JP2008539713A5 - - Google Patents
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- Publication number
- JP2008539713A5 JP2008539713A5 JP2008509505A JP2008509505A JP2008539713A5 JP 2008539713 A5 JP2008539713 A5 JP 2008539713A5 JP 2008509505 A JP2008509505 A JP 2008509505A JP 2008509505 A JP2008509505 A JP 2008509505A JP 2008539713 A5 JP2008539713 A5 JP 2008539713A5
- Authority
- JP
- Japan
- Prior art keywords
- glp
- analogue
- leu10
- analog
- ala
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- TWSALRJGPBVBQU-PKQQPRCHSA-N glucagon-like peptide 2 Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(O)=O)[C@@H](C)CC)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)CC)C1=CC=CC=C1 TWSALRJGPBVBQU-PKQQPRCHSA-N 0.000 claims description 28
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 9
- 239000003814 drug Substances 0.000 claims description 9
- 238000011282 treatment Methods 0.000 claims description 9
- 208000035475 disorder Diseases 0.000 claims description 8
- 230000000968 intestinal effect Effects 0.000 claims description 8
- 238000004519 manufacturing process Methods 0.000 claims description 7
- 150000003839 salts Chemical class 0.000 claims description 7
- 102000016622 Dipeptidyl Peptidase 4 Human genes 0.000 claims description 6
- 101000930822 Giardia intestinalis Dipeptidyl-peptidase 4 Proteins 0.000 claims description 6
- 208000015943 Coeliac disease Diseases 0.000 claims description 5
- 208000004232 Enteritis Diseases 0.000 claims description 5
- 208000024891 symptom Diseases 0.000 claims description 5
- 206010049416 Short-bowel syndrome Diseases 0.000 claims description 4
- 230000002496 gastric effect Effects 0.000 claims description 4
- 208000011231 Crohn disease Diseases 0.000 claims description 3
- 206010012735 Diarrhoea Diseases 0.000 claims description 3
- 208000001132 Osteoporosis Diseases 0.000 claims description 3
- 230000006378 damage Effects 0.000 claims description 3
- 230000001404 mediated effect Effects 0.000 claims description 3
- 208000008190 Agammaglobulinemia Diseases 0.000 claims description 2
- 206010009900 Colitis ulcerative Diseases 0.000 claims description 2
- 208000007882 Gastritis Diseases 0.000 claims description 2
- 206010020983 Hypogammaglobulinaemia Diseases 0.000 claims description 2
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims description 2
- 208000004155 Malabsorption Syndromes Diseases 0.000 claims description 2
- 208000025865 Ulcer Diseases 0.000 claims description 2
- 201000006704 Ulcerative Colitis Diseases 0.000 claims description 2
- 208000002551 irritable bowel syndrome Diseases 0.000 claims description 2
- 208000011580 syndromic disease Diseases 0.000 claims description 2
- 206010044697 tropical sprue Diseases 0.000 claims description 2
- 231100000397 ulcer Toxicity 0.000 claims description 2
- 229940121355 glucagon like peptide 2 (glp-2) analogues Drugs 0.000 claims 13
- 150000007523 nucleic acids Chemical class 0.000 claims 7
- 238000006467 substitution reaction Methods 0.000 claims 7
- 239000013604 expression vector Substances 0.000 claims 6
- 108020004707 nucleic acids Proteins 0.000 claims 5
- 102000039446 nucleic acids Human genes 0.000 claims 5
- 230000002265 prevention Effects 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 101800000221 Glucagon-like peptide 2 Proteins 0.000 claims 3
- 102100040918 Pro-glucagon Human genes 0.000 claims 3
- 239000002246 antineoplastic agent Substances 0.000 claims 3
- 238000002512 chemotherapy Methods 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
- 238000001959 radiotherapy Methods 0.000 claims 3
- 208000002720 Malnutrition Diseases 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 230000001071 malnutrition Effects 0.000 claims 2
- 235000000824 malnutrition Nutrition 0.000 claims 2
- 208000015380 nutritional deficiency disease Diseases 0.000 claims 2
- 210000002784 stomach Anatomy 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- 208000004998 Abdominal Pain Diseases 0.000 claims 1
- 206010006895 Cachexia Diseases 0.000 claims 1
- 208000014540 Functional gastrointestinal disease Diseases 0.000 claims 1
- 206010059017 Intestinal mass Diseases 0.000 claims 1
- 206010047700 Vomiting Diseases 0.000 claims 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 150000001413 amino acids Chemical group 0.000 claims 1
- 208000022531 anorexia Diseases 0.000 claims 1
- 230000003796 beauty Effects 0.000 claims 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 1
- 230000004071 biological effect Effects 0.000 claims 1
- 201000007637 bowel dysfunction Diseases 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 206010061428 decreased appetite Diseases 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 230000029087 digestion Effects 0.000 claims 1
- 230000004064 dysfunction Effects 0.000 claims 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 230000002458 infectious effect Effects 0.000 claims 1
- 238000001802 infusion Methods 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 208000037817 intestinal injury Diseases 0.000 claims 1
- 210000004347 intestinal mucosa Anatomy 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 238000013268 sustained release Methods 0.000 claims 1
- 239000012730 sustained-release form Substances 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 231100000331 toxic Toxicity 0.000 claims 1
- 230000002588 toxic effect Effects 0.000 claims 1
- 125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 claims 1
- 230000008673 vomiting Effects 0.000 claims 1
- 241000252983 Caecum Species 0.000 description 1
- 206010025476 Malabsorption Diseases 0.000 description 1
- 210000004534 cecum Anatomy 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 230000003871 intestinal function Effects 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 208000001162 steatorrhea Diseases 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67806605P | 2005-05-04 | 2005-05-04 | |
| US60/678,066 | 2005-05-04 | ||
| PCT/GB2006/001633 WO2006117565A2 (en) | 2005-05-04 | 2006-05-04 | Glucagon-like-peptide-2 (glp-2) analogues |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013077830A Division JP5876434B2 (ja) | 2005-05-04 | 2013-04-03 | グルカゴン様ペプチド−２（ｇｌｐ−２）アナログ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008539713A JP2008539713A (ja) | 2008-11-20 |
| JP2008539713A5 true JP2008539713A5 (enExample) | 2012-04-19 |
| JP5405105B2 JP5405105B2 (ja) | 2014-02-05 |
Family
ID=36649773
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008509505A Active JP5405105B2 (ja) | 2005-05-04 | 2006-05-04 | グルカゴン様ペプチド−２（ｇｌｐ−２）アナログ |
| JP2013077830A Expired - Fee Related JP5876434B2 (ja) | 2005-05-04 | 2013-04-03 | グルカゴン様ペプチド−２（ｇｌｐ−２）アナログ |
| JP2015196105A Active JP6272284B2 (ja) | 2005-05-04 | 2015-10-01 | グルカゴン様ペプチド−２（ｇｌｐ−２）アナログ |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013077830A Expired - Fee Related JP5876434B2 (ja) | 2005-05-04 | 2013-04-03 | グルカゴン様ペプチド−２（ｇｌｐ−２）アナログ |
| JP2015196105A Active JP6272284B2 (ja) | 2005-05-04 | 2015-10-01 | グルカゴン様ペプチド−２（ｇｌｐ−２）アナログ |
Country Status (24)
| Country | Link |
|---|---|
| US (7) | US7563770B2 (enExample) |
| EP (4) | EP2295451A1 (enExample) |
| JP (3) | JP5405105B2 (enExample) |
| KR (3) | KR101200227B1 (enExample) |
| CN (2) | CN101171262B (enExample) |
| AT (1) | ATE498631T1 (enExample) |
| AU (1) | AU2006242998B2 (enExample) |
| BR (1) | BRPI0610091B1 (enExample) |
| CA (1) | CA2607150C (enExample) |
| CY (1) | CY1111411T1 (enExample) |
| DE (1) | DE602006020123D1 (enExample) |
| DK (1) | DK1877435T4 (enExample) |
| EA (1) | EA014184B1 (enExample) |
| ES (1) | ES2361095T5 (enExample) |
| IL (3) | IL186746A (enExample) |
| MX (1) | MX2007013431A (enExample) |
| NO (1) | NO345236B1 (enExample) |
| NZ (4) | NZ591179A (enExample) |
| PL (1) | PL1877435T5 (enExample) |
| PT (1) | PT1877435E (enExample) |
| SI (1) | SI1877435T2 (enExample) |
| UA (1) | UA95235C2 (enExample) |
| WO (1) | WO2006117565A2 (enExample) |
| ZA (2) | ZA200709384B (enExample) |
Families Citing this family (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6057287A (en) | 1994-01-11 | 2000-05-02 | Dyax Corp. | Kallikrein-binding "Kunitz domain" proteins and analogues thereof |
| ATE528014T1 (de) | 2002-06-07 | 2011-10-15 | Dyax Corp | Polypeptid mit modifizierten kunitz domains |
| US7153829B2 (en) | 2002-06-07 | 2006-12-26 | Dyax Corp. | Kallikrein-inhibitor therapies |
| EP1542710B1 (en) | 2002-08-28 | 2012-09-26 | Dyax Corp. | Methods for preserving organs and tissues |
| US7235530B2 (en) | 2004-09-27 | 2007-06-26 | Dyax Corporation | Kallikrein inhibitors and anti-thrombolytic agents and uses thereof |
| CN101171262B (zh) | 2005-05-04 | 2012-06-27 | 西兰制药公司 | 胰高血糖素样肽-2(glp-2)类似物 |
| WO2007106746A2 (en) * | 2006-03-10 | 2007-09-20 | Dyax Corp. | Formulations for ecallantide |
| ES2401299T5 (es) * | 2006-07-26 | 2016-04-06 | Sandoz Ag | Formulaciones de caspofungina |
| KR20090086060A (ko) * | 2006-09-12 | 2009-08-10 | 코스모 테크놀러지스 리미티드 | 단백질의 경구 또는 직장 투여를 위한 약학적 조성물 |
| NZ576260A (en) | 2006-11-08 | 2012-04-27 | Zealand Pharma As | GLUCAGON-LIKE-PEPTIDE-2 (GLP-2) ANALOGUES comprising one of more substitutions as compared to h[Gly2]GLP-2 |
| US20090004243A1 (en) | 2007-06-29 | 2009-01-01 | Pacetti Stephen D | Biodegradable triblock copolymers for implantable devices |
| KR20090035279A (ko) * | 2007-10-05 | 2009-04-09 | 경희대학교 산학협력단 | 위장관 손상 예방 및 치료용 조성물 |
| US20090110713A1 (en) * | 2007-10-31 | 2009-04-30 | Florencia Lim | Biodegradable polymeric materials providing controlled release of hydrophobic drugs from implantable devices |
| JP2013516389A (ja) | 2009-01-06 | 2013-05-13 | ダイアックス コーポレーション | カリクレイン阻害剤による粘膜炎治療 |
| CN101824087A (zh) * | 2009-03-05 | 2010-09-08 | 连云港恒邦医药科技有限公司 | 胰高血糖素样肽-2类似物及其制备方法和用途 |
| EP2314616A1 (en) * | 2009-10-23 | 2011-04-27 | Ferring B.V. | Peptidic GLP-2 agonists |
| ES2905545T3 (es) | 2010-01-06 | 2022-04-11 | Takeda Pharmaceuticals Co | Proteínas de unión a calicreína plasmática |
| EP2611825B1 (en) | 2010-08-30 | 2015-09-02 | NPS Pharmaceuticals, Inc. | Solid phase synthesis of h(gly2)glp-2 |
| IL269565B2 (en) | 2011-01-06 | 2024-06-01 | Dyax Corp | Plasma kallikrein binding proteins |
| CN102212127B (zh) * | 2011-05-17 | 2015-02-04 | 上海景泽生物技术有限公司 | 胰高血糖素样肽-2聚乙二醇结合物及其制备方法和用途 |
| CN102924589B (zh) * | 2011-08-11 | 2016-08-24 | 中肽生化有限公司 | 胰高血糖素样肽-2(glp-2)的类似物及其制备方法和用途 |
| PT2755675T (pt) | 2011-09-12 | 2018-10-11 | Amunix Operating Inc | Composições de péptido semelhante a glucagão-2 e métodos para produzir e utilizar as mesmas |
| KR101895047B1 (ko) | 2011-12-30 | 2018-09-06 | 한미사이언스 주식회사 | 면역글로불린 단편을 이용한 위치 특이적 글루카곤 유사 펩타이드-2 약물 결합체 |
| CN107496932A (zh) | 2012-02-27 | 2017-12-22 | 阿穆尼克斯运营公司 | Xten缀合组合物和制造其的方法 |
| CN104540850B (zh) | 2012-05-03 | 2018-05-18 | 西兰制药公司 | 胰高血糖素样肽2(glp-2)类似物 |
| US20150038674A1 (en) * | 2013-08-05 | 2015-02-05 | Bayrak Bertan Boran | Use of glp-2 analogues in pulmonary diseases for therapeutic purpose |
| EP3122782A4 (en) | 2014-03-27 | 2017-09-13 | Dyax Corp. | Compositions and methods for treatment of diabetic macular edema |
| US20160067311A1 (en) * | 2014-09-10 | 2016-03-10 | Helsinn Healthcare Sa | Use of elsiglutide to treat gastrointestinal mucositis including chemotherapy-induced diarrhea |
| US20170087216A1 (en) * | 2015-09-17 | 2017-03-30 | Helsinn Healthcare Sa | Therapeutic Uses of Elsiglutide |
| CN116077648A (zh) | 2015-12-11 | 2023-05-09 | 武田药品工业株式会社 | 血浆激肽释放酶抑制剂及其治疗遗传性血管性水肿发作的用途 |
| CN107987170B (zh) * | 2016-10-27 | 2018-12-18 | 浙江道尔生物科技有限公司 | 一种用于治疗肠道疾病的融合蛋白 |
| WO2018104558A1 (en) * | 2016-12-09 | 2018-06-14 | Zealand Pharma A/S | Acylated glp-1/glp-2 dual agonists |
| KR102587196B1 (ko) | 2016-12-09 | 2023-10-10 | 질랜드 파마 에이/에스 | Glp-1/glp-2 이중 효능제 |
| WO2018104559A1 (en) * | 2016-12-09 | 2018-06-14 | Zealand Pharma A/S | Glp-1/glp-2 dual agonists |
| CA3043151A1 (en) * | 2016-12-09 | 2018-06-14 | Zealand Pharma A/S | Acylated glp-1/glp-2 dual agonists |
| WO2018142363A1 (en) * | 2017-02-06 | 2018-08-09 | Orbicular Pharmaceutical Technologies Private Limited | Ready to use compositions of glp-2 analogues through self-administrable devices |
| EP4424362A3 (en) * | 2017-06-16 | 2024-11-27 | Zealand Pharma A/S | Dosage regimes for the administration of glucagon-like-peptide-2 (glp-2) analogues |
| CA3084326A1 (en) | 2017-09-28 | 2019-04-04 | Jaehyuk Choi | Long-acting conjugates of glp-2 derivatives |
| WO2019086559A1 (fr) | 2017-10-31 | 2019-05-09 | Adocia | Composition comprenant un agoniste du recepteur du glp-2 et un co-polyaminoacide porteur de charges carboxylates et de radicaux hydrophobes |
| WO2020020904A1 (en) | 2018-07-23 | 2020-01-30 | Zealand Pharma A/S | Therapeutic uses of glp-2 agonists |
| EP3628682A1 (en) | 2018-09-28 | 2020-04-01 | Zealand Pharma A/S | Formulations of glucagon-like-peptide-2 (glp-2) analogues |
| EP3628683A1 (en) * | 2018-09-28 | 2020-04-01 | Zealand Pharma A/S | Formulations of glucagon-like-peptide-2 (glp-2) analogues |
| WO2020165900A1 (en) * | 2019-02-11 | 2020-08-20 | Opko Biologics Ltd. | Long-acting glp-2 analogs |
| CN110305223B (zh) | 2019-06-26 | 2022-05-13 | 重庆派金生物科技有限公司 | 重组串联融合蛋白制备目标多肽的方法 |
| JP2022552655A (ja) | 2019-10-07 | 2022-12-19 | キャリーオペ，インク． | Ｇｐｒ１１９アゴニスト |
| PH12022552277A1 (en) | 2020-02-28 | 2024-03-04 | Kallyope Inc | Gpr40 agonists |
| EP4126004A1 (en) | 2020-03-30 | 2023-02-08 | Zealand Pharma A/S | Agonist combination |
| CA3173353A1 (en) * | 2020-04-03 | 2021-10-07 | Jin Bong Lee | Pharmaceutical composition for preventing or treating mucositis induced by radiotherapy, chemotherapy, or combination thereof, comprising glp-2 derivatives or long-acting conjugate of same |
| CA3178994A1 (en) | 2020-05-19 | 2021-11-25 | Iyassu Sebhat | Ampk activators |
| CN111560062A (zh) * | 2020-05-26 | 2020-08-21 | 成都圣诺生物制药有限公司 | 一种Elisiglutide的制备方法 |
| CN111560061A (zh) * | 2020-05-26 | 2020-08-21 | 成都圣诺生物制药有限公司 | 一种Gelpaglutide的制备方法 |
| IL298964A (en) | 2020-06-09 | 2023-02-01 | Vectivbio Ag | Manufacture, formulation and dosing of apraglutide |
| JP2023531726A (ja) | 2020-06-26 | 2023-07-25 | キャリーオペ，インク． | Ａｍｐｋアクチベーター |
| US20240091317A1 (en) | 2020-12-16 | 2024-03-21 | Zealand Pharma A/S | Use of glp-2 analogues in patients with renal insufficiency |
| CN116723850A (zh) * | 2020-12-16 | 2023-09-08 | 西兰制药公司 | Glp-1/glp-2双重激动剂的药物组合物 |
| AU2022289610A1 (en) | 2021-06-09 | 2024-01-25 | The Scripps Research Institute | Long-acting dual gip/glp-1 peptide conjugates and methods of use |
| CN115636876A (zh) * | 2021-07-20 | 2023-01-24 | 重庆派金生物科技有限公司 | 胰高血糖素样肽-2突变体的定向化学偶联物及其应用 |
| TW202327643A (zh) | 2021-09-10 | 2023-07-16 | 丹麥商西蘭製藥公司 | 包含類升糖素肽2(glp-2)類似物之組合物之調配方法 |
| JP2024544418A (ja) | 2021-12-23 | 2024-11-29 | ジーランド・ファルマ・アー／エス | グルカゴン様ペプチド２（ｇｌｐ－２）アナログを合成するためのプロセス |
| JP2025532701A (ja) | 2022-09-30 | 2025-10-01 | ジーランド・ファルマ・アー／エス | グルカゴン様ペプチド－２（ｇｌｐ－２）類似体および短腸症候群（ｓｂｓ）の治療のためのそれらの医学的使用 |
| TW202436330A (zh) | 2023-01-27 | 2024-09-16 | 丹麥商西蘭製藥公司 | 類升糖素胜肽-2(glp-2)類似物及其用於治療短腸症候群(sbs)之醫藥用途 |
| CN118005766B (zh) * | 2023-06-21 | 2024-09-27 | 杭州信海医药科技有限公司 | 一种Glepaglutide的固相合成方法 |
| WO2025141129A1 (en) | 2023-12-28 | 2025-07-03 | Zealand Pharma A/S | Formulations of glucagon-like-peptide 2 (glp-2) analogues and their uses |
| WO2025162422A1 (zh) * | 2024-01-31 | 2025-08-07 | 杭州先为达生物科技股份有限公司 | 胰高血糖素样肽2衍生物及其应用 |
| WO2025181330A1 (en) | 2024-02-29 | 2025-09-04 | Vectivbio Ag | Dosage regimens for glucagon-like peptide 2 (glp-2) analogs |
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