd18 utilizados contra el ictus cerebral. |
EP0842184B1 (fr) | 1996-03-20 | 2003-01-29 | Bio Merieux | Isolement de l'acide nucleique |
FR2749082B1 (fr) | 1996-05-24 | 1998-06-26 | Bio Merieux | Particules superparamagnetiques et monodispersees |
US7147851B1 (en) | 1996-08-15 | 2006-12-12 | Millennium Pharmaceuticals, Inc. | Humanized immunoglobulin reactive with α4β7 integrin |
US5994560A (en) | 1996-08-29 | 1999-11-30 | Hoechst Celanese Corp. | Resolution of racemic mixtures using polymers containing chiral units |
PT950067E (pt) | 1996-11-27 | 2007-12-06 | Genentech Inc | Purificação por afinidade de um polipéptido numa matriz de proteína a. |
PT941344E (pt) | 1996-11-27 | 2004-10-29 | Genentech Inc | Anticorpos anti-cd11a humanizados |
WO1998033064A1 (fr) | 1997-01-24 | 1998-07-30 | Amersham Pharmacia Biotech K.K. | Procede de separation d'amino-acides pth |
US5942444A (en) | 1997-01-27 | 1999-08-24 | Biocode, Inc. | Marking of products to establish identity, source and fate |
CA2278630C (en) | 1997-01-29 | 2008-03-18 | Pall Corporation | Filtration assembly |
US5929214A (en) | 1997-02-28 | 1999-07-27 | Cornell Research Foundation, Inc. | Thermally responsive polymer monoliths |
ES2236634T3 (es) | 1997-04-07 | 2005-07-16 | Genentech, Inc. | Anticuerpos anti-vegf. |
ES2293682T5 (es) | 1997-05-15 | 2011-11-17 | Genentech, Inc. | Anticuerpo anti-apo2. |
US5994511A (en) | 1997-07-02 | 1999-11-30 | Genentech, Inc. | Anti-IgE antibodies and methods of improving polypeptides |
EP0922715B8 (en) | 1997-12-09 | 2008-05-21 | National Institute of Advanced Industrial Science and Technology | Stimuli-responsive polymer utilizing keto-enol tautomerization |
FR2773416B1 (fr) | 1998-01-06 | 2000-02-11 | Bio Merieux | Particules magnetiques perfectionnees, leurs procedes d'obtention et leurs utilisations dans la separation de molecules |
US6109780A (en) | 1998-01-22 | 2000-08-29 | S. P. Industries Inc. | Dynamic vortex impeller |
ATE420722T1 (de) | 1998-05-22 | 2009-01-15 | Cellseed Inc | Füllkörpermaterial für chromatographie mit neuen charakteristika und verfahren zur isolierung von substanzen unter verwendung desselben |
US6756217B1 (en) | 1998-05-29 | 2004-06-29 | Southern Illinois University | Glass composite materials containing alkoxosilane derivative having alterable charge, hydrophobic and hydrophilic groups |
DE59904017D1 (de) | 1998-06-02 | 2003-02-20 | Buechs Jochen | Anordnung zur kontinuierlichen Fermentation |
WO2000005261A1 (en) | 1998-07-21 | 2000-02-03 | Monsanto Company | Clarification of protein precipitate suspensions using anionic polymeric flocculants |
SE9802882D0 (sv) | 1998-08-28 | 1998-08-28 | Amersham Pharm Biotech Ab | Kompositmaterial och dess användning |
US6245555B1 (en) | 1998-09-01 | 2001-06-12 | The Penn State Research Foundation | Method and apparatus for aseptic growth or processing of biomass |
ES2293748T3 (es) | 1998-10-21 | 2008-03-16 | Altor Bioscience Corporation | Moleculas de fijacion poliespecificas y usos de las mismas. |
US6641735B1 (en) | 2000-03-23 | 2003-11-04 | Japan Chemical Innovation Institute | Separatory material with the use of stimulus-responsive polymer and separation method by using the separatory material |
US6454950B1 (en) | 1998-12-30 | 2002-09-24 | Amersham Pharmacia Biotech Ab | Separation method utilizing liquid-liquid partition |
FR2788008B1 (fr) | 1998-12-30 | 2001-03-23 | Inst Curie | Milieu thermosensible pour la separation electrocinetique d'especes au sein d'un canal de separation |
AU781633B2 (en) | 1999-01-29 | 2005-06-02 | Ge Healthcare Bio-Sciences Kk | Temperature-responsive polymer compound and process for producing the same |
SE9900378D0 (sv) | 1999-02-05 | 1999-02-05 | Forskarpatent I Syd Ab | Gels with shape memory |
US6565872B2 (en) | 1999-02-16 | 2003-05-20 | Xiao Yu Wu | Polymeric system for drug delivery and solute separation |
US6214221B1 (en) | 1999-02-22 | 2001-04-10 | Henry B. Kopf | Method and apparatus for purification of biological substances |
AU3867400A (en) | 1999-03-19 | 2000-10-09 | Duke University | Methods of using bioelastomers |
WO2000067901A1 (en) | 1999-05-11 | 2000-11-16 | Japan Chemical Innovation Institute | Affinity-controlling material with the use of stimulus-responsive polymer and separation/purification method with the use of the material |
US6946129B1 (en) | 1999-06-08 | 2005-09-20 | Seattle Genetics, Inc. | Recombinant anti-CD40 antibody and uses thereof |
US6211140B1 (en) | 1999-07-26 | 2001-04-03 | The Procter & Gamble Company | Cationic charge boosting systems |
DE60022762T2 (de) | 1999-07-29 | 2006-07-13 | National Institute Of Advanced Industrial Science And Technology | Polymerisierbare biotinderivate, bioptinpolymer und polymer, das auf stimulierung durch avidin reagiert |
GB9919187D0 (en) | 1999-08-14 | 1999-10-20 | Ciba Spec Chem Water Treat Ltd | Flocculation of cell material |
US6420487B1 (en) | 1999-09-08 | 2002-07-16 | Council Of Scientific And Industrial Research | Process for the preparation of thermoprecipitating affinity polymers |
US6294622B1 (en) | 1999-09-27 | 2001-09-25 | Ecole Polytechnique Federale De Lausanne (Epfl) | Polymer flocculants with improved dewatering characteristics |
US6258275B1 (en) | 1999-10-01 | 2001-07-10 | Ecole Polytechnique Federale De Lausanne | Affinity macroligands |
EP1226177B1 (en) | 1999-10-29 | 2008-07-09 | Genentech, Inc. | Anti-prostate stem cell antigen (psca) antibody compositions and methods of use |
US6544424B1 (en) | 1999-12-03 | 2003-04-08 | Refined Technology Company | Fluid filtration system |
WO2001074482A1 (fr) | 2000-04-05 | 2001-10-11 | Japan Chemical Innovation Institute | Nouveau materiau utilise pour la separation et procede de separation |
WO2002016571A1 (fr) | 2000-08-21 | 2002-02-28 | National Institute Of Advanced Industrial Science And Technology | Particules magnetiques ayant une temperature de solution critique de limite inferieure |
JP4969760B2 (ja) | 2000-08-21 | 2012-07-04 | 独立行政法人産業技術総合研究所 | ポリマー |
US7393698B2 (en) | 2000-08-21 | 2008-07-01 | National Institute Of Advanced Industrial Science And Technology | Magnetic fine particles and process for producing the same |
US6863437B2 (en) | 2000-08-23 | 2005-03-08 | National Institute Of Advanced Industrial Science And Technology | Temperature-responsive polymer/polymer complex |
JP5109003B2 (ja) | 2000-10-13 | 2012-12-26 | 岡野 光夫 | 刺激応答型アフィニティクロマトグラフィー材料等の分離材料および分離精製方法 |
US6605714B2 (en) | 2000-11-29 | 2003-08-12 | Council Of Scientific And Industrial Research | Thermoprecipitating polymer containing enzyme specific ligands, process for the preparation thereof, and use thereof for the separation of enzymes |
US6367749B2 (en) * | 2001-03-21 | 2002-04-09 | Southern Imperial, Inc. | Stand base |
GB0108548D0 (en) | 2001-04-05 | 2001-05-23 | Ciba Spec Chem Water Treat Ltd | Process for flocculating suspensions |
US7001953B2 (en) | 2001-04-16 | 2006-02-21 | Wsp Chemicals & Technology, Llc | Water-soluble polymer complexes |
WO2002092642A1 (de) | 2001-05-14 | 2002-11-21 | Polytag Technology Sa | Verfahren zur abtrennung von reversibel thermopräzipitierbaren oligomeren n-substituierten (meth)acrylamidverbindungen und deren konjugate |
GB0126923D0 (en) | 2001-11-09 | 2002-01-02 | Procter & Gamble | Chitosan compositions |
TWI288758B (en) | 2001-12-19 | 2007-10-21 | Ind Tech Res Inst | Thermal responsive, water-soluble polymers |
US6723245B1 (en) | 2002-01-04 | 2004-04-20 | Nalco Company | Method of using water soluble cationic polymers in membrane biological reactors |
US6998456B1 (en) | 2002-02-15 | 2006-02-14 | Iowa State University Research Foundation | pH-sensitive methacrylic copolymers and the production thereof |
AU2003233400A1 (en) | 2002-03-15 | 2003-09-29 | The Penn State Research Foundation | Method for control of temperature-sensitivity of polymers in solution |
EP1499383B1 (en) | 2002-04-26 | 2011-01-19 | Millipore Corporation | Disposable, sterile fluid transfer device |
DE10224352A1 (de) | 2002-06-01 | 2003-12-11 | Mueller Schulte Detlef | Thermosensitive Polymerträger mit veränderbarer physikalischer Struktur für die biochemische Analytik, Diagnostik und Therapie |
AU2003211701B2 (en) | 2002-06-21 | 2007-09-06 | Hymo Corporation | Water-soluble polymer dispersion, process for producing the same and method of use therefor |
US7442515B2 (en) | 2002-07-30 | 2008-10-28 | University Of Washington | Apparatus and methods for binding molecules and cells |
US7422724B1 (en) | 2002-08-07 | 2008-09-09 | Sandia Corporation | Biological preconcentrator |
SE0202552D0 (sv) | 2002-08-27 | 2002-08-27 | Amersham Biosciences Ab | Recovery of plasmids in an aqueous two-phase system |
US6837610B2 (en) * | 2002-09-27 | 2005-01-04 | Ilc Dover Lpp | Bioprocess container, bioprocess container mixing device and method of use thereof |
US6673598B1 (en) | 2002-10-29 | 2004-01-06 | Synthecon, Inc. | Disposable culture bag |
RS51318B (sr) | 2002-12-16 | 2010-12-31 | Genentech Inc. | Varijante imunoglobulina i njihova upotreba |
US7083948B1 (en) | 2002-12-24 | 2006-08-01 | Immunex Corporation | Polypeptide purification reagents and methods for their use |
TWI257928B (en) | 2002-12-27 | 2006-07-11 | Ind Tech Res Inst | Method for the separation of polysaccharides |
RU2337968C2 (ru) | 2003-01-09 | 2008-11-10 | Дженентек, Инк. | Способ очистки гетерологичного полипептида |
WO2004072258A2 (en) | 2003-02-11 | 2004-08-26 | University Of Washington | Stimuli-responsive polymer conjugates and related methods |
WO2004078968A1 (ja) | 2003-03-04 | 2004-09-16 | Hideko Kanazawa | 薬物代謝能評価システム及びその利用方法 |
SE0300791D0 (sv) | 2003-03-20 | 2003-03-20 | Amersham Biosciences Ab | Use of ph-responsive polymers |
US7153021B2 (en) | 2003-03-28 | 2006-12-26 | Hyclone Laboratories, Inc. | Container systems for mixing fluids with a magnetic stir bar |
EP1584633B1 (en) | 2003-04-01 | 2010-10-20 | Nitto Boseki Co., Ltd. | Modified polyallylamine and process for producing the same |
IL157086A0 (en) | 2003-07-24 | 2004-02-08 | Guy Patchornik | Multivalent ligand complexes |
US8486274B2 (en) | 2003-08-29 | 2013-07-16 | Newcastle Innovation Limited | Stimulant sensitive flocculation and consolidation |
US7377686B2 (en) | 2003-09-04 | 2008-05-27 | Millipore Corporation | Disposable mixing system |
JP4231759B2 (ja) | 2003-09-22 | 2009-03-04 | 株式会社日立メディアエレクトロニクス | 光情報記録装置 |
DE10350248A1 (de) | 2003-10-28 | 2005-06-16 | Magnamedics Gmbh | Thermosensitive, biokompatible Polymerträger mit veränderbarer physikalischer Struktur für die Therapie, Diagnostik und Analytik |
US7875448B2 (en) | 2004-01-12 | 2011-01-25 | Single Use Brx, Llc | Bioreactor systems and disposable bioreactor |
US20050282169A1 (en) | 2004-01-29 | 2005-12-22 | Turner Allen C | Signatory sequences |
CA2559527C (en) * | 2004-03-12 | 2015-11-24 | University Of Utah | Cyclone reactor and associated methods |
SE0400916D0 (sv) | 2004-04-05 | 2004-04-05 | Amersham Biosciences Ab | Polymeric ligands |
EP1856262B1 (en) | 2005-01-31 | 2012-08-15 | Merck Sharp & Dohme Corp. | Upstream and a downstream purification process for large scale production of plasmid dna |
EP1856528A2 (en) | 2005-02-10 | 2007-11-21 | Affisink Biotechnology Ltd. | Compositions and methods for purifying and crystallizing molecules of interest |
US8603805B2 (en) | 2005-04-22 | 2013-12-10 | Hyclone Laboratories, Inc. | Gas spargers and related container systems |
JP2006312117A (ja) | 2005-05-06 | 2006-11-16 | Canon Inc | 生理活性物質の分離用材料及びその製造方法 |
WO2006135673A2 (en) * | 2005-06-10 | 2006-12-21 | Nanologix, Inc. | Production of hydrogen gas and isolation of hydrogen producing microorganisms using replenishing coated substrates |
WO2006138143A1 (en) | 2005-06-15 | 2006-12-28 | Amprotein Corporation | Suspension culture vessels |
WO2007002690A2 (en) | 2005-06-24 | 2007-01-04 | William Marsh Rice University | Nano-encapsulated triggered-release viscosity breakers |
CA2625499A1 (en) | 2005-09-27 | 2007-04-05 | Lance Liotta | Method of isolating analytes from a sample |
WO2007050143A2 (en) | 2005-10-27 | 2007-05-03 | Applera Corporation | Surface modification in a manipulation chamber |
US8263343B2 (en) | 2005-12-22 | 2012-09-11 | Ge Healthcare Bio-Science Ab | Preparation of biomolecules |
EP1832341A1 (en) | 2006-03-10 | 2007-09-12 | MPG Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Highly efficient desalination and ion exchange using a thermoreversible polymer |
WO2007109584A1 (en) | 2006-03-16 | 2007-09-27 | University Of Washington | Temperature-and ph-responsive polymer compositions |
AU2007262448A1 (en) | 2006-04-14 | 2007-12-27 | Interface Biologics Incorporated | Grafted polymers and uses thereof |
EP2010573B1 (en) | 2006-04-24 | 2017-03-29 | Chemigate Oy | Cationic polysaccharide, its preparation and use |
KR100766444B1 (ko) | 2006-05-23 | 2007-10-11 | 주식회사 케이씨텍 | 슬릿 노즐의 폭방향 토출 균일도 측정 장치 및 방법 |
EP1873205A1 (en) | 2006-06-12 | 2008-01-02 | Corning Incorporated | Thermo-responsive blends and uses thereof |
US20100159508A1 (en) | 2006-07-06 | 2010-06-24 | Agency For Science, Technology And Research | Thermally responsive micelles |
US20080032396A1 (en) * | 2006-08-02 | 2008-02-07 | Becton, Dickinson And Company | Bioreactor and Method |
US7935518B2 (en) | 2006-09-27 | 2011-05-03 | Alessandra Luchini | Smart hydrogel particles for biomarker harvesting |
EP1923461A1 (en) | 2006-11-15 | 2008-05-21 | Millipore Corporation | A bioreactor |
US8057092B2 (en) | 2006-11-30 | 2011-11-15 | Corning Incorporated | Disposable spinner flask |
WO2008079302A2 (en) | 2006-12-21 | 2008-07-03 | Millipore Corporation | Purification of proteins |
US8569464B2 (en) | 2006-12-21 | 2013-10-29 | Emd Millipore Corporation | Purification of proteins |
US8362217B2 (en) | 2006-12-21 | 2013-01-29 | Emd Millipore Corporation | Purification of proteins |
US7947813B2 (en) | 2007-01-22 | 2011-05-24 | Genentech, Inc. | Polyelectrolyte precipitation and purification of proteins |
WO2008097154A1 (en) | 2007-02-09 | 2008-08-14 | Ge Healthcare Bio-Sciences Ab | Liquid clarification |
US7981688B2 (en) | 2007-03-08 | 2011-07-19 | University Of Washington | Stimuli-responsive magnetic nanoparticles and related methods |
US20080284163A1 (en) | 2007-05-15 | 2008-11-20 | Millipore Corporation | Connector for flexible tubing |
US8105493B2 (en) | 2007-06-29 | 2012-01-31 | Jnc Corporation | Aggregation and dispersion methods of magnetic particles, separation and detection methods using the same and detection kit |
US8915374B2 (en) | 2008-01-14 | 2014-12-23 | The University Of Melbourne | Flotation aids and processes for using the same |
GB0809404D0 (en) | 2008-05-23 | 2008-07-02 | Univ Sheffield | Method |
WO2009158606A2 (en) | 2008-06-27 | 2009-12-30 | Stc.Unm | Structure, synthesis, and applications for oligo phenylene ethynylenes |
JP2012511929A (ja) | 2008-12-16 | 2012-05-31 | イー・エム・デイー・ミリポア・コーポレイシヨン | 攪拌タンク反応器及び方法 |
US20110020327A1 (en) | 2008-12-16 | 2011-01-27 | Millipore Corporation | Purification of proteins |
AU2010205007A1 (en) | 2009-01-13 | 2011-07-07 | Ge Healthcare Bio-Sciences Ab | Precipitation of biomolecules with negatively charged polymers |
ES2521520T3 (es) | 2009-01-30 | 2014-11-12 | Solenis Technologies Cayman Lp | Polímeros que contienen vinilamina cuaternaria como aditivos en la fabricación de papel |
KR101551295B1 (ko) | 2010-05-17 | 2015-09-08 | 이엠디 밀리포어 코포레이션 | 생체분자 정제용 자극 반응성 중합체 |
EP2580349A2 (en) | 2010-06-08 | 2013-04-17 | EMD Millipore Corporation | Methods of detecting residual amounts of polymers used in the purification of biomolecules |
-
2009
- 2009-05-06 US US12/387,688 patent/US8999702B2/en active Active
- 2009-05-06 WO PCT/US2009/002787 patent/WO2009151514A1/en active Application Filing
- 2009-05-11 SG SG200903205-3A patent/SG158007A1/en unknown
- 2009-05-13 AU AU2009201890A patent/AU2009201890B2/en active Active
- 2009-05-28 KR KR1020090046849A patent/KR101386026B1/ko active IP Right Grant
- 2009-05-28 JP JP2009128573A patent/JP5281483B2/ja active Active
- 2009-06-04 ES ES09161982T patent/ES2808600T3/es active Active
- 2009-06-04 EP EP09161982.5A patent/EP2141224B1/en active Active
- 2009-06-10 CN CN2009101406384A patent/CN101724548B/zh active Active
-
2015
- 2015-04-02 US US14/677,670 patent/US20150210973A1/en not_active Abandoned
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH02283274A (ja) * | 1989-04-24 | 1990-11-20 | Tetsuya Toge | 膜型細胞培養装置 |
JP2001522710A (ja) * | 1997-11-12 | 2001-11-20 | ダイアックス コーポレイション | クロマトグラフィカートリッジとのシール可能な連結をもたらすための装置および方法 |
JP2007522801A (ja) * | 2004-01-07 | 2007-08-16 | リーブテック,インコーポレイテッド | 一体のスパージャーとセンサー受け器を有する混合用袋 |
JP2007534335A (ja) * | 2004-04-27 | 2007-11-29 | バクスター・インターナショナル・インコーポレイテッド | 攪拌タンク反応器システム |
JP2008501347A (ja) * | 2004-06-04 | 2008-01-24 | エクセラーエックス, インコーポレイテッド | 使い捨て可能なバイオリアクターシステムおよび方法 |
JP2008505650A (ja) * | 2004-07-12 | 2008-02-28 | ソリン・グループ・イタリア・ソシエタ・ア・レスポンサビリタ・リミタータ | ヒト細胞を増殖させるための装置及び方法 |
JP2007282629A (ja) * | 2006-03-23 | 2007-11-01 | Fujimori Kogyo Co Ltd | 培養袋及び培養器 |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2016534728A (ja) * | 2013-10-31 | 2016-11-10 | ハミルトン・ボナドゥウ・アーゲー | 細胞培養容器の蓋 |
JP2016059355A (ja) * | 2014-09-19 | 2016-04-25 | 株式会社ジェイ・エム・エス | 細胞培養容器 |
Also Published As
Publication number | Publication date |
---|---|
KR20090129330A (ko) | 2009-12-16 |
US8999702B2 (en) | 2015-04-07 |
ES2808600T3 (es) | 2021-03-01 |
CN101724548B (zh) | 2013-03-27 |
US20150210973A1 (en) | 2015-07-30 |
CN101724548A (zh) | 2010-06-09 |
WO2009151514A1 (en) | 2009-12-17 |
EP2141224B1 (en) | 2020-06-03 |
SG158007A1 (en) | 2010-01-29 |
US20090311776A1 (en) | 2009-12-17 |
EP2141224A1 (en) | 2010-01-06 |
AU2009201890A1 (en) | 2010-01-07 |
JP5281483B2 (ja) | 2013-09-04 |
AU2009201890B2 (en) | 2013-11-07 |
KR101386026B1 (ko) | 2014-04-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP5281483B2 (ja) | 撹拌タンクバイオリアクタ | |
CA3017434C (en) | A bioreactor system and method thereof | |
US8822208B2 (en) | Bioreactor and method | |
US20200296905A1 (en) | Methods and Systems for Culturing Microbial and Cellular See Cultures | |
US20100028990A1 (en) | Sterile bioreactor bag with integrated drive unit | |
US20180362909A1 (en) | Method for Using a Disposable Bioreactor | |
US20090269849A1 (en) | Bioreactor Apparatus | |
US20230082880A1 (en) | System and method for packaging a bioprocessing bag and associated components, and packaging for a bioprocessing bag | |
EP2986367B1 (en) | Flexible film baffle in single use bioreactor | |
US11708552B2 (en) | Multi-chamber bioreactor apparatus | |
US20240018453A1 (en) | Bioprocessing vessel having integral fluid conduit |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20111221 |
|
A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20121012 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20121023 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20130122 |
|
RD02 | Notification of acceptance of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7422 Effective date: 20130122 |
|
RD04 | Notification of resignation of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7424 Effective date: 20130227 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20130514 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20130524 |
|
R150 | Certificate of patent or registration of utility model |
Free format text: JAPANESE INTERMEDIATE CODE: R150 Ref document number: 5281483 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
S531 | Written request for registration of change of domicile |
Free format text: JAPANESE INTERMEDIATE CODE: R313531 |
|
R350 | Written notification of registration of transfer |
Free format text: JAPANESE INTERMEDIATE CODE: R350 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |